Elise Dalmas
@edal84.bsky.social
Immunoregulation of pancreatic islets, physiology and diabetes, macrophage enthousiast ! @INEM INSERM, Paris
Reposted by Elise Dalmas
New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
While islet amyloid harms β cells in T2D, research reveals amyloid protects against β cell autoimmunity and diabetes in NOD mice by disrupting MHCII antigen presentation in islet macrophages link.springer.com/article/10.1... 🔓
Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice - Diabetologia
Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...
link.springer.com
January 14, 2026 at 7:14 AM
New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Reposted by Elise Dalmas
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 21, 2025 at 2:11 AM
Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Elise Dalmas
A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M
An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
scim.ag
November 18, 2025 at 4:00 PM
A new #ScienceImmunology study finds that mice and humans have pancreatic islet-resident macrophages with elevated antioxidant profiles, which could shield β cells from oxidative stress. https://scim.ag/49cqs3M
Very excited to share that our paper on pancreatic islet-resident macrophages is out ! Grateful to contribute to our understanding of these fascinating cells - special thanks to all of our collaborators ! #worlddiabetesday www.science.org/doi/10.1126/...
An islet-resident macrophage antioxidant program preserves β cell physiology
SLC7A11 licenses metabolic and antioxidant activities in islet macrophages, supporting β cell insulin secretion and redox homeostasis.
www.science.org
November 14, 2025 at 10:03 PM
Very excited to share that our paper on pancreatic islet-resident macrophages is out ! Grateful to contribute to our understanding of these fascinating cells - special thanks to all of our collaborators ! #worlddiabetesday www.science.org/doi/10.1126/...
Reposted by Elise Dalmas
Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 31, 2025 at 1:19 PM
Excited to share my latest postdoc work on systemic metabolic homeostasis! We show that nutrient consumption fluxes compete, and this competitive catabolism helps explain why obesity drives diabetes. Explore the model with our interactive web app: compcat.princeton.edu
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Elise Dalmas
Nature research paper: Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
go.nature.com/476WZqg
go.nature.com/476WZqg
Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death - Nature
Enrichment for efferocytic macrophages in the islets of Langerhans promotes the accumulation of anergic-like CD4+ T cells and dampens autoimmune diabetes.
go.nature.com
October 2, 2025 at 2:26 PM
Nature research paper: Efferocytic remodelling of pancreatic islet macrophages by limited β-cell death
go.nature.com/476WZqg
go.nature.com/476WZqg