Hugo Talibart
@hugotalibart.bsky.social
Postdoctoral researcher in bioinformatics at Université Libre de Bruxelles. Proteins, (co-)evolution, drug design, AI (-skeptic). Computer geek, python enthousiast. 🏳️🌈
It's easy to receive an email when a job finishes on a computer cluster, but setting that up on a single machine is a little less straightforward. Thanks to my colleague Benoît I discovered you can very easily send yourself messages via a Telegram bot from Python!
github.com/Benoitdw/war...
github.com/Benoitdw/war...
GitHub - Benoitdw/warnme: Library / CLI to communicate with me
Library / CLI to communicate with me. Contribute to Benoitdw/warnme development by creating an account on GitHub.
github.com
October 18, 2025 at 12:21 PM
It's easy to receive an email when a job finishes on a computer cluster, but setting that up on a single machine is a little less straightforward. Thanks to my colleague Benoît I discovered you can very easily send yourself messages via a Telegram bot from Python!
github.com/Benoitdw/war...
github.com/Benoitdw/war...
This week I discovered the python library polars, it's like pandas but based on Rust so it's much faster. I was working with a big dataframe (around 100 million rows) and I was blown away by its speed. Highly recommend you try it!
github.com/pola-rs/polars
github.com/pola-rs/polars
GitHub - pola-rs/polars: Dataframes powered by a multithreaded, vectorized query engine, written in Rust
Dataframes powered by a multithreaded, vectorized query engine, written in Rust - pola-rs/polars
github.com
September 6, 2025 at 4:40 PM
This week I discovered the python library polars, it's like pandas but based on Rust so it's much faster. I was working with a big dataframe (around 100 million rows) and I was blown away by its speed. Highly recommend you try it!
github.com/pola-rs/polars
github.com/pola-rs/polars
Reposted by Hugo Talibart
Interested in a tool that aligns millions of proteins in minutes with quality similar to or better than the state-of-the-art utilities? Please take a look at our FAMSA2 paper: www.biorxiv.org/content/10.1...
and GH repo: github.com/refresh-bio/...
and GH repo: github.com/refresh-bio/...
FAMSA2 enables accurate multiple sequence alignment at protein-universe scale
We introduce FAMSA2, an algorithm that produces high-accuracy multiple protein sequence alignments with unprecedented speed. Across structural, phylogenetic, and functional benchmarks, FAMSA2 matches ...
www.biorxiv.org
July 19, 2025 at 9:28 PM
Interested in a tool that aligns millions of proteins in minutes with quality similar to or better than the state-of-the-art utilities? Please take a look at our FAMSA2 paper: www.biorxiv.org/content/10.1...
and GH repo: github.com/refresh-bio/...
and GH repo: github.com/refresh-bio/...
Reposted by Hugo Talibart
A simple flow of gas over water may have helped kickstart life on early Earth.
Research shows how evaporation and fluid flow in a narrow channel can drive isothermal DNA replication, offering a plausible, low-temp setting for early molecular evolution.
buff.ly/ADgyeFk
Research shows how evaporation and fluid flow in a narrow channel can drive isothermal DNA replication, offering a plausible, low-temp setting for early molecular evolution.
buff.ly/ADgyeFk
July 24, 2025 at 10:28 PM
A simple flow of gas over water may have helped kickstart life on early Earth.
Research shows how evaporation and fluid flow in a narrow channel can drive isothermal DNA replication, offering a plausible, low-temp setting for early molecular evolution.
buff.ly/ADgyeFk
Research shows how evaporation and fluid flow in a narrow channel can drive isothermal DNA replication, offering a plausible, low-temp setting for early molecular evolution.
buff.ly/ADgyeFk
Reposted by Hugo Talibart
A paper thar took too long to finish. We show that AlphaFold3 its clearly better than AlphaFold2 (and Boltz-1 and Chai-1) to predict the structure of antibody-Antigens, but only for cases with (har to detect) similarity in the training set.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Evaluating Deep Learning Based Structure Prediction Methods on Antibody-Antigen Complexes
Motivation: AlphaFold2 significantly improved the prediction of protein complex structures. However, its accuracy is lower for interactions without co-evolutionary signals, such as host-pathogen and a...
www.biorxiv.org
July 12, 2025 at 2:13 AM
A paper thar took too long to finish. We show that AlphaFold3 its clearly better than AlphaFold2 (and Boltz-1 and Chai-1) to predict the structure of antibody-Antigens, but only for cases with (har to detect) similarity in the training set.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Two weeks from now I'll be at ISMB 2025 in Liverpool with a poster presenting our Transformer-based small molecule VAE with a chemistry-aware latent space. In the meantime, if you're attending, you can already see it online: iscb.junolive.co/ISMB/live/ex...
Looking forward to seeing you there!
Looking forward to seeing you there!
July 8, 2025 at 12:00 PM
Two weeks from now I'll be at ISMB 2025 in Liverpool with a poster presenting our Transformer-based small molecule VAE with a chemistry-aware latent space. In the meantime, if you're attending, you can already see it online: iscb.junolive.co/ISMB/live/ex...
Looking forward to seeing you there!
Looking forward to seeing you there!
Reposted by Hugo Talibart
Most proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms
https://go.nature.com/4mCImRm
https://go.nature.com/4mCImRm
Rare ‘ambidextrous’ protein breaks rules of handedness
Most proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms.
go.nature.com
May 29, 2025 at 3:48 PM
Most proteins are left-handed, but scientists have found an ancient molecule that works in both mirror-image forms
https://go.nature.com/4mCImRm
https://go.nature.com/4mCImRm
Reposted by Hugo Talibart
1/n
Looking through this. Will pull tidbits out and put them in this thread.
Looking through this. Will pull tidbits out and put them in this thread.
Here's the NIH's proposed budget - from $48 billion to $27 billion. NIAID, current ~$7 billion cut to ~$4.2 billion.
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
The proposed 15% cap on indirect costs remains.
Again, these budgets are passed, and our leadership in science, technology, and innovation is gone.
www.hhs.gov/sites/defaul...
May 30, 2025 at 11:39 PM
1/n
Looking through this. Will pull tidbits out and put them in this thread.
Looking through this. Will pull tidbits out and put them in this thread.
Reposted by Hugo Talibart
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
May 22, 2025 at 12:42 PM
NIH funding supporting the HMMER and Infernal software projects has been terminated. NIH states that our work, as well as all other federally funded research at Harvard, is of no benefit to the US.
Did you know smell detection relies on specialized proteins called "olfactory receptors"?
Located in olfactory neuron membranes inside the nose, they change shape when a molecule binds, triggering reactions that ultimately open ion channels, depolarize the membrane and send a signal to the brain.
Located in olfactory neuron membranes inside the nose, they change shape when a molecule binds, triggering reactions that ultimately open ion channels, depolarize the membrane and send a signal to the brain.
May 24, 2025 at 1:45 PM
Did you know smell detection relies on specialized proteins called "olfactory receptors"?
Located in olfactory neuron membranes inside the nose, they change shape when a molecule binds, triggering reactions that ultimately open ion channels, depolarize the membrane and send a signal to the brain.
Located in olfactory neuron membranes inside the nose, they change shape when a molecule binds, triggering reactions that ultimately open ion channels, depolarize the membrane and send a signal to the brain.
Hi! I'm a little late to the party, but glad to be finally joining BlueSky! I'll be posting a little bit about the work I do as a postdoctoral researcher at ULB, also probably random fun facts I learn here and there, because biology never ceases to amaze me.
May 18, 2025 at 6:12 PM
Hi! I'm a little late to the party, but glad to be finally joining BlueSky! I'll be posting a little bit about the work I do as a postdoctoral researcher at ULB, also probably random fun facts I learn here and there, because biology never ceases to amaze me.