Michael Lustgarten, PhD
@conquer-aging-123y.bsky.social
Scientist
The video is now live on YT! www.youtube.com/watch?v=gqTq...
B2M is a biomarker that (imo) we should try to optimize
B2M is a biomarker that (imo) we should try to optimize
Beta-2-Microglobulin Is Bad For Neurogenesis: What's My Data? (6-Test Analysis)
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
www.youtube.com
February 8, 2026 at 1:48 PM
The video is now live on YT! www.youtube.com/watch?v=gqTq...
B2M is a biomarker that (imo) we should try to optimize
B2M is a biomarker that (imo) we should try to optimize
Reposted by Michael Lustgarten, PhD
The inaugural season of the @LongevityWorldC has officially concluded. Congratulations to Mike Lustgarten for winning, and @bryan_johnson for winning the @agingolympics!
Comparison and demystification below.
Article: klaustownsend.com/longevity-wo...
Video: www.youtube.com/watch?v=WERn...
Comparison and demystification below.
Article: klaustownsend.com/longevity-wo...
Video: www.youtube.com/watch?v=WERn...
Longevity World Cup vs Rejuvenation Olympics + Biological Aging Clocks - Klaus Townsend
The inaugural season of the Longevity World Cup (LWC) has officially concluded, and huge congratulations to Mike Lustgarten for taking first place overall, and Bryan Johnson for his first place in th...
klaustownsend.com
January 18, 2026 at 9:09 PM
The inaugural season of the @LongevityWorldC has officially concluded. Congratulations to Mike Lustgarten for winning, and @bryan_johnson for winning the @agingolympics!
Comparison and demystification below.
Article: klaustownsend.com/longevity-wo...
Video: www.youtube.com/watch?v=WERn...
Comparison and demystification below.
Article: klaustownsend.com/longevity-wo...
Video: www.youtube.com/watch?v=WERn...
High HDL? Measure These Liver Biomarkers
YouTube video by Conquer Aging Or Die Trying! Mike Lustgarten, PhD
youtu.be
December 31, 2025 at 1:31 PM
Reposted by Michael Lustgarten, PhD
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
Jin Y. et al. report that physical activity decreases the risks of inflammation-related
cancer and cancer-related mortality at least partially by alleviating aging-associated
systemic inflammation and...
www.cell.com
December 21, 2025 at 12:53 AM
Physical activity decreases cancer burden by alleviating immunosenescence-related inflammation and improving overall immunity
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Michael Lustgarten, PhD
The antiviral Interferon pathway drives astrocyte aging and motor decline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
December 16, 2025 at 11:55 PM
The antiviral Interferon pathway drives astrocyte aging and motor decline
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Michael Lustgarten, PhD
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
www.jstage.jst.go.jp/article/bst/...
www.jstage.jst.go.jp/article/bst/...
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
Inflammatory bowel disease (IBD) and physiological gut aging present with overlapping clinical features, including impaired barrier functioning, decre …
www.jstage.jst.go.jp
December 8, 2025 at 7:54 PM
The inflammation-aging axis: Shared and distinct mechanisms in physiological gut aging and IBD-associated accelerated gut aging
www.jstage.jst.go.jp/article/bst/...
www.jstage.jst.go.jp/article/bst/...
Reposted by Michael Lustgarten, PhD
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
Arif et al. show that lysosomes in aged HSCs are hyperacidic and dysfunctional, and
that lysosomal alterations are central to HSCs’ decline with age. cGAS-STING signaling,
driven by misprocessed mtDNA...
www.cell.com
December 7, 2025 at 11:37 PM
Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Michael Lustgarten, PhD
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
Mitochondrial respiratory supercomplex assembly factor COX7RP improves metabolic homeostasis and contributes to lifespan extension in mice. The overexpression of COX7RP reduces white adipose tissue m...
onlinelibrary.wiley.com
December 3, 2025 at 1:18 PM
Mitochondrial Respiratory Supercomplex Assembly Factor COX7RP Contributes to Lifespan Extension in Mice
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Michael Lustgarten, PhD
How a mattress sensor and smartwatch confirmation led to a patient's diagnosis of complete heart block and need for a pacemaker @nejm.org www.nejm.org/doi/full/10....
November 29, 2025 at 4:02 PM
How a mattress sensor and smartwatch confirmation led to a patient's diagnosis of complete heart block and need for a pacemaker @nejm.org www.nejm.org/doi/full/10....
Reposted by Michael Lustgarten, PhD
As I've said before, the distinction drawn between acute infectious diseases and chronic diseases is, in many cases, artificial. This is the huge flaw in MAHA: infections can and often do cause chronic disease; vaccines can thus prevent some chronic diseases.
stanmed.stanford.edu/infections-l...
stanmed.stanford.edu/infections-l...
Why acute infections can lead to neurodegeneration
Researchers are uncovering the mysteries of why early-in-life acute infections can lead to neurodegenerative diseases in later years.
stanmed.stanford.edu
November 21, 2025 at 4:52 PM
As I've said before, the distinction drawn between acute infectious diseases and chronic diseases is, in many cases, artificial. This is the huge flaw in MAHA: infections can and often do cause chronic disease; vaccines can thus prevent some chronic diseases.
stanmed.stanford.edu/infections-l...
stanmed.stanford.edu/infections-l...
