@jonrennhack.bsky.social
I'm an Assistant Professor of Cancer Biology at Loyola University Chicago. Check us out at RennhackLab.com
Pinned
RENNHACK LAB
Welcome! Our lab uses bioinformatic techniques in combination with model systems to identify new therapeutic targets. We are excited about doing translational research to impact cancer patients with.....
RennhackLab.com
Hi everyone! I'm a new faculty member at Loyola University Chicago interesting in studying colorectal cancer metastasis. Check us out at RennhackLab.com!
Reposted
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
The value of publishing negative data - News
Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...
www.rockefeller.edu
December 23, 2025 at 1:26 PM
Giving the gift of negative data 🥰
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!
Thanks @rockefeller.edu news team for the article!
www.rockefeller.edu/news/38829-t...
Reposted
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
TAD boundary architecture and gene activity are uncoupled
Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...
www.biorxiv.org
December 18, 2025 at 11:43 AM
"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"
I'm thrilled to host @lindsaylafave.bsky.social at Loyola today! She gave an incredible talk describing chromatin biology throughout lung cancer progression!
December 17, 2025 at 7:17 PM
I'm thrilled to host @lindsaylafave.bsky.social at Loyola today! She gave an incredible talk describing chromatin biology throughout lung cancer progression!
Reposted
Comparative characterization of OncoPro and Wnt-Based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoids https://www.biorxiv.org/content/10.64898/2025.12.13.693944v1
December 16, 2025 at 3:47 PM
Comparative characterization of OncoPro and Wnt-Based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoids https://www.biorxiv.org/content/10.64898/2025.12.13.693944v1
Reposted
A spatial atlas of colorectal cancer reveals the influence of stromal niches on tumour differentiation https://www.biorxiv.org/content/10.64898/2025.12.09.693138v1
December 11, 2025 at 3:47 PM
A spatial atlas of colorectal cancer reveals the influence of stromal niches on tumour differentiation https://www.biorxiv.org/content/10.64898/2025.12.09.693138v1
Reposted
Many thanks to #AmyGladstein & #DavidFeldser for this great perspective on our recent paper @natcancer.nature.com. As they say in it (and have elegantly shown in their work): "‘Flip the switch’ and let nature show you the way!" 🔦🧬🐭
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Primary tumor chromatin landscape governs metastatic organotropism - Nature Cancer
Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites...
www.nature.com
October 15, 2025 at 9:32 PM
Many thanks to #AmyGladstein & #DavidFeldser for this great perspective on our recent paper @natcancer.nature.com. As they say in it (and have elegantly shown in their work): "‘Flip the switch’ and let nature show you the way!" 🔦🧬🐭
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted
G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us.
<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@genesdev.bsky.social
➡️ https://tinyurl.com/GenesDev-MeetTheEditors
<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@genesdev.bsky.social
➡️ https://tinyurl.com/GenesDev-MeetTheEditors
September 16, 2025 at 6:00 PM
G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us.
<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@genesdev.bsky.social
➡️ https://tinyurl.com/GenesDev-MeetTheEditors
<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky-mention">@genesdev.bsky.social
➡️ https://tinyurl.com/GenesDev-MeetTheEditors
Reposted
Positive Selection Screen for Natural Product β-Catenin Inactivators https://www.biorxiv.org/content/10.1101/2025.08.27.671140v1
August 28, 2025 at 1:48 AM
Positive Selection Screen for Natural Product β-Catenin Inactivators https://www.biorxiv.org/content/10.1101/2025.08.27.671140v1
Reposted
🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
August 25, 2025 at 10:00 PM
🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2
❗Free registration for MRS Members! #MRS #Research #EarlyCareer
Reposted
This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...
Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer
Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …
www.sciencedirect.com
June 14, 2025 at 5:23 AM
This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...
Reposted
Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature
The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.
www.nature.com
June 4, 2025 at 8:09 PM
Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
🚨 PERSEPCTIVE
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Evolutionary paths towards metastasis - Nature Reviews Cancer
In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.
bit.ly
April 30, 2025 at 3:43 PM
🚨 PERSEPCTIVE
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.
📖 👇
Reposted
new out in Nature today www.nature.com/articles/s41...
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature
PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...
www.nature.com
May 21, 2025 at 4:09 PM
new out in Nature today www.nature.com/articles/s41...
Reposted
rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for melanoma metastasis-initiating cells in lymph nodes
Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...
rdcu.be
May 17, 2025 at 8:25 AM
rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention
The size of the plenary hall is always inspiring. So many cancer researchers in one place!
April 26, 2025 at 9:02 PM
The size of the plenary hall is always inspiring. So many cancer researchers in one place!
Tumor metabolism is always a tough topic but the speakers at the microenvironment and metabolism session at #AACR25 are doing a great job making it accessible.
While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?
While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?
April 26, 2025 at 3:34 PM
Tumor metabolism is always a tough topic but the speakers at the microenvironment and metabolism session at #AACR25 are doing a great job making it accessible.
While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?
While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?
Fantastic first session at #AACR25 on non-genetic drivers of metastasis!
While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.
While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.
April 26, 2025 at 1:54 PM
Fantastic first session at #AACR25 on non-genetic drivers of metastasis!
While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.
While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.
Reposted
Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes
Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...
bit.ly
April 3, 2025 at 9:20 PM
Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO
Reposted
Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...
www.cell.com/trends/cance...
Regulation of metastatic organotropism
Metastasis is responsible for most cancer-related deaths. Different cancers have their
own preferential sites of metastases, a phenomenon termed metastatic organotropism.
The mechanisms underlying org...
www.cell.com
March 29, 2025 at 6:16 AM
Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...
www.cell.com/trends/cance...
Reposted
Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions
Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....
Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....
March 29, 2025 at 9:51 AM
Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions
Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....
Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....
Reposted
Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb
rdcu.be/dItUy
rdcu.be/dItUy
Decoding gene regulation with CRISPR perturbations - Nature Biotechnology
Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.
go.nature.com
March 24, 2025 at 7:39 PM
Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb
rdcu.be/dItUy
rdcu.be/dItUy