Jack Sanford
@jacksanfordphd.bsky.social
Postdoc in the Goncalves lab. Studying cancer cachexia and tumor secreted proteins.
Today is the first cancer cachexia day. Please share to spread awareness.
For patients, these are symptoms to keep track of and let your doctor know if you are experiencing.
For medical professionals, a big hurdle is dietitian visits are not commonly reimbursed, despite benefiting patients
For patients, these are symptoms to keep track of and let your doctor know if you are experiencing.
For medical professionals, a big hurdle is dietitian visits are not commonly reimbursed, despite benefiting patients
September 26, 2025 at 1:44 PM
Today is the first cancer cachexia day. Please share to spread awareness.
For patients, these are symptoms to keep track of and let your doctor know if you are experiencing.
For medical professionals, a big hurdle is dietitian visits are not commonly reimbursed, despite benefiting patients
For patients, these are symptoms to keep track of and let your doctor know if you are experiencing.
For medical professionals, a big hurdle is dietitian visits are not commonly reimbursed, despite benefiting patients
Authors, please upload a gene count matrix or even t-test excel sheet in your paper. I don’t want to have to download the raw counts
September 24, 2025 at 6:03 PM
Authors, please upload a gene count matrix or even t-test excel sheet in your paper. I don’t want to have to download the raw counts
Reposted by Jack Sanford
You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office!
There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB and keep the momentum going! 🦆
There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB and keep the momentum going! 🦆
September 17, 2025 at 9:34 PM
You asked for it! We delivered Quack-O-Grams to our members of Congress urging them to #ImpeachRFK, and get that Quack out of office!
There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB and keep the momentum going! 🦆
There's still time for you to get in on this fluffy, feathery action: Send your own duck at zurl.co/W1ZnB and keep the momentum going! 🦆
Reposted by Jack Sanford
Contrasting cell count and biomass distributions by cell type:
◼️ Human cell size and count are nearly inversely related. More quantitatively, ...
🧵
◼️ Human cell size and count are nearly inversely related. More quantitatively, ...
🧵
September 13, 2025 at 11:25 AM
Contrasting cell count and biomass distributions by cell type:
◼️ Human cell size and count are nearly inversely related. More quantitatively, ...
🧵
◼️ Human cell size and count are nearly inversely related. More quantitatively, ...
🧵
Massive study just published for the field of appetite control! Now only if we could harness it!
(Check out the video at the end)
www.cell.com/cell/fulltex...
(Check out the video at the end)
www.cell.com/cell/fulltex...
A brain center that controls consummatory responses
The BNST brain region integrates a broad range of external and internal signals to
flexibly regulate consumption, revealing a unified control over consummatory responses.
www.cell.com
September 11, 2025 at 11:30 AM
Massive study just published for the field of appetite control! Now only if we could harness it!
(Check out the video at the end)
www.cell.com/cell/fulltex...
(Check out the video at the end)
www.cell.com/cell/fulltex...
Phospholipid looking like a wacky inflatable tube man
27 simulations of capturing hundreds of lipid scrambling events reveal mechanisms of lipid translocation.
However, according to reviewers, more evidence is needed on outside-the-groove scramblase activity.
buff.ly/LTxy4yX
However, according to reviewers, more evidence is needed on outside-the-groove scramblase activity.
buff.ly/LTxy4yX
September 10, 2025 at 11:23 AM
Phospholipid looking like a wacky inflatable tube man
Reposted by Jack Sanford
The Mag-Net paper is out! We've now put 1000s of plasma samples through this protocol and we know others have too. We've used it to study dozens of diseases. Looking forward to seeing what others apply this towards. The preprint already has >39 citations. www.nature.com/articles/s41...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome - Nature Communications
Authors report MagNet, a plasma extracellular vesicle (EV) enrichment strategy using magnetic beads. Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyon...
www.nature.com
July 1, 2025 at 2:01 PM
The Mag-Net paper is out! We've now put 1000s of plasma samples through this protocol and we know others have too. We've used it to study dozens of diseases. Looking forward to seeing what others apply this towards. The preprint already has >39 citations. www.nature.com/articles/s41...
Incredible! Once/year HIV prevention injection
THIS IS HUGE! An HIV PrEP drug candidate in the form of a ONCE-yearly intramuscular injection has been shown to BLOCK HIV infections AND participants achieved AND maintained protection ABOVE the 95% efficacy threshold for UP TO 56 WEEKS. Phase III trials are scheduled for later this year! 🧪🧵⬇️
March 19, 2025 at 10:07 PM
Incredible! Once/year HIV prevention injection
Well said. This will not stop at Columbia.
Today I'm filled with admiration for my university's president, Chris Eisgruber. He's standing up for Columbia and for universities as a home for freedom of ideas, debate, and thought - free of government attack. www.theatlantic.com/ideas/archiv...
The Cost of the Government’s Attack on Columbia
American universities have given the country prosperity and security. The Trump administration’s attack on academic freedom endangers all of that.
www.theatlantic.com
March 19, 2025 at 4:25 PM
Well said. This will not stop at Columbia.
I made my NCAA bracket based on how much each university received in funding from the NIH last year. The NIH funds incredible, life saving research at all of these universities that we cheer for.
March 19, 2025 at 2:45 AM
I made my NCAA bracket based on how much each university received in funding from the NIH last year. The NIH funds incredible, life saving research at all of these universities that we cheer for.
Really interesting findings. My interpretation: Large, high profile research groups create a survival of the fittest mentality. Those who survive do quite well, but many end up dropping out of academia
Lower survival rate among trainees in labs with highly productive mentors raises important concerns about what we value in academia. Many interesting things to stew over with this paper!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Academic mentees thrive in big groups, but survive in small groups - Nature Human Behaviour
Using longitudinal genealogical data on mentor–mentee relations and their publications, the authors find that mentees trained in larger groups tend to exhibit superior academic performance compared wi...
www.nature.com
March 18, 2025 at 4:13 PM
Really interesting findings. My interpretation: Large, high profile research groups create a survival of the fittest mentality. Those who survive do quite well, but many end up dropping out of academia
Reposted by Jack Sanford
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
A Bifunctional Degrader Reads Out in Phase 3
www.science.org
March 12, 2025 at 6:53 PM
The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:
We need to change how we talk about the NIH funding another vaccines and autism study.
Don’t say “this is settled science, we already studied this”
Talk about the opportunity cost. We are NOT going to find the next cancer causing agent because we are studying this instead
Don’t say “this is settled science, we already studied this”
Talk about the opportunity cost. We are NOT going to find the next cancer causing agent because we are studying this instead
March 11, 2025 at 12:14 PM
We need to change how we talk about the NIH funding another vaccines and autism study.
Don’t say “this is settled science, we already studied this”
Talk about the opportunity cost. We are NOT going to find the next cancer causing agent because we are studying this instead
Don’t say “this is settled science, we already studied this”
Talk about the opportunity cost. We are NOT going to find the next cancer causing agent because we are studying this instead
Eating a western diet during pregnancy is associated with ADHD and autism development in offspring.
March 10, 2025 at 11:45 AM
Eating a western diet during pregnancy is associated with ADHD and autism development in offspring.
Got my sign ready for the #StandUpForScience march in DC! Hope to see many of you out there!
March 6, 2025 at 5:35 PM
Got my sign ready for the #StandUpForScience march in DC! Hope to see many of you out there!
Reposted by Jack Sanford
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
March 5, 2025 at 4:54 PM
It is important at this pivotal moment to @standupforscience.bsky.social. Looking forward to sharing my thoughts on why this should be a national priority at tomorrow’s rally in SF:
Reposted by Jack Sanford
What Hank said!
Yall better be both sharing the Stand up for Science posts /and/ figuring out how to get your butt to one of them!
@standupforscience.bsky.social
@standupforscience.bsky.social
March 3, 2025 at 6:43 PM
What Hank said!
I was lucky enough to have been one of these interns. Not only did this program give me practical experience that helped me get into a PhD program, but it was as an NIH intern that I learned that I loved science.
What a loss.
What a loss.
BREAKING:
The NIH summer internship program (SIP) has been officially cancelled, across all institutes.
It’s a sad loss for the brightest science students in America, for American science, and for future cures for diseases like cancer and Alzheimer’s. 🧪 1/
The NIH summer internship program (SIP) has been officially cancelled, across all institutes.
It’s a sad loss for the brightest science students in America, for American science, and for future cures for diseases like cancer and Alzheimer’s. 🧪 1/
NIDA has announced it, but all the NIH summer internship programs are likely cancelled.
Sorry college students interested in STEM jobs, sorry high school students looking at science 🧪 careers. Trump and Musk are cancelling your futures.
Sorry college students interested in STEM jobs, sorry high school students looking at science 🧪 careers. Trump and Musk are cancelling your futures.
February 27, 2025 at 11:02 PM
I was lucky enough to have been one of these interns. Not only did this program give me practical experience that helped me get into a PhD program, but it was as an NIH intern that I learned that I loved science.
What a loss.
What a loss.
Reposted by Jack Sanford
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come! @standupforscience.bsky.social
February 15, 2025 at 7:51 PM
We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should come! @standupforscience.bsky.social
Just signed up to attend the March 7th Stand up for Science march in DC. Similar marches happening at state capitals nationwide.
Now is the time to double down on science. Not cut back. Make your voice heard on March 7th.
www.standupforscience2025.org/STAND-UP-FOR...
Now is the time to double down on science. Not cut back. Make your voice heard on March 7th.
www.standupforscience2025.org/STAND-UP-FOR...
STAND UP FOR SCIENCE 2025
Join us in Washington, DC or your state capitol on March 7th, 2025 to stand up for science!
www.standupforscience2025.org
February 16, 2025 at 6:46 PM
Just signed up to attend the March 7th Stand up for Science march in DC. Similar marches happening at state capitals nationwide.
Now is the time to double down on science. Not cut back. Make your voice heard on March 7th.
www.standupforscience2025.org/STAND-UP-FOR...
Now is the time to double down on science. Not cut back. Make your voice heard on March 7th.
www.standupforscience2025.org/STAND-UP-FOR...
Cancer is non-partisan. Cardiovascular disease is non-partisan. This will be devastating if not resolved quickly.
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 10:50 PM
Cancer is non-partisan. Cardiovascular disease is non-partisan. This will be devastating if not resolved quickly.
I’m finding a lot of proteins in my blood proteomics work that have no known secretion pathway. Proteins like histone subunits, parts of the nuclear pore complex, and proteosome subunits. Does anyone know how these get into the blood stream? It has to be cell turnover, right?
January 14, 2025 at 5:37 PM
I’m finding a lot of proteins in my blood proteomics work that have no known secretion pathway. Proteins like histone subunits, parts of the nuclear pore complex, and proteosome subunits. Does anyone know how these get into the blood stream? It has to be cell turnover, right?
Reposted by Jack Sanford
All these pipelines for spatial transcriptomics really need to be aware of this. Don't turn your expensive output into a puddle.
(please amplify) 4% of scientists face an important barrier to an the ENTIRE FIELD of single-cell genomics and here is why
December 1, 2024 at 1:32 AM
All these pipelines for spatial transcriptomics really need to be aware of this. Don't turn your expensive output into a puddle.
Reposted by Jack Sanford
Clear ⏬ with GLP-1RA by ~15% for all clinical outcomes including:
Kidney failure ✅
Major CV events ✅
Heart failure ✅
CV death ✅
All-cause death ✅
Updated systematic review/meta-analysis of 11 trials ~85,000 participants, with & without diabetes
Now in Lancet D&E: www.thelancet.com/journals/lan...
Kidney failure ✅
Major CV events ✅
Heart failure ✅
CV death ✅
All-cause death ✅
Updated systematic review/meta-analysis of 11 trials ~85,000 participants, with & without diabetes
Now in Lancet D&E: www.thelancet.com/journals/lan...
November 26, 2024 at 10:07 AM
Clear ⏬ with GLP-1RA by ~15% for all clinical outcomes including:
Kidney failure ✅
Major CV events ✅
Heart failure ✅
CV death ✅
All-cause death ✅
Updated systematic review/meta-analysis of 11 trials ~85,000 participants, with & without diabetes
Now in Lancet D&E: www.thelancet.com/journals/lan...
Kidney failure ✅
Major CV events ✅
Heart failure ✅
CV death ✅
All-cause death ✅
Updated systematic review/meta-analysis of 11 trials ~85,000 participants, with & without diabetes
Now in Lancet D&E: www.thelancet.com/journals/lan...