Julien Vibert (李满山)
@julienmanshan.bsky.social
MD, PhD | Medical Oncologist & Postdoctoral Researcher | AI & Computational Oncology | Sarcoma & Rare Cancers | Gustave Roussy & Heidelberg | Kung Fu practitioner | Philosophy lover |
Reposted by Julien Vibert (李满山)
Using genomic data, researchers have uncovered the origins and cultural practices of the people of Shimao, a 4,000-year-old fortified settlement in northern China
go.nature.com/4olfAV9
go.nature.com/4olfAV9
Ancient DNA offers clues about mysterious prehistoric settlement in China
Using genomic data, researchers have uncovered the origins and cultural practices of the people of Shimao, a 4,000-year-old fortified settlement in northern China.
go.nature.com
November 28, 2025 at 1:02 PM
Using genomic data, researchers have uncovered the origins and cultural practices of the people of Shimao, a 4,000-year-old fortified settlement in northern China
go.nature.com/4olfAV9
go.nature.com/4olfAV9
Reposted by Julien Vibert (李满山)
Join us:
With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.
If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.
karriere.klinikum.uni-heidelberg.de/index.php?ac...
With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.
If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.
karriere.klinikum.uni-heidelberg.de/index.php?ac...
November 28, 2025 at 2:11 PM
Join us:
With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.
If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.
karriere.klinikum.uni-heidelberg.de/index.php?ac...
With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.
If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.
karriere.klinikum.uni-heidelberg.de/index.php?ac...
Reposted by Julien Vibert (李满山)
Multi-omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
November 28, 2025 at 5:30 PM
Multi-omics profiling identified two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Julien Vibert (李满山)
FYI: New online! Genomics of drug target prioritization for complex diseases
Genomics of drug target prioritization for complex diseases
Nature Reviews Genetics, Published online: 06 November 2025; doi:10.1038/s41576-025-00904-4In this Review, Chen et al. discuss how the advancement and integration of large-scale genetic resources, multi-omics data and sophisticated computational tools are improving drug development pipelines.
www.nature.com
November 27, 2025 at 3:08 PM
FYI: New online! Genomics of drug target prioritization for complex diseases
Reposted by Julien Vibert (李满山)
This will be a very exciting meeting!
Looking forward to see you there
Please spread the word
Looking forward to see you there
Please spread the word
We have a fantastic line up of speakers for our 2026 Journal Meeting organised by @amatrudalab.bsky.social, @bandolab.bsky.social, @banitolab.bsky.social and Elaine Mardis @nationwidekids.bsky.social!
🚨Register your interest now so you're first to get updates🚨
www.biologists.com/meetings/dmm...
🚨Register your interest now so you're first to get updates🚨
www.biologists.com/meetings/dmm...
November 26, 2025 at 5:46 AM
This will be a very exciting meeting!
Looking forward to see you there
Please spread the word
Looking forward to see you there
Please spread the word
Reposted by Julien Vibert (李满山)
In a phase 1 trial, treatment of fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the DNAJB1::PRKACA fusion, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses. https://www.nature.com/articles/s41591-025-03995-y
November 26, 2025 at 1:01 PM
In a phase 1 trial, treatment of fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the DNAJB1::PRKACA fusion, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses. https://www.nature.com/articles/s41591-025-03995-y
Reposted by Julien Vibert (李满山)
Blending ‘old-fashioned’ logic systems with the neural networks that power large language models is one of the hottest trends in AI
go.nature.com/4oUA1cw
go.nature.com/4oUA1cw
This AI combo could unlock human-level intelligence
Blending ‘old-fashioned’ logic systems with the neural networks that power large language models is one of the hottest trends in artificial intelligence.
go.nature.com
November 25, 2025 at 2:35 PM
Blending ‘old-fashioned’ logic systems with the neural networks that power large language models is one of the hottest trends in AI
go.nature.com/4oUA1cw
go.nature.com/4oUA1cw
Reposted by Julien Vibert (李满山)
🚀 Ready to lead the next frontier of AI in health care and research?
UHN is hiring a Coordinator to spearhead the Blue Vest #AI Initiative at @PMResearch_UHN @PM_CDI to train student volunteers and empower clinicians & scientists.
📍 Toronto
🔗 Apply: smrtr.io/vC7zh
UHN is hiring a Coordinator to spearhead the Blue Vest #AI Initiative at @PMResearch_UHN @PM_CDI to train student volunteers and empower clinicians & scientists.
📍 Toronto
🔗 Apply: smrtr.io/vC7zh
smrtr.io
November 24, 2025 at 7:25 PM
🚀 Ready to lead the next frontier of AI in health care and research?
UHN is hiring a Coordinator to spearhead the Blue Vest #AI Initiative at @PMResearch_UHN @PM_CDI to train student volunteers and empower clinicians & scientists.
📍 Toronto
🔗 Apply: smrtr.io/vC7zh
UHN is hiring a Coordinator to spearhead the Blue Vest #AI Initiative at @PMResearch_UHN @PM_CDI to train student volunteers and empower clinicians & scientists.
📍 Toronto
🔗 Apply: smrtr.io/vC7zh
Reposted by Julien Vibert (李满山)
Although sensing is one of the more established quantum technologies, translating quantum science into real-world biomedical impact requires further effort to overcome technical hurdles as well as structural and societal challenges, according to a Comment article in Nature Reviews Physics. 🔒
How quantum biosensing is transforming healthcare - Nature Reviews Physics
Although sensing is one of the more established quantum technologies, translating quantum science into real-world biomedical impact requires further effort to overcome technical hurdles as well as structural and societal challenges.
go.nature.com
November 22, 2025 at 2:11 PM
Although sensing is one of the more established quantum technologies, translating quantum science into real-world biomedical impact requires further effort to overcome technical hurdles as well as structural and societal challenges, according to a Comment article in Nature Reviews Physics. 🔒
Reposted by Julien Vibert (李满山)
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
November 21, 2025 at 8:20 AM
We are honored that our lab was awarded with the Henrik Kreibohm Research Award to seed-fund our immunotherapy efforts in DSRCT
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
www.deutsches-stiftungszentrum.de/stiftungen/h...
onlinelibrary.wiley.com/doi/10.1002/...
Many thanks to the foundation and Kreibohm family for their generous support!
Reposted by Julien Vibert (李满山)
Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells
go.nature.com/3JLvsSJ
go.nature.com/3JLvsSJ
Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature
A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing cells and persist across generations.
go.nature.com
November 20, 2025 at 9:13 AM
Nature research paper: Genetic elements promote retention of extrachromosomal DNA in cancer cells
go.nature.com/3JLvsSJ
go.nature.com/3JLvsSJ
Reposted by Julien Vibert (李满山)
I am honoured to step into the role of @uhn.ca
Executive AI Scientific Director and Co-Director of the
@uhnaihub.bsky.social
This is a major opportunity to accelerate how we bring responsible, transparent and effective AI into patient care, research, education and operations across UHN.
Executive AI Scientific Director and Co-Director of the
@uhnaihub.bsky.social
This is a major opportunity to accelerate how we bring responsible, transparent and effective AI into patient care, research, education and operations across UHN.
November 11, 2025 at 11:14 PM
I am honoured to step into the role of @uhn.ca
Executive AI Scientific Director and Co-Director of the
@uhnaihub.bsky.social
This is a major opportunity to accelerate how we bring responsible, transparent and effective AI into patient care, research, education and operations across UHN.
Executive AI Scientific Director and Co-Director of the
@uhnaihub.bsky.social
This is a major opportunity to accelerate how we bring responsible, transparent and effective AI into patient care, research, education and operations across UHN.
Reposted by Julien Vibert (李满山)
Rare cancers make up 22% of adult cases but cause 30% of cancer deaths.
At EORTC, we fight for patients with rare & ultra-rare cancers, creating trials that set new standards of care.
Help us keep hope alive.
🔗 Donate: donate.eortcresearchfund.org/eoy/
#NoPatientLeftBehind
At EORTC, we fight for patients with rare & ultra-rare cancers, creating trials that set new standards of care.
Help us keep hope alive.
🔗 Donate: donate.eortcresearchfund.org/eoy/
#NoPatientLeftBehind
November 18, 2025 at 10:53 AM
Rare cancers make up 22% of adult cases but cause 30% of cancer deaths.
At EORTC, we fight for patients with rare & ultra-rare cancers, creating trials that set new standards of care.
Help us keep hope alive.
🔗 Donate: donate.eortcresearchfund.org/eoy/
#NoPatientLeftBehind
At EORTC, we fight for patients with rare & ultra-rare cancers, creating trials that set new standards of care.
Help us keep hope alive.
🔗 Donate: donate.eortcresearchfund.org/eoy/
#NoPatientLeftBehind
Reposted by Julien Vibert (李满山)
📢 @fionakolbinger.bsky.social and @jnkt.bsky.social characterize the discordance between metrics used to evaluate AI tools and their clinical impact, proposing a framework to reduce this disconnect. www.nature.com/articles/s43... @tudresden.bsky.social @ekfzdigital.bsky.social
🔓 rdcu.be/eQmQp
🔓 rdcu.be/eQmQp
Adaptive validation strategies for real-world clinical artificial intelligence - Nature Computational Science
Technical metrics used to evaluate medical artificial intelligence tools often fail to predict their clinical impact. We characterize this discordance and propose a framework of study designs to guide...
www.nature.com
November 17, 2025 at 3:23 PM
📢 @fionakolbinger.bsky.social and @jnkt.bsky.social characterize the discordance between metrics used to evaluate AI tools and their clinical impact, proposing a framework to reduce this disconnect. www.nature.com/articles/s43... @tudresden.bsky.social @ekfzdigital.bsky.social
🔓 rdcu.be/eQmQp
🔓 rdcu.be/eQmQp
Reposted by Julien Vibert (李满山)
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
November 15, 2025 at 8:26 PM
Register for the next EuSARC conference in Oslo, Norway, in June 2026
oslocancercluster.no/events/8th-e...
oslocancercluster.no/events/8th-e...
Reposted by Julien Vibert (李满山)
Brian lived a life driven by compassion, service, & deep impact on the global #sarcomacommunity. We will honor him by staying steadfast in our commitment to research, collaboration, and supporting every patient and family affected by this disease.
November 15, 2025 at 8:17 PM
Brian lived a life driven by compassion, service, & deep impact on the global #sarcomacommunity. We will honor him by staying steadfast in our commitment to research, collaboration, and supporting every patient and family affected by this disease.
Reposted by Julien Vibert (李满山)
🚀 Excited to share our preprint scConcept: a contrastive pretraining framework for technology-agnostic single-cell representations.
We move beyond reconstruction to learn rich, cell-level embeddings for diverse omics.
📘 www.biorxiv.org/content/10.1...
We move beyond reconstruction to learn rich, cell-level embeddings for diverse omics.
📘 www.biorxiv.org/content/10.1...
scConcept: Contrastive pretraining for technology-agnostic single-cell representations beyond reconstruction
Recent large-scale single-cell foundation models have shown promise for exploring cellular states, yet they often underperform compared to simpler, domain-specific methods, raising concerns about…
www.biorxiv.org
November 13, 2025 at 5:17 PM
🚀 Excited to share our preprint scConcept: a contrastive pretraining framework for technology-agnostic single-cell representations.
We move beyond reconstruction to learn rich, cell-level embeddings for diverse omics.
📘 www.biorxiv.org/content/10.1...
We move beyond reconstruction to learn rich, cell-level embeddings for diverse omics.
📘 www.biorxiv.org/content/10.1...
Reposted by Julien Vibert (李满山)
Reposted by Julien Vibert (李满山)
Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
go.nature.com
November 11, 2025 at 4:58 PM
Multimodal learning enables chat-based exploration of single-cell data - @bocklab.bsky.social @cemm.oeaw.ac.at @meduniwien.ac.at go.nature.com/3WPGJnW
Reposted by Julien Vibert (李满山)
November 11, 2025 at 5:49 PM
Reposted by Julien Vibert (李满山)
#PEAKtrial in #GIST positive as it could be.. great news for parients!! Congrats to @cogent
mPFS of 16.5 months is very impressive. Topline suggests new standard of care!!
@saxotomy.bsky.social @herbloongmd.bsky.social and @ all other folks out there
mPFS of 16.5 months is very impressive. Topline suggests new standard of care!!
@saxotomy.bsky.social @herbloongmd.bsky.social and @ all other folks out there
November 10, 2025 at 2:19 PM
#PEAKtrial in #GIST positive as it could be.. great news for parients!! Congrats to @cogent
mPFS of 16.5 months is very impressive. Topline suggests new standard of care!!
@saxotomy.bsky.social @herbloongmd.bsky.social and @ all other folks out there
mPFS of 16.5 months is very impressive. Topline suggests new standard of care!!
@saxotomy.bsky.social @herbloongmd.bsky.social and @ all other folks out there
Reposted by Julien Vibert (李满山)
I'm impressed by how far this model class has taken us—MOFA-FLEX may be the final iteration—a framework geared more towards generating models than being a standalone model itself. User-friendly, probabilistic programming rocks! We look forward to your feedback and experiences trying it out!
Are you using any of our factor models, such as MOFA? 🛵
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
You might’ve found it challenging to tailor them to your specific use cases - not anymore!
Introducing MOFA-FLEX: a flexible, modular factor analysis framework designed for customizable modeling across diverse multi-omics data scenarios. 1/n
November 8, 2025 at 9:06 PM
I'm impressed by how far this model class has taken us—MOFA-FLEX may be the final iteration—a framework geared more towards generating models than being a standalone model itself. User-friendly, probabilistic programming rocks! We look forward to your feedback and experiences trying it out!
Reposted by Julien Vibert (李满山)
🎗️ Attending #CTOS2025? Don’t miss the Foundational Science of Sarcomas Symposium!
This year’s highlights include sessions on
🔹 Cancer Metabolism & Drug Development
🔹 AI Applications in Sarcoma Diagnostics & Care
🔹 Publishing Your Research — In Conversation with Editors of Leading Oncology Journals
This year’s highlights include sessions on
🔹 Cancer Metabolism & Drug Development
🔹 AI Applications in Sarcoma Diagnostics & Care
🔹 Publishing Your Research — In Conversation with Editors of Leading Oncology Journals
November 7, 2025 at 3:20 PM
🎗️ Attending #CTOS2025? Don’t miss the Foundational Science of Sarcomas Symposium!
This year’s highlights include sessions on
🔹 Cancer Metabolism & Drug Development
🔹 AI Applications in Sarcoma Diagnostics & Care
🔹 Publishing Your Research — In Conversation with Editors of Leading Oncology Journals
This year’s highlights include sessions on
🔹 Cancer Metabolism & Drug Development
🔹 AI Applications in Sarcoma Diagnostics & Care
🔹 Publishing Your Research — In Conversation with Editors of Leading Oncology Journals
Reposted by Julien Vibert (李满山)
🚀 Prophet v3 is out!
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
November 4, 2025 at 5:40 PM
🚀 Prophet v3 is out!
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning
AI that predicts how cells respond to genetic & chemical perturbations across readouts.
Now scales to 1.9 M molecules + in vitro validation of melanoma-specific hits 🧬💊
📄 biorxiv.org/content/10.1...
#AI #Biology #DeepLearning