Isaac Stoner
@isaacbstoner.bsky.social
Biotech optimist and enthusiast. Dreamer, thinker, and loudmouth. Opinions are my own and likely not well composed. www.isaacstoner.com
Simultaneous failures:
- Novo's semaglutide study
- J&J's anti-Tau
Alzheimer's Disease is TOUGH. We need as many differentiated first-in-class plays as possible.
- Novo's semaglutide study
- J&J's anti-Tau
Alzheimer's Disease is TOUGH. We need as many differentiated first-in-class plays as possible.
November 26, 2025 at 1:49 AM
Simultaneous failures:
- Novo's semaglutide study
- J&J's anti-Tau
Alzheimer's Disease is TOUGH. We need as many differentiated first-in-class plays as possible.
- Novo's semaglutide study
- J&J's anti-Tau
Alzheimer's Disease is TOUGH. We need as many differentiated first-in-class plays as possible.
Reposted by Isaac Stoner
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
November 24, 2025 at 1:42 AM
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
Inside all of us there are two wolves....
In my case there are 3 and they were out back by the pool last night.
In my case there are 3 and they were out back by the pool last night.
November 24, 2025 at 12:20 AM
Inside all of us there are two wolves....
In my case there are 3 and they were out back by the pool last night.
In my case there are 3 and they were out back by the pool last night.
Biggest drugs of the year. Study this well: it is a lagging indicator of hot disease areas.
What are the huge indications that are not represented here?
What are the huge indications that are not represented here?
November 24, 2025 at 12:19 AM
Biggest drugs of the year. Study this well: it is a lagging indicator of hot disease areas.
What are the huge indications that are not represented here?
What are the huge indications that are not represented here?
Socialism = collective cooperation
Capitalism = coercion by those with the capital
Capitalism = coercion by those with the capital
November 24, 2025 at 12:17 AM
Socialism = collective cooperation
Capitalism = coercion by those with the capital
Capitalism = coercion by those with the capital
Did the bubble pop this week?
November 21, 2025 at 2:58 AM
Did the bubble pop this week?
Trains dude. Trains.
September 23, 2025 at 11:55 PM
Trains dude. Trains.
It's a freakin car company!
I will never understand this nonsense.
I will never understand this nonsense.
September 6, 2025 at 12:06 AM
It's a freakin car company!
I will never understand this nonsense.
I will never understand this nonsense.
alright bluesky I'm back.
anything cool going on?
not THIS cool....
anything cool going on?
not THIS cool....
July 16, 2025 at 1:31 AM
alright bluesky I'm back.
anything cool going on?
not THIS cool....
anything cool going on?
not THIS cool....
Late night orders from Pentagon-adjacent Dominos predict US military action....
June 17, 2025 at 10:33 AM
Late night orders from Pentagon-adjacent Dominos predict US military action....
Pretty sure I pulled a muscle in my calf getting out of bed this morning.
Ugh
Ugh
May 24, 2025 at 12:47 AM
Pretty sure I pulled a muscle in my calf getting out of bed this morning.
Ugh
Ugh
An old and classic Boston Whaler is a joy forever. Grateful to have had time for some proper rehab and restoration this past spring #bostonwhaler #boatlife
May 16, 2025 at 12:14 AM
An old and classic Boston Whaler is a joy forever. Grateful to have had time for some proper rehab and restoration this past spring #bostonwhaler #boatlife
Absolute poetic irony that Octagon Therapeutics gets significant press coverage when we announce we are winding down the company.
I would have begged for this kind of exposure when things were going well! 😂
endpts.com/octagon-ther...
www.fiercebiotech.com/biotech/octa...
I would have begged for this kind of exposure when things were going well! 😂
endpts.com/octagon-ther...
www.fiercebiotech.com/biotech/octa...
Octagon Therapeutics shuts down after 'unresolved biology questions'
Octagon Therapeutics, led by CEO Isaac Stoner, is shutting down after halting work on B cell immunomodulator and facing biology questions in pipeline program.
endpts.com
April 30, 2025 at 12:17 AM
Absolute poetic irony that Octagon Therapeutics gets significant press coverage when we announce we are winding down the company.
I would have begged for this kind of exposure when things were going well! 😂
endpts.com/octagon-ther...
www.fiercebiotech.com/biotech/octa...
I would have begged for this kind of exposure when things were going well! 😂
endpts.com/octagon-ther...
www.fiercebiotech.com/biotech/octa...
Within every startup ecosystem there exists a class of company that:
- is extremely well-funded by non-specialist VCs
- gets a ton of press and meetings with high profile non-specialists (politicians and dignitaries)
- everyone in the ecosystem knows it is AT BEST a dud and AT WORST a total scam
- is extremely well-funded by non-specialist VCs
- gets a ton of press and meetings with high profile non-specialists (politicians and dignitaries)
- everyone in the ecosystem knows it is AT BEST a dud and AT WORST a total scam
March 25, 2025 at 11:54 PM
Within every startup ecosystem there exists a class of company that:
- is extremely well-funded by non-specialist VCs
- gets a ton of press and meetings with high profile non-specialists (politicians and dignitaries)
- everyone in the ecosystem knows it is AT BEST a dud and AT WORST a total scam
- is extremely well-funded by non-specialist VCs
- gets a ton of press and meetings with high profile non-specialists (politicians and dignitaries)
- everyone in the ecosystem knows it is AT BEST a dud and AT WORST a total scam
I have seen this bar chart in investor decks, published manuscripts, and everywhere else...
Stop cropping your y-axis to make small differences look huge!
Stop cropping your y-axis to make small differences look huge!
March 11, 2025 at 2:01 PM
I have seen this bar chart in investor decks, published manuscripts, and everywhere else...
Stop cropping your y-axis to make small differences look huge!
Stop cropping your y-axis to make small differences look huge!
Reposted by Isaac Stoner
Be employed, exercise, don’t smoke, live with your partner, eat cheese. www.nature.com/articles/s41...
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range...
www.nature.com
February 28, 2025 at 2:05 AM
Be employed, exercise, don’t smoke, live with your partner, eat cheese. www.nature.com/articles/s41...
If you're a life science company and you use "foundry" or "full stack" in your pitch....you are probably full of shit.
February 24, 2025 at 10:57 PM
If you're a life science company and you use "foundry" or "full stack" in your pitch....you are probably full of shit.
4th birthday. My boy RIPS.
February 23, 2025 at 8:08 PM
4th birthday. My boy RIPS.
Compared to the speed, skill, power, and athleticism on display in a top tier hockey game, all other sports are boring.
Go Canada!
Go Canada!
February 21, 2025 at 3:36 AM
Compared to the speed, skill, power, and athleticism on display in a top tier hockey game, all other sports are boring.
Go Canada!
Go Canada!
Right?
STOP TAKING THE BAIT.
STOP TAKING THE BAIT.
“ ‘The Gulf of America’ Is the Wrong Fight to Pick” is the wrong op-ed subject to pick
February 16, 2025 at 2:31 AM
Right?
STOP TAKING THE BAIT.
STOP TAKING THE BAIT.
Palm Springs (2020) is the best millennial Valentine's movie.
No further debate will be tolerated.
No further debate will be tolerated.
February 15, 2025 at 2:04 AM
Palm Springs (2020) is the best millennial Valentine's movie.
No further debate will be tolerated.
No further debate will be tolerated.