They also compared their identified ligand binding sites to those predicted by Boltz-2. They find that Boltz-2 predicts orthosteric binding well, but tends to also localize non-orthosteric binders to the orthosteric binding site. (2/2)
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I had a hunch about a bunch of RNA binding proteins that could pick up sugars, but absolutely did not expect all those proteins that were detected. CD44, the LAMPs, ITGB1, LRP1, CALX/CALR? Points to some pretty interesting trafficking going on with RNA around endosome/lysosome.