Clemens Mauksch (he/him)
@clemauksch.bsky.social
IMPRS-GS PhD student in genome organization and regulation | Marieke Oudelaar's lab @mpi-nat.bsky.social Göttingen | nucleosomes, compsci, science shenanigans, anti-fascism
🏳🌈
🏳🌈
Pinned
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Happy to report that the first part of my PhD work is published! Thank you to everyone involved!
Reposted by Clemens Mauksch (he/him)
This is misinformation by default, so if you're a journal and you use AI slop for your cover or your announcements, you're not scientific in any way and should be shamed mercilessly 🧪
AI slop gracing the cover of Royal Society B. Not only in AI yellow but scientifically nonsensical. Come on. I'm certain human photographs and artworks were ignored to platform ... this.
November 18, 2025 at 2:07 PM
This is misinformation by default, so if you're a journal and you use AI slop for your cover or your announcements, you're not scientific in any way and should be shamed mercilessly 🧪
Reposted by Clemens Mauksch (he/him)
🧬 PhD Position: Evolutionary & Comparative Genomics 🕷️
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics
Posnien - Georg-August-Universität Göttingen
Webseiten der Georg-August-Universität Göttingen
s.gwdg.de
November 18, 2025 at 7:04 AM
🧬 PhD Position: Evolutionary & Comparative Genomics 🕷️
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics
Join us at @uni-goettingen.de for a 3-year PhD (65% TV-L E13).
We will investigate the genomic & phenotypic impact of gene duplication across 233 arthropod genomes!
More infos 👇 and s.gwdg.de/eDrAAY
#Evolution #Genomics #Bioinformatics
Reposted by Clemens Mauksch (he/him)
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
November 18, 2025 at 3:07 PM
Very excited to present OpenCGChromatin🔥🔥🔥
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation
Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups
Reposted by Clemens Mauksch (he/him)
POV: you are a young woman celebrating a recent academic success
November 17, 2025 at 7:20 PM
POV: you are a young woman celebrating a recent academic success
Reposted by Clemens Mauksch (he/him)
🧬 10 @dfg.de-funded PhD positions at @goettingen-campus.de 🧬
❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians).
💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging.
📌Start: June 2026.
#EvoDevo #Genomics #Bioinformatics
❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians).
💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging.
📌Start: June 2026.
#EvoDevo #Genomics #Bioinformatics
November 18, 2025 at 2:04 PM
🧬 10 @dfg.de-funded PhD positions at @goettingen-campus.de 🧬
❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians).
💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging.
📌Start: June 2026.
#EvoDevo #Genomics #Bioinformatics
❗Focus: Evolution of gene regulatory networks & Wnt signaling in emerging models (insects, snails, flatworms, cnidarians).
💻 Methods: 'Omics, Bioinformatics, CRISPR/RNAi & Imaging.
📌Start: June 2026.
#EvoDevo #Genomics #Bioinformatics
Reposted by Clemens Mauksch (he/him)
Reposted by Clemens Mauksch (he/him)
The Closing Scientific Retreat of @spp2202.bsky.social is under way in Goettingen with Gerd Blobel delivering the first Keynote lecture on LDB11-mediated looping of chromatin.
November 10, 2025 at 2:51 PM
The Closing Scientific Retreat of @spp2202.bsky.social is under way in Goettingen with Gerd Blobel delivering the first Keynote lecture on LDB11-mediated looping of chromatin.
Reposted by Clemens Mauksch (he/him)
📢 Last days to apply for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...
November 10, 2025 at 9:14 AM
📢 Last days to apply for our #PhD and #MDPhD programs! Become part of Basel, Europe’s #LifeScience hub, and grow in a dynamic, international, and supportive community. Apply by Nov 15: www.fmi.ch/education-ca...
Reposted by Clemens Mauksch (he/him)
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
November 5, 2025 at 5:20 PM
Our latest paper has just been published in Cell!
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
doi.org/10.1016/j.ce...
We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
Reposted by Clemens Mauksch (he/him)
JD Vance claims that diversity weakens unions, as people end up distrusting each other and not organizing.
Let me tell you two menswear stories related to this claim. 🧵
Let me tell you two menswear stories related to this claim. 🧵
October 30, 2025 at 8:07 AM
JD Vance claims that diversity weakens unions, as people end up distrusting each other and not organizing.
Let me tell you two menswear stories related to this claim. 🧵
Let me tell you two menswear stories related to this claim. 🧵
Reposted by Clemens Mauksch (he/him)
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 11:49 AM
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
Happy to report that the first part of my PhD work is published! Thank you to everyone involved!
Happy to share our latest publication, in which we show that the arrangement of nucleosomes around CTCF sites contributes to higher-order organisation of chromatin into TADs: www.embopress.org/doi/full/10....
October 27, 2025 at 12:35 PM
Happy to report that the first part of my PhD work is published! Thank you to everyone involved!
Reposted by Clemens Mauksch (he/him)
"Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research"
Frequently the trans and intersex communities are excluded from population-based genomics studies because they cannot be put in a neat box. But sex is a complex trait, like many other traits we study #ASHG25
Frequently the trans and intersex communities are excluded from population-based genomics studies because they cannot be put in a neat box. But sex is a complex trait, like many other traits we study #ASHG25
October 15, 2025 at 12:34 PM
"Genes, Traits, and Identities: Navigating Sex, Gender, and Sexuality in Modern Research"
Frequently the trans and intersex communities are excluded from population-based genomics studies because they cannot be put in a neat box. But sex is a complex trait, like many other traits we study #ASHG25
Frequently the trans and intersex communities are excluded from population-based genomics studies because they cannot be put in a neat box. But sex is a complex trait, like many other traits we study #ASHG25
Reposted by Clemens Mauksch (he/him)
Deutsche Hunger Games
October 14, 2025 at 1:50 PM
Deutsche Hunger Games
Reposted by Clemens Mauksch (he/him)
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes
Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...
www.science.org
October 2, 2025 at 10:55 PM
Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Clemens Mauksch (he/him)
Gesetzesnovelle von 700 Seiten: Grundrechtsfreundliche Politik vorbei. Nun biometrische Massenüberwachung & #Staatstrojaner für Polizei Berlin netzpolitik.org/2025/neues-p...
Neues Polizeigesetz in Berlin: „Abkehr von der grundrechtsfreundlichen Politik“
Die schwarz-rote Berliner Landesregierung bastelt an einem neuen Polizeigesetz, das mehr Videoüberwachung, Staatstrojaner und viele weitere Befugnisse für die Polizei bereit hält. Dafür gab es…
netzpolitik.org
September 29, 2025 at 7:21 PM
Gesetzesnovelle von 700 Seiten: Grundrechtsfreundliche Politik vorbei. Nun biometrische Massenüberwachung & #Staatstrojaner für Polizei Berlin netzpolitik.org/2025/neues-p...
Reposted by Clemens Mauksch (he/him)
How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
September 21, 2025 at 7:31 PM
How do flexible regions of histone chaperones team up to handle histones? Together with Fred Winston’s lab
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
@harvardmed.bsky.social, we reveal new insights in our study just out in Mol Cell. Hats off to James Warner and Vanda Lux @iocbprague.bsky.social for their key contributions! dlvr.it/TNB145
Reposted by Clemens Mauksch (he/him)
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 19, 2025 at 2:09 PM
✨Exciting news: the main story of my PhD is out in Science!
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.
📖 Read the full story here: www.science.org/doi/10.1126/...
Reposted by Clemens Mauksch (he/him)
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
September 18, 2025 at 6:59 PM
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Clemens Mauksch (he/him)
Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
www.science.org
September 19, 2025 at 6:20 AM
Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
Reposted by Clemens Mauksch (he/him)
In kaum einem Land ist Vermögen so ungleich verteilt wie in Deutschland. Die reichsten zehn Prozent der Bevölkerung besitzen sagenhafte 11,4 Billionen Euro – und werden immer reicher. Sparen aber will die Regierung bei den Ärmsten.
www.t-online.de/nachrichten/...
www.t-online.de/nachrichten/...
September 17, 2025 at 7:20 AM
In kaum einem Land ist Vermögen so ungleich verteilt wie in Deutschland. Die reichsten zehn Prozent der Bevölkerung besitzen sagenhafte 11,4 Billionen Euro – und werden immer reicher. Sparen aber will die Regierung bei den Ärmsten.
www.t-online.de/nachrichten/...
www.t-online.de/nachrichten/...
Reposted by Clemens Mauksch (he/him)
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
September 4, 2025 at 11:48 AM
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
Reposted by Clemens Mauksch (he/him)
Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing
Full story & movies👇
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing
Full story & movies👇
Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...
www.biorxiv.org/cgi/content/...
August 28, 2025 at 3:11 PM
Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing
Full story & movies👇
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing
Full story & movies👇
Reposted by Clemens Mauksch (he/him)
Tabea Marx from the Department of Meiosis @schuhlab.bsky.social talks about the group’s ovulation research in the new SWR Wissen video (in German)! Why is ovulation research so challenging for scientists? What did the team find out? Watch the video to learn more👇
www.youtube.com/watch?v=UDz-...
www.youtube.com/watch?v=UDz-...
Was ihr noch NICHT über den Eisprung wusstet! | SWR Wissen
YouTube video by SWR Wissen
www.youtube.com
August 27, 2025 at 2:44 PM
Tabea Marx from the Department of Meiosis @schuhlab.bsky.social talks about the group’s ovulation research in the new SWR Wissen video (in German)! Why is ovulation research so challenging for scientists? What did the team find out? Watch the video to learn more👇
www.youtube.com/watch?v=UDz-...
www.youtube.com/watch?v=UDz-...
Reposted by Clemens Mauksch (he/him)
Contributions of local structural and energetic features of DNA to large-scale genomic organization [perspective by Wilma Olson & Co) www.sciencedirect.com/science/arti...
August 23, 2025 at 11:33 AM
Contributions of local structural and energetic features of DNA to large-scale genomic organization [perspective by Wilma Olson & Co) www.sciencedirect.com/science/arti...