Mill_lab
@cilialab.bsky.social
Group at MRC HGU using genetics, cell biology and lots of imaging to unlock the mysteries of mammalian #cilia. #cilia. #centrioles #cytoskeleton #RareDisease www.cilialab.co.uk
We finished with our panel discussion with some very #HotTakes revisited and directions of travel for the field debated … #UKCilia2025 /8
November 25, 2025 at 7:26 PM
We finished with our panel discussion with some very #HotTakes revisited and directions of travel for the field debated … #UKCilia2025 /8
We finish #MetabolicDisease- cilia on preadipocytes controlling 2 competing ciliary signaling cascades to differentiate or proliferate via FFAR4 or PGE2/EP4, via ROCK2 on actin stress fibers to grow lipid droplets. Wowed by @guacamarklee.bsky.social from the Hilgendorf lab! #UKCilia2025 /7
November 25, 2025 at 7:25 PM
We finish #MetabolicDisease- cilia on preadipocytes controlling 2 competing ciliary signaling cascades to differentiate or proliferate via FFAR4 or PGE2/EP4, via ROCK2 on actin stress fibers to grow lipid droplets. Wowed by @guacamarklee.bsky.social from the Hilgendorf lab! #UKCilia2025 /7
Alexis Semmel from Jessica Tanis lab wows us with how distinct ciliary #EV contents are released from either the cilia base or tip by local phosphoinositide codes in worms without affecting cilia length or presence. How is the cadence of release set? #UKCilia2025 /6
November 25, 2025 at 7:23 PM
Alexis Semmel from Jessica Tanis lab wows us with how distinct ciliary #EV contents are released from either the cilia base or tip by local phosphoinositide codes in worms without affecting cilia length or presence. How is the cadence of release set? #UKCilia2025 /6
We go big picture to see how ciliary dysfunction can regulate tissue niche remodelling and cystic disease progression in kidney via macrophage reprogramming in #ADPKD with Rudi Karl from @wachtenlab.bsky.social. #UKCilia2025 /5
November 25, 2025 at 7:22 PM
We go big picture to see how ciliary dysfunction can regulate tissue niche remodelling and cystic disease progression in kidney via macrophage reprogramming in #ADPKD with Rudi Karl from @wachtenlab.bsky.social. #UKCilia2025 /5
No momentum lost as we dazzled with the ciliary necklace, CEP290 and transition zone integrity in #photoreceptors, inner scaffold maintenance & membrane attachment key for gating with the amazing @abimoye.bsky.social (Wensel group and current @carlorivolta.bsky.social ). #IRDs #UKCilia2025 /4
November 25, 2025 at 7:21 PM
No momentum lost as we dazzled with the ciliary necklace, CEP290 and transition zone integrity in #photoreceptors, inner scaffold maintenance & membrane attachment key for gating with the amazing @abimoye.bsky.social (Wensel group and current @carlorivolta.bsky.social ). #IRDs #UKCilia2025 /4
Next up @computingcaitie.bsky.social from @cellarchlab.com marvels us with in situ structural biology of mammalian motile cilia base- power of #cryoET with #XL-MS & #UExM! Stunning cataloguing of MIPs in different axial positions & cilia types, filamentous actin in action. #UKCilia2025 /3
November 25, 2025 at 7:19 PM
Next up @computingcaitie.bsky.social from @cellarchlab.com marvels us with in situ structural biology of mammalian motile cilia base- power of #cryoET with #XL-MS & #UExM! Stunning cataloguing of MIPs in different axial positions & cilia types, filamentous actin in action. #UKCilia2025 /3
A superbly synchronized talk from Joy Zheng & Yan Li, from Mu He's lab, Hong Kong Univeristy on airway epithelial-mesenchymal organoids from #hIPSCs for modelling syndromic #ciliopathies. More mature lineages in a dish. Fascinating work on TZ components and motile cilia function. #UKCilia2025 /2
November 25, 2025 at 7:16 PM
A superbly synchronized talk from Joy Zheng & Yan Li, from Mu He's lab, Hong Kong Univeristy on airway epithelial-mesenchymal organoids from #hIPSCs for modelling syndromic #ciliopathies. More mature lineages in a dish. Fascinating work on TZ components and motile cilia function. #UKCilia2025 /2
Our 53rd BSCB GenSoc UK Cilia Network e-symposium: JCS Special Issue on Cilia and Flagella was a smash hit! A staggering 🤩 435 participants 🤩 for outstanding and sometimes contentious takes on fantastic #cilia & #centrosome research. From 🇨🇱 Chile to 🇨🇳 China to the 🇨🇿 Czech Republic- #UKCilia2025 /1
November 25, 2025 at 7:14 PM
Our 53rd BSCB GenSoc UK Cilia Network e-symposium: JCS Special Issue on Cilia and Flagella was a smash hit! A staggering 🤩 435 participants 🤩 for outstanding and sometimes contentious takes on fantastic #cilia & #centrosome research. From 🇨🇱 Chile to 🇨🇳 China to the 🇨🇿 Czech Republic- #UKCilia2025 /1
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
November 14, 2025 at 6:40 PM
Just heading home from our @mrcmousenetwork.bsky.social MRC NMGN Science Meeting 2025 in York where our Congenital Anomalies Cluster shared updates on our clinical VUS & phenotyping pipelines at the podium! Great discussions! #FunctionalGenomics #RareDisease #CongenitalAnomalies
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
October 21, 2025 at 6:15 PM
With @jcellsci.bsky.social, we're 🥂 celebrating the Special Issue on Cilia & Flagella, guest edited by myself & @lottepedersen.bsky.social. We've handpicked 4 standout papers – research from our community, for our community – paired with 2 cutting-edge talks showcasing latest breakthroughs. /2
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
October 21, 2025 at 6:11 PM
🎆 Join us for an unmissable finale to 2025! 🎆 We're thrilled to bring our #cilia & #centrosome community together 25/11/2025 15:00-17:45 GMT! Our 53rd @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium schedule is live: www.eventbrite.co.uk/e/bscb-genso... /1
This government's ambition? 50% of clinical decisions will be genomics-informed by 2035! 🧬 Harness the power of partnerships and openly share data. Patient voice MUST remain at the center. A coalition of the determined to shift not needles, but systems!
#RareDiseaseSummit2025 #RareDisease
/6
#RareDiseaseSummit2025 #RareDisease
/6
October 15, 2025 at 12:33 PM
This government's ambition? 50% of clinical decisions will be genomics-informed by 2035! 🧬 Harness the power of partnerships and openly share data. Patient voice MUST remain at the center. A coalition of the determined to shift not needles, but systems!
#RareDiseaseSummit2025 #RareDisease
/6
#RareDiseaseSummit2025 #RareDisease
/6
🏗️ Turn vision into action. Let's ensure our bold plans don't get buried in bureaucracy and printed in glossy documents...
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
October 15, 2025 at 12:33 PM
🏗️ Turn vision into action. Let's ensure our bold plans don't get buried in bureaucracy and printed in glossy documents...
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
💡 Despite the challenges, I left energized. Change feels possible—we're on the cusp of something transformative.
/5
🔨 Break down silos. We need to tackle data fragmentation to build a connected and resilient rare disease ecosystem.
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
October 15, 2025 at 12:33 PM
🔨 Break down silos. We need to tackle data fragmentation to build a connected and resilient rare disease ecosystem.
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
🛣️ Revolutionary therapies need revolutionary regulatory routes. Who pays 💰 ? How do we create bespoke and novel paths to commercialization?
/4
🫥 Make it routine. Genetic testing as standard as whole blood work in the NHS—& we need to tackle stigma around genetic disorders.
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
October 15, 2025 at 12:33 PM
🫥 Make it routine. Genetic testing as standard as whole blood work in the NHS—& we need to tackle stigma around genetic disorders.
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
💪 "Nothing about us, without us." Patients must be active participants, not just subjects of our research. Their voices constantly challenge us to do better.
/3
⏳ The opportunity is NOW. The UK has huge potential to accelerate innovation and clinical trials if we "move fast and in different ways."
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
October 15, 2025 at 12:33 PM
⏳ The opportunity is NOW. The UK has huge potential to accelerate innovation and clinical trials if we "move fast and in different ways."
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
⚖️ Equity matters. How do we avoid a two-tiered system and ensure everyone has access to diagnosis & delivery?
/2
Organized by @alexionpharma.bsky.social & Harriet Holme PCD Research, this Rare Disease Summit: Transforming Diagnosis and Treatment yesterday @crick.ac.uk brought together diverse experts to tackle critical challenges: too few diagnosed, too slow, & too few therapies.
🔑 Key takeaways:
/1
🔑 Key takeaways:
/1
October 15, 2025 at 12:33 PM
Organized by @alexionpharma.bsky.social & Harriet Holme PCD Research, this Rare Disease Summit: Transforming Diagnosis and Treatment yesterday @crick.ac.uk brought together diverse experts to tackle critical challenges: too few diagnosed, too slow, & too few therapies.
🔑 Key takeaways:
/1
🔑 Key takeaways:
/1
Happy Canadian Thanksgiving to those who celebrate!! 20 years on I have finally managed to source key ingredients ahead of the American date… We are grateful for the people, the interactions & opportunities to move needles…
October 12, 2025 at 6:02 PM
Happy Canadian Thanksgiving to those who celebrate!! 20 years on I have finally managed to source key ingredients ahead of the American date… We are grateful for the people, the interactions & opportunities to move needles…
Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025
August 20, 2025 at 7:57 PM
Incredibly powerful patient panel to counter narrative that PCD is mild- importance of advocacy for care for their own health in a system where PCD is under appreciated. Burden of airway clearance & toll of school, family & work. Trade-offs choice of nebs, commitments & health trade-offs. #OTM2025
PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025
August 20, 2025 at 5:23 PM
PCD Foundation On The Move 2025 kicks off in Minneapolis. President Michele Manion welcomes an audience of 200! Exciting times ahead for #PrimaryCiliaryDyskinesia- registries, clinical trials and more! #OTM2025
We wrap-up with our deep-dive panel discussion. #FanFavorite #UKCilia2025 /7
August 19, 2025 at 5:37 PM
We wrap-up with our deep-dive panel discussion. #FanFavorite #UKCilia2025 /7
We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6
August 19, 2025 at 5:35 PM
We have a fabulous finish with @konjikusicmia.bsky.social (@reiterlab.bsky.social, UCSF) on #GPCRs, #signaling, and #hypogonadism in #BBS models across the hypothalamus-pituitary-gonad axes and its many ciliated cell types! #Ciliopathies? www.biorxiv.org/content/10.1... #UKCilia2025 /6
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
August 19, 2025 at 5:30 PM
What do #DNADamageRepair, #CentrioleBiogenesis and #R-loops have in common- required for multiciliogenesis, where DNA damage scales with number of forming #centrioles! Masterclass talk Cayla Jewett (Pearson lab, Anschutz, UColorado). www.biorxiv.org/content/10.1... #UKCilia2025 /5
CSF-flow and ependymal cilia in #MultipleSclerosis pathophysiology (ventricular enlargement & decreased flow) in human & mouse models of disease- intriguing talk by Maxime Bigotte (Stratton lab, McGill) from his recently pre-printed work www.biorxiv.org/content/10.1... #UKCilia2025 /4
August 19, 2025 at 5:23 PM
CSF-flow and ependymal cilia in #MultipleSclerosis pathophysiology (ventricular enlargement & decreased flow) in human & mouse models of disease- intriguing talk by Maxime Bigotte (Stratton lab, McGill) from his recently pre-printed work www.biorxiv.org/content/10.1... #UKCilia2025 /4
Soon to be #NewPI Yinwen Liang (Joyner lab, MSKCC) on informatics approach to find novel transcriptional regulators of #ciliogenesis- SP5 and SP8 specificity protein TFs drive expression of core ciliary machinery in primary & motile cilia! www.biorxiv.org/content/10.1... #UKCilia2025 /3
August 19, 2025 at 5:18 PM
Soon to be #NewPI Yinwen Liang (Joyner lab, MSKCC) on informatics approach to find novel transcriptional regulators of #ciliogenesis- SP5 and SP8 specificity protein TFs drive expression of core ciliary machinery in primary & motile cilia! www.biorxiv.org/content/10.1... #UKCilia2025 /3