Jake Wintermute
@synbio1.bsky.social
Synthetic Biologist - Foundry Theorist
foundrytheory.substack.com
stay humble biodesigners
foundrytheory.substack.com
stay humble biodesigners
If human genetics becomes more engineerable in the future many social conventions about the human body (race, gender, beauty, parenthood) will become untenable and, I suppose, be replaced with other social conventions that we cannot see from this side of history
November 29, 2025 at 2:47 PM
If human genetics becomes more engineerable in the future many social conventions about the human body (race, gender, beauty, parenthood) will become untenable and, I suppose, be replaced with other social conventions that we cannot see from this side of history
Americans make great biologists because we are forged by the hardest challenge in all of biotech: getting flavor from a turkey
November 27, 2025 at 2:35 PM
Americans make great biologists because we are forged by the hardest challenge in all of biotech: getting flavor from a turkey
You can't judge a scientific discipline by it's cover
November 26, 2025 at 11:21 PM
You can't judge a scientific discipline by it's cover
Amplicon sequencing is getting close to the price point where it starts to makes sense to just sequence your PCR product instead of running an agarose gel to see if it worked.
Imagine a future without agarose gels. What will grad students do all day?
Imagine a future without agarose gels. What will grad students do all day?
November 26, 2025 at 5:20 PM
Amplicon sequencing is getting close to the price point where it starts to makes sense to just sequence your PCR product instead of running an agarose gel to see if it worked.
Imagine a future without agarose gels. What will grad students do all day?
Imagine a future without agarose gels. What will grad students do all day?
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
November 25, 2025 at 4:42 PM
Given that GLP-1 drugs were found in gila monster venom it's not totally unrealistic to imagine that one day a breakthrough drug will be discovered in literal snake oil and a biotech startup will be like "ok how do we market this"
I dare you to put this in your next talk instead of the slide acknowledging funding sources
November 24, 2025 at 6:52 PM
I dare you to put this in your next talk instead of the slide acknowledging funding sources
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
November 24, 2025 at 1:42 AM
"We should keep saying how AI can enable biomedical breakthroughs people seem to like that"
These hotdog looking plants are magic there has to be some kind of cool biotech we can invent from this
November 20, 2025 at 1:09 PM
These hotdog looking plants are magic there has to be some kind of cool biotech we can invent from this
Biotech needs a tickle-me-elmo moment a product so desirable that people will stampede over police barricades to get it
November 19, 2025 at 12:59 PM
Biotech needs a tickle-me-elmo moment a product so desirable that people will stampede over police barricades to get it
Has anyone explored the possibility that Eroom's law and the decline in biotech R&D productivity may be due to the fact that our reagent packaging no longer gives sleek midcentury optimism
November 18, 2025 at 6:34 PM
Has anyone explored the possibility that Eroom's law and the decline in biotech R&D productivity may be due to the fact that our reagent packaging no longer gives sleek midcentury optimism
Somebody once sent me a DNA sequence in a Microsoft Word document and something about seeing nucleotides in Times New Roman font really stresses me out
November 16, 2025 at 4:04 PM
Somebody once sent me a DNA sequence in a Microsoft Word document and something about seeing nucleotides in Times New Roman font really stresses me out
There's a lot of bioproduct innovation happening in the world that isn't well connected with academia or the industrial biotech scene like what conferences is this guy attending and how do I get invited
November 15, 2025 at 4:44 PM
There's a lot of bioproduct innovation happening in the world that isn't well connected with academia or the industrial biotech scene like what conferences is this guy attending and how do I get invited
How it feels to add the transformation recovery broth to your microbes after electroporation
November 14, 2025 at 8:22 PM
How it feels to add the transformation recovery broth to your microbes after electroporation
Justice for furbaby
November 14, 2025 at 1:29 PM
Justice for furbaby
Enemies to lovers but make it biology and engineering
November 13, 2025 at 2:07 PM
Enemies to lovers but make it biology and engineering
The application of humanoid robots that I’m the most excited about and one that will definitely work is super dope ass fortune teller machines
November 10, 2025 at 1:50 AM
The application of humanoid robots that I’m the most excited about and one that will definitely work is super dope ass fortune teller machines
Victor frankenstein did nothing wrong
November 9, 2025 at 7:33 PM
Victor frankenstein did nothing wrong
Will AI-generated genomes read like AI slop?
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
November 9, 2025 at 4:10 PM
Will AI-generated genomes read like AI slop?
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
Like you’ll be scrolling GenBank one day and it will be full of microbial genomes with the nucleotide equivalent of
“This lac operon doesn’t just encode LacA and LacY — it expresses LacZ”
It may seem obvious but honestly it is worth taking a moment to reflect on how amazing this actually is
November 7, 2025 at 12:03 PM
It may seem obvious but honestly it is worth taking a moment to reflect on how amazing this actually is
If you study cholinesterases in plant tissues you have legendary opportunity to make your work relatable to gen z by showing them this article from 1975 that has PubMed ID # 67
pubmed.ncbi.nlm.nih.gov/67
pubmed.ncbi.nlm.nih.gov/67
November 6, 2025 at 1:38 PM
If you study cholinesterases in plant tissues you have legendary opportunity to make your work relatable to gen z by showing them this article from 1975 that has PubMed ID # 67
pubmed.ncbi.nlm.nih.gov/67
pubmed.ncbi.nlm.nih.gov/67
Pink olives (soaked in beet juice) and purple olives (soaked on blueberry juice) is this the next gen of olives only time will tell
November 4, 2025 at 1:42 PM
Pink olives (soaked in beet juice) and purple olives (soaked on blueberry juice) is this the next gen of olives only time will tell
The hottest girl you know isn't trying to industrialize biology she wants to biologize industry
November 3, 2025 at 10:13 PM
The hottest girl you know isn't trying to industrialize biology she wants to biologize industry
Consider the importance of form factor when designing a bioproduct
November 3, 2025 at 3:14 PM
Consider the importance of form factor when designing a bioproduct