Gatikrushna Mishra
@krisgates03.bsky.social
BS-MS @IISER TVM
Master's student at the Chavhan Lab for Understanding Evolution.
Trying to be better at stuff😄
🤔: Evolution. Multicellularity. Evo-Devo, Phenotypic Plasticity. Bio(phy/chem), Collectivity.
😌: Sci-Comm. Events. Quiz. Writing. Music. Movies
Master's student at the Chavhan Lab for Understanding Evolution.
Trying to be better at stuff😄
🤔: Evolution. Multicellularity. Evo-Devo, Phenotypic Plasticity. Bio(phy/chem), Collectivity.
😌: Sci-Comm. Events. Quiz. Writing. Music. Movies
After a small break we resumed with day 7 of Darwinter 2025. Anuraag presented a 2013 paper about how phages try to evolve as generalists and expand their host range over time, a paper by @lisabono.bsky.social
Day 6 of Darwinter 2025. We discussed a preprint by @wcratcliff.bsky.social about costs of germ-soma differentiation, its relation to organismal size and developmental time, and what condition could drive the selection for higher organismal size given somatic cells exist. Presenter:Jyotishko, Intern
December 23, 2025 at 10:00 AM
After a small break we resumed with day 7 of Darwinter 2025. Anuraag presented a 2013 paper about how phages try to evolve as generalists and expand their host range over time, a paper by @lisabono.bsky.social
Reposted by Gatikrushna Mishra
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!
pubs.acs.org/doi/full/10....
pubs.acs.org/doi/full/10....
Reposted by Gatikrushna Mishra
🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
December 9, 2025 at 5:08 PM
🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Fisher's Fishes, a local yet all India theoretical bio student collective in India has arranged for the IgNobel Talk about the phase behaviour of cacio e pepe sauce. Join in on 17th December at 7 pm IST | 2:30 PM CET | 8 AM EST.
Excited for this Ignobel talk organized by @fishersfishes.bsky.social!!
You can join here: northeastern.zoom.us/j/9832742702...
And shoutout to this lovely poster by Meyvizhi :)
You can join here: northeastern.zoom.us/j/9832742702...
And shoutout to this lovely poster by Meyvizhi :)
December 16, 2025 at 12:30 AM
Fisher's Fishes, a local yet all India theoretical bio student collective in India has arranged for the IgNobel Talk about the phase behaviour of cacio e pepe sauce. Join in on 17th December at 7 pm IST | 2:30 PM CET | 8 AM EST.
Day 6 of Darwinter 2025. We discussed a preprint by @wcratcliff.bsky.social about costs of germ-soma differentiation, its relation to organismal size and developmental time, and what condition could drive the selection for higher organismal size given somatic cells exist. Presenter:Jyotishko, Intern
December 15, 2025 at 2:43 PM
Day 6 of Darwinter 2025. We discussed a preprint by @wcratcliff.bsky.social about costs of germ-soma differentiation, its relation to organismal size and developmental time, and what condition could drive the selection for higher organismal size given somatic cells exist. Presenter:Jyotishko, Intern
Reposted by Gatikrushna Mishra
It is amazing that @dudinlab.bsky.social beautiful #ExM composition has been selected to highlight our #6mA work for the cover of @natgenet.nature.com. #Protists (and ichthyosporeans in particular) in the cover of NG must be quite unique!
December 11, 2025 at 11:59 AM
It is amazing that @dudinlab.bsky.social beautiful #ExM composition has been selected to highlight our #6mA work for the cover of @natgenet.nature.com. #Protists (and ichthyosporeans in particular) in the cover of NG must be quite unique!
Reposted by Gatikrushna Mishra
Interested in cell adhesion, evolution of multicellularity, or developing tools for emerging marine models?
My lab at UM is hiring a postdoc, and the application is now open:
🔗 tinyurl.com/28jvu4aa
If you know anyone looking for a postdoc, please pass this along!
My lab at UM is hiring a postdoc, and the application is now open:
🔗 tinyurl.com/28jvu4aa
If you know anyone looking for a postdoc, please pass this along!
December 8, 2025 at 6:37 PM
Interested in cell adhesion, evolution of multicellularity, or developing tools for emerging marine models?
My lab at UM is hiring a postdoc, and the application is now open:
🔗 tinyurl.com/28jvu4aa
If you know anyone looking for a postdoc, please pass this along!
My lab at UM is hiring a postdoc, and the application is now open:
🔗 tinyurl.com/28jvu4aa
If you know anyone looking for a postdoc, please pass this along!
4th day of Darwinter 2025. We discussed a paper by our PI @yashrajchavhan.bsky.social The paper was about how population size can shape trade off dilutions and adaptation to a marginal niche unconstrained by sympatric habitual conditions. Paper was presented by Akash P, an intern in the lab.
December 13, 2025 at 2:54 AM
4th day of Darwinter 2025. We discussed a paper by our PI @yashrajchavhan.bsky.social The paper was about how population size can shape trade off dilutions and adaptation to a marginal niche unconstrained by sympatric habitual conditions. Paper was presented by Akash P, an intern in the lab.
3rd day of Darwinter 2025. We discussed a paper on Trait and Plasticity Evolution in mutualistic and competitive interactions. The discussion was moderated by Harini, an IPhD student.
December 12, 2025 at 8:43 AM
3rd day of Darwinter 2025. We discussed a paper on Trait and Plasticity Evolution in mutualistic and competitive interactions. The discussion was moderated by Harini, an IPhD student.
After discussing how multicellularity can be clonal, Aggregative or mixed depending on the salinity levels and starting cell density in C. flexa, we moved forward to understand how metabolic constraints can shape spatial organisation in clusters.
Presenter: Anjali B
@yashrajchavhan.bsky.social
Presenter: Anjali B
@yashrajchavhan.bsky.social
December 10, 2025 at 1:00 PM
After discussing how multicellularity can be clonal, Aggregative or mixed depending on the salinity levels and starting cell density in C. flexa, we moved forward to understand how metabolic constraints can shape spatial organisation in clusters.
Presenter: Anjali B
@yashrajchavhan.bsky.social
Presenter: Anjali B
@yashrajchavhan.bsky.social
We have started Darwinter, a winter paper seminar at the Chavhan Lab for Understanding Evolution. Lab members and interns choose a recent interesting work or a seminal paper revolving around the research done in our lab and present it. I started with the C. flexa paper by @thibautbrunet.bsky.social
December 10, 2025 at 5:30 AM
We have started Darwinter, a winter paper seminar at the Chavhan Lab for Understanding Evolution. Lab members and interns choose a recent interesting work or a seminal paper revolving around the research done in our lab and present it. I started with the C. flexa paper by @thibautbrunet.bsky.social
Reposted by Gatikrushna Mishra
1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
The fitness costs of reproductive specialization scale inversely with organismal size
The evolution of reproductive specialization represents a fundamental innovation in multicellular life, yet the conditions favoring its evolution remain poorly understood. Here, we develop a populatio...
www.biorxiv.org
December 9, 2025 at 7:44 PM
1/28 New preprint up, which I think is the best theoretical idea I've ever had. We asked a simple question: what are the costs of investment into non-reproductive somatic cells? Turns out these costs decrease with the *logarithm* of organism size!
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Gatikrushna Mishra
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
An archaeal genetic code with all TAG codons as pyrrolysine
Multiple genetic codes developed during the evolution of eukaryotes and bacteria, yet no alternative genetic code is known for archaea. We used proteomics to confirm our prediction that certain archae...
scim.ag
November 25, 2025 at 8:24 PM
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. https://scim.ag/4omApQ7
Reposted by Gatikrushna Mishra
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
November 25, 2025 at 8:41 PM
So happy to announce our new preprint, “A geothermal amoeba sets a new upper temperature limit for eukaryotes.” We cultured a novel amoeba from Lassen Volcanic NP (CA, USA) that divides at 63°C (145°F) 🔥 - a new record for euk growth!
#protistsonsky 🧵
#protistsonsky 🧵
Reposted by Gatikrushna Mishra
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
December 2, 2025 at 1:12 PM
New preprint from our lab www.biorxiv.org/content/10.1...! Andrea Dos Santos and Clément Vulin combine experiments and models showing how adding glucose can strengthen negative interactions between microbial species. This can be used in tandem with antibiotic treatment to inhibit pathogens!
Reposted by Gatikrushna Mishra
Tony Burnetti and I recorded this super fun podcast in which we rank evolution's craziest adaptations. I think it turned out great! I might make this an exercise for one of my final evolution lectures next time I teach (dynamically rank / debate in class!).
www.youtube.com/watch?v=JSum...
www.youtube.com/watch?v=JSum...
Ranking Evolution’s Most Outrageous Survival Strategies! Tier List
YouTube video by Giant's Shoulder
www.youtube.com
December 2, 2025 at 7:38 PM
Tony Burnetti and I recorded this super fun podcast in which we rank evolution's craziest adaptations. I think it turned out great! I might make this an exercise for one of my final evolution lectures next time I teach (dynamically rank / debate in class!).
www.youtube.com/watch?v=JSum...
www.youtube.com/watch?v=JSum...
#ThursdayThoughts I will never understand the hate theoretical biophysicists have for students with a biology background trying to do theory. "You will never be able to do theory," is something I have heard very often from them.
November 27, 2025 at 12:20 PM
#ThursdayThoughts I will never understand the hate theoretical biophysicists have for students with a biology background trying to do theory. "You will never be able to do theory," is something I have heard very often from them.
Reposted by Gatikrushna Mishra
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
November 20, 2025 at 11:42 AM
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji.
It ships many new features, detailed below, but that are articulated around the following:
It ships many new features, detailed below, but that are articulated around the following:
Reposted by Gatikrushna Mishra
Dang, hard disagree. The best papers to write and read are works of art, not merely a list of data and statements.
Don’t let LLMs take this away too, for gods sake.
Don’t let LLMs take this away too, for gods sake.
I honestly think we would all be a lot more productive if papers were bullet points with plots.
November 14, 2025 at 10:22 PM
Dang, hard disagree. The best papers to write and read are works of art, not merely a list of data and statements.
Don’t let LLMs take this away too, for gods sake.
Don’t let LLMs take this away too, for gods sake.
Reposted by Gatikrushna Mishra
Interesting cancer grand challenges just announced. Funders looking for interdisciplinary & international teams. I'm an outsider, but fascinated that some of them have clear eco-evo cell-population dynamical component.
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
Cancer Grand Challenges Announces Seven New Challenges Representing Some of the Toughest Questions Facing Cancer Research Today
BOSTON, March 05, 2025--Cancer Grand Challenges announces seven new challenges representing some of the toughest questions facing cancer research today.
finance.yahoo.com
March 5, 2025 at 3:58 PM
Interesting cancer grand challenges just announced. Funders looking for interdisciplinary & international teams. I'm an outsider, but fascinated that some of them have clear eco-evo cell-population dynamical component.
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
finance.yahoo.com/news/cancer-...
@cancergrand.bsky.social @cancerresearchuk.org
Reposted by Gatikrushna Mishra
Do you want to #model quantitative trait #evolution? Do you like #SPDEs? Happy to say my first solo author paper, now out in Theoretical Population Biology, is about just this! Check it out here:
www.sciencedirect.com/science/arti...
I'm super proud of this y'all :')
#scisky 🧪 🧬 #mathsky #physics
www.sciencedirect.com/science/arti...
I'm super proud of this y'all :')
#scisky 🧪 🧬 #mathsky #physics
December 3, 2024 at 7:19 PM
Do you want to #model quantitative trait #evolution? Do you like #SPDEs? Happy to say my first solo author paper, now out in Theoretical Population Biology, is about just this! Check it out here:
www.sciencedirect.com/science/arti...
I'm super proud of this y'all :')
#scisky 🧪 🧬 #mathsky #physics
www.sciencedirect.com/science/arti...
I'm super proud of this y'all :')
#scisky 🧪 🧬 #mathsky #physics
Reposted by Gatikrushna Mishra
What if, instead of sampling hundreds of phages, we could just make the right ones glow? Enter Phage Discovery by Co-culture (Phage DisCo)! Simply, this method combines two strains: a wildtype and a modified strain, each fluorescently tagged. Now, fluorescent signal will mark plaques of interest. 3/
November 23, 2024 at 6:16 PM
What if, instead of sampling hundreds of phages, we could just make the right ones glow? Enter Phage Discovery by Co-culture (Phage DisCo)! Simply, this method combines two strains: a wildtype and a modified strain, each fluorescently tagged. Now, fluorescent signal will mark plaques of interest. 3/
Reposted by Gatikrushna Mishra
Phages! At the Disco!
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
November 23, 2024 at 6:34 PM
Phages! At the Disco!
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Here's Ellie (the first author's) thread on our new preprint on how to discover weird new phages using glowing bacteria:
Reposted by Gatikrushna Mishra
I recently resurrected my website and added a space for me to dump all my harebrained ideas out into the void in case someone else with more free time stumbles upon them and wants a free harebrained idea. Anyway, here's one. magaro.net/cressida/por...
June 22, 2024 at 3:05 AM
I recently resurrected my website and added a space for me to dump all my harebrained ideas out into the void in case someone else with more free time stumbles upon them and wants a free harebrained idea. Anyway, here's one. magaro.net/cressida/por...
Reposted by Gatikrushna Mishra
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
November 13, 2024 at 12:46 PM
Incredible graphic - the myriad of ways that bacteria defend themselves against antibiotics.
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...
14 resistance mechanisms, summarised by Idan Yelin & Roy Kishony in Cell
www.sciencedirect.com/science/arti...