New on my blog: OpenAI dropped a trio of models yesterday that they claim result from "focusing closely on real-world developer needs." I was curious whether this might mean stronger #rstats coding performance.

www.simonpcouch.com/blog/2025-04...

What is happening here? Suddenly our nanopore reads containing big gaps? Good that we always sequence the ONT Lambda control sample with it. Top track flongle with issues, bottom track earlier flongle run.(minor snps/indels are hidden)
btw,3 flongles with same library show this problem. #ONT #NGS

New from @doudna-lab.bsky.social in @narjournal.bsky.social: "Packaged delivery of #CRISPR–Cas9 ribonucleoproteins accelerates genome editing"

Read here: shorturl.at/AcZ8i

🧪🧬

No wonder it takes long to load, lets say, just *anything*

For a while now, I've noticed this curious thing with large chromosomes where they have a backbone reverse-complement repeat pattern that spreads throughout the chromosome, with a repeat distance of hundreds of thousands to millions of bases.

Here it is for a human chromosome; that orange stuff.

New preprint from the lab! 🚨

🧫 New galactose #CRISPR screening strategy
🎯 481 genes required for #OXPHOS
⚙️ #FAM136A in IMS proteostasis
👂Mito defects in #Menieres disease

by @marcellharhai.bsky.social @fbm-unil.bsky.social

A short thread 1/5

www.biorxiv.org/content/10.1...

The Raspberry Pi CM5 changes EVERYTHING—except the form factor. I tested 4K eGPU gaming, upgrading my better-than-a-smart TV from a CM4, and even built a better Pi 5. Check out the video: www.youtube.com/watch?v=X4bl...