Eugene Valkov
@eugenevalkov.bsky.social
mRNA regulation & decay | biochemistry | structural biology | molecular biology | cancer
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
All views are personal.
Google Scholar: tinyurl.com/EuValScholar
ORCID: 0000-0002-3721-1739
Reposted by Eugene Valkov
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
November 19, 2025 at 11:22 PM
Finally out in @nature.com! We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. www.nature.com/articles/s41.... 1/
Reposted by Eugene Valkov
The bioRxiv and medRxiv sites are currently inaccessible because of an issue with the Cloudflare cybersecurity service. This is affecting many sites but we’re told it’s being resolved.
November 18, 2025 at 1:21 PM
The bioRxiv and medRxiv sites are currently inaccessible because of an issue with the Cloudflare cybersecurity service. This is affecting many sites but we’re told it’s being resolved.
Reposted by Eugene Valkov
🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI.
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
November 17, 2025 at 9:43 PM
🚨I am looking for a POSTDOC, LAB MANAGER/TECH and GRAD STUDENTS to join my new lab in beautiful Madison, WI.
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
We study how our brains perceive and represent the physical world around us using behavioral, computational, and neuroimaging methods.
paulunlab.psych.wisc.edu
#VisionScience #NeuroSkyence
Reposted by Eugene Valkov
This is Fendi. He is seen here demonstrating the internationally acknowledged sign language for politely requesting uppies. 13/10 would pick him up immediately (TT: isthat_jojo)
November 17, 2025 at 11:41 PM
This is Fendi. He is seen here demonstrating the internationally acknowledged sign language for politely requesting uppies. 13/10 would pick him up immediately (TT: isthat_jojo)
Reposted by Eugene Valkov
We are seeking postdoctoral researchers to study viral RNA and macromolecular complexes using X-ray crystallography, cryo-EM, and biochemical methods.
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
November 16, 2025 at 9:17 PM
We are seeking postdoctoral researchers to study viral RNA and macromolecular complexes using X-ray crystallography, cryo-EM, and biochemical methods.
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Structural biology experience is required. Interested candidates should send a CV, a brief research statement, and 2–3 references to [email protected].
Reposted by Eugene Valkov
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
November 14, 2025 at 6:38 PM
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Or from a single dish of HEK cell culture in the case of two membrane proteins.
Out in Nature Methods now! lnkd.in/gpyBSceg
Wonderful collaboration with the Efremov lab.
Reposted by Eugene Valkov
Multiple tenure-track faculty positions at the UNC Lineberger Comprehensive Cancer Center in Chapel Hill!
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
Open Rank
The UNC Lineberger Comprehensive Cancer Center, in collaboration with departments in the School of Medicine and across the entire University of North Carolina at Chapel Hill, is seeking outstanding ca...
unc.peopleadmin.com
November 14, 2025 at 1:05 PM
Multiple tenure-track faculty positions at the UNC Lineberger Comprehensive Cancer Center in Chapel Hill!
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
We seek creative scientists working in fundamental molecular, cellular, and computational areas. Basic and translational cancer research, all ranks.
unc.peopleadmin.com/postings/309...
Reposted by Eugene Valkov
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
November 12, 2025 at 4:01 PM
RESEARCH PAPER: A kinetic ruler controls mRNA poly(A) tail length
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
By Gabs et al. and Matti Turtola
➡️ https://genesdev.cshlp.org/content/39/21-22/1377.full
#RNAprocessing #mRNA #polyadenylation #ribonucleoprotein #CPAC
A #VeteransDay walk along the Monocacy Battlefield, Frederick, Maryland.
November 11, 2025 at 6:19 PM
A #VeteransDay walk along the Monocacy Battlefield, Frederick, Maryland.
Tremendous paper from Narry Kim’s lab identifying a sequence element that recruits cellular factors to exogenous mRNAs to ‘rejuvenate’ their poly(A) tails leading to a huge boost in output. Significant implications for therapeutics. Now, I wonder what the factor X is…
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RNA stability enhancers for durable base-modified mRNA therapeutics - Nature Biotechnology
A systematic screen identifies RNA elements that enhance the stability and translation of base-modified mRNA.
www.nature.com
November 10, 2025 at 9:34 PM
Tremendous paper from Narry Kim’s lab identifying a sequence element that recruits cellular factors to exogenous mRNAs to ‘rejuvenate’ their poly(A) tails leading to a huge boost in output. Significant implications for therapeutics. Now, I wonder what the factor X is…
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eugene Valkov
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #Sequencing #RNAmodifications @nanoporetech.com
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 6, 2025 at 11:30 AM
Establishing benchmarks for quantitative mapping of m6A by Nanopore Direct RNA Sequencing. #DirectRNAseq #Sequencing #RNAmodifications @nanoporetech.com
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:24 AM
Reposted by Eugene Valkov
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
An autism spectrum disorder mutation in Topoisomerase 3β causes accumulation of covalent mRNA intermediates by disrupting metal binding within the zinc finger domain
Abstract. The loss and mutation of Topoisomerase 3β (TOP3B), the only known eukaryotic topoisomerase with the ability to catalyze RNA strand passage reacti
academic.oup.com
November 10, 2025 at 12:21 AM
Very proud of our recently published work in @narjournal.bsky.social led by senior PhD candidate Julia Warrick. #RNA
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
I’m perfectly fine with journals conducting reviews by their editors. What we, as a scientific community, need to learn is how to decouple journal titles from assessments for hiring or promotion.
The idea is to decouple the journals from the review step. They’ll still exist, but they’ll need to add other value. They’ll highlight, curate, add new perspectives. If they do a good job they can still be prestigious (like Scientific American or Wired) (1.2) 👇
November 9, 2025 at 12:35 PM
I’m perfectly fine with journals conducting reviews by their editors. What we, as a scientific community, need to learn is how to decouple journal titles from assessments for hiring or promotion.
Reposted by Eugene Valkov
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!
November 7, 2025 at 4:58 PM
CryoSift is now out @actacrystf.iucr.org doi.org/10.1107/S205... Thanks to all involved. Happy processing!
Reposted by Eugene Valkov
Happy 423 years of us! 🎉 📚
The Bodleian Libraries opened for the first time on 8 November 1602...
This means, we're older than the refracting telescope (1608), the publication of Shakespeare's Hamlet (1623) and Sir Isaac Newton's apple (1666)! 😅
The Bodleian Libraries opened for the first time on 8 November 1602...
This means, we're older than the refracting telescope (1608), the publication of Shakespeare's Hamlet (1623) and Sir Isaac Newton's apple (1666)! 😅
November 8, 2025 at 7:01 AM
Happy 423 years of us! 🎉 📚
The Bodleian Libraries opened for the first time on 8 November 1602...
This means, we're older than the refracting telescope (1608), the publication of Shakespeare's Hamlet (1623) and Sir Isaac Newton's apple (1666)! 😅
The Bodleian Libraries opened for the first time on 8 November 1602...
This means, we're older than the refracting telescope (1608), the publication of Shakespeare's Hamlet (1623) and Sir Isaac Newton's apple (1666)! 😅
Reposted by Eugene Valkov
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth
MicroRNAs direct downregulation of target mRNAs. Sometimes, however, this regulatory paradigm inverts, and a target RNA triggers the degradation of a microRNA. This target-directed microRNA degradatio...
www.biorxiv.org
November 7, 2025 at 6:33 PM
Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)
Reposted by Eugene Valkov
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Enabling options for review: from training and transparency to author-centered AI tools - openRxiv
Peer review is widely viewed as a critical aspect of biomedical communication. Ideally, it provides authors with feedback so they can improve manuscripts and gives readers, particularly nonspecialists...
openrxiv.org
November 6, 2025 at 2:32 PM
Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n
openrxiv.org/enabling-rev...
openrxiv.org/enabling-rev...
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
New online: DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
DICER1 hotspot mutation induces 3p microRNA gain of function via Argonaute strand switch
Nature Structural & Molecular Biology, Published online: 04 November 2025; doi:10.1038/s41594-025-01671-wMalagobadan et al. show that a DICER1 hotspot mutation, previously thought to cause partial loss of function, also leads to unexpected gain of function by activating normally silent 3p passenger microRNAs, revealing a strand-switch mechanism in tumorigenesis.
go.nature.com
November 4, 2025 at 11:47 AM
Great work from my colleague and neighbor Shuo Gu and his team! #RNAsky #RNAbiology
I had a decision email arrive just as I was about to speak at a meeting.
Ranked worst times to open a "decision email":
1. Your birthday
2. Vacation
3. Dinner with loved ones
1. Your birthday
2. Vacation
3. Dinner with loved ones
November 2, 2025 at 11:37 AM
I had a decision email arrive just as I was about to speak at a meeting.
Reposted by Eugene Valkov
On All Saints' Day or All Hallows' Day a beautiful poem to remember our departed loved ones 🖤
November 1, 2025 at 11:29 AM
On All Saints' Day or All Hallows' Day a beautiful poem to remember our departed loved ones 🖤
There is also a gene named holE
November 2, 2025 at 12:55 AM
There is also a gene named holE
Reposted by Eugene Valkov
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
Wilkinson Lab
We discover and study reverse transcriptases
wilkinsonlab.bio
October 31, 2025 at 7:00 PM
The Wilkinson Lab is open for science! @mskcancercenter.bsky.social
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬
annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)