Joram Mooiweer
@jorammooiweer.bsky.social
Celiac disease mucosal immunity | Engineering intestine models | iPSCs, Organoids, T cells & organ-chips🔬| PhD candidate | Dept. of Genetics 🧬 | University Medical Center Groningen | University of Groningen (@rug.nl) |
📍Groningen, the Netherlands
📍Groningen, the Netherlands
Totally psyched that our paper is out in @stemcellreports.bsky.social!
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
November 19, 2025 at 10:13 PM
Totally psyched that our paper is out in @stemcellreports.bsky.social!
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue?
We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head.
Spoiler: the chip wins.
🧵&🔗👇
Reposted by Joram Mooiweer
Proud to share our work now out in Cell. We hope what we learned about IgA immune responses to rotavirus can be translated into better vaccines. Congratulations Dr. Kei Haniuda, an amazing PDF. TY
@uoftmedicine.bsky.social
for covering.
temertymedicine.utoronto.ca/news
@uoftmedicine.bsky.social
for covering.
temertymedicine.utoronto.ca/news
Recent News
temertymedicine.utoronto.ca
November 17, 2025 at 11:12 PM
Proud to share our work now out in Cell. We hope what we learned about IgA immune responses to rotavirus can be translated into better vaccines. Congratulations Dr. Kei Haniuda, an amazing PDF. TY
@uoftmedicine.bsky.social
for covering.
temertymedicine.utoronto.ca/news
@uoftmedicine.bsky.social
for covering.
temertymedicine.utoronto.ca/news
Yes!!! This is the way forward for fairer science evaluation:
(“high-impact”) journals give stamps of interest/impact on peer-reviewed preprints (i.e. still add value). In parallel, societies can use a similar ‘approval stamp’ especially to highlight excellent work in less “sexy” fields.
(“high-impact”) journals give stamps of interest/impact on peer-reviewed preprints (i.e. still add value). In parallel, societies can use a similar ‘approval stamp’ especially to highlight excellent work in less “sexy” fields.
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 8, 2025 at 11:19 AM
Yes!!! This is the way forward for fairer science evaluation:
(“high-impact”) journals give stamps of interest/impact on peer-reviewed preprints (i.e. still add value). In parallel, societies can use a similar ‘approval stamp’ especially to highlight excellent work in less “sexy” fields.
(“high-impact”) journals give stamps of interest/impact on peer-reviewed preprints (i.e. still add value). In parallel, societies can use a similar ‘approval stamp’ especially to highlight excellent work in less “sexy” fields.
Reposted by Joram Mooiweer
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
TGF-β builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages - Nature Genetics
Targeting TGFBR1 in transplantable mouse colorectal tumor organoids improves response to anti-PD-L1 therapy. Mechanistically, TGF-β abrogates clonal expansion of T effector and memory phenotypes and i...
www.nature.com
November 7, 2025 at 12:30 PM
1/17 🧵
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇
➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC).
Very proud of the team and efforts behind it.
www.nature.com/articles/s41...
🚨‼️
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
November 6, 2025 at 5:38 PM
🚨‼️
Reposted by Joram Mooiweer
Big New! @elife.bsky.social @genetics-gsa.bsky.social #G3journal are joining editorial forces with @reviewcommons.org - bringing not just field-specific expertise to the process but also making #PreprintPeerReview a truly collaborative effort!🎉👏
Read more to find out👇
www.embo.org/features/pub...
Read more to find out👇
www.embo.org/features/pub...
Publishers join the Review Commons peer review process – Features – EMBO
Editors from eLife, Genetics, G3 and Journal of Cell Biology will contribute to the EMBO preprint peer review platform
www.embo.org
November 3, 2025 at 9:33 AM
Big New! @elife.bsky.social @genetics-gsa.bsky.social #G3journal are joining editorial forces with @reviewcommons.org - bringing not just field-specific expertise to the process but also making #PreprintPeerReview a truly collaborative effort!🎉👏
Read more to find out👇
www.embo.org/features/pub...
Read more to find out👇
www.embo.org/features/pub...
Genetically editing iPSCs is challenging.
But here’s thoroughly expedited how to do it anyway
👇
But here’s thoroughly expedited how to do it anyway
👇
1/ Happy to share important work done with my co-author Andrew Khalil in the labs of Rudolf Jaenisch @whiteheadinstitute.bsky.social @mit.edu and David Mooney @harvard.edu @wyssinstitute.bsky.social trying to assess and fix the major problem of transgene silencing in human ESC/iPSC based work
November 2, 2025 at 10:47 PM
Genetically editing iPSCs is challenging.
But here’s thoroughly expedited how to do it anyway
👇
But here’s thoroughly expedited how to do it anyway
👇
Reposted by Joram Mooiweer
Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Memory CD8+ T cells can undergo TCR-dependent or -independent activation. Here, Lee et al. show that IL-15-induced bystander activation of human memory CD8+ T cells is suppressed by concurrent TCR signaling through NFATc1-AP-1 interactions. Furthermore, they validate a bystander activation gene set induced by IL-15 and decreased upon TCR stimulation.
dlvr.it
October 31, 2025 at 7:55 PM
Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells
Reposted by Joram Mooiweer
Excited to share a preprint from my postdoc @theGarrettLab- now on bioRxiv!
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Acetoacetate suppresses colon cancer via an MR1-MAIT axis
Colorectal cancer (CRC) is a leading cause of cancer mortality and additional preventative, and therapeutic strategies are urgently needed. Ketogenic diets have mixed effects on tumorigenesis and comp...
www.biorxiv.org
November 2, 2025 at 2:27 PM
Excited to share a preprint from my postdoc @theGarrettLab- now on bioRxiv!
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10)
www.biorxiv.org/content/10.1...
Stop 👏 judging 👏 science 👏 with 👏 bad 👏 metrics 👏!!!!!
Google Scholar has introduced a 'Sh-index' metric that scores papers higher if you are first or last author. Apart from the fact metrics are generally bad, this one explicitly punishes PIs who often collaborate, publishing with 2 or 3 equal PIs at the end of the list.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Google Scholar tool gives extra credit to first and last authors
Researchers welcome the initiative, but say it doesn’t go far enough to capture the nuance of researcher productivity and impact.
www.nature.com
October 26, 2025 at 8:11 PM
Stop 👏 judging 👏 science 👏 with 👏 bad 👏 metrics 👏!!!!!
It’s unbelievable how side quests somehow take over your whole week.
But hey; every day eventually becomes 6 PM, and you can finally start the thing you were actually supposed to do!
But hey; every day eventually becomes 6 PM, and you can finally start the thing you were actually supposed to do!
October 23, 2025 at 4:36 PM
It’s unbelievable how side quests somehow take over your whole week.
But hey; every day eventually becomes 6 PM, and you can finally start the thing you were actually supposed to do!
But hey; every day eventually becomes 6 PM, and you can finally start the thing you were actually supposed to do!
Reposted by Joram Mooiweer
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
October 22, 2025 at 2:06 PM
📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...
events.ibecbarcelona.eu/embl-ibec-co...
Restoring Oral tolerance in 🐭
Continuous oral antigen exposure + CD28 blockade (CTLA4-Ig) = generation of CD101⁺ Tregs that enforce antigen-specific tolerance.
Even in primed hosts.
So pTregs can be reprogrammed into durable peacekeepers!
#immunology #Tregs #immunosky
Continuous oral antigen exposure + CD28 blockade (CTLA4-Ig) = generation of CD101⁺ Tregs that enforce antigen-specific tolerance.
Even in primed hosts.
So pTregs can be reprogrammed into durable peacekeepers!
#immunology #Tregs #immunosky
Arai, Kawakami, Sakaguchi (2025 #Nobel laureate) and colleagues show that oral antigen exposure combined with CD28 costimulation blockade generates functionally stable antigen-specific CD101⁺ pTreg cells even in previously antigen-sensitized hosts. rupress.org/jem/article/...
October 21, 2025 at 9:36 PM
Restoring Oral tolerance in 🐭
Continuous oral antigen exposure + CD28 blockade (CTLA4-Ig) = generation of CD101⁺ Tregs that enforce antigen-specific tolerance.
Even in primed hosts.
So pTregs can be reprogrammed into durable peacekeepers!
#immunology #Tregs #immunosky
Continuous oral antigen exposure + CD28 blockade (CTLA4-Ig) = generation of CD101⁺ Tregs that enforce antigen-specific tolerance.
Even in primed hosts.
So pTregs can be reprogrammed into durable peacekeepers!
#immunology #Tregs #immunosky
Back to back commentaries in @natureportfolio.nature.com today. Clearly NAMs are causing a stir!
October 20, 2025 at 8:14 PM
Back to back commentaries in @natureportfolio.nature.com today. Clearly NAMs are causing a stir!
As a researcher at the start of its career, I find this very frightening…
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Is academic research becoming too competitive? Nature examines the data
Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.
www.nature.com
October 20, 2025 at 7:16 PM
As a researcher at the start of its career, I find this very frightening…
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Joram Mooiweer
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
Isolation, engineering and ecology of temperate phages from the human gut - Nature
Human host-associated cellular products may act as induction agents for bacteriophages.
nature.com
October 15, 2025 at 9:41 PM
Very excited to share the latest work from our lab, which was published today in Nature!
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
nature.com/articles/s41...
PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.
In the light of “#mTOR regulates everything,” HDAC5 just gave it access to your mucus factory.
Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus.
Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫
www.biorxiv.org/content/10.1...
Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus.
Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫
www.biorxiv.org/content/10.1...
Translational control of innate barrier defense by the gut microbiota
The intestinal epithelium is protected by a mucus barrier, infused with antimicrobial proteins, that restricts microbial access to host tissue. Because assembling this barrier is energetically costly,...
www.biorxiv.org
October 8, 2025 at 8:17 AM
In the light of “#mTOR regulates everything,” HDAC5 just gave it access to your mucus factory.
Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus.
Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫
www.biorxiv.org/content/10.1...
Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus.
Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫
www.biorxiv.org/content/10.1...
CD74 — once thought of as a marker of antigen-presenting or regulatory cells — marks and even supports cytotoxic T cell function!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
ETV4 restrains the formation of CD74+ cytotoxic exhausted CD8+ T cells
Exhausted CD8+ T (Tex) cells comprise heterogeneous subsets with varying cytotoxic and dysfunctional properties, making inhibitory receptor profiles unreliable indicators of function. Therefore, it is...
www.biorxiv.org
October 7, 2025 at 9:31 PM
CD74 — once thought of as a marker of antigen-presenting or regulatory cells — marks and even supports cytotoxic T cell function!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Joram Mooiweer
PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids
Decoding γδ T cell-epithelial interactions in the human intestine in health and disease - MRC DTP
The human gut epithelium performs vital absorptive functions, while simultaneously forming a physical barrier between the gut contents and the body. As such it is essential for health and its dysregul...
kcl-mrcdtp.com
October 7, 2025 at 8:13 AM
PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids
Reposted by Joram Mooiweer
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
Exercise enhances antitumor immunity and immunotherapy effectiveness by increasing
microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker
of melanoma suppression.
www.cell.com
July 9, 2025 at 6:12 PM
Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy.
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Joram Mooiweer
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
September 19, 2025 at 7:21 PM
Excited to share our new study:
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection
bioRxiv: doi.org/10.1101/2025...
🧵 Key findings below 👇
Reposted by Joram Mooiweer
📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells
Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...
www.biorxiv.org
September 21, 2025 at 6:58 PM
📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky
Reposted by Joram Mooiweer
I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf
July 29, 2025 at 10:30 AM
I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf