Colin Sparano
@csparano.bsky.social
Postdoc @ReiseSousaLab 🔬 @crick.ac.uk | Immunologist with focus on Tumorimmunology
Reposted by Colin Sparano
Excited to share our new study out in Nature Communications! 🎉 We show that NK cell localization in the lung determines their ability to eliminate tumor cells.
🫁 www.nature.com/articles/s41...
🫁 www.nature.com/articles/s41...
Tissue localization of natural killer cells dictates surveillance of lung metastasis - Nature Communications
Many cancers metastasize to the lungs, yet immune cells rarely succeed in eliminating them. Here we show that although NK cells that patrol the lung vasculature are highly differentiated and cytotoxic...
www.nature.com
October 29, 2025 at 9:47 AM
Excited to share our new study out in Nature Communications! 🎉 We show that NK cell localization in the lung determines their ability to eliminate tumor cells.
🫁 www.nature.com/articles/s41...
🫁 www.nature.com/articles/s41...
Reposted by Colin Sparano
Tissue localization of NK cells dictates surveillance of lung metastasis, with TGF-β-resistant CD27high NK cells infiltrating metastatic nodules with therapeutic promise @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
October 27, 2025 at 3:38 PM
Tissue localization of NK cells dictates surveillance of lung metastasis, with TGF-β-resistant CD27high NK cells infiltrating metastatic nodules with therapeutic promise @natcomms.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Colin Sparano
MOG antibody-associated disease (MOGAD) affects the central nervous system, but our new immunophenotyping data show that it also profoundly alters circulating immune cells.
www.science.org/doi/10.1126/...
#Immunology #MOGAD #Autoimmunity #Neurology
www.science.org/doi/10.1126/...
#Immunology #MOGAD #Autoimmunity #Neurology
Immune signatures link myelin oligodendrocyte glycoprotein antibody–associated disease to other autoantibody-mediated conditions
Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.
www.science.org
October 9, 2025 at 9:13 AM
MOG antibody-associated disease (MOGAD) affects the central nervous system, but our new immunophenotyping data show that it also profoundly alters circulating immune cells.
www.science.org/doi/10.1126/...
#Immunology #MOGAD #Autoimmunity #Neurology
www.science.org/doi/10.1126/...
#Immunology #MOGAD #Autoimmunity #Neurology
Reposted by Colin Sparano
Memory CD4 T cells orchestrate neoadjuvant-responsive niches in colorectal cancer liver metastases https://www.biorxiv.org/content/10.1101/2025.08.22.671704v1
August 27, 2025 at 6:16 PM
Memory CD4 T cells orchestrate neoadjuvant-responsive niches in colorectal cancer liver metastases https://www.biorxiv.org/content/10.1101/2025.08.22.671704v1
Reposted by Colin Sparano
Nature research paper: EBV induces CNS homing of B cells attracting inflammatory T cells
go.nature.com/41wd99s
go.nature.com/41wd99s
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
go.nature.com
August 8, 2025 at 8:20 AM
Nature research paper: EBV induces CNS homing of B cells attracting inflammatory T cells
go.nature.com/41wd99s
go.nature.com/41wd99s
Reposted by Colin Sparano
Excited to share our new story in @cp-iscience.bsky.social ! We show how iNKT cells promote CRC-derived liver metastasis by driving the formation of a fibrotic niche. Check it out here:
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver
Microenvironment; Natural sciences; Biological sciences; Immunology; Immune response
www.cell.com
April 21, 2025 at 2:57 AM
Excited to share our new story in @cp-iscience.bsky.social ! We show how iNKT cells promote CRC-derived liver metastasis by driving the formation of a fibrotic niche. Check it out here:
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Colin Sparano
Insights: Jacob Myers, Shanelle Reilly, and Laurent Brossay discuss new work by Sonia Tugues and colleagues (https://buff.ly/40sZtwc) which shows that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. https://buff.ly/4gQjFOk
January 8, 2025 at 3:45 PM
Insights: Jacob Myers, Shanelle Reilly, and Laurent Brossay discuss new work by Sonia Tugues and colleagues (https://buff.ly/40sZtwc) which shows that tissue-resident NK cells produce TGF-β1 themselves to establish and maintain residency in glandular tissues. https://buff.ly/4gQjFOk