Ira 'Bluebeard Homer' Goldman
@kdbyproxy.bsky.social
I used to write laws… then I invented Knee Defender. ex-HPSCI, ex-Senate tech, taxes, trade/FP, ethics, antitrust… crime & even reputed parliamentarian
Well, maybe not. I shall try to get an answer from someone I know who does research using rats.
November 27, 2025 at 8:28 AM
Well, maybe not. I shall try to get an answer from someone I know who does research using rats.
Good question. I assumed (🤷🏻♂️) it'd be pretty good, else they wouldn't do these studies. Not an especially rigorous assessment by me, but hey. Anyway, you inspired me to find this www.nature.com/articles/s41..., which I have not yet read, but seems likely to provide insight.
Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies - Molecular Psychiatry
Molecular Psychiatry - Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies
www.nature.com
November 27, 2025 at 8:23 AM
Good question. I assumed (🤷🏻♂️) it'd be pretty good, else they wouldn't do these studies. Not an especially rigorous assessment by me, but hey. Anyway, you inspired me to find this www.nature.com/articles/s41..., which I have not yet read, but seems likely to provide insight.
I get that. And in other sorts of matters, 🤷🏻♂️. But on this one, on ones _like_ this, no. There's an outrageous number of deaths and serious injuries to which (as we lawyers say) Trump's actions have been the proximate cause. This isn't one of them.
Of course, YMMV.
Of course, YMMV.
November 27, 2025 at 6:47 AM
I get that. And in other sorts of matters, 🤷🏻♂️. But on this one, on ones _like_ this, no. There's an outrageous number of deaths and serious injuries to which (as we lawyers say) Trump's actions have been the proximate cause. This isn't one of them.
Of course, YMMV.
Of course, YMMV.
If he did travel X-country to DC, and acted alone, then for all we know now, even with no troops on DC's streets he might have been so angry or upset or whatever to have come here anyway and shot other people.
Regardless, Trump's deployment of troops, wrong as it is, isn't to blame for this.
2/2
Regardless, Trump's deployment of troops, wrong as it is, isn't to blame for this.
2/2
November 27, 2025 at 6:16 AM
If he did travel X-country to DC, and acted alone, then for all we know now, even with no troops on DC's streets he might have been so angry or upset or whatever to have come here anyway and shot other people.
Regardless, Trump's deployment of troops, wrong as it is, isn't to blame for this.
2/2
Regardless, Trump's deployment of troops, wrong as it is, isn't to blame for this.
2/2
Link to the full study: "Adolescent Opioid Abuse: Role of Glial and Neuroimmune Mechanisms". scholarworks.indianapolis.iu.edu/server/api/c... And I'm posting the screen grab of the Conclusion section again, this time with the Alt text.
Study abridged version: www.sciencedirect.com/science/chap...
Study abridged version: www.sciencedirect.com/science/chap...
![Adolescent Opioid Abuse: Role of Glial and Neuroimmune Mechanisms
S. Rahman - 1, Z.I. Rahman - 2, P.J. Ronan - 3, K. Lutfy - 4, R.L. Bell - 5
1Department of Pharmaceutical Sciences, South Dakota State University, Brookings, SD 57007, USA; 2 – University of Minnesota Medical School, Minneapolis, MN 55455, USA 3 – Department of Psychiatry and Basic Biomedical Sciences, Sanford USD School of Medicine, University of South Dakota; Sioux Falls VA Healthcare System Sioux Falls, SD 57105, USA; 4 – Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA; 5 – Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
[snip]
7. CONCLUSIONS
In this review, we have explored evidence that opioid abuse during adolescence can modify brain functions and produce drug–specific neurobehavioral consequences. The preclinical and clinical data discussed above indicate that exposure to opioids during adolescence can cause long-lasting neurobiological, cognitive, affective, and behavioral dysfunctions. The net result is an impaired brain function that lasts into adulthood. Moreover, the development of multiple brain regions is particularly sensitive to adolescent opioid exposure. In addition, we have reviewed that neuroimmune signaling pathways mediate opioid-induced glial activation and associated cellular and molecular mechanisms. Furthermore, recent studies have revealed an important role for neuroimmune mechanisms, including glial activation, in many actions of opioids in the brain. These actions include neural damage, cognitive dysfunction, and alterations to reward neurocircuitry. Therefore, targeting neuroimmune signaling, including glial activation is a viable therapeutic strategy for future prevention and treatment of OUDs.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:mf6x4tcxia23iqiflhqtv2dg/bafkreidkzbfsawtnfh2usfk4p3uvlaqnqxiftoz7fltkvxtb25mp6ko6iu@jpeg)
November 27, 2025 at 4:37 AM
Link to the full study: "Adolescent Opioid Abuse: Role of Glial and Neuroimmune Mechanisms". scholarworks.indianapolis.iu.edu/server/api/c... And I'm posting the screen grab of the Conclusion section again, this time with the Alt text.
Study abridged version: www.sciencedirect.com/science/chap...
Study abridged version: www.sciencedirect.com/science/chap...
… IANAD. I am not asserting as facts anything about the long-term effects, if any, on RFKjr of his admitted use of heroin starting at 15 and for >10 years. It's just my lay-opinion that studies on this subject are noteworthy for anyone looking to understand RFKjr's decisions & actions as HHS Sec'y.
November 27, 2025 at 4:26 AM
… IANAD. I am not asserting as facts anything about the long-term effects, if any, on RFKjr of his admitted use of heroin starting at 15 and for >10 years. It's just my lay-opinion that studies on this subject are noteworthy for anyone looking to understand RFKjr's decisions & actions as HHS Sec'y.
Another study: "Adolescent Opioid Abuse: Role of Glial and Neuroimmune Mechanisms"
"[O]pioid abuse during adolescence […] can cause long-lasting neurobiological, cognitive, affective, and behavioral dysfunctions. The net result is an impaired brain function that lasts into adulthood."
That said…
"[O]pioid abuse during adolescence […] can cause long-lasting neurobiological, cognitive, affective, and behavioral dysfunctions. The net result is an impaired brain function that lasts into adulthood."
That said…
November 27, 2025 at 4:26 AM
Another study: "Adolescent Opioid Abuse: Role of Glial and Neuroimmune Mechanisms"
"[O]pioid abuse during adolescence […] can cause long-lasting neurobiological, cognitive, affective, and behavioral dysfunctions. The net result is an impaired brain function that lasts into adulthood."
That said…
"[O]pioid abuse during adolescence […] can cause long-lasting neurobiological, cognitive, affective, and behavioral dysfunctions. The net result is an impaired brain function that lasts into adulthood."
That said…
Reposted by Ira 'Bluebeard Homer' Goldman
If you think studies w/ mice & rats cld be applicable to humans, then RFKjr's adolescent use of heroin may be a part of the problem. Eg, "Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice"
doi.org/10.1016/j.he...
doi.org/10.1016/j.he...
![Research article
Adolescent morphine exposure induced long-term cognitive
impairment and prefrontal neurostructural abnormality in
adulthood in male mice
Ye Lu, Yijie Guo, Lulu Sun, Tong Liu, Ziqing Dong, Min Jia, Lixia Zhuo, Fangyuan Yin, Yongsheng Zhu, Xiancang Ma, Yunpeng Wang, Department of Psychiatry, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China Shaanxi Key Laboratory of Biological Psychiatry, Xi’an, Shaanxi, 710061, China c College of Forensic Science, School of Medicine […] China
School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu, 211166, China, Lead Contact, China
A B S T R A C T
Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adolescent morphine exposure and used the 5-choice serial reaction time task (5-CSRTT), along with the open field, novel object recognition, Y maze and Barnes maze tests, to assess changes in cognitive behavior. We found that exposure to morphine during adolescence led to deficits in multidimensional cognitive functions in mice, including attention, information processing speed, and behavior inhibition. Notable, these impairments persisted into adulthood. Furthermore, the morphine-exposed mice exhibited decreased learning efficiency and spatial memory. Adolescent morphine exposure also induced significant and persistent morphological changes and synaptic abnormalities in medial prefrontal cortex (mPFC) neurons, which may be responsible for cognitive impairments in adulthood. Together, our study suggests that opioid exposure during adolescence profoundly affects cognitive development and emphasizes that opioid-induced disruption of neurons in adolescence may link mPFC-associated cognitive impairments in adulthood.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:mf6x4tcxia23iqiflhqtv2dg/bafkreidse3uokxqug5mox432f7rrmd3ug7tnmutaayx6lbthbyupimy6ra@jpeg)
November 27, 2025 at 1:49 AM
If you think studies w/ mice & rats cld be applicable to humans, then RFKjr's adolescent use of heroin may be a part of the problem. Eg, "Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice"
doi.org/10.1016/j.he...
doi.org/10.1016/j.he...
If you think studies w/ mice & rats cld be applicable to humans, then RFKjr's adolescent use of heroin may be a part of the problem. Eg, "Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice"
doi.org/10.1016/j.he...
doi.org/10.1016/j.he...
November 27, 2025 at 1:49 AM
If you think studies w/ mice & rats cld be applicable to humans, then RFKjr's adolescent use of heroin may be a part of the problem. Eg, "Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice"
doi.org/10.1016/j.he...
doi.org/10.1016/j.he...
Oh, I thought it was a desktop version of this.
November 26, 2025 at 10:20 PM
Oh, I thought it was a desktop version of this.
DATA: When something bad happens, MAGA blames it on whoever they last rage-tweeted about.
November 26, 2025 at 10:00 PM
DATA: When something bad happens, MAGA blames it on whoever they last rage-tweeted about.
IN SECOND PLACE: The Republicanish Party, and its members Republicanishes*.
(* – "reh-PUH-bleh ka-NISH-ez")
2/
(* – "reh-PUH-bleh ka-NISH-ez")
2/
November 26, 2025 at 9:36 PM
IN SECOND PLACE: The Republicanish Party, and its members Republicanishes*.
(* – "reh-PUH-bleh ka-NISH-ez")
2/
(* – "reh-PUH-bleh ka-NISH-ez")
2/
But golly, should we be surprised Trump wants his manspreading ballroom to be bigger than the White House? Recall, on 9/11 after the WTC twin towers collapsed, one of his first takes was to brag about his 40 Wall Street building – "And now it’s the tallest."
2/
www.thedailybeast.com/trump-79-feu...
2/
www.thedailybeast.com/trump-79-feu...
Trump, 79, Feuds With His White House Ballroom Architect Over Bonkers Demand
The president and architect James McCrery II have butted heads, insiders claim.
www.thedailybeast.com
November 26, 2025 at 7:54 PM
But golly, should we be surprised Trump wants his manspreading ballroom to be bigger than the White House? Recall, on 9/11 after the WTC twin towers collapsed, one of his first takes was to brag about his 40 Wall Street building – "And now it’s the tallest."
2/
www.thedailybeast.com/trump-79-feu...
2/
www.thedailybeast.com/trump-79-feu...
At Boston U's College of Communications (aka, SPC), some students made a short film about a couple of guys deciding to sell shit in a can and then marketing it into a huge success... ~55 years ago.
November 26, 2025 at 7:13 PM
At Boston U's College of Communications (aka, SPC), some students made a short film about a couple of guys deciding to sell shit in a can and then marketing it into a huge success... ~55 years ago.
The key distinction between retribution and revenge.
November 26, 2025 at 6:55 PM
The key distinction between retribution and revenge.