Mach’s gut! 🇨🇭

So many questions Ben- it was an outstanding talk… let us know when the preprint drops! 😍😍

In the meantime, try a deep dive into our JCS Special Issue on Cilia and Flagella to fully immerse yourself into some great research, fantastic insight and provocative opinions: journals.biologists.com/jcs/issue/13... /fin

And we’ll be back for four sessions in 2026- first 14/01/2026! Register: www.eventbrite.co.uk/e/bscb-genso...
#UKCilia2025 /9

We finished with our panel discussion with some very #HotTakes revisited and directions of travel for the field debated … #UKCilia2025 /8

We finish #MetabolicDisease- cilia on preadipocytes controlling 2 competing ciliary signaling cascades to differentiate or proliferate via FFAR4 or PGE2/EP4, via ROCK2 on actin stress fibers to grow lipid droplets. Wowed by @guacamarklee.bsky.social from the Hilgendorf lab! #UKCilia2025 /7

Alexis Semmel from Jessica Tanis lab wows us with how distinct ciliary #EV contents are released from either the cilia base or tip by local phosphoinositide codes in worms without affecting cilia length or presence. How is the cadence of release set? #UKCilia2025 /6

We go big picture to see how ciliary dysfunction can regulate tissue niche remodelling and cystic disease progression in kidney via macrophage reprogramming in #ADPKD with Rudi Karl from @wachtenlab.bsky.social. #UKCilia2025 /5

No momentum lost as we dazzled with the ciliary necklace, CEP290 and transition zone integrity in #photoreceptors, inner scaffold maintenance & membrane attachment key for gating with the amazing @abimoye.bsky.social (Wensel group and current @carlorivolta.bsky.social ). #IRDs #UKCilia2025 /4

Next up @computingcaitie.bsky.social from @cellarchlab.com marvels us with in situ structural biology of mammalian motile cilia base- power of #cryoET with #XL-MS & #UExM! Stunning cataloguing of MIPs in different axial positions & cilia types, filamentous actin in action. #UKCilia2025 /3

A superbly synchronized talk from Joy Zheng & Yan Li, from Mu He's lab, Hong Kong Univeristy on airway epithelial-mesenchymal organoids from #hIPSCs for modelling syndromic #ciliopathies. More mature lineages in a dish. Fascinating work on TZ components and motile cilia function. #UKCilia2025 /2

And yes, the swag bags. Attendees received MAHA-branded tote bags with:

- Packets of creatine
- Beef tallow potato chips ($79 for a 6-pack!!)
- Mouth tape
- RFK Jr's biography
- Beef protein bars

Key transcripts encoded centrin-like proteins, a frequent component of sensory/contractile structures in protists. We visualized tentacle ultrastructure by U-ExM with @dudinlab.bsky.social lab, discovering stunning tip and collar structures 🤯that add structural complexity to new tentacle formation.

To hear more about Rudolfo’s research, published in #JCSciliaSI, join us at the 53rd BSCB GenSoc UK Cilia and Centrosome Network e-symposium.
www.eventbrite.co.uk/e/bscb-genso...