Been waiting for such a study to relate #psilocybin dose to 5-HT2AR occupancy in the mouse brain.

They found RO₅₀ = 0.88 mg/kg.

journals.sagepub.com/doi/10.1177/...

New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.

www.nature.com/articles/s41...

🐁 Very concerning finding: Psilocybin promotes brain tumour growth

Authors caution against use of 5-HT2A agonists like psilocybin in patients with glioma, "given the profound and sustained tumor growth-promoting effects observed."

Extends to other serotonergic drugs like LSD.

fMRI signals “up,” but neural metabolism might be going “down.”

In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes.

rdcu.be/eUPO8
funds @erc.europa.eu
#neuroskyence 🧵:

“Basic neuroscience hasn’t produced new drugs.” 💊

Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab.

I wrote a Perspective on why this matters. @thetransmitter.bsky.social

www.thetransmitter.org/drug-develop...

A new PNAS paper finds that polarization increased immediately after the invention of smartphones and the advent of social media, which both appeared around the same year, 2008.
www.pnas.org/doi/10.1073/...

New study out today in Nature Comms: www.nature.com/articles/s41..., in which we set out to test whether ultrasound could influence the reward-related learning computations of the nucleus accumbens, building on decades of work on dopaminergic prediction error and reinforcement learning. And it did.

My dissertation paper finally dropped in Nature Communications!

Overall, the conclusion is that psilocybin may be useful in reducing drug craving that often precipitates relapse through mechanisms related to 5-HT2A activation.

www.nature.com/articles/s41...

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging.
👇🧵

nature.com/articles/s41...
#Neuroscience #Psychedelics #BrainImaging

New paper in Nature Neuro, with very impressive results (in mice):
Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain
www.nature.com/articles/s41...

Considering the phase 2 LSD for anxiety study has been published and is in the news a bit right now, here's a piece from last year where I spoke to the CMO of MindMed about the trial's somewhat unique protocol. Bit more detail here about how the dose sessions worked than in the actual study.

Neat- Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses www.pnas.org/doi/10.1073/...

Does #ketamine work via opioid system?

This controversial idea finds new support in a randomized trial, where the opioid blocker naltrexone impeded ketamine's #antidepressant and glutamatergic effects:
www.ncbi.nlm.nih.gov/pubmed/40707...

#depression #psychiatry #pmhnp

www.nature.com/articles/s41...

The emotional architecture of the psychedelic
brain: If you are interested in #psychedelics and #emotions, take a look at our new paper: authors.elsevier.com/sd/article/S.... With Flora Moujaes, @nathalierieser.bsky.social, Lydia Belinger, Marcus Herdener, & Zarmeen Zahid. Just published in TICS.

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵
www.medrxiv.org/content/10.1...