Sebastian S. Cocioba
@atinygreencell.bsky.social
Flower Designer at Neoplants 🌺
Researcher at Binomica Labs
Degreeless Heathen
Petunia and Snapdragon Breeder
Open Lab Notebook: http://tinyurl.com/ATGCFFE
Researcher at Binomica Labs
Degreeless Heathen
Petunia and Snapdragon Breeder
Open Lab Notebook: http://tinyurl.com/ATGCFFE
Pinned
Sebastian's Biotech Bazaar
Designer of fine, hand-crafted, bespoke, and fully open source biotechnology tools for educators and researchers. Plasmids, lab equipment, cell lines, and seeds. An ever-growing collection of high qua...
ATinyGreenCell.com
Excited to announce some new plasmid offerings in my shop at atinygreencell.com! Here's a thread of the current catalog. All proceeds directly support my lab and my continued effort to build useful open-source tools. Feel free to get in touch if you want to know more. Please share! 💚
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Reposted by Sebastian S. Cocioba
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Bacterial immune systems as causes and consequences of microbiome structure
Bacterial immune systems have evolved in response to diverse molecular "parasites", yet their ecological roles remain poorly understood. This Essay explores how interactions between mobile genetic ele...
journals.plos.org
November 19, 2025 at 6:35 PM
Very happy to see this piece out in @plosbiology.org, on the bacterial immune systems and microbial communities. It was a great team effort with Rafael Custodio, @brockhurstlab.bsky.social , @brownlab.bsky.social, and Edze Westra! 🦠🧫 #phagesky #mevosky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Happy International Mens Day!
If you are a teen, find a role model that exemplifies the honorable virtues of masculinity and strive toward compassion.
If you are an adult, strive to be a pillar of your community...but also go get a colonoscopy and check your prostate please.
If you are a teen, find a role model that exemplifies the honorable virtues of masculinity and strive toward compassion.
If you are an adult, strive to be a pillar of your community...but also go get a colonoscopy and check your prostate please.
November 19, 2025 at 9:20 PM
Happy International Mens Day!
If you are a teen, find a role model that exemplifies the honorable virtues of masculinity and strive toward compassion.
If you are an adult, strive to be a pillar of your community...but also go get a colonoscopy and check your prostate please.
If you are a teen, find a role model that exemplifies the honorable virtues of masculinity and strive toward compassion.
If you are an adult, strive to be a pillar of your community...but also go get a colonoscopy and check your prostate please.
As depressing as the regression of the laws around the deregulation of genetically modified plants may be, the few years the SECURE rules were active gave way to glowing plants, nutrient-dense tomatoes, and a hunger for more consumer-facing innovations.
Precedence.
Hope.
Precedence.
Hope.
November 19, 2025 at 6:42 PM
As depressing as the regression of the laws around the deregulation of genetically modified plants may be, the few years the SECURE rules were active gave way to glowing plants, nutrient-dense tomatoes, and a hunger for more consumer-facing innovations.
Precedence.
Hope.
Precedence.
Hope.
I *love* flowers so much. Look at my lil Alice goooooo. Proud dad. 🥰💚
November 19, 2025 at 5:44 PM
I *love* flowers so much. Look at my lil Alice goooooo. Proud dad. 🥰💚
I feel like this could be used for science somehow, but also baking is science and I want an excuse to make statistically significant inroads into the ideal pancake recipe lol
November 19, 2025 at 2:39 PM
I feel like this could be used for science somehow, but also baking is science and I want an excuse to make statistically significant inroads into the ideal pancake recipe lol
Reposted by Sebastian S. Cocioba
Blue Soup pub target journal
November 19, 2025 at 6:41 AM
Blue Soup pub target journal
Truly the most important thing of this entire gig, by far. I haven't had real health insurance in YEARS. More than anything I'm so thankful for the chance to take care of myself. Worth every penny.
November 19, 2025 at 5:26 AM
Truly the most important thing of this entire gig, by far. I haven't had real health insurance in YEARS. More than anything I'm so thankful for the chance to take care of myself. Worth every penny.
Reposted by Sebastian S. Cocioba
Our lab's new CS student is working on our supercomputers in lab and wants us to move off Ubuntu bc package manager reasons, and suggests Manjaro, Pop! (even tho same pkgmngr), or Debian. For the comp (bio) people in my feed, thoughts?
November 18, 2025 at 9:50 PM
Our lab's new CS student is working on our supercomputers in lab and wants us to move off Ubuntu bc package manager reasons, and suggests Manjaro, Pop! (even tho same pkgmngr), or Debian. For the comp (bio) people in my feed, thoughts?
"We have rupture disks at home..."
Found a nice bladed gizmo that cuts perfect circles of anything up to 0.4mm thick with a tungsten blade. Very clean once you get the blade depth dialed in. Identical disks. Time to test all the sheet plastics, lol.
a.co/d/2daeOJK
Found a nice bladed gizmo that cuts perfect circles of anything up to 0.4mm thick with a tungsten blade. Very clean once you get the blade depth dialed in. Identical disks. Time to test all the sheet plastics, lol.
a.co/d/2daeOJK
November 18, 2025 at 9:42 PM
"We have rupture disks at home..."
Found a nice bladed gizmo that cuts perfect circles of anything up to 0.4mm thick with a tungsten blade. Very clean once you get the blade depth dialed in. Identical disks. Time to test all the sheet plastics, lol.
a.co/d/2daeOJK
Found a nice bladed gizmo that cuts perfect circles of anything up to 0.4mm thick with a tungsten blade. Very clean once you get the blade depth dialed in. Identical disks. Time to test all the sheet plastics, lol.
a.co/d/2daeOJK
Reposted by Sebastian S. Cocioba
Nature research paper: Florigen activation complex forms via multifaceted assembly in Arabidopsis
go.nature.com/4pd26f8
go.nature.com/4pd26f8
Florigen activation complex forms via multifaceted assembly in Arabidopsis - Nature
In flowering plants, DNA–FD–14-3-3 recruits FT to the florigen activation complex both through DNA–FT interactions and by reducing liquid phase condensation of FD protein, which promotes dimerization, leading to FT recruitment.
go.nature.com
November 18, 2025 at 10:50 AM
Nature research paper: Florigen activation complex forms via multifaceted assembly in Arabidopsis
go.nature.com/4pd26f8
go.nature.com/4pd26f8
One of the most interesting documentaries of early radio technology I have ever seen. Worth a full viewing; analog magic.
youtu.be/wHenisSTUQY?...
youtu.be/wHenisSTUQY?...
Crystals Go to War, 1943
YouTube video by Awareness Bureau
youtu.be
November 18, 2025 at 4:18 AM
One of the most interesting documentaries of early radio technology I have ever seen. Worth a full viewing; analog magic.
youtu.be/wHenisSTUQY?...
youtu.be/wHenisSTUQY?...
Weak men aplenty these days, it seems. I guess there isn't enough struggle in their lives to temper them into something better than whatever the fuck this is.
Pathetic.
Pathetic.
POV: you are a young woman celebrating a recent academic success
November 18, 2025 at 1:58 AM
Weak men aplenty these days, it seems. I guess there isn't enough struggle in their lives to temper them into something better than whatever the fuck this is.
Pathetic.
Pathetic.
My battle flag
November 18, 2025 at 1:17 AM
My battle flag
Reposted by Sebastian S. Cocioba
Working with one of @atinygreencell.bsky.social E. coli strains with a plasmid encoding blue pigment, I tried to see if I could "lose" the plasmid in the absence of antibiotics. Turns out that didn't work as expected. But I did see some weird hybrid colonies in the absence of selection!
November 17, 2025 at 11:17 PM
Working with one of @atinygreencell.bsky.social E. coli strains with a plasmid encoding blue pigment, I tried to see if I could "lose" the plasmid in the absence of antibiotics. Turns out that didn't work as expected. But I did see some weird hybrid colonies in the absence of selection!
White snapdragon mutant seed pod lookin HEALTHY. Definitely selfable. Fingers crossed a few of the others also take. Gonna self all the other flowers later this evening after my first shift at Neoplants is done. So excited to make some very cool plants!!!
November 17, 2025 at 4:20 PM
White snapdragon mutant seed pod lookin HEALTHY. Definitely selfable. Fingers crossed a few of the others also take. Gonna self all the other flowers later this evening after my first shift at Neoplants is done. So excited to make some very cool plants!!!
Reposted by Sebastian S. Cocioba
I'm stoked next semester to collab with our Literature & Writing colleagues to pilot a general education writing course that combines humanities and life science discipline-specific student learning outcomes. Let's see how this goes 🤞🏻🤞🏻
November 16, 2025 at 11:51 PM
I'm stoked next semester to collab with our Literature & Writing colleagues to pilot a general education writing course that combines humanities and life science discipline-specific student learning outcomes. Let's see how this goes 🤞🏻🤞🏻
Reposted by Sebastian S. Cocioba
Wow
'MHRA-led study reveals major inconsistencies in global microbiome research'
www.gov.uk/government/n...
'Species identification varied from 63% to 100% accuracy across different methods, meaning that some laboratories failed to detect a third of the bacterial species present in the sample'
'MHRA-led study reveals major inconsistencies in global microbiome research'
www.gov.uk/government/n...
'Species identification varied from 63% to 100% accuracy across different methods, meaning that some laboratories failed to detect a third of the bacterial species present in the sample'
MHRA-led study reveals major inconsistencies in global microbiome research
International collaboration establishes new quality standards to improve reliability of gut health studies – improving accuracy to provide better diagnosis and treatment.
www.gov.uk
November 16, 2025 at 12:51 PM
Wow
'MHRA-led study reveals major inconsistencies in global microbiome research'
www.gov.uk/government/n...
'Species identification varied from 63% to 100% accuracy across different methods, meaning that some laboratories failed to detect a third of the bacterial species present in the sample'
'MHRA-led study reveals major inconsistencies in global microbiome research'
www.gov.uk/government/n...
'Species identification varied from 63% to 100% accuracy across different methods, meaning that some laboratories failed to detect a third of the bacterial species present in the sample'
Yup, right is RUBY driven by 35s and left petal is RUBY driven by my broken lotus ubiquitin promoter. Gonna fix the 3' intron and try again. Should be very strong once its fixed. Dang introns, lol.
November 16, 2025 at 5:52 PM
Yup, right is RUBY driven by 35s and left petal is RUBY driven by my broken lotus ubiquitin promoter. Gonna fix the 3' intron and try again. Should be very strong once its fixed. Dang introns, lol.
A great teaching moment here for genetic design students:
NEVER assume any annotation that just says "promoter" and always inspect the elements along with the publication where said genetic part was designed/discovered no matter how long ago the article was written.
NEVER assume any annotation that just says "promoter" and always inspect the elements along with the publication where said genetic part was designed/discovered no matter how long ago the article was written.
Arrg, 3bp messed up my experiments lol. I was having problems getting any expression from this UBQ1 promoter from lotus, and it turns out the promoter is actually promoter+exon1+INTRON where the YAG acceptor is CRITICAL for proper splicing. Wasted 1 month on 3bp; fixed it now.
November 15, 2025 at 11:17 PM
A great teaching moment here for genetic design students:
NEVER assume any annotation that just says "promoter" and always inspect the elements along with the publication where said genetic part was designed/discovered no matter how long ago the article was written.
NEVER assume any annotation that just says "promoter" and always inspect the elements along with the publication where said genetic part was designed/discovered no matter how long ago the article was written.
Arrg, 3bp messed up my experiments lol. I was having problems getting any expression from this UBQ1 promoter from lotus, and it turns out the promoter is actually promoter+exon1+INTRON where the YAG acceptor is CRITICAL for proper splicing. Wasted 1 month on 3bp; fixed it now.
November 15, 2025 at 11:04 PM
Arrg, 3bp messed up my experiments lol. I was having problems getting any expression from this UBQ1 promoter from lotus, and it turns out the promoter is actually promoter+exon1+INTRON where the YAG acceptor is CRITICAL for proper splicing. Wasted 1 month on 3bp; fixed it now.
I heard y'all like cells...
Petunia leaf disk cells undergoing swelling due to exogenous phyohormones. Quite the departure from the jigsaw puzzle piece shape of normal plant leaf cells.
Petunia leaf disk cells undergoing swelling due to exogenous phyohormones. Quite the departure from the jigsaw puzzle piece shape of normal plant leaf cells.
November 15, 2025 at 8:10 PM
I heard y'all like cells...
Petunia leaf disk cells undergoing swelling due to exogenous phyohormones. Quite the departure from the jigsaw puzzle piece shape of normal plant leaf cells.
Petunia leaf disk cells undergoing swelling due to exogenous phyohormones. Quite the departure from the jigsaw puzzle piece shape of normal plant leaf cells.
Having a formal title of flower designer on my CV, and it not be just something I made up, is low key a highlight of my uncareer. Dreams come true in the strangest ways.
November 15, 2025 at 3:55 AM
Having a formal title of flower designer on my CV, and it not be just something I made up, is low key a highlight of my uncareer. Dreams come true in the strangest ways.
I know we are shutdown but wow are US court document databases slow to register new users. Waiting for my PACER account to be updated so I can read the actual Center For Food Safety vs USDA APHIS case that changed everything. Meanwhile my account authorized for days now...
November 15, 2025 at 1:45 AM
I know we are shutdown but wow are US court document databases slow to register new users. Waiting for my PACER account to be updated so I can read the actual Center For Food Safety vs USDA APHIS case that changed everything. Meanwhile my account authorized for days now...
If anyone wants to read the drama regarding unraveling the progressive GMO plant rules to pre-2019, here is a letter from the plantif, the activist group Center For Food Safety
www.centerforfoodsafety.org/files/cfs-pa...
www.centerforfoodsafety.org/files/cfs-pa...
www.centerforfoodsafety.org
November 15, 2025 at 1:23 AM
If anyone wants to read the drama regarding unraveling the progressive GMO plant rules to pre-2019, here is a letter from the plantif, the activist group Center For Food Safety
www.centerforfoodsafety.org/files/cfs-pa...
www.centerforfoodsafety.org/files/cfs-pa...
I'm slowly becoming a plant GMO deregulation sherpa, lol. Been neck deep in the repeal documents; that activist lawsuit set plant biotech back a decade and folks entering this industrial space should read the gudience the USDA put out to help. The game is back to Ultra Hard Mode.
snoop dogg wearing sunglasses and a ronin camera
ALT: snoop dogg wearing sunglasses and a ronin camera
media.tenor.com
November 15, 2025 at 12:57 AM
I'm slowly becoming a plant GMO deregulation sherpa, lol. Been neck deep in the repeal documents; that activist lawsuit set plant biotech back a decade and folks entering this industrial space should read the gudience the USDA put out to help. The game is back to Ultra Hard Mode.