Charles Dussiau
@charlesdussiau.bsky.social
Postdoc at EMBL and DKFZ at Judith Zaugg and Mick Milsom labs
Computational Hematologist
Computational Hematologist
Reposted by Charles Dussiau
#Medsky🧪 A comprehensive single-cell atlas of endothelial cell (EC) development during mouse embryonic stages, covering 8 major organs and 26 time points.
The atlas reveals that
@cellpress.bsky.social
www.cell.com/cell/fulltex...
The atlas reveals that
@cellpress.bsky.social
www.cell.com/cell/fulltex...
A single-cell time-series atlas of endothelial cell embryonic development
The STED-EC atlas enables inter-organ and multi-time-point comparisons of gene expression
in endothelial cells, revealing substantial transcriptomic variations across endothelial
cells from different ...
www.cell.com
February 17, 2026 at 4:01 AM
#Medsky🧪 A comprehensive single-cell atlas of endothelial cell (EC) development during mouse embryonic stages, covering 8 major organs and 26 time points.
The atlas reveals that
@cellpress.bsky.social
www.cell.com/cell/fulltex...
The atlas reveals that
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Reposted by Charles Dussiau
anndataR: converting single-cell data, from R to python and back tomsing1.github.io/blog/posts/a... #Rstats
February 17, 2026 at 9:01 PM
anndataR: converting single-cell data, from R to python and back tomsing1.github.io/blog/posts/a... #Rstats
Reposted by Charles Dussiau
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
rdcu.be/e3smG
rdcu.be/e3smG
February 11, 2026 at 11:43 AM
Want to understand complex intrinsic and extrinsic metabolic regulation of HSCs? Our latest @natcellbio.nature.com review, led by @aysegulerdemm.bsky.social, synthesize insights into cell fate decisions and highlight implications for leukemogenesis. @nickvangastel.bsky.social
rdcu.be/e3smG
rdcu.be/e3smG
Reposted by Charles Dussiau
For anyone who asked "Do you have genome-wide trans-eQTLs?" when we published the first eQTLGen paper: we do now! 💫
See Robert's thread for details on eQTLGen phase 2, including finemapped cis-eQTLs, cis-trans gene pairs and integration of GWAS to identify trait-relevant pathways 🧬🖥
Congrats team!
See Robert's thread for details on eQTLGen phase 2, including finemapped cis-eQTLs, cis-trans gene pairs and integration of GWAS to identify trait-relevant pathways 🧬🖥
Congrats team!
🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)
February 11, 2026 at 7:49 AM
For anyone who asked "Do you have genome-wide trans-eQTLs?" when we published the first eQTLGen paper: we do now! 💫
See Robert's thread for details on eQTLGen phase 2, including finemapped cis-eQTLs, cis-trans gene pairs and integration of GWAS to identify trait-relevant pathways 🧬🖥
Congrats team!
See Robert's thread for details on eQTLGen phase 2, including finemapped cis-eQTLs, cis-trans gene pairs and integration of GWAS to identify trait-relevant pathways 🧬🖥
Congrats team!
Reposted by Charles Dussiau
Our new paper: Entropy Sorting Feature Selection (ESFS)
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
www.biorxiv.org
February 3, 2026 at 6:44 PM
Our new paper: Entropy Sorting Feature Selection (ESFS)
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
A computational framework for gene selection from single cell data that extracts biological signals in noisy data while avoiding artefacts from conventional dimensionality reduction
A thread
www.biorxiv.org/content/10.6...
Reposted by Charles Dussiau
Lots of tools out there in the "AI for Science" space. I don't want something to slop-write my papers and "do my research" for me. But I have a ton of PDFs in Zotero, and I'd love an AI thing to help me understand what's in there. I found it today blog.stephenturner.us/p/zotero-con... 🧵 1/
January 29, 2026 at 9:52 PM
Lots of tools out there in the "AI for Science" space. I don't want something to slop-write my papers and "do my research" for me. But I have a ton of PDFs in Zotero, and I'd love an AI thing to help me understand what's in there. I found it today blog.stephenturner.us/p/zotero-con... 🧵 1/
Reposted by Charles Dussiau
A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures, according to a paper in Nature Genetics. go.nature.com/4taJRJT 🧬 🧪
February 1, 2026 at 8:39 PM
A single-cell epigenomic atlas of human immune cells highlights cell-type-specific features associated with genetic or environmental exposures, according to a paper in Nature Genetics. go.nature.com/4taJRJT 🧬 🧪
Reposted by Charles Dussiau
Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social
For decades, memory-like responses in immune cells have remained unexplained
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
@thekinglab.bsky.social & team reveal epigenetic changes in hematopoietic stem & progenitor cells in a mycobacterial infection model that are retained in downstream macrophages: doi.org/10.1172/jci....
January 29, 2026 at 1:35 PM
Happy to share our latest work on the epigenetic basis of trained immunity in hematopoietic stem cells! @bcmhouston.bsky.social @texaschildrens.bsky.social
Reposted by Charles Dussiau
Fantastic read. How a billionaire saved himself (for now) from cancer.
Not everyone has resources like Sid.
centuryofbio.com/p/sid
This imposes a bigger question on how we can bring therapeutics to every patient.
Not everyone has resources like Sid.
centuryofbio.com/p/sid
This imposes a bigger question on how we can bring therapeutics to every patient.
January 25, 2026 at 2:45 PM
Fantastic read. How a billionaire saved himself (for now) from cancer.
Not everyone has resources like Sid.
centuryofbio.com/p/sid
This imposes a bigger question on how we can bring therapeutics to every patient.
Not everyone has resources like Sid.
centuryofbio.com/p/sid
This imposes a bigger question on how we can bring therapeutics to every patient.
Reposted by Charles Dussiau
We wrote a review of representation learning methods of single-cell RNA-seq data, where we compare factor models, autoencoders, contrastive learning, and foundation models 🎉
rnajournal.cshlp.org/content/earl...
rnajournal.cshlp.org/content/earl...
January 21, 2026 at 9:56 AM
We wrote a review of representation learning methods of single-cell RNA-seq data, where we compare factor models, autoencoders, contrastive learning, and foundation models 🎉
rnajournal.cshlp.org/content/earl...
rnajournal.cshlp.org/content/earl...
Reposted by Charles Dussiau
Very early days, but delighted that our recent review on reevaluation of aging hematopoiesis published in Experimental Hematology, official journal of @isehsociety.bsky.social is classified as highly cited by web of science. Open access here: www.exphem.org/article/S030...
Reconsidering the usual suspects in age-related hematologic disorders: is stem cell dysfunction a root cause of aging?
The global trend toward an increasing aged population demographic raises significant
societal challenges, particularly concerning health. As organisms age, progressive
tissue dysfunction increases the...
www.exphem.org
January 15, 2026 at 10:31 AM
Very early days, but delighted that our recent review on reevaluation of aging hematopoiesis published in Experimental Hematology, official journal of @isehsociety.bsky.social is classified as highly cited by web of science. Open access here: www.exphem.org/article/S030...
Reposted by Charles Dussiau
OpenAI and Anthropic launch life sciences research and healthcare connectors doi.org/10.59350/t7h...
OpenAI and Anthropic launch life sciences research and healthcare connectors
This week OpenAI and Anthropic launched their health/bio updates. While both companies are leaning into consumer-facing health concierges, Claude now has better tooling for life science researchers.
doi.org
January 14, 2026 at 10:18 AM
OpenAI and Anthropic launch life sciences research and healthcare connectors doi.org/10.59350/t7h...
Reposted by Charles Dussiau
I think I learned more from @andrew.heiss.phd about Positron (and generally automating my life on MacOS) in one hour than I have in the past year, from his talk on the @posit.co data science lab yesterday. Talk will be posted on YouTube soon. www.andrewheiss.com/blog/2026/01... #Rstats
How to make your data analysis life easier using Positron, Raycast, and Espanso | Andrew Heiss
Links and resources from my time on Posit’s Data Science Lab in January 2026
www.andrewheiss.com
January 14, 2026 at 10:36 AM
I think I learned more from @andrew.heiss.phd about Positron (and generally automating my life on MacOS) in one hour than I have in the past year, from his talk on the @posit.co data science lab yesterday. Talk will be posted on YouTube soon. www.andrewheiss.com/blog/2026/01... #Rstats
Reposted by Charles Dussiau
My "Friends don't let friends make bad graphs" repo is approaching 7k stars on GitHub. As of this moment, 6962, to be exact. 38 more to go to 7000.
github.com/cxli233/Frie...
github.com/cxli233/Frie...
January 13, 2026 at 12:56 PM
My "Friends don't let friends make bad graphs" repo is approaching 7k stars on GitHub. As of this moment, 6962, to be exact. 38 more to go to 7000.
github.com/cxli233/Frie...
github.com/cxli233/Frie...
Reposted by Charles Dussiau
A newly identified and rare genetic variant slows the growth of mutated blood stem cells, researchers report in Science, and it reduces the risk of leukemia. https://scim.ag/4jrn1sR
Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation
Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...
scim.ag
January 7, 2026 at 4:04 PM
A newly identified and rare genetic variant slows the growth of mutated blood stem cells, researchers report in Science, and it reduces the risk of leukemia. https://scim.ag/4jrn1sR
Reposted by Charles Dussiau
Now online in Cancer Discovery @aacrjournals.bsky.social: Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations & mRNA Transcripts by @dennisjyuan.bsky.social, @landau.bsky.social, et al. doi.org/10.1158/2159... @nygenome.org @weillcornell.bsky.social
January 7, 2026 at 2:51 PM
Now online in Cancer Discovery @aacrjournals.bsky.social: Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations & mRNA Transcripts by @dennisjyuan.bsky.social, @landau.bsky.social, et al. doi.org/10.1158/2159... @nygenome.org @weillcornell.bsky.social
Reposted by Charles Dussiau
New paper out in Communications Biology!
We performed an integrated transcriptomic–proteomic analysis to investigate how post-transcriptional regulation shapes gene expression in acute myeloid leukemia (AML).
www.nature.com/articles/s42...
We performed an integrated transcriptomic–proteomic analysis to investigate how post-transcriptional regulation shapes gene expression in acute myeloid leukemia (AML).
www.nature.com/articles/s42...
December 17, 2025 at 12:43 PM
New paper out in Communications Biology!
We performed an integrated transcriptomic–proteomic analysis to investigate how post-transcriptional regulation shapes gene expression in acute myeloid leukemia (AML).
www.nature.com/articles/s42...
We performed an integrated transcriptomic–proteomic analysis to investigate how post-transcriptional regulation shapes gene expression in acute myeloid leukemia (AML).
www.nature.com/articles/s42...
Reposted by Charles Dussiau
New paper by Khadra E. et al. & Ismael Boussaid "Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia" in Nat. Commun. Biology!
🔎 doi.org/10.1038/s420...
#AML #RNA #Proteomics #Bioinformatics #CancerResearch
@cnrs.fr @inserm.fr @upcite.bsky.social
🔎 doi.org/10.1038/s420...
#AML #RNA #Proteomics #Bioinformatics #CancerResearch
@cnrs.fr @inserm.fr @upcite.bsky.social
Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia - Communications Biology
An integrative proteo-transcriptomic analysis reveals conserved post-transcriptional regulation mechanisms in acute myeloid leukemia and introduces POSTCODE, a tool to detect regulatory alterations in...
doi.org
December 17, 2025 at 12:24 PM
New paper by Khadra E. et al. & Ismael Boussaid "Integrated analysis of post-transcriptional regulations reveals insights into acute myeloid leukemia" in Nat. Commun. Biology!
🔎 doi.org/10.1038/s420...
#AML #RNA #Proteomics #Bioinformatics #CancerResearch
@cnrs.fr @inserm.fr @upcite.bsky.social
🔎 doi.org/10.1038/s420...
#AML #RNA #Proteomics #Bioinformatics #CancerResearch
@cnrs.fr @inserm.fr @upcite.bsky.social
Reposted by Charles Dussiau
last week before christmas break, always intense! 2026 will be a new start as the Perié lab will be moving to Biogipuzkoa in San Sebastian. New challenges and adventures to come! Some of us will stay at #InstitutCurie for a little while. We are hiring a lab manager and more to come! Stay tuned.
December 15, 2025 at 8:14 AM
last week before christmas break, always intense! 2026 will be a new start as the Perié lab will be moving to Biogipuzkoa in San Sebastian. New challenges and adventures to come! Some of us will stay at #InstitutCurie for a little while. We are hiring a lab manager and more to come! Stay tuned.
Reposted by Charles Dussiau
👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social
December 7, 2025 at 3:34 PM
👉🏼 @milsommick.bsky.social talking about the role of inflammation on HSC aging in the “Game of Clones” Scientific Session at #ASH25. #epigenomics #hematopoiesis #HemeSky @dkfz.bsky.social
Reposted by Charles Dussiau
10 courses for my dream bioinformatics curriculum:
1. Unix Commands with Greg Wilson www.youtube.com/watch?v=U3i...
2. statistics and R with Rafael Irizarry rafalab.dfci.harvard.edu/pages/harva...
1. Unix Commands with Greg Wilson www.youtube.com/watch?v=U3i...
2. statistics and R with Rafael Irizarry rafalab.dfci.harvard.edu/pages/harva...
December 2, 2025 at 3:15 PM
10 courses for my dream bioinformatics curriculum:
1. Unix Commands with Greg Wilson www.youtube.com/watch?v=U3i...
2. statistics and R with Rafael Irizarry rafalab.dfci.harvard.edu/pages/harva...
1. Unix Commands with Greg Wilson www.youtube.com/watch?v=U3i...
2. statistics and R with Rafael Irizarry rafalab.dfci.harvard.edu/pages/harva...
Reposted by Charles Dussiau
We’re recruiting a Research Engineer in #bioengineering
Join a dynamic multi-institute environment at @upcite.bsky.social to support cutting-edge work in #microfluidics #organoids & tissue #manufacture
Apply👇🏻 if you’re excited about interdisciplinary collaborative science🔬🧪⚗️🧑🔬
Join a dynamic multi-institute environment at @upcite.bsky.social to support cutting-edge work in #microfluidics #organoids & tissue #manufacture
Apply👇🏻 if you’re excited about interdisciplinary collaborative science🔬🧪⚗️🧑🔬
November 27, 2025 at 11:55 AM
We’re recruiting a Research Engineer in #bioengineering
Join a dynamic multi-institute environment at @upcite.bsky.social to support cutting-edge work in #microfluidics #organoids & tissue #manufacture
Apply👇🏻 if you’re excited about interdisciplinary collaborative science🔬🧪⚗️🧑🔬
Join a dynamic multi-institute environment at @upcite.bsky.social to support cutting-edge work in #microfluidics #organoids & tissue #manufacture
Apply👇🏻 if you’re excited about interdisciplinary collaborative science🔬🧪⚗️🧑🔬
Reposted by Charles Dussiau
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
We are all mosaics: vast genetic diversity found between cells in a single person
Technical advances allow researchers to trace the genetic changes that occur over time.
go.nature.com
November 26, 2025 at 9:28 AM
“There were some cells in there that were very messed up”
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
In a technological tour-de-force, researchers have sequenced the whole genomes of more than 100 individual cells from one 74-year-old man
go.nature.com/44yj4MN
Reposted by Charles Dussiau
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
November 20, 2025 at 9:36 AM
We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...
Reposted by Charles Dussiau
Capsule: Comprehensive Reproducibility Framework for R and Bioinformatics Workflows github.com/SAADAT-Abu/C... ...Generates Docker containers, exports to Nextflow & Snakemake #Rstats
November 19, 2025 at 7:02 PM
Capsule: Comprehensive Reproducibility Framework for R and Bioinformatics Workflows github.com/SAADAT-Abu/C... ...Generates Docker containers, exports to Nextflow & Snakemake #Rstats