Carolina Parada Borja
@caroparadab.bsky.social
Developmental biologist. Permanent researcher at J. Gros lab, Institut Pasteur.
#LimbDevelopment 🔬✋
#LimbDevelopment 🔬✋
Reposted by Carolina Parada Borja
The talks (in english) can be accessed from the @college-de-france.fr website. A great journey through ‘Our ancestors the fish’, from 380 Mio years ago to their hidden presence inside ourselves. Lessons #1 and #2 👇🏼
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
Neil Shubin (1) | Collège de France
www.college-de-france.fr
November 7, 2025 at 3:49 PM
The talks (in english) can be accessed from the @college-de-france.fr website. A great journey through ‘Our ancestors the fish’, from 380 Mio years ago to their hidden presence inside ourselves. Lessons #1 and #2 👇🏼
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...
Reposted by Carolina Parada Borja
The Friday crème brûlée is back! @institutpasteur.bsky.social
October 31, 2025 at 4:34 PM
The Friday crème brûlée is back! @institutpasteur.bsky.social
Reposted by Carolina Parada Borja
A newly uncovered set of 1.5-million-year-old fossils that includes the first unambiguous Paranthropus boisei hand bones are reported in Nature. The findings offer insights into the evolution of hominin hands. go.nature.com/495cW1I 🧪 🏺
October 16, 2025 at 4:26 PM
A newly uncovered set of 1.5-million-year-old fossils that includes the first unambiguous Paranthropus boisei hand bones are reported in Nature. The findings offer insights into the evolution of hominin hands. go.nature.com/495cW1I 🧪 🏺
Reposted by Carolina Parada Borja
transport yourself to the late 90s with this really cool paper on digit number regulation by Shh and BMP, ZPA and AER. www.pnas.org/doi/10.1073/...
Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS
Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod
vertebrates is constrained to the pentadactyl state by inter...
www.pnas.org
September 26, 2025 at 6:54 PM
transport yourself to the late 90s with this really cool paper on digit number regulation by Shh and BMP, ZPA and AER. www.pnas.org/doi/10.1073/...
Reposted by Carolina Parada Borja
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The evolution of hominin bipedalism in two steps - Nature
The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...
www.nature.com
August 27, 2025 at 3:13 PM
1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Carolina Parada Borja
How can cells self-organize rapidly into complex patterns during development?
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
July 30, 2025 at 7:00 AM
How can cells self-organize rapidly into complex patterns during development?
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).
Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...
👇Thread 🧵(1/11)
Reposted by Carolina Parada Borja
A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification. https://www.biorxiv.org/content/10.1101/2025.07.17.665381v1
July 21, 2025 at 6:30 PM
A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification. https://www.biorxiv.org/content/10.1101/2025.07.17.665381v1
Reposted by Carolina Parada Borja
Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!
Seeing and (not) believing! On the role of hypoblast in primitive streak induction.
In her second #preLight, Ruoheng Li covers the #preprint by
@aurelienvilledieu.bsky.social and the @jeromegros.bsky.social's research team.
In her second #preLight, Ruoheng Li covers the #preprint by
@aurelienvilledieu.bsky.social and the @jeromegros.bsky.social's research team.
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction - preLights
Seeing and (not) believing the role of hypoblast in primitive streak induction
prelights.biologists.com
July 10, 2025 at 5:08 PM
Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!
Reposted by Carolina Parada Borja
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
July 7, 2025 at 6:47 AM
We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...
🚨 Early bird deadline: July 15th!
Registration is now open!
Gastrulation Reloaded: Developing, engineering & evolving the body plan
📅 October 14–17, 2025
📍 Paris, France
🗓️ Abstract & early bird deadline: July 15, 2025
www.gastrulation-reloaded.conferences-pasteur.org/home
Exceptional lineup of speakers & many selected talks
Gastrulation Reloaded: Developing, engineering & evolving the body plan
📅 October 14–17, 2025
📍 Paris, France
🗓️ Abstract & early bird deadline: July 15, 2025
www.gastrulation-reloaded.conferences-pasteur.org/home
Exceptional lineup of speakers & many selected talks
July 3, 2025 at 11:34 AM
🚨 Early bird deadline: July 15th!
Reposted by Carolina Parada Borja
Preprint alert from our lab!
Human fingertip regeneration is not reserved for infants. Adults can regenerate with little to no scarring! We analysed wound fluids of patients during the course of regeneration and found that...
www.medrxiv.org/content/10.1...
Human fingertip regeneration is not reserved for infants. Adults can regenerate with little to no scarring! We analysed wound fluids of patients during the course of regeneration and found that...
www.medrxiv.org/content/10.1...
Human fingertip regeneration follows clinical phases with distinct proteomic signatures – a Comprehensive MS/MS analysis
Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap,...
www.medrxiv.org
June 25, 2025 at 8:07 AM
Preprint alert from our lab!
Human fingertip regeneration is not reserved for infants. Adults can regenerate with little to no scarring! We analysed wound fluids of patients during the course of regeneration and found that...
www.medrxiv.org/content/10.1...
Human fingertip regeneration is not reserved for infants. Adults can regenerate with little to no scarring! We analysed wound fluids of patients during the course of regeneration and found that...
www.medrxiv.org/content/10.1...
Changes in Evolutionary Developmental Control Points in the Amniote Limb May Explain Hyperphalangy academic.oup.com/mbe/article/...
June 17, 2025 at 8:11 AM
Changes in Evolutionary Developmental Control Points in the Amniote Limb May Explain Hyperphalangy academic.oup.com/mbe/article/...
Reposted by Carolina Parada Borja
Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
F-BIAS: Towards a distributed national core facility for bioimage analysis †
Author summary We describe our experience in creating a nationwide core facility offering services in bioimage analysis. This virtual facility federates existing resources scattered across the territo...
journals.plos.org
June 11, 2025 at 8:29 AM
Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
🎉✌️
journals.plos.org/ploscompbiol...
So happy about this paper and how the work turned out.
A small thread 👇
#bioimageanalysis #corefacility
Reposted by Carolina Parada Borja
Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons
https://go.nature.com/4jduyKk
https://go.nature.com/4jduyKk
The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature
Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be an arthropod, and shifting the origin of vertebrate hard tissues to the Middle Ordovician.
go.nature.com
May 27, 2025 at 10:31 AM
Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons
https://go.nature.com/4jduyKk
https://go.nature.com/4jduyKk
Reposted by Carolina Parada Borja
Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 21, 2025 at 9:40 AM
Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Carolina Parada Borja
Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14
May 21, 2025 at 3:05 PM
Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14
Reposted by Carolina Parada Borja
🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction
In birds and mammals, the formation of the primitive streak, the hallmark of the primary axis and site of gastrulation, is thought to occur when an anterior displacement of the hypoblast (visceral end...
doi.org
May 19, 2025 at 8:59 AM
🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...
Reposted by Carolina Parada Borja
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
May 12, 2025 at 2:01 PM
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Reposted by Carolina Parada Borja
A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!
April 22, 2025 at 4:36 PM
A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!
Reposted by Carolina Parada Borja
Do you like Dev Bio ? Yes !
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
April 18, 2025 at 3:28 PM
Do you like Dev Bio ? Yes !
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology
Reposted by Carolina Parada Borja
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
April 7, 2025 at 7:16 AM
🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏
We are looking for a postdoc! Please repost 🙏
Reposted by Carolina Parada Borja
Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
March 21, 2025 at 10:06 AM
Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Carolina Parada Borja
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
March 20, 2025 at 12:13 PM
Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980
Thankful for any retweet! 🫶
imba.onlyfy.jobs/job/l6u2m980