Elisa Fadda
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elisafadda.bsky.social
Elisa Fadda
@elisafadda.bsky.social
2.5K followers 1.6K following 1.4K posts
Associate Professor in the School of Biological Sciences at the University of Southampton, head chef at https://GlycoShape.org, Salem's butler, fucose fanatic #glycotime everyday! She/Her
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elisafadda.bsky.social
Elisa Fadda @elisafadda.bsky.social · Nov 13
As we (my lab and I) are new here 😻, let me introduce some exciting #glycotime work we recently published in Nature Methods doi.org/10.1038/s415... GlycoShape is a completely OA database and toolbox to restore the 3D structure of glycans on glycoproteins 🥳 You can find it at glycoshape.org 1/2
artistic rendition of glycoproteins 3D structures anchored on the cell surface and soluble with the glycans restored with https://glycoshape.org
Reposted by Elisa Fadda
sundersays.bsky.social
PM describes net migration of 205k as "a step in the right direction". His govt has no public position on a sustainable level of immigration is, nor any known process to decide what, why & how. Starmer is now implying he wants it significantly lower
www.standard.co.uk/news/politic...
Net migration drop ‘step in the right direction’ – Starmer
Net migration peaked at a record 944,000 in the year to March 2023 but has fallen sharply since then.
www.standard.co.uk
November 27, 2025 at 2:35 PM
Reposted by Elisa Fadda
carolecadwalla.bsky.social
Yay!! I couldn’t be there but Sergei & the Westminster Spy Ring just won gold at the APA podcast awards!!

Whole thing was crowdfunded by @the-citizens.bsky.social to highlight 5-year legal case to get an investigation into Russian interference in UK politics. Power to the people!
November 27, 2025 at 9:33 PM
Reposted by Elisa Fadda
elife.bsky.social
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly/7mX8aWS
Viral mutations
The continuous evolution of HIV shows strong parallels in macaques and humans.
buff.ly
November 27, 2025 at 9:01 PM
Reposted by Elisa Fadda
quantamagazine.bsky.social
Being hungry literally makes you see the world differently. “The photons hitting your retinas are the same, but the representation in your brain is very different.” — Christian Burgess, neuroscientist
The Brain Has a ‘Low-Power Mode’ That Blunts Our Senses | Quanta Magazine
Neuroscientists uncovered an energy-saving mode in vision-system neurons that works at the cost of being able to see fine-grained details.
www.quantamagazine.org
November 27, 2025 at 9:04 PM
Reposted by Elisa Fadda
glycoshape.org
7/n There are many more papers to come from Silvia's work, so this is only the first part of her journey! Thank you to all the wonderful colleagues that contributed to her success thus far! 👏👏 And stay tuned for more #glycotime news! Brava Silvia!!
a group of minions are standing next to each other in a classroom and saying `` great job '' .
ALT: a group of minions are standing next to each other in a classroom and saying `` great job '' .
media.tenor.com
November 27, 2025 at 6:35 PM
Reposted by Elisa Fadda
glycoshape.org
To wish our friend and main O-glycan 3D structure contributor extraordinaire @silviadandrea.bsky.social all the best with the submission of her PhD thesis tomorrow, today's 🥄🍬 is dedicated to sialic acid 💜 with a mini 🧵 about all the wonderful functions Silvia worked on
Overview of the different roles of sialic acid (NeuAc) in glycans and glycoconjugates. Bottom left, sialic acid is represented with his chemical 3D structure (grey C atoms, red O and blue N) with a purple diamond at the back (SNFG symbol)
November 27, 2025 at 6:14 PM
Reposted by Elisa Fadda
treasurymog.bsky.social
Happy Thanksgiving to all of my American friends.
Hope you get to enjoy your day, whatever you're doing.
a cat wearing a hat and bow tie is sitting in front of a wall that says happy thanksgiving
ALT: a cat wearing a hat and bow tie is sitting in front of a wall that says happy thanksgiving
media.tenor.com
November 27, 2025 at 1:28 PM
Reposted by Elisa Fadda
jacksonwryan.com
Uhh,,, Figure 1 shows you... what exactly? Trying to understand Medical fryrmbial, runctitional features and mum's legs going through concrete.

This whole article is a bit of a disaster. And it's very difficult to find other published work for the author. Strange! 🧪

(via @smutclyde.bsky.social)
Text says: This section provides a comprehensive description of the methodology employed in this study to develop an explainable XAI framework for ASD diagnosis and parental support. The proposed framework integrates the TabPFNMix regressor, a state-of-the-art machine learning (ML) model for tabular data, with SHapley Additive exPlanations (SHAP) to ensure both high predictive accuracy and interpretability. The methodology is structured into five subsections: (1) Dataset Description, (2) TabPFNMix Overview, (3) SHAP for Explainability, (4) Framework Design, and (5) Evaluation Metrics. Figure 1 shows the overall methodology. Informed consent was obtained from all participants involved in the study, and, where applicable, consent was obtained from legal guardians for minor participants as approved by the IRB. And then Figure 1 is shown with lots of AI errors on the image. An absolutely totally fine this can be published in a science journal image that purports to show how the study was carried out but instead is just AI slop.
November 27, 2025 at 3:09 AM
elisafadda.bsky.social
Will governments EVER realize that the prosperity of a nation is bound to the education of its citizens and residents?

We need a serious commitment to research and education and also pls avoid killing unis by making it very tough for students to come here to get the education the UK is famous for
rsc.org Royal Society of Chemistry @rsc.org · 22h
While there was little directly about science in the Chancellor's speech, chemistry skills and knowledge will be critical to make Government plans a reality. Read more Royal Society of Chemistry reaction to #Budget2025 https://www.rsc.org/news/rsc-reaction-budget-2025 #ChemSky
Photo of the Chancellor
November 27, 2025 at 9:20 AM
Reposted by Elisa Fadda
thebookseller.com
Waterstones has named Lucy Steeds' debut novel, and winner of the Waterstones Debut Fiction Prize, The Artist, its Book of the Year for 2025 👇 #BookSky
Waterstones names Lucy Steed's The Artist as Book of the Year
ebx.sh
November 27, 2025 at 8:55 AM
Reposted by Elisa Fadda
mikegalsworthy.bsky.social
The black hole in Durham County Council’s budget has grown by £11.1mn in the past two months under the control of Reform UK.

Its cabinet has been forced to approve a £10mn list of cuts.
Reform cabinet backs £10mn cuts to start filling Durham’s growing black hole
Reform is now learning that running a big council is not as easy as it probably thought
northeastbylines.co.uk
November 27, 2025 at 7:16 AM
Reposted by Elisa Fadda
carlowweather.bsky.social
Fierce mild! Ireland is one of the warmest spots in Europe this morning, up to 15c at 7am on the 27th of November. It will turn much cooler later after band of rain clears East.
November 27, 2025 at 7:33 AM
Reposted by Elisa Fadda
peterstefanovic.bsky.social
🚨The Petition calling for a public inquiry into Russian influence on UK politics & democracy has now rocketed past 65,000 signatures! Let’s get it to 70,000 tonight. If a petition is what it’s going to take let’s get this done!

petition.parliament.uk/petitions/74...
November 26, 2025 at 8:55 PM
elisafadda.bsky.social
Following pointless rankings is a complete waste of time while we should focus on showcasing the uniqueness of our offering instead

"As universities publicly denounce rankings (..) we may be well-positioned to witness a global change in how rankings are perceived"

blog.litmaps.com/p/abandon-yo...
Abandon Your University Rankings, It's a Flawed System
Institutions are dropping out of the U.S. News & World Report, Times Higher Ed and QS rankings. As existing scores may exacerbate inequity across the globe, change has never been so important.
blog.litmaps.com
November 26, 2025 at 10:11 PM
Reposted by Elisa Fadda
glygen.bsky.social
This Thanksgiving let's acknowledge Kobayshi et al.'s findings: turkeys can act as bridges for influenza across avian species that are well insulated from each other. Suddenly, TurDuckEn has a much more sinister meaning.

Learn more: www.sciencedirect.com/science/arti...

#GlycoThanksgiving
November 26, 2025 at 4:36 PM
Reposted by Elisa Fadda
bioinfo.se
www.nature.com/articles/d41...
AlphaFold is five years old — these charts show how it revolutionized science
Since it was unveiled in 2020, Google DeepMind's game-changing AI tool has helped researchers all over the world to predict the 3D structures of hundreds of millions of proteins.
www.nature.com
November 26, 2025 at 8:25 PM
Reposted by Elisa Fadda
adamjschwarz.bsky.social
Sign and share if you're a UK citizen or UK resident!

petition.parliament.uk/petitions/74...
November 26, 2025 at 8:23 PM
elisafadda.bsky.social
Like... they aren't racists? 🤔
November 26, 2025 at 8:15 PM
Reposted by Elisa Fadda
wiringthebrain.bsky.social
There's just an awful lot of bad shit out there, people...
powerathletehq.bsky.social PowerAthleteHQ @powerathletehq.bsky.social · Apr 5
Anxiety might not be just in your head, it could be in your gut.

Dr. Sabine Hazan explains how gut bugs from an anxious donor can transfer that anxiety through fecal transplant.

🎧 TUNE IN to Power Athlete Radio Ep 802: The Gut War w/ Dr. Sabine Hazan

🔗 pahq.co/EP802
November 25, 2025 at 6:39 PM
Reposted by Elisa Fadda
colindickey.com
Handing back student work that’s been written by ChatGPT with a 0 followed by the comment “This essay will never stand in authentic wonder before the Beauty of God’s creation.”
vulture.com Vulture @vulture.com · 1d
Pope Leo XIV told students not to use artificial intelligence for homework, saying that AI ‘won’t stand in authentic wonder before the beauty of God’s creation.’
Even God Is Worried About ChatGPT
Pope Leo XIV told students not to use artificial intelligence for homework, saying that AI ‘won’t stand in authentic wonder before the beauty of God’s creation.’
www.vulture.com
November 26, 2025 at 3:35 PM
elisafadda.bsky.social
Probably some teaching we should pay attention to? ⬇️🤔
science.org Science Magazine @science.org · 1d
Archaeologists find evidence that a wave of mass brutality accompanied the collapse of the first pan-European culture.

Learn more: https://scim.ag/4abcijL
An illustration showing an aerial view of Vráble, showing three neighborhoods. Walled off: The fortified neighborhood was surrounded by a deep, V-shaped ditch 1 kilometer long, reinforced by an earthen wall and another ditch. While digging trenches to understand the fortifications, researchers found headless bodies buried near one entrance. Ditch burials: Nearly 100 people were placed in the ditch near the wall's southernmost opening or gate, in a layer of bodies extending more than 45 meters along the ditch. The densest concentration of bodies was closest to the gate.
November 26, 2025 at 5:52 PM
Reposted by Elisa Fadda
science.org
Archaeologists find evidence that a wave of mass brutality accompanied the collapse of the first pan-European culture.

Learn more: https://scim.ag/4abcijL
An illustration showing an aerial view of Vráble, showing three neighborhoods. Walled off: The fortified neighborhood was surrounded by a deep, V-shaped ditch 1 kilometer long, reinforced by an earthen wall and another ditch. While digging trenches to understand the fortifications, researchers found headless bodies buried near one entrance. Ditch burials: Nearly 100 people were placed in the ditch near the wall's southernmost opening or gate, in a layer of bodies extending more than 45 meters along the ditch. The densest concentration of bodies was closest to the gate.
November 26, 2025 at 5:49 PM
Reposted by Elisa Fadda
cashwood.proteaglyco.com
Excited to share our (@maiakelly.bsky.social and @proteaglyco.bsky.social) most recent research, showing how negative ion supercharging achieves high quality oxidatively released glycan characterisation
TLDR: Singly charge MS2 bad, multiply charge MS2 good.
www.biorxiv.org/content/10.1...
#glycotime
Anion supercharging enables structural assignment of oxidatively released O-glycans
O-glycan analysis faces analytical challenges due to poor fragmentation characteristics of oxidatively released O-glycan acids, which can preserve labile O-acetyl modifications but suffer from charge ...
www.biorxiv.org
November 26, 2025 at 5:57 AM
Reposted by Elisa Fadda
glycoshape.org
Today we used Re-Glyco to rebuild human EPO from AF-P01588 with glycosylation selected from Lippold et al [10.1021/acs.analchem.0c01794] From the 3D structure we identified ideal locations for extra N-glycans, some of which are actually in NESP [10.1054/bjoc.2001.1746]

Super fun 3D edu #glycotime!
title slide of the workshop held today for the Advance Pharmacology module at the University of Southampton (E. Fadda lecturer and coordinator) right-hand side in the bubble, human EPO (grey) with glycosylation reconstructed according to [10.1021/acs.analchem.0c01794] bound to the EPO receptor (cyan) in PDB 1CN4. Slide background is blue
November 26, 2025 at 3:28 PM
Reposted by Elisa Fadda
treasurymog.bsky.social
It's budget day. Whatever happens, I had nothing to do with it!
November 26, 2025 at 7:04 AM