Background: Migrant health, including reproductive health, is an important public health priority. The postpartum period is a critical window for establishing healthy behaviors that can impact long-term health. Mobile health interventions offer a scalable solution, but existing tools are often not culturally or linguistically adapted for diverse populations. To the best of our knowledge, no previous #Study has evaluated the effectiveness of a culturally targeted mobile health intervention delivered after childbirth to promote a healthy diet and physical activity among migrant women. Objective: The PRIMI (Promoting Reproductive Health in Migrant Women) trial will determine the effectiveness of a #Smartphone #mHealth #App (the PRIMI #App) on primary (diet quality and moderate-to-vigorous physical activity) and secondary (health literacy, BMI, self-efficacy, and self-rated health) outcomes in first-generation migrant women after childbirth. Methods: A 2-arm #RCT #ClinicalTrial will be conducted to examine the effectiveness of the PRIMI #App. First-generation migrant women who have given birth within 6 months, are aged 18 years or older, and prefer to receive health-related information in any of the provided languages are eligible to participate in the #Study and will be recruited through health care services in Sweden. The women will be randomized to the control group (standard care, eg, parental guidance and support within child health care) or the intervention group (PRIMI #App+standard care) in a 1:1 ratio. A total of 200 women (100 per group) will be included in the #Study. A waitlist control strategy will be applied so that women in the control group will receive the PRIMI #App after the follow-up measurement at 6 months. Outcomes will be assessed at baseline and at the 6-month follow-up. The PRIMI #App, developed within the PRIMI project, is compatible with both Android and iOS. It contains weekly changing themes focusing on physical activity, diet, and health literacy throughout the 6-month intervention period. The #App integrates behavior change techniques such as feedback and monitoring, goal setting, and instructions on how to perform the behavior. The #App’s language can be switched among 4 common languages (Arabic, Somali, English, and Swedish), and all textual content can be accessed through audio files for listening. All procedures have been approved by the Swedish Ethical Review Authority (reference 2022-06733-01 and 2024-00135-02). Results: Recruitment of #Study participants is planned to begin in September 2025. We anticipate completing recruitment in 2026 and that the results of the PRIMI trial will be available in 2027. Conclusions: This #Study will provide novel evidence on the effectiveness of the PRIMI #App in promoting healthy behaviors and supporting postpartum health among migrant women. This is highly relevant given the lack of previous comparable studies and the urgent need for tailored postpartum interventions for migrant populations. Trial Registration: ClinicalTrials.gov NCT06881277; https://clinicaltrials.gov/#Study/NCT06881277

Background: Rural people living with HIV in the United States have higher mortality rates and lower rates of HIV suppression compared to nonrural people living with HIV. In addition, compared to younger people living with HIV, older people living with HIV face numerous challenges to maintaining health and well-being. However, few interventions have targeted health or quality-of-life outcomes in rural older people living with HIV. Objective: This #RCT #ClinicalTrial will evaluate the efficacy of 2 remotely delivered interventions—supportive-expressive peer social support groups and strengths-based case management—to improve viral suppression, medication adherence, quality of life, and depressive symptoms in people living with HIV aged >50 years in rural counties in the southern United States. Methods: We will enroll 352 rural older (aged >50 y) people living with HIV and test the interventions using a 2 (social support groups: yes or no) × 2 (strengths-based case management: yes or no) factorial design. Supportive-expressive peer social support groups aim to increase social support and lower HIV stigma, thereby improving HIV health outcomes and quality of life. Trained facilitators will deliver the 8 weekly sessions with a set curriculum to groups of 8 to 12 participants via videoconference. Strengths-based case management is an individual-level, individually tailored intervention delivered by trained staff. Over 5 sessions, the participant-staff duo selects a barrier impacting HIV care or quality of life and identifies short-term goals to overcome the barrier, focusing on the process of incremental problem-solving while recognizing accomplishments. We will assess HIV viral load—using participant-collected dried blood spot samples—at baseline and 8 and 12 months after the intervention. Using surveys, we will assess adherence, quality of life, depressive symptoms, and secondary outcomes at baseline and 4, 8, and 12 months after the intervention. We hypothesize that participants randomly assigned to each intervention will be more likely to be virally suppressed and adherent to antiretroviral therapy and have higher quality of life and fewer depressive symptoms at follow-up than those not assigned to each intervention. Secondary hypotheses are that, compared to those not receiving each intervention, participants in each intervention will report greater social support, self-efficacy, and likelihood of accessing needed services; less loneliness and internalized HIV stigma; and fewer structural barriers. Data will be analyzed using generalized linear mixed models. Results: Funded in April 2023, the #Study began enrollment in April 2024, with 177 participants having given consent by July 2025. Data collection will run through 2027 followed by analysis and publication by 2028. Conclusions: This #Study will evaluate 2 remotely delivered interventions for rural older people living with HIV for their effects on HIV health outcomes, quality of life, and depressive symptoms. If effective, these scalable interventions could improve outcomes for this growing population. Trial Registration: ClinicalTrials.gov NCT06269081; https://www.clinicaltrials.gov/#Study/NCT06269081

Background: Black individuals are more likely to die from colorectal #Cancer (CRC) and experience more treatment-related side effects compared to White individuals. Physical activity (PA) has been associated with decreased side effects, improved CRC treatment completion rates and responses, and survival. However, Black survivors of CRC are 60% less likely to engage in PA than White survivors. The Physical Activity Centers Empowerment (PACE) #Study is testing an intervention specifically designed to increase PA among Black individuals diagnosed with CRC. Objective: This #Study outlines the #Protocol for a #RCT #ClinicalTrial. The #Study aims to test the feasibility of PACE and will use the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework. Methods: The PACE #Study was developed in partnership with a community advisory board consisting of Black #Cancer advocates and survivors of #Cancer. The #Study aims to recruit 72 participants aged >18 years from North Carolina who have been diagnosed with CRC. These participants will be randomized in a 1:1 ratio to an intervention or control group. During the 12-week intervention, all participants will receive a ##Wearable activity tracker and informational materials from the American College of Sports Medicine’s “Moving through #Cancer” program. The intervention group will also receive additional PACE theory–guided intervention components, including personalized daily adaptive step goals, access to the PACE video library, and optional video chat meetings for PA support. Data will be collected at 3 time points: baseline, after the intervention (3 months), and 6 months after the intervention (9 months). Using the RE-AIM framework, the #Study aims to evaluate the intervention’s reach, effectiveness, acceptability, implementation, and maintenance. Results: The National Institute on Minority Health and Health Disparities funded this #Study in 2021. #Study enrollment began in August 2024 and is anticipated to conclude in December 2024. Conclusions: This #Study will advance our understanding of effective behavioral strategies to increase PA and help advance the use of PA as a form of complementary #Cancer treatment, with the aim of improving health outcomes for Black survivors of CRC. Trial Registration: ClinicalTrials.gov NCT06411756; https://clinicaltrials.gov/#Study/NCT06411756

MSU's Technology Transfer Office is facilitating the commercialisation process of the device.

Background: The transition to parenthood requires adjustments to new norms and expectations. While there is significant focus on the parenting transition for birthing parents (persons with a uterus), nonbirthing parents (parents who do not give birth, including fathers, gender-diverse parents, adoptive parents, or nongestational coparents) are less supported. Preventive education via SMS text messaging can fill a health service gap and provide timely, standardized, evidence-based information. The Essential Coaching Postpartum program includes 6 weeks of evidence-based daily SMS text messages on topics such as infant care, normal development, parental mental health, and self-care, with streams designed for birthing parents (Essential Coaching for Every Mother) and nonbirthing parents (Essential Coaching for Every Partner). Objective: The primary objective of this #Study is to compare the effectiveness of Essential Coaching Postpartum to standard care on parenting self-efficacy, mental health (ie, depression, anxiety, and stress), well-being (ie, general distress and sleep), and parenting outcomes (ie, relationship satisfaction and coparenting) among first-time nonbirthing parents in Nova Scotia, Canada. The secondary objective is to compare the effectiveness of Essential Coaching Postpartum to standard care among first-time birthing parents in Nova Scotia. The exploratory objective is to compare the effectiveness of Essential Coaching Postpartum to standard care among first-time parent dyads (ie, both birthing parent and nonbirthing parent) in Nova Scotia. Methods: This will be a #RCT #ClinicalTrial. A total of 166 first-time birthing parents and 166 first-time nonbirthing parents from Nova Scotia will be recruited and randomly assigned to the intervention or control arm. The intervention arm will receive standard care plus the Essential Coaching Postpartum #Digital health solution, which consists of twice-daily SMS text messages in the first 3 weeks and daily messages in the next 3 weeks. The control group will receive standard care. Messages are personalized based on the infant’s age and the parent’s self-selected feeding preference (ie, breast or chest feeding, formula feeding, or combination feeding). The first message is sent on the second evening after birth, with parents being eligible to enroll up to 7 days post partum. Participants will complete questionnaires assessing parenting self-efficacy, mental health, well-being, and parenting outcomes at baseline (enrollment after birth), 6 weeks post partum (after the intervention), and 6 months post partum (follow-up). Results: Recruitment for this #Study started in June 2025 and is currently ongoing. As of September 15, 2025, 11 birthing and 5 nonbirthing parents have been recruited. Conclusions: We anticipate that providing parents with SMS text messages (ie, Essential Coaching Postpartum) during the 6-week postpartum period to complement standard care will improve parenting self-efficacy, mental health, well-being, and parenting outcomes. Trial Registration: ClincalTrials.gov NCT06996067; https://www.clinicaltrials.gov/#Study/NCT06996067

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