Abdel-Wahab Lab, MSKCC
@oawlab.bsky.social
We are a cancer genetics lab studying functional genomics of blood cancers. We have a special interest in altered RNA processing in cancer.
Excited to announce a new publication from our @mskcancercenter.bsky.social Histiocytosis group identifying a predictor for impaired response to MEK inhibition in histiocytosis patients and potential for ERK inhibition. Out today in @Cancer_Cell.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition
Histiocytic neoplasms are clonal disorders of the monocyte/macrophage lineage defined by mutations activating mitogen-activated protein kinase (MAPK) …
www.sciencedirect.com
October 23, 2025 at 3:26 PM
Excited to announce a new publication from our @mskcancercenter.bsky.social Histiocytosis group identifying a predictor for impaired response to MEK inhibition in histiocytosis patients and potential for ERK inhibition. Out today in @Cancer_Cell.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
August 12, 2025 at 5:09 PM
Excited to announce a new paper in @aacrjournals.bsky.social with Junwei Shi and Tony Daniyan. We perform screens of GAPs and GEFs in AML and discover a hematopoietic-specific GAP (ARHGAP45) required in a variety of hematologic malignancies:
aacrjournals.org/cancerdiscov...
aacrjournals.org/cancerdiscov...
Reposted by Abdel-Wahab Lab, MSKCC
Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Evaluation of GAPs & GEFs Identifies a Targetable Dependency for Hematopoietic Malignancies - by Pu Zhang, Zhendong Cao, Anthony Daniyan, Omar Abdel-Wahab, Junwei Shi, et al. doi.org/10.1158/2159...
August 12, 2025 at 4:06 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Systematic Evaluation of GAPs & GEFs Identifies a Targetable Dependency for Hematopoietic Malignancies - by Pu Zhang, Zhendong Cao, Anthony Daniyan, Omar Abdel-Wahab, Junwei Shi, et al. doi.org/10.1158/2159...
Excited to announce our annual New York City Edward P. Evans MDS Centers Symposium across @mskcancercenter.bsky.socia & @columbiacancer.bsky.social. This year to be held at @mskcancercenter.bsky.socia. See this flyer below and register here:
forms.fillout.com/t/1wX3dGmym4us
forms.fillout.com/t/1wX3dGmym4us
May 3, 2025 at 12:27 PM
Excited to announce our annual New York City Edward P. Evans MDS Centers Symposium across @mskcancercenter.bsky.socia & @columbiacancer.bsky.social. This year to be held at @mskcancercenter.bsky.socia. See this flyer below and register here:
forms.fillout.com/t/1wX3dGmym4us
forms.fillout.com/t/1wX3dGmym4us
Excited to announce a new paper out today in @cp-cell.bsky.social discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
ScienceDirect.com | Science, health and medical journals, full text articles and books.
authors.elsevier.com
April 23, 2025 at 8:30 PM
Excited to announce a new paper out today in @cp-cell.bsky.social discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients.
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...