Journal of Clinical Investigation
@jci.org
The JCI is a premiere venue for discoveries in basic and clinical biomedical science that will advance the practice of medicine. Est. 1924
ICYMI: A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
November 22, 2025 at 2:01 PM
ICYMI: A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fungal vaccines: so needed, so feasible, and yet so far off: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
November 21, 2025 at 5:15 PM
Fungal vaccines: so needed, so feasible, and yet so far off: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
Arturo Casadevall @acasadevall1.bsky.social comments on Uju J. Okaa et al.: www.jci.org/articles/vie...
GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
November 21, 2025 at 2:03 PM
GSK3β guides chromosomal repair pathway selection to support BRCA1-independent PARP inhibitor sensitivity: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Justin W. Leung & David Gius comment on Heba S. Allam et al.: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
JCI -
Effect of external cues on clock-driven protection from influenza A infection
www.jci.org
November 20, 2025 at 9:49 PM
Ilucidating the critical interplay between environmental timing cues and endogenous #CircadianRhythms for #Influenza outcomes www.jci.org/articles/vie... @sengupta_shaon #ImmuneResponse #Chronobiology #CircadianMedicine #TranslationalScience
Currently there are no anti-fungal vaccines
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
November 20, 2025 at 5:15 PM
Currently there are no anti-fungal vaccines
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Here, Bruce S. Klein & team identify a major antigen expressed in a family of fungal infectious diseases common in North America—and it stimulates potent immunity in mice and humans: www.jci.org/articles/vie...
Can in vitro–induced regulatory T cells promote lung recovery?
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
November 20, 2025 at 2:02 PM
Can in vitro–induced regulatory T cells promote lung recovery?
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Benjamin D. Singer & team find maintenance DNA methylation stabilizes induced Tregs to promote repair of the alveolar epithelium during viral pneumonia in mice.
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Hello Beta Cell folks, here's my final work as a postdoc with Michigan Medicine! Beta cell ERAD impairment affects proinsulin proteostasis not just by blocking degradation, but also by triggering stress that shuts down new synthesis. Happy reading!
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
November 19, 2025 at 1:35 AM
Hello Beta Cell folks, here's my final work as a postdoc with Michigan Medicine! Beta cell ERAD impairment affects proinsulin proteostasis not just by blocking degradation, but also by triggering stress that shuts down new synthesis. Happy reading!
Genetic and environmental influences in autism: Guiding the future of tailored early detection and intervention
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
November 19, 2025 at 5:15 PM
Genetic and environmental influences in autism: Guiding the future of tailored early detection and intervention
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A Viewpoint by Alexandra L. Bey et al.: www.jci.org/articles/vie...
A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
November 19, 2025 at 2:03 PM
A strategy to overcome tumor cell resistance to PARP inhibitors—regardless of BRCA1 status
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Fen Xia & team identify GSK3B as a regulator that determines DNA double-strand break repair pathway choice, signaling through the phosphorylation of 53BP1: www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
November 18, 2025 at 7:39 PM
New insights into islet ER stress responses, proinsulin biosynthesis, ERAD and ERD1 using β-cell-specific Hrd1-KO mice & rodent (and human islet) β-cells treated acutely with HRD1 inhibitor. jci.org/articles/vie...
@jci.org
@jci.org
Reposted by Journal of Clinical Investigation
Also, quick additional post to highlight this fantastic work on novel genetic mutations in the ARHGAP19 gene that cause Charcot-Marie-Tooth (CMT) Disease, now published in @jci.org .
www.jci.org/articles/vie...
www.jci.org/articles/vie...
JCI -
Biallelic variants in ARHGAP19 cause a progressive inherited motor-predominant neuropathy
www.jci.org
November 18, 2025 at 8:23 PM
Also, quick additional post to highlight this fantastic work on novel genetic mutations in the ARHGAP19 gene that cause Charcot-Marie-Tooth (CMT) Disease, now published in @jci.org .
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Microcephaly, epilepsy & diabetes syndrome (MEDS) is a rare disease
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
November 18, 2025 at 5:15 PM
Microcephaly, epilepsy & diabetes syndrome (MEDS) is a rare disease
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
@evirgilio.bsky.social et al. now identify biallelic variants in the TMEM167A gene as a third cause of #MEDS & show TMEM167A is involved in protein trafficking in pancreatic beta-cells: www.jci.org/articles/vie...
A potential marker for pancreatic cancer tumor formation…
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
November 18, 2025 at 2:03 PM
A potential marker for pancreatic cancer tumor formation…
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Thomas Mandel Clausen & team discover antithrombin-binding heparan sulfate is ubiquitously expressed in epithelial cells and a key enzyme involved with its synthesis is elevated in the early stages of PDAC development: buff.ly/CNCz0iW
Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy: www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 17, 2025 at 7:30 PM
Expanding the landscape of nucleotide excision repair disorders: from discovery to therapy: www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
Arjan F. Theil & Jan H.J. Hoeijmakers discuss two articles by Tomoo Ogi & team: www.jci.org/articles/vie...
www.jci.org/articles/vie...
This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
November 17, 2025 at 5:15 PM
This issue’s cover features work by Fassihi et al. and Nakazawa et al. on the C-terminal deletion of transcription factor TFIIH-p52 subunit as a cause of xeroderma pigmentosum.
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Image credit: Keiko Itano
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Journal of Clinical Investigation
Dr. Matlawska-Wasowska, was published in the @jci.org for her study, “T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.” Learn more: www.jci.org/articles/vie...
November 14, 2025 at 9:01 PM
Dr. Matlawska-Wasowska, was published in the @jci.org for her study, “T-cell acute lymphoblastic leukemia exploits a neural proinflammatory pathway to colonize the meninges.” Learn more: www.jci.org/articles/vie...
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
November 16, 2025 at 2:00 PM
ICYMI: Prostate tumor–mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL-10 signaling
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
Mindy K Graham @mindykimgraham.bsky.social & team analyze a published sc-RNA-Seq dataset involving metastatic tumors of the bone: www.jci.org/articles/vie...
ICYMI: Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
November 15, 2025 at 2:00 PM
ICYMI: Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
Jaehyuk Choi & team map immune cells in L-HES, finding drug targets and showing targeted therapy removes disease-causing cells and eases symptoms: www.jci.org/articles/vie...
S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
November 14, 2025 at 7:30 PM
S-TIR-ring up TLR7 and TLR9: signaling domain substitutions clarify the TLR paradox: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
@rosertp.bsky.social & @carovinuesa.bsky.social provide a Commentary on Claire Leibler et al.: www.jci.org/articles/vie...
GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
November 14, 2025 at 5:15 PM
GAB2 couples genetic drivers and signaling networks in acute myeloid leukemia: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
Amanda Luvisotto & Lu Wang provide a Commentary on Michael H. Kramer et al.: www.jci.org/articles/vie...
Repurposing the antihistamine cyproheptadine for osteoarthritis: Nothing to sneeze at- www.jci.org/articles/vie...
Richard F. Loeser & team Comment on Ichiro Kurakazu: www.jci.org/articles/vie...
Richard F. Loeser & team Comment on Ichiro Kurakazu: www.jci.org/articles/vie...
November 14, 2025 at 2:02 PM
Repurposing the antihistamine cyproheptadine for osteoarthritis: Nothing to sneeze at- www.jci.org/articles/vie...
Richard F. Loeser & team Comment on Ichiro Kurakazu: www.jci.org/articles/vie...
Richard F. Loeser & team Comment on Ichiro Kurakazu: www.jci.org/articles/vie...
Hypercapnia promotes maladaptive airway and vascular remodeling in mice
In this Research Letter, Masahiko Shigemura & team show CO2 can remodel lungs and worsen COPD with partial reversibility through lowered CO2: www.jci.org/articles/vie...
In this Research Letter, Masahiko Shigemura & team show CO2 can remodel lungs and worsen COPD with partial reversibility through lowered CO2: www.jci.org/articles/vie...
November 13, 2025 at 7:30 PM
Hypercapnia promotes maladaptive airway and vascular remodeling in mice
In this Research Letter, Masahiko Shigemura & team show CO2 can remodel lungs and worsen COPD with partial reversibility through lowered CO2: www.jci.org/articles/vie...
In this Research Letter, Masahiko Shigemura & team show CO2 can remodel lungs and worsen COPD with partial reversibility through lowered CO2: www.jci.org/articles/vie...
A Research Letter by Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
November 13, 2025 at 5:15 PM
A Research Letter by Joshua T. Schiffer & team:
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
Molnupiravir clinical trial simulation suggests that polymerase chain reaction underestimates antiviral potency against SARS-CoV-2: www.jci.org/articles/vie...
New insights into lipid redistribution!
Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
November 13, 2025 at 2:04 PM
New insights into lipid redistribution!
Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
Bin Gao & team show macrophages promote fat redistribution from adipocytes to hepatocytes and development of steatotic liver disease: www.jci.org/articles/vie...
The figure shows MASH liver has elevated S100A8+ macrophages.
What is the missing link between initiating and progression mutations in acute myeloid leukemia?
Timothy J. Ley & team reveal Gab2 can accelerate AML development in mice and its overexpression may facilitate signaling mutations in AML and other cancers.
www.jci.org/articles/vie...
Timothy J. Ley & team reveal Gab2 can accelerate AML development in mice and its overexpression may facilitate signaling mutations in AML and other cancers.
www.jci.org/articles/vie...
November 12, 2025 at 5:15 PM
What is the missing link between initiating and progression mutations in acute myeloid leukemia?
Timothy J. Ley & team reveal Gab2 can accelerate AML development in mice and its overexpression may facilitate signaling mutations in AML and other cancers.
www.jci.org/articles/vie...
Timothy J. Ley & team reveal Gab2 can accelerate AML development in mice and its overexpression may facilitate signaling mutations in AML and other cancers.
www.jci.org/articles/vie...