Jorge García
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jgarcia-cal.bsky.social
Jorge García
@jgarcia-cal.bsky.social
150 followers 260 following 21 posts
PhD candidate at the Institute of Evolutionary Biology (IBE, UPF-CSIC), Barcelona.
Bioinformatician inferring local adaptation and introgression in Humans 🧬
Fan of coalescence theory.
Posts Replies Media Videos
Reposted by Jorge García
huwgroucutt.bsky.social
The debate on when people first arrived in Australia continues! www.science.org/doi/10.1126/...
Genomic evidence supports the “long chronology” for the peopling of Sahul
Genome data provide support for the first settlement of Australia and New Guinea via at least two routes by 60,000 years ago.
www.science.org
November 29, 2025 at 8:49 AM
Reposted by Jorge García
natrevgenet.nature.com
Free to read here: rdcu.be/d64zN
November 28, 2025 at 12:28 PM
Reposted by Jorge García
genetisaur.bsky.social
Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ
Dissecting pleiotropy to gain mechanistic insights into human disease
Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...
rdcu.be
November 28, 2025 at 1:10 PM
Reposted by Jorge García
davidposada.bsky.social
🧬 New preprint out on bioRxiv!

Using single-cell WGS and Bayesian phylodynamics, we show that some CRC tumors arise decades before diagnosis, remain indolent, then expand rapidly in the last ~2 years.

📄 doi.org/10.1101/2025...

🙏 Huge thanks to all co-authors
Single-cell phylodynamics reveal rapid late-stage colorectal cancer expansions
Single-cell whole-genome sequencing of 335 cells from seven colorectal cancers, coupled with Bayesian phylodynamic modeling, revealed tumors often originate decades before diagnosis, remain indolent, ...
doi.org
November 28, 2025 at 7:54 AM
Reposted by Jorge García
mads100tist.bsky.social
"Postdoc in the job market"
A headline: Scientists have discovered a 'third state' between life and death
November 16, 2025 at 7:52 PM
Reposted by Jorge García
alanrogers.bsky.social
I taught (and co-taught) a course on human population genetics from 2000-2024. Having retired, I'm now making all the course materials public: github.com/alanrogers/p... #popgen #evbio
GitHub - alanrogers/popgen: A course on population genetics
A course on population genetics. Contribute to alanrogers/popgen development by creating an account on GitHub.
github.com
November 27, 2025 at 7:10 PM
Reposted by Jorge García
chikichanka.bsky.social
Do you know how crayfish arrived to the Iberian Peninsula?
Tomorrow I´ll be describing the introductions of the Italian crayfish in the 1580s and the red swamp crayfish in the 1970s
Historical events with long-lasting biodiversity effects
14:30 Lisbon time
Link & details below
@ebdonana.bsky.social
November 26, 2025 at 6:46 PM
Reposted by Jorge García
leyan-wang.bsky.social
We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7
Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors
Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...
biorxiv.org
November 26, 2025 at 5:09 PM
Reposted by Jorge García
celsoneto.bsky.social
Are you interested in messy, imprecise concepts in science with huge social implications?

Join us online on Tuesday, Dec 2nd, for Yasmin’s talk. Register here: hugera.org/lecture-seri...

#philsci #STS #popgen #HPbio
November 26, 2025 at 9:12 AM
Reposted by Jorge García
evanirvingpease.bsky.social
Delighted to see our paper characterising the inbreeding history of dogs and wolves over the past 10,000 years published this week in @pnas.org. Work led by the excellent @katiabou.bsky.social, and co-supervised by me, Laurent Frantz and Fernando Racimo www.pnas.org/doi/10.1073/...
(A) Genomic inbreeding coefficient (FROH) of imputed and modern dogs plotted as a function of time, calculated based on ROH. Imputed samples are colored based on their geographic grouping, while modern samples are colored in gray. A loess regression was applied with each colored shaded area depicting the SE. (B) Total number of ROH segments plotted against total ROH length for the imputed dogs. Colors correspond to age of imputed samples in years before present (ybp)., while modern samples belonging to each dog group are colored in gray. (C) Map of imputed dog samples colored by their inbreeding coefficient (FROH). Samples with FROH values above 0.1 are indicated.
November 25, 2025 at 11:08 AM
Reposted by Jorge García
genetics-gsa.bsky.social
Latest in #GENETICS: @petrelharp.bsky.social and the team show how non-coalescing haplotypes can be inserted into ancestral recombination graphs (ARGs), resulting in ARGs that are smaller, faster to compute with, and have additional ancestral information. buff.ly/X801LTO
November 21, 2025 at 7:02 PM
Reposted by Jorge García
kuhlwilm.bsky.social
And another paper from the admixlab: SAI - statistics for adaptive introgression!
doi.org/10.1093/molb...
SAI: A Python Package for Statistics for Adaptive Introgression
Abstract. Adaptive introgression is an important evolutionary process, which can be identified with widely used summary statistics, such as the number of u
doi.org
November 20, 2025 at 12:51 PM
Reposted by Jorge García
kuhlwilm.bsky.social
Paper out now: A curated dataset of the great ape genome diversity!
rdcu.be/eQLCi
A curated dataset of great ape genome diversity
Scientific Data - A curated dataset of great ape genome diversity
rdcu.be
November 19, 2025 at 2:27 PM
Reposted by Jorge García
jbenning.bsky.social
We detail how multiple modes of confounding are incompletely understood and underappreciated in many contemporary papers. We illustrate these issues through reanalysis of data from case studies and discussion of the literature. We focus on…
November 7, 2025 at 7:06 PM
Reposted by Jorge García
samuelmoore.org
Newly released Stockholm Declaration recommends the following reforms to publishing:

1. Academia resumes control of publishing

2. Incentive systems to merit quality, not quantity

3. Independent fraud detection and prevention

4. Legislation and policies to protect science quality and integrity
Reformation of science publishing: the Stockholm Declaration | Royal Society Open Science
Science relies on integrity and trustworthiness. But scientists under career pressure are lured to purchase fake publications from ‘paper mills’ that use AI-generated data, text and image fabrication....
royalsocietypublishing.org
November 5, 2025 at 7:07 PM
Reposted by Jorge García
elife.bsky.social
Evidence from 14 research funding programmes confirms that early winners tend to keep winning (Matthew effect). But the idea that an early setback makes you stronger later doesn’t replicate widely.
buff.ly/UEtcRd4
eLife Assessment This important study reports the results of efforts to replicate two phenomena of significant interest to early-career scientists and scientific policymakers: the Matthew effect and the early-career setback effect. Several previous studies of these effects have focused on early-career researchers with grant proposals that fell just below or just above a funding threshold. Those just above the threshold were more likely to be successful when they applied for funding later in the career (an example of the well-known Matthew effect), while those just below were more likely to go on to have stronger publication records (the early-career setback effect). In this study the Matthew effect was found to be robust across funders, and to generalize from those close to the funding threshold to the whole population. The early-career setback effect was not robust across funders and did not generalize to the whole population. The evidence reported is convincing.
October 28, 2025 at 9:03 PM
Reposted by Jorge García
johriparul.bsky.social
The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.
October 28, 2025 at 9:31 PM
Reposted by Jorge García
kuhlwilm.bsky.social
New paper on a late Neanderthal, with contribution from the lab:
dx.doi.org/10.1073/pnas...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
dx.doi.org
October 27, 2025 at 7:29 PM
Reposted by Jorge García
pleunipennings.bsky.social
I started a new job in Montpellier, France!
Happy about new opportunities, sad about the state of things in the US.

abetterscientist.wordpress.com/2025/10/26/w...
We left the US and moved to France
Hello readers, I got big updates! Some of you already know this, but it’s getting more real and more official every month: my family and I have left the US and moved to France! A few months ago I q…
abetterscientist.wordpress.com
October 27, 2025 at 7:19 PM
Reposted by Jorge García
fridowelker.bsky.social
I'm hiring!⭐ As part of the DFF Sapere Aude-funded project MiddleEarth, I am looking for 1 postdoctoral researcher and 1 research assistant.
October 27, 2025 at 9:54 AM
Reposted by Jorge García
ybrandvain.bsky.social
Proud of the latest edition of my free intro biostats book.

gitrepo: github.com/ybrandvain/b...
book: ybrandvain.github.io/biostats/

Not complete but at a good point to take a break, and I think its quite usable

dm me with comments , ideas etc
Applied Biostatistics
ybrandvain.github.io
October 24, 2025 at 2:33 PM
Reposted by Jorge García
janetk.bsky.social
In a new paper led by Jiaqi Yang we trace the distribution of Denisovan introgressed DNA in ancient modern human genomes over time.

www.cell.com/current-biol...
An early East Asian lineage with unexpectedly low Denisovan ancestry
Yang et al. study Denisovan ancestry in ancient and present-day humans. In contrast to other East Asians, genomic comparisons suggest that the Jomon derived most of their ancestry from a deep lineage ...
www.cell.com
October 20, 2025 at 7:39 PM
Reposted by Jorge García
boothicus.bsky.social
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more ‘archaic’ hominid.

www.biorxiv.org/content/10.1...
A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
www.biorxiv.org
October 20, 2025 at 7:07 PM
Reposted by Jorge García
lperezsorribes.bsky.social
🐈🧬I recently presented the preliminary results of my first PhD chapter at Biología Investiga 2025, the scientific #outreach days organized by the @unisevilla.bsky.social

A great space for scientific exchange within the Faculty of Biology.

#PhDlife #WomenInSTEM #Genomics @ebdonana.bsky.social
October 17, 2025 at 8:51 AM
Reposted by Jorge García
gcbias.bsky.social
We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT
October 15, 2025 at 3:53 PM