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gl-hooper.bsky.social
@gl-hooper.bsky.social
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gl-hooper.bsky.social
gl-hooper.bsky.social @gl-hooper.bsky.social · Jan 16
Check out our recent review on "Cell entry mechanisms of African swine fever virus" #ASFV #virology www.sciencedirect.com/science/arti...
Cell entry mechanisms of African swine fever virus
African swine fever virus (ASFV) is a highly complex virus that poses a significant threat to the global swine industry. However, little is known abou…
www.sciencedirect.com
gl-hooper.bsky.social
New study uses computational modelling + pseudotyped virus assays to identify broad-spectrum antivirals that block coronavirus cell entry. A step forward in rapid antiviral development.
www.frontiersin.org/journals/mol...
#Virology #PseudotypedVirus #DrugDiscovery #COVID19 #Pseudotyping
Frontiers | Broad-spectrum coronavirus inhibitors discovered by modeling viral fusion dynamics
Development of oral, broad-spectrum therapeutics targeting SARS-CoV-2, its variants, and related coronaviruses could curb the spread of COVID-19 and avert fu...
www.frontiersin.org
June 2, 2025 at 10:11 AM
gl-hooper.bsky.social
🧬This study used a luciferase-expressing influenza virus pseudotype to track infection in mice via bioluminescent imaging, following immunisation with a quadrivalent influenza vaccine.
www.mdpi.com/1999-4915/17...
#Influenza #PseudotypedVirus #VaccineResearch #Virology #Pseudotyping
www.mdpi.com
May 29, 2025 at 11:19 AM
gl-hooper.bsky.social
This recent study highlights how contemporary HIV-1 clade C viruses circulating in India are evolving in ways that significantly affect the effectiveness of broadly neutralising antibodies.
journals.asm.org/doi/10.1128/... #Virology #HIV #AntiViral #Virology #PseudotypedVirus
Distinct region-specific neutralization profiles of contemporary HIV-1 clade C against best-in-class broadly neutralizing antibodies | Journal of Virology
While the development of vaccines to prevent HIV infection remains a global priority, their potential effectiveness is limited by the extraordinarily diversified circulating forms of HIV-1. The prospect of best-in-class broadly neutralizing antibodies (...
journals.asm.org
May 21, 2025 at 2:51 PM
gl-hooper.bsky.social
🧬 Could a probiotic be a vaccine?
Mice given engineered E. coli produced SARS-Cov-2 neutralising antibodies, high IgA, CD8⁺ T cell activation & balanced cytokines.
🤔 Live bacteria as vaccine platforms—what's your take?
🔗 www.tandfonline.com/doi/full/10....
#Vaccines #SARSCoV2
Engineered bacteria as an orally administered anti-viral treatment and immunization system
The emergence of new viral pathogens necessitates innovative antiviral therapies and vaccines. Traditional approaches, such as monoclonal antibodies and vaccines, are often hindered by resistance, ...
www.tandfonline.com
May 15, 2025 at 10:49 AM
gl-hooper.bsky.social
🧬 New BASV Vaccine Study 🧪
Researchers immunised rabbits with four vaccine types targeting BASV glycoprotein and assessed neutralising antibodies using a pseudotyped virus microneutralisation assay.
www.nature.com/articles/s41...
#Vaccines #BASV #VaccineDevelopment #PseudotypedVirus
Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities - Scientific Reports
Scientific Reports - Comparison of the induction of neutralizing antibodies against Bas congo virus using several vaccine modalities
www.nature.com
May 14, 2025 at 2:15 PM
gl-hooper.bsky.social
🚨Computationally designed peptides can block the SARS-CoV-2 spike protein from binding to human ACE2.
PEP10, showed strong, stable binding in simulations which was tested using a pseudotyped virus system.
🔗https://www.mdpi.com/1420-3049/30/8/1750
#COVID19 #SARSCoV2 #Virology #DrugDiscovery
May 9, 2025 at 2:07 PM
gl-hooper.bsky.social
🧬This study investigates the antiviral potential of 5,6-dihydroxyflavone (5,6-DHF), a naturally occurring flavonoid, against betacoronaviruses including SARS-CoV-2 Omicron EG.5.1.1 and HCoV-OC43. www.sciencedirect.com/science/arti...
#Virology #PseudotypedVirus #Antivirals #SARSCoV2
5,6-dihydroxyflavone exerts anti-betacoronavirus activity by blocking viral entry to host cells
Baicalin, a bioactive flavone found in Scutellaria baicalensis Georgi has anti-SARS-CoV-2 infection by targeting viral 3C-like protease (3CLpro). Howe…
www.sciencedirect.com
April 30, 2025 at 11:04 AM
gl-hooper.bsky.social
🔬Novel tri-specific antibodies demonstrate potent neutralisation of SARS-CoV-2 variants and related sarbecovirus pseudotyped viruses.🧬

onlinelibrary.wiley.com/doi/10.1002/...
#Virology #Pseudotyping #PseudotypedVirus #Abs #Antivirals #COVID19 #SARSCoV2 #VirusNeutralisation
Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses
Multispecific antibodies harness the advantages of two or more mAbs. In this study, we designed novel trispecific antibodies, Tri-1 and Tri-2, derived from our previously identified mAbs, PW5-5, PW5-...
onlinelibrary.wiley.com
April 23, 2025 at 12:43 PM
gl-hooper.bsky.social
This recent preprint used HPV16 viral pseudotypes to explore the diversity and molecular characteristics of human monoclonal antibodies (mAbs) generated following HPV vaccination.
#Virology #Pseudotyping #PseudotypedVirus #HPV #mAbs #Vaccination
www.biorxiv.org/content/10.1...
HPV16 neutralizing monoclonal antibodies show evidence for common developmental pathways and public epitopes
Antibodies to human papillomavirus (HPV) primarily recognize surface exposed residues on five loops of the major capsid protein (L1) that vary significantly among HPV types. We determined which loops ...
www.biorxiv.org
April 22, 2025 at 9:49 AM
gl-hooper.bsky.social
The GamEvac-Combi Ebola vaccine, which employs rVSV and rAd5 vectors in a heterologous prime-boost format, was found to be safe and immunogenic in healthy adults in a phase 1-2 clinical clinical trial.
www.frontiersin.org/journals/imm...
#Virology #Vaccine #ClinicalTrials #EbolaVaccine
Frontiers | Safety and immunogenicity of GamEvac-Combi, a heterologous rVSV- and rAd5-vectored Ebola vaccine: a randomized controlled multicenter clinical trial in the Republic of Guinea and Russia
www.frontiersin.org
April 17, 2025 at 12:51 PM
gl-hooper.bsky.social
🧬Rabies Pseudotype Neutralisation Assay: A Safer, Faster Way to Monitor Vaccine Responses

journals.plos.org/plosntds/art...
#RABV #Rabies #Pseudotyping #PseudotypedVirus #Virology #HighThroughPut #NeutralisationAssay #PublicHealth #VaccineResearch
Assessing anti-rabies vaccine response in humans: A rapid and high-throughput adaptable, pseudovirus-based neutralization assay as an alternative to rapid fluorescence focus inhibition test (RFFIT)
Author summary Rabies causes approximately 59000 deaths every year world-wide. It is also among one of the neglected tropical diseases aimed to achieve ‘Zero by 30’ as per the UN Sustainable Developme...
journals.plos.org
April 11, 2025 at 8:25 AM
Reposted
biochembiomeduos.bsky.social
Congratulations double star @gl-hooper.bsky.social from the Edward Wright lab who presented both a poster AND a talk showcasing his research on a pan-lyssavirus vaccine and an African swine fever virus pseudotype at the annual @microbiologysociety.org meeting in Liverpool this week. 👊 #microbio25
April 3, 2025 at 7:44 PM
gl-hooper.bsky.social
🧪 Drug repurposing using pseudotyped virus
A recent study used a SARS-CoV-2 pseudotyped virus system to screen drugs for potential inhibitors of viral entry. frontiersin.org/journals/pha...
#PseudotypedVirus #SARSCoV2 #Virology #AntiviralResearch #COVID19 #VirusEntry #Pseudotyping
Frontiers | FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry
frontiersin.org
April 7, 2025 at 11:16 AM
gl-hooper.bsky.social
🚨New data on inhaled siRNA therapies for respiratory viruses!
ascpt.onlinelibrary.wiley.com/doi/10.1111/...
#COVID19 #SARSCoV2 #Antivirals #ClinicalTrials #RNAtherapy #Phase1Trial
Pharmacokinetics and Safety Profile of SNS812, a First in Human Fully Modified siRNA Targeting Wide‐Spectrum SARS‐CoV‐2, in Healthy Subjects
Severe acute respiratory syndrome caused by the coronavirus (SARS-CoV-2) in the COVID-19 pandemic has highlighted the need for effective treatments, as rapid viral mutations complicate therapeutic de....
ascpt.onlinelibrary.wiley.com
March 28, 2025 at 1:00 PM
gl-hooper.bsky.social
🧬 DelS31 Mutation: A Key Player in COVID-19 Evolution 🧬
This study investigates the impact of the DelS31 mutation in JN.1-derived COVID-19 variants.
journals.asm.org/doi/10.1128/...
#COVID19 #SARSCoV2 #Pseudotyping #PseudotypedVirus #Vaccine
Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants | mBio
The emergence of novel severe acute respiratory syndrome coronavirus 2 variants continues to pose challenges for global public health, particularly in the context of immune evasion and viral stability...
journals.asm.org
March 27, 2025 at 9:22 AM
gl-hooper.bsky.social
VH4524184 (VH-184), a third-generation integrase strand transfer inhibitor (INSTI), has shown promising results in a recent Phase 1 trial. read how they utilised pseudotyped virus here: linkedin.com/posts/george...
#HIV #PseudotypedViruses #ClinicalTrials #Pseudotying #Antivirals
Phase 1 Evaluation of VH4524184, a Third-Generation Integrase Strand… | George Hooper
Assessing HIV-1 Drug Resistance: The Use of Pseudotyped Viruses in VH-184 Trials The development of long-acting therapies remains a key focus in HIV-1…
linkedin.com
March 25, 2025 at 10:38 AM
gl-hooper.bsky.social
This study identifies MITD1 as a novel interferon-stimulated gene (ISG) capable of inhibiting multiple flaviviruses.
www.pnas.org/doi/10.1073/...
#Flavivirus #Virology #InfectiousDiseases #Immunology
MITD1 is a brain-specific interferon-inducible factor that inhibits flavivirus replication | PNAS
West Nile virus (WNV) and Usutu virus (USUV) are closely related mosquito-borne neurotropic flaviviruses that share common transmission cycle and c...
www.pnas.org
March 21, 2025 at 3:41 PM
gl-hooper.bsky.social
The mRNA-1083 vaccine showed a good safety profile and strong immune response in a phase 1/2 trial, supporting further development as a single-shot vaccine for both flu and COVID-19.
www.nature.com/articles/s41...
#Vaccine #Covid #ClinicalTrial
mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine in healthy adults: a phase 1/2 trial - Nature Medicine
An interim analysis shows that a new mRNA influenza and SAR-CoV-2 combination vaccine is safe and triggers an encouraging immune response.
www.nature.com
March 20, 2025 at 1:55 PM
gl-hooper.bsky.social
🚨 New study on broad-spectrum HIV-1 inhibitors!
Tested via pseudotyped virus & cell fusion assays, these NPIs offer promising potential.
🔗https://www.sciencedirect.com/science/article/pii/S2666517425000264?via%3Dihub
#Virology #Pseudotyping #HIV #Antivirals #DrugDiscovery
March 18, 2025 at 3:16 PM
gl-hooper.bsky.social
🚨 Rabies-related virus detected in domestic cat in the Netherlands

This case highlights the risks of rabies-related viruses in Europe and the importance of vaccination for pets with outdoor access.
www.eurosurveillance.org/content/10.2...
#Rabies #Lyssavirus #Virology #ZoonoticDiseases
A case report of a cat infected with European bat lyssavirus type 1, the Netherlands, October 2024
In October 2024, an infection of European bat lyssavirus type 1 was confirmed in a domestic cat in the Netherlands. Several weeks before, the owners had found a dead bat considered to be caught by the...
www.eurosurveillance.org
March 17, 2025 at 12:48 PM
Reposted
virionx.bsky.social
🚨 We Want to Hear from You! 🚨Please take a moment to complete our quick 5-question survey. It will only take a minute, but your input will help shape the future of our work.
👉https://virion-dde96pr8.scoreapp.com
#Virology #Research #VirionX #PseudotypedVirus #Pseudotyping #biotech
March 14, 2025 at 3:54 PM
gl-hooper.bsky.social
This study explored Exifone, a clinical polyphenolic compound, as a potential treatment for COVID-19. It binds to the SARS-CoV-2 3CL protease and disrupts ACE2/S-RBD interaction. lnkd.in/e7sMyMcB
#Pseudotyping #Antiviral #COVID19 #Virology #SARSCoV2 #PseudotypedVirus
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lnkd.in
March 14, 2025 at 10:23 AM
gl-hooper.bsky.social
Bats are reservoir hosts of many viruses yet stay asymptomatic. A new preprint finds GBP5, a rapidly evolving immune gene, plays a key role in antiviral defence of HIV, VSV & lyssaviruses.
www.biorxiv.org/content/10.1...
#Virology #BatImmunity #ZoonoticViruses #Evolution #OneHealth
Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity
Bats are asymptomatic reservoirs of several zoonotic viruses. This may result from long-term coevolution between viruses and bats, that have led to host adaptations contributing to an effective balanc...
www.biorxiv.org
March 3, 2025 at 12:18 PM
Reposted
banerjeelab.ca
🚨 FINALLY OUT IN @Nature.

A tour de force effort. 🦇 10 new bat genomes, excess of immune gene adaptations, species specific adaptations in ISG15, and anti-SARS-CoV-2 activity of bat ISG15. @hillermich.bsky.social @batresearch.bsky.social #LZCI #Bat1K

www.nature.com/articles/s41...
Bat genomes illuminate adaptations to viral tolerance and disease resistance - Nature
A systematic analysis of 115 mammalian genomes, including 10 new bat genomes, reveals prevalent positive selection in immune genes in bats and shows key adaptations in the antiviral gene ISG15 that ai...
www.nature.com
January 29, 2025 at 4:14 PM
gl-hooper.bsky.social
Researchers captured MOKV and IKOV glycoproteins in pre- and post-fusion states, revealing pH-induced changes in membrane fusion. This study presents the first solved IKOV structure. journals.plos.org/plospathogen... #virology #Lyssavirus #IKOV #MOKV
Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease
Author summary Lyssavirus, as represented by the prototypic rabies virus, is responsible for approximately 60,000 human fatalities annually. The glycoprotein of lyssavirus is a key factor mediating th...
journals.plos.org
February 28, 2025 at 3:05 PM