So proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍

The mighty yeast reveals what we believe are general principles of centromere evolution!

Behind the curtain: communities.springernature.com/posts/counti...

#MEvoSky 🧪🌎

How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1

Now published on @plos.org Computational Biology!

Same findings as the preprint, with improved analyses suggested by reviewers!

Check it out and let us know how RepliFlow works for you!

journals.plos.org/ploscompbiol...

I'm curious if other mid career PIs have considered completely abandoning the trad publication model. We've been making gradual moves towards that end goal. But it's been difficult to completely jump ship for one main reason for me at least. 1/

I’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵

doi.org/10.1101/2025...

A thread 👇

how (yeast) cells re-climb the fitness landscape when they are reprogrammed to a different telomere DNA sequences (human-like)? read the latest from @melaniadangiolo.bsky.social etal , with great help and insights from Eric Gilson, Jonas Warringer and @juliamuenzner.bsky.social (& Ralser lab)

@mariananatalin6.bsky.social @marcofumasoni.bsky.social show evolutionary repair in response to DNA replication stress in yeast is predictable and consistent across different environments #CompensatoryEvolution #NutrientAvailability #ReplicationStress #GxE ➡️ www.embopress.org/doi/full/10....

📢 New paper out in Mol Syst Biol!
During the development of WT yeast colonies, small cell subpopulations experience transient, high-intensity mutational bursts. Such hypermutation episodes are modulated by the DNA damage tolerance pathway 🧬
🔗 www.embopress.org/doi/full/10....

Superhappy to share the last paper from my PhD in @litinice.bsky.social lab. We evolved yeasts with humanized telomeric repeats and discovered that they adapt through amplification of telomere-binding proteins and inactivation of the DNA damage response.

www.biorxiv.org/content/10.1...

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...

Happy to be the next (and 1st female) @crg.eu director. The CRG always stood out to me, for its excellence in understanding life's principles, with implications for health and biodiversity, & its collaborative, open and innovative way of doing science. Thrilled to join its amazing community in 2026!

The work of brilliant PhD student @mariananatalin6.bsky.social is now out in @molsystbiol.org! We asked how nutrients shape compensatory evolution to DNA replication stress. We find changes in physiology and adaptation rates, yet core genetic adaptation remains robust! See her thread for details!👇

This is wild. Chromosome distributions into different nuclei!

Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
www.science.org/doi/10.1126/...

🔬 Just like species evolve to survive, tumours adapt to resist treatment.

A new computational tool reveals how cancers rewire driver genes to beat chemotherapy.

Published in @natcomms.nature.com
Read the news ➡️ bit.ly/43tyKko

#CancerResearch #Genomics #ComputationalBiology #DrugResistance
⬇️

And just like that, overnight our lab loses two 5-year R01s (both of which just started) because of the new NIH rules about foreign co-PIs. This is so painful.

🗞️New preprint out! Together with Adolfo Alsina and Pablo Sartori (both not on here), we combined experiments and theory to extract detailed information on DNA replication dynamics from simple DNA content flow cytometry data.
www.biorxiv.org/content/10.1...

Postdoctoral fellow position in the Genome Maintenance and Evolution lab @ jobrxiv.org/job/inst... #ScienceJobs #AcademicSky

🎺Please RT! We have a funded #Postdocposition in our lab at @IGCiencia in Portugal 🇵🇹🇪🇺! Come and join us in exploring the wonders and evolution of genome maintenance processes, and engage with the extended #LifeScience community in #Lisbon! Details here: fumalab.github.io/join

The strain on scientific publishing 📄:

We've got issues. Scientists overwhelmed, editors overworked, constant special issue invites, mass article retractions, journal delistings… JUST WHAT IS GOING ON!?

See: arxiv.org/abs/2309.15884

A 🧵1/n
#AcademicChatter #PublishOrPerish #PhDAdvice #PhDChat