Klebanoff Lab
@klebanofflab.bsky.social
A translational research lab @mskcancercenter.bsky.social focused on the immunobiology and therapeutic potential of genetically engineered #Tcells and #TCRs. Est. 2016 @NYC
Reposted by Klebanoff Lab
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
August 12, 2025 at 5:09 PM
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Klebanoff Lab
📢New Article published at Nature Cancer!
✒️By Christopher Klebanoff and colleagues
'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit'
🔗 www.nature.com/articles/s43...
✒️By Christopher Klebanoff and colleagues
'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit'
🔗 www.nature.com/articles/s43...
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit - Nature Cancer
Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS signaling enhances their an...
www.nature.com
July 30, 2025 at 11:51 AM
📢New Article published at Nature Cancer!
✒️By Christopher Klebanoff and colleagues
'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit'
🔗 www.nature.com/articles/s43...
✒️By Christopher Klebanoff and colleagues
'CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit'
🔗 www.nature.com/articles/s43...
Reposted by Klebanoff Lab
MSK’s @klebanofflab.bsky.social and team found that FAS ligand, which hampers #CAR-T and #CAR-NK therapies, is actually produced by immune cells themselves.
Cellular Immunotherapies Carry Seeds of Self-Destruction but Can Be Rescued With Genetic Engineering
Read about a new discovery that could lead to more powerful cell-based therapies for cancer.
www.mskcc.org
July 28, 2025 at 3:07 PM
MSK’s @klebanofflab.bsky.social and team found that FAS ligand, which hampers #CAR-T and #CAR-NK therapies, is actually produced by immune cells themselves.
Reposted by Klebanoff Lab
Complete tumor eradication with cell therapies depends on persistence of donor CAR-cells in the patient
@klebanofflab.bsky.social show that deletion of Fas on donor CAR-T/CAR-NK improves persistence in FasL-dependent (host NK & T) manner @natcancer.nature.com
www.nature.com/articles/s43...
@klebanofflab.bsky.social show that deletion of Fas on donor CAR-T/CAR-NK improves persistence in FasL-dependent (host NK & T) manner @natcancer.nature.com
www.nature.com/articles/s43...
July 24, 2025 at 8:27 PM
Complete tumor eradication with cell therapies depends on persistence of donor CAR-cells in the patient
@klebanofflab.bsky.social show that deletion of Fas on donor CAR-T/CAR-NK improves persistence in FasL-dependent (host NK & T) manner @natcancer.nature.com
www.nature.com/articles/s43...
@klebanofflab.bsky.social show that deletion of Fas on donor CAR-T/CAR-NK improves persistence in FasL-dependent (host NK & T) manner @natcancer.nature.com
www.nature.com/articles/s43...
🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social
CAR-engineered lymphocyte persistence is governed by a FAS ligand–FAS autoregulatory circuit
Nature Cancer - Klebanoff and colleagues report that survival and persistence of CAR-T and CAR-NK cells are regulated by a FAS ligand–FAS autoregulatory circuit, showing that disabling FAS...
rdcu.be
July 23, 2025 at 8:39 PM
🚨Today, in #NatureCancer, we show that #CAR-T cells and #CAR-NK cells contain the seeds of their own self-destruction. Disruption of a FAS-L/FAS enhances CAR potency against liquid and solid cancers. rdcu.be/exjEy. @mskcancercenter.bsky.social @parkerici.bsky.social
Reposted by Klebanoff Lab
MSK physician-scientist Dr. Christopher Klebanoff talked about all things #neoantigens for the Novel Classes of Human Cancer Rejection Antigens session this morning at #AACR25.
April 29, 2025 at 4:58 PM
MSK physician-scientist Dr. Christopher Klebanoff talked about all things #neoantigens for the Novel Classes of Human Cancer Rejection Antigens session this morning at #AACR25.
Reposted by Klebanoff Lab
This is part of a long-standing collaboration with Rob Bradley’s lab
@fredhutch.bsky.social and with amazing TCR discovery expertise from Chris Klebanoff’s lab @klebanofflab.bsky.social @mskcancercenter.bsky.social. Also incredible help from Jeff Molldrem @mdanderson.bsky.social
@fredhutch.bsky.social and with amazing TCR discovery expertise from Chris Klebanoff’s lab @klebanofflab.bsky.social @mskcancercenter.bsky.social. Also incredible help from Jeff Molldrem @mdanderson.bsky.social
April 23, 2025 at 8:30 PM
This is part of a long-standing collaboration with Rob Bradley’s lab
@fredhutch.bsky.social and with amazing TCR discovery expertise from Chris Klebanoff’s lab @klebanofflab.bsky.social @mskcancercenter.bsky.social. Also incredible help from Jeff Molldrem @mdanderson.bsky.social
@fredhutch.bsky.social and with amazing TCR discovery expertise from Chris Klebanoff’s lab @klebanofflab.bsky.social @mskcancercenter.bsky.social. Also incredible help from Jeff Molldrem @mdanderson.bsky.social