Danve Castroverde
@danvec.bsky.social
Associate Professor, Wilfrid Laurier University
Research interests: Plant immunity | Hormone signaling | Plant stress resilience
Funded by NSERC, CFI, ORF and NFRF
Research interests: Plant immunity | Hormone signaling | Plant stress resilience
Funded by NSERC, CFI, ORF and NFRF
Pinned
Reposted by Danve Castroverde
Nature research paper: A benchmark of expert-level academic questions to assess AI capabilities
go.nature.com/45zkozH
go.nature.com/45zkozH
A benchmark of expert-level academic questions to assess AI capabilities - Nature
Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.
go.nature.com
January 28, 2026 at 6:54 PM
Nature research paper: A benchmark of expert-level academic questions to assess AI capabilities
go.nature.com/45zkozH
go.nature.com/45zkozH
Can we have one for plants please?! 😍🌱
Advancing regulatory variant effect prediction with AlphaGenome: www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome: www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect...
www.nature.com
January 28, 2026 at 7:28 PM
Can we have one for plants please?! 😍🌱
Advancing regulatory variant effect prediction with AlphaGenome: www.nature.com/articles/s41...
Advancing regulatory variant effect prediction with AlphaGenome: www.nature.com/articles/s41...
Reposted by Danve Castroverde
Our breakthrough AI model AlphaGenome is helping scientists understand our DNA, predict the molecular impact of genetic changes, and drive new biological discoveries. 🧬
Find out more in https://xcancel.com/Nature ↓ 🔗↗️
https://goo.gle/4bXlV6y
Find out more in https://xcancel.com/Nature ↓ 🔗↗️
https://goo.gle/4bXlV6y
Advancing regulatory variant effect prediction with AlphaGenome - Nature
AlphaGenome, a deep learning model that inputs 1-Mb DNA sequence to predict functional genomic tracks at single-base resolution across diverse modalities, outperforms existing models in variant effect prediction and enables comprehensive genomic analysis.
www.nature.com
January 28, 2026 at 4:05 PM
Our breakthrough AI model AlphaGenome is helping scientists understand our DNA, predict the molecular impact of genetic changes, and drive new biological discoveries. 🧬
Find out more in https://xcancel.com/Nature ↓ 🔗↗️
https://goo.gle/4bXlV6y
Find out more in https://xcancel.com/Nature ↓ 🔗↗️
https://goo.gle/4bXlV6y
Reposted by Danve Castroverde
Our new paper is out in @nature.com
"Pesticide residues alter taxonomic and functional biodiversity in soils"
Largest in field assessmnt of pesticide effects on soil life🧬🇪🇺🦠🍄
www.nature.com/articles/s41...
@scienceinnovation.ec.europa.eu @panospanagos.bsky.social @mvanderheijden.bsky.social
"Pesticide residues alter taxonomic and functional biodiversity in soils"
Largest in field assessmnt of pesticide effects on soil life🧬🇪🇺🦠🍄
www.nature.com/articles/s41...
@scienceinnovation.ec.europa.eu @panospanagos.bsky.social @mvanderheijden.bsky.social
January 28, 2026 at 4:17 PM
Our new paper is out in @nature.com
"Pesticide residues alter taxonomic and functional biodiversity in soils"
Largest in field assessmnt of pesticide effects on soil life🧬🇪🇺🦠🍄
www.nature.com/articles/s41...
@scienceinnovation.ec.europa.eu @panospanagos.bsky.social @mvanderheijden.bsky.social
"Pesticide residues alter taxonomic and functional biodiversity in soils"
Largest in field assessmnt of pesticide effects on soil life🧬🇪🇺🦠🍄
www.nature.com/articles/s41...
@scienceinnovation.ec.europa.eu @panospanagos.bsky.social @mvanderheijden.bsky.social
"This One Piece was not made with just one piece."
Love the annual #LEGO analogy & showcase when discussing cytoskeletal systems in #BI236 (Cell Biology class)!
@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social
Love the annual #LEGO analogy & showcase when discussing cytoskeletal systems in #BI236 (Cell Biology class)!
@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social
January 28, 2026 at 5:42 PM
"This One Piece was not made with just one piece."
Love the annual #LEGO analogy & showcase when discussing cytoskeletal systems in #BI236 (Cell Biology class)!
@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social
Love the annual #LEGO analogy & showcase when discussing cytoskeletal systems in #BI236 (Cell Biology class)!
@laurierbiology.bsky.social @wilfridlaurieruni.bsky.social
PDLP5 regulates aquaporin-mediated hydrogen peroxide transport in Arabidopsis
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
www.biorxiv.org
January 26, 2026 at 6:37 PM
PDLP5 regulates aquaporin-mediated hydrogen peroxide transport in Arabidopsis
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways
bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways
The effector RipAW facilitates R. solanacearum infection by suppressing CBP60g/SARD1-dependent SA pathway and triggering CBP60g/SARD1-independent root architecture changes.
bsppjournals.onlinelibrary.wiley.com
January 26, 2026 at 3:07 PM
The Effector RipAW Enhances Ralstonia solanacearum Invasion in Arabidopsis via CBP60g/SARD1‐Dependent and ‐Independent Pathways
bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
bsppjournals.onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Danve Castroverde
Decoding plant defense signaling using the defenseless mutant
Baral and Brosché
nph.onlinelibrary.wiley.com/doi/10.1111/...
Baral and Brosché
nph.onlinelibrary.wiley.com/doi/10.1111/...
January 26, 2026 at 7:35 AM
Decoding plant defense signaling using the defenseless mutant
Baral and Brosché
nph.onlinelibrary.wiley.com/doi/10.1111/...
Baral and Brosché
nph.onlinelibrary.wiley.com/doi/10.1111/...
Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature
academic.oup.com/plcell/advan...
academic.oup.com/plcell/advan...
Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature
Plants adapt to low ambient temperatures using a temperature-sensitive control system that remodels chromatin to control growth.
academic.oup.com
January 26, 2026 at 3:04 PM
Chromatin remodeling at the C-REPEAT BINDING FACTOR cluster controls growth retardation at low ambient temperature
academic.oup.com/plcell/advan...
academic.oup.com/plcell/advan...
Reposted by Danve Castroverde
This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience
Chromatin state architecture governs transcription factor accessibility across plant genomes
Author summary In eukaryotes, DNA is tightly associated with histone proteins. Histone covalent modifications and histones isoforms, also called histone variants provide most of the complexity of chro...
journals.plos.org
January 23, 2026 at 3:17 PM
This is a very special paper for me. I had the idea of combining transcription factor binding with chromatin in 2016/8. It took some time, but thanks to Fred and Vikas, we can finally share the story in @plos.org Genetics looking at chromatin states in Arabidopsis and Marchantia. #PlantScience
A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy
Inflorescences of flowering plants adopt diverse genetically programmed and environmentally tuned architectures. By contrast, continued maintenance of the stem-cell pool within the apical meristem is ...
www.science.org
January 22, 2026 at 7:57 PM
A negative feedback loop between TERMINAL FLOWER1 and LEAFY protects inflorescence indeterminacy
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The salicylic acid receptor NPR1 mediates the polyubiquitination and degradation of the transcription factors ABF3/4 to inhibit drought resistance
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com
January 22, 2026 at 2:15 PM
The salicylic acid receptor NPR1 mediates the polyubiquitination and degradation of the transcription factors ABF3/4 to inhibit drought resistance
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
🌱🌱🌱 Laurier Biology ( @laurierbiology.bsky.social ) is excited to host Dr. Tom DeFalco ( @westernu.ca ) on Friday (Jan 23rd).
He will be delivering his seminar on plant receptor kinases at 2:30 PM EST.
Please DM for the Zoom registration link! Hope to see you there.
He will be delivering his seminar on plant receptor kinases at 2:30 PM EST.
Please DM for the Zoom registration link! Hope to see you there.
January 21, 2026 at 8:05 PM
🌱🌱🌱 Laurier Biology ( @laurierbiology.bsky.social ) is excited to host Dr. Tom DeFalco ( @westernu.ca ) on Friday (Jan 23rd).
He will be delivering his seminar on plant receptor kinases at 2:30 PM EST.
Please DM for the Zoom registration link! Hope to see you there.
He will be delivering his seminar on plant receptor kinases at 2:30 PM EST.
Please DM for the Zoom registration link! Hope to see you there.
Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors
Hosts deploy mechanosensory systems to intercept herbivory threats, yet how plants decode insect-derived mechanical force remains unclear. Here, we de…
www.sciencedirect.com
January 21, 2026 at 3:27 PM
Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Danve Castroverde
New Brief Communication: "A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins" rdcu.be/eZLUP
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
January 19, 2026 at 6:36 PM
New Brief Communication: "A CRISPR-based sequence proximity binding protein labelling system for scanning upstream regulatory proteins" rdcu.be/eZLUP
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
CRISPR-based proximity labelling system to profile DNA-binding proteins such as PIF4 transcription factor .
The Wheat CRK-RLCK-MAPKs Signalling Module Confers High-Temperature All-Stage Resistance to Stripe Rust
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
January 19, 2026 at 2:52 PM
The Wheat CRK-RLCK-MAPKs Signalling Module Confers High-Temperature All-Stage Resistance to Stripe Rust
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Some assembly required: Modularity and programmability as keys to decoupling growth-defence trade-offs in plants
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Some assembly required: Modularity and programmability as keys to decoupling growth-defence trade-offs in plants
Growth-defence trade-off has long been considered an inevitable consequence of resource competition in plants. However, emerging evidence from autoimm…
www.sciencedirect.com
January 19, 2026 at 2:51 PM
Some assembly required: Modularity and programmability as keys to decoupling growth-defence trade-offs in plants
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Danve Castroverde
🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
A genetically encoded device for transcriptome storage in mammalian cells
Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...
www.science.org
January 15, 2026 at 8:31 PM
🧬🔬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org
Reposted by Danve Castroverde
In this week’s @science.org cover article, we discover tree bark is a hidden habitat for abundant, diverse, and specialized microbial life that actively regulate our climate 🦠. Bark isn't just an inert armor of tree but an active interface for climate and biodiversity
www.science.org/eprint/7H9PX...
www.science.org/eprint/7H9PX...
Bark microbiota modulate climate-active gas fluxes in Australian forests
Recent studies suggest that microbes inhabit tree bark, yet little is known about their identities, functions, and environmental roles. Here we reveal, through gene-centric and genome-resolved metagen...
www.science.org
January 8, 2026 at 8:37 PM
In this week’s @science.org cover article, we discover tree bark is a hidden habitat for abundant, diverse, and specialized microbial life that actively regulate our climate 🦠. Bark isn't just an inert armor of tree but an active interface for climate and biodiversity
www.science.org/eprint/7H9PX...
www.science.org/eprint/7H9PX...
Reposted by Danve Castroverde
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
January 15, 2026 at 7:45 AM
Excited to share our new Nature study! 🧬
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.
Full paper: www.nature.com/articles/s41...
Reposted by Danve Castroverde
Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬
Full paper : rdcu.be/eY5gx
Full paper : rdcu.be/eY5gx
N1-Methylpseudouridine directly modulates translation dynamics
Nature - N1-Methylpseudouridine enhances the translation of synthetic mRNAs, independently of innate immunity.
rdcu.be
January 15, 2026 at 11:56 AM
Our new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬
Full paper : rdcu.be/eY5gx
Full paper : rdcu.be/eY5gx
Extracellular NAD(P) links hypersensitive response to localized acquired resistance
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Extracellular NAD(P) links hypersensitive response to localized acquired resistance
Effector-triggered immunity (ETI) generates cell non-autonomous signals that activate localized acquired resistance (LAR) in neighboring cells and systemic acquired resistance (SAR) in distant tissues...
www.biorxiv.org
January 15, 2026 at 3:57 PM
Extracellular NAD(P) links hypersensitive response to localized acquired resistance
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Pathogen-inspired engineering of plant protease enhances late blight resistance
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 12, 2026 at 3:03 PM
Pathogen-inspired engineering of plant protease enhances late blight resistance
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Rapid local and systemic jasmonate signalling drives the initiation and establishment of plant systemic immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Client Challenge
www.nature.com
January 8, 2026 at 8:15 PM
Rapid local and systemic jasmonate signalling drives the initiation and establishment of plant systemic immunity
www.nature.com/articles/s41...
www.nature.com/articles/s41...