Center for Cancer Immunotherapy and Immunobiology
@ccii-kyoto.bsky.social
Conquering cancer by advancing immunotherapy.
The CCII is a research center at Kyoto University, led by Nobel Laureate Prof Tasuku Honjo.
https://www.ccii.med.kyoto-u.ac.jp/en/
The CCII is a research center at Kyoto University, led by Nobel Laureate Prof Tasuku Honjo.
https://www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Center for Cancer Immunotherapy and Immunobiology
🌟EFIS & EJI launch the #ECR Article of the Year Prize
🏆€5,000 for the best research article in EJI
🌍Open to ECRs worldwide - 10 yrs post-PhD or post-MD (extensions apply)
🖊️Must be first or senior corresponding author
🎤Winner will present at ECI + receive a travel grant to attend
ℹ️Check the QR code👇
🏆€5,000 for the best research article in EJI
🌍Open to ECRs worldwide - 10 yrs post-PhD or post-MD (extensions apply)
🖊️Must be first or senior corresponding author
🎤Winner will present at ECI + receive a travel grant to attend
ℹ️Check the QR code👇
November 11, 2025 at 7:27 AM
🌟EFIS & EJI launch the #ECR Article of the Year Prize
🏆€5,000 for the best research article in EJI
🌍Open to ECRs worldwide - 10 yrs post-PhD or post-MD (extensions apply)
🖊️Must be first or senior corresponding author
🎤Winner will present at ECI + receive a travel grant to attend
ℹ️Check the QR code👇
🏆€5,000 for the best research article in EJI
🌍Open to ECRs worldwide - 10 yrs post-PhD or post-MD (extensions apply)
🖊️Must be first or senior corresponding author
🎤Winner will present at ECI + receive a travel grant to attend
ℹ️Check the QR code👇
CCII Vice Director Sidonia Fagarasan introducing Michael Dustin (Oxford), who gave a great talk on the immunological synapse.
For a list of upcoming seminars & events at CCII, visit our webpage.
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/events/
For a list of upcoming seminars & events at CCII, visit our webpage.
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/events/
November 11, 2025 at 9:13 AM
CCII Vice Director Sidonia Fagarasan introducing Michael Dustin (Oxford), who gave a great talk on the immunological synapse.
For a list of upcoming seminars & events at CCII, visit our webpage.
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/events/
For a list of upcoming seminars & events at CCII, visit our webpage.
#Immunology #Immunotherapy
www.ccii.med.kyoto-u.ac.jp/en/events/
Reposted by Center for Cancer Immunotherapy and Immunobiology
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Discovery and development of an oral analgesic targeting the α2B adrenoceptor | PNAS
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation
through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...
www.pnas.org
August 22, 2025 at 1:03 AM
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Center for Cancer Immunotherapy and Immunobiology
The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.
The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇
www.cell.com/current-biol...
The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇
www.cell.com/current-biol...
September 4, 2025 at 12:35 AM
The conference was held in Basel & Sidonia also took the opportunity to pay homage to Fritz Melchers, former Director of the Basel Institute of Immunology.
The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇
www.cell.com/current-biol...
The BII has closed, but you can read about it in this 1997 @currentbiology.bsky.social piece 👇
www.cell.com/current-biol...
Reposted by Center for Cancer Immunotherapy and Immunobiology
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
#EMBObarrierTissues
September 3, 2025 at 11:02 PM
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
#EMBObarrierTissues
Reposted by Center for Cancer Immunotherapy and Immunobiology
To find out more about research in the Hagiwara group at CCII, click on 👇
www.ccii.med.kyoto-u.ac.jp/en/research/...
www.ccii.med.kyoto-u.ac.jp/en/research/...
August 22, 2025 at 1:04 AM
To find out more about research in the Hagiwara group at CCII, click on 👇
www.ccii.med.kyoto-u.ac.jp/en/research/...
www.ccii.med.kyoto-u.ac.jp/en/research/...
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
#EMBObarrierTissues
September 3, 2025 at 11:02 PM
CCII's Sidonia Fagarasan presenting on "The intersection of adaptive & innate immunity in the lung: implications for chronic pulmonary insufficiency" at the @embo.org workshop on Adaptive Immunity at Barrier Tissues organized by @immunologyking.bsky.social @maurogaya.bsky.social
#EMBObarrierTissues
#EMBObarrierTissues
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Discovery and development of an oral analgesic targeting the α2B adrenoceptor | PNAS
Noradrenaline is a major monoaminergic neurotransmitter involved in pain modulation
through an α2A-adrenergic receptor. Hence, α2-adrenergic agonis...
www.pnas.org
August 22, 2025 at 1:03 AM
A promising new avenue for non-opiod pain management fm CCII's Hagiwara group, using dexmedetomidine (a α2-adrenergic receptor agonist) without cardiovascular side effects in mice & NHPs. An oral tablet formulation of the candidate drug is currently in phase I/II trials.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Center for Cancer Immunotherapy and Immunobiology
“I have a friend who told me: “This is my last round in my life because I have lung cancer”. But half a year later he came back and had just started the treatment we developed, and he was just completely cured.”
Tasuku Honjo (1942- )
NobelPrize in Medicine 2018
Tasuku Honjo (1942- )
NobelPrize in Medicine 2018
February 6, 2025 at 1:52 PM
“I have a friend who told me: “This is my last round in my life because I have lung cancer”. But half a year later he came back and had just started the treatment we developed, and he was just completely cured.”
Tasuku Honjo (1942- )
NobelPrize in Medicine 2018
Tasuku Honjo (1942- )
NobelPrize in Medicine 2018
Reposted by Center for Cancer Immunotherapy and Immunobiology
The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Center for Cancer Immunotherapy and Immunobiology
京都大学大学院医学研究科附属 がん免疫総合研究センター（Center for Cancer Immunotherapy and Immunobiology（CCII））は、2020年4月1日に開設されました。 このセンターでは、「がんの征圧」という大きな夢に向かって集う世界各国から集まった研究者が活発な研究を行います。
www.ccii.med.kyoto-u.ac.jp
July 28, 2025 at 3:21 PM
The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Center for Cancer Immunotherapy and Immunobiology
Happy 50th birthday to monoclonal antibodies! While researching antibody diversity, Köhler and Milstein developed a technique for generating large amounts of monoclonal antibodies: www.nature.com/articles/256... #immunosky #immunology
Continuous cultures of fused cells secreting antibody of predefined specificity - Nature
Nature - Continuous cultures of fused cells secreting antibody of predefined specificity
www.nature.com
August 7, 2025 at 3:47 PM
Happy 50th birthday to monoclonal antibodies! While researching antibody diversity, Köhler and Milstein developed a technique for generating large amounts of monoclonal antibodies: www.nature.com/articles/256... #immunosky #immunology
Reposted by Center for Cancer Immunotherapy and Immunobiology
🗓️ Mark your calendars – #IMMUNOLOGY2026™ abstract submissions open on September 3! Get ready to share your latest research with the global immunology community. ow.ly/ekqM50WBK9q
#immunology #scicomm
#immunology #scicomm
August 11, 2025 at 1:28 PM
🗓️ Mark your calendars – #IMMUNOLOGY2026™ abstract submissions open on September 3! Get ready to share your latest research with the global immunology community. ow.ly/ekqM50WBK9q
#immunology #scicomm
#immunology #scicomm
Reposted by Center for Cancer Immunotherapy and Immunobiology
Common origins of autoimmune diseases and lymphoid malignancies #immunology
Common origins of autoimmune diseases and lymphoid malignancies
Interactions between autoimmune disorders and lymphoid malignancies have long been recognized; for instance, with prominent autoimmune manifestations in B- and T-cell lymphomas and an increased risk of lymphoma development in individuals with autoimmune diseases. More recently, several lines of evidence have shown that these two disease types have shared origins, defined by common genetic lesions and pathogenic cell states. Recent work suggests that the safeguards that protect normal lymphocyte development and adaptive immunity against the development of autoimmune diseases and lymphoid malignancies are based on similar sensing mechanisms of pathological lymphocytes. Here, we propose that mechanisms of negative selection that are designed to eliminate autoreactive lymphocytes also operate in suppressing the development of lymphoid malignancies.
dlvr.it
August 14, 2025 at 11:15 PM
Common origins of autoimmune diseases and lymphoid malignancies #immunology
Reposted by Center for Cancer Immunotherapy and Immunobiology
A great talk — Hiroshi has just arrived back in Japan after a postdoc in Ron Germain's lab & he showed some beautiful 3D high rez images. The paper is not out yet, but watch this space
Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
August 20, 2025 at 12:15 AM
A great talk — Hiroshi has just arrived back in Japan after a postdoc in Ron Germain's lab & he showed some beautiful 3D high rez images. The paper is not out yet, but watch this space
Reposted by Center for Cancer Immunotherapy and Immunobiology
Hey everybody! @drjuliawester.bsky.social and I have a new paper!
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky
Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For
doi.org
August 19, 2025 at 2:34 PM
Hey everybody! @drjuliawester.bsky.social and I have a new paper!
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
We surveyed over 800 scientists, science communicators, and science educators who use social media.
Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑
doi.org/10.1093/icb/...
Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
August 20, 2025 at 12:04 AM
Sidonia Fagarasan introducing CCII seminar speaker Hiroshi Ichise (University of Osaka). He presented advances in 3D imaging & what new biology it can help reveal, including a new immune cluster organized around the vagal nerves in the lung
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
Tomorrow (Tuesday) at CCII, Hiroshi Ichise on
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
August 18, 2025 at 2:05 AM
Tomorrow (Tuesday) at CCII, Hiroshi Ichise on
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
“Highly multiplex volumetric imaging Ce3D-IBEX reveals commensal-induced immune clustering along sensory nerves in the lung”
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Center for Cancer Immunotherapy and Immunobiology
#NACLC25 is open! Registration & abstracts are live for Dec 5–7, 2025, in Chicago.
Hear from co‑chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Considered—insights, highlights & why you should be there.
🎧 bit.ly/NACLC25Preview
#LungCancer @ascocancer.bsky.social
Hear from co‑chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Considered—insights, highlights & why you should be there.
🎧 bit.ly/NACLC25Preview
#LungCancer @ascocancer.bsky.social
Preview: IASLC | ASCO 2025 North American Conference on Lung Cancer | IASLC
Join Dr. Stephen Liu on Lung Cancer Considered as he sits down with two co-chairs of the upcoming IASLC | ASCO 2025 North American Conference on Lung Cancer (NA ...
bit.ly
July 25, 2025 at 10:24 PM
#NACLC25 is open! Registration & abstracts are live for Dec 5–7, 2025, in Chicago.
Hear from co‑chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Considered—insights, highlights & why you should be there.
🎧 bit.ly/NACLC25Preview
#LungCancer @ascocancer.bsky.social
Hear from co‑chairs @kamarronemd.bsky.social & Ramesh Rengan, MD, PhD, FASTRO on Lung Cancer Considered—insights, highlights & why you should be there.
🎧 bit.ly/NACLC25Preview
#LungCancer @ascocancer.bsky.social
The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Center for Cancer Immunotherapy and Immunobiology
京都大学大学院医学研究科附属 がん免疫総合研究センター（Center for Cancer Immunotherapy and Immunobiology（CCII））は、2020年4月1日に開設されました。 このセンターでは、「がんの征圧」という大きな夢に向かって集う世界各国から集まった研究者が活発な研究を行います。
www.ccii.med.kyoto-u.ac.jp
July 28, 2025 at 3:21 PM
The Center for Cancer #Immunotherapy & Immunobiology at Kyoto University is headed by Prof. Tasuku Honjo, our founding Director, and vice Director Sidonia Fagarasan.
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Visit our site to learn about our research, events, news, & opportunities at CCII.
#Immunology
www.ccii.med.kyoto-u.ac.jp/en/
Reposted by Center for Cancer Immunotherapy and Immunobiology
For readers interested in anticancer drugs, this Review in the July issue discusses progress and challenges in the development of tumour-agnostic kinase inhibitors
www.nature.com/articles/s41...
rdcu.be/eybm4
www.nature.com/articles/s41...
rdcu.be/eybm4
July 28, 2025 at 2:44 PM
For readers interested in anticancer drugs, this Review in the July issue discusses progress and challenges in the development of tumour-agnostic kinase inhibitors
www.nature.com/articles/s41...
rdcu.be/eybm4
www.nature.com/articles/s41...
rdcu.be/eybm4
Reposted by Center for Cancer Immunotherapy and Immunobiology
Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiome” this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
July 24, 2025 at 9:07 AM
Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiome” this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
Reposted by Center for Cancer Immunotherapy and Immunobiology
ICYMI
"Here, we investigated the effect of chronological aging on anti–PD-(L)1 therapy–induced irAE-like lung toxicity, utilizing tumor-bearing aged mice"
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
July 24, 2025 at 9:32 AM
ICYMI
ICYMI
"Here, we investigated the effect of chronological aging on anti–PD-(L)1 therapy–induced irAE-like lung toxicity, utilizing tumor-bearing aged mice"
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
Yokoi et al show that ICOS upregulation in CD4 T cells is linked to increased adverse ICB effects in the aged lung.
#Immunology #Immunotherapy
July 24, 2025 at 9:32 AM
ICYMI
Reposted by Center for Cancer Immunotherapy and Immunobiology
An unforgettable week of science and collaboration in Kyoto! 🔬 A huge thank you to the brilliant Sidonia Făgărășan and her entire lab for hosting me at the Center for Cancer Immunotherapy and Immunobiology (CCII).
Looking forward to future collaborations!
Looking forward to future collaborations!
July 6, 2025 at 2:51 PM
An unforgettable week of science and collaboration in Kyoto! 🔬 A huge thank you to the brilliant Sidonia Făgărășan and her entire lab for hosting me at the Center for Cancer Immunotherapy and Immunobiology (CCII).
Looking forward to future collaborations!
Looking forward to future collaborations!
Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiome” this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
July 24, 2025 at 9:07 AM
Vice director Sidonia Fagarasan introducing Jianguo (Jeff) Xia from McGill University, who gave a seminar on "Leveraging #metabolomics and biological networks for functional insights into microbiome” this week at CCII.
www.ccii.med.kyoto-u.ac.jp/en/event/eve...
www.ccii.med.kyoto-u.ac.jp/en/event/eve...