Arthur Esquer
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arthuresquer.bsky.social
Arthur Esquer
@arthuresquer.bsky.social
65 followers 260 following 15 posts
CCU-AH en gériatrie à Strasbourg. Je travaille au sein d’une équipe spécialisée dans la maladie à corps de Lewy et autres maladies neuroévolutives ainsi qu’au développement de nouveaux biomarqueurs. Geek 👾 et jeux de rôle sur le temps libre
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Reposted by Arthur Esquer
vincentgranier.bsky.social
Au #JORF Décret relatif au diplôme d'Etat de masseur-kinésithérapeute, afin de mettre à niveau sa valeur (en crédits ECTS) avec le grade Master www.legifrance.gouv.fr/jorf/id/JORF...
www.legifrance.gouv.fr
December 19, 2025 at 7:30 AM
arthuresquer.bsky.social
Deux univers dont la rencontre est… inattendue
Des mini bretzels goût aïoli
December 18, 2025 at 6:05 PM
Reposted by Arthur Esquer
erictopol.bsky.social
The p-tau217 biomarker by age and prevalence of Alzheimer's disease in the community of ~12,000 people in Norway
www.nature.com/articles/s41...
December 17, 2025 at 4:08 PM
Reposted by Arthur Esquer
jama.com
Valacyclovir was associated with greater cognitive decline and did not improve disease markers in patients with symptomatic #AlzheimerDisease and HSV seropositivity.

ja.ma/4rYMRZe
JAMA infographic: study on valacyclovir for Alzheimer's. Question: Can valacyclovir provide benefit? Conclusion: Not efficacious. Population: 66 women, 54 men, mean age 71.4. Intervention: 120 patients randomized to valacyclovir or placebo. Findings: Valacyclovir worsened cognition vs. placebo.
December 17, 2025 at 4:15 PM
Reposted by Arthur Esquer
jama.com
💬 Editorial: Valacyclovir showed no benefit for cognitive outcomes in symptomatic #AlzheimerDisease, challenging the therapeutic role of antiviral agents in treating HSV-1 in #dementia.

ja.ma/3MGGxFJ
An editorial from JAMA, published online December 17, 2025, titled "Valacyclovir and Symptomatic Alzheimer Disease—No Evidence for Benefit" by David S. Knopman, MD. It discusses the viral hypothesis of Alzheimer's and a trial targeting HSV-1.
December 17, 2025 at 4:30 PM
Reposted by Arthur Esquer
jama.com
📊 Research Summary: Valacyclovir did not improve cognition or function in patients with early symptomatic #AlzheimerDisease with HSV seropositivity and is not supported for use in this population.

ja.ma/3YuB2fN
JAMA Research Summary: A trial assessing valacyclovir, an antiviral for herpes simplex, on cognitive outcomes in early Alzheimer's patients. Results: valacyclovir didn't improve cognition. Participants: 120 adults; mean age 71.4.
December 17, 2025 at 4:45 PM
Reposted by Arthur Esquer
ariellekeller.bsky.social
Our paper on the ☀️ "summer slide" 🛝 is out now @pnas.org!
www.pnas.org/doi/10.1073/...
Summer slide is a replicable phenomenon across diverse datasets that's more than "forgetting" school material in vacation months, but effects of socioeconomic inequality are ➡️ 7x bigger! ⬅️
#PsychSciSky #DevPsy
🧵👇
December 16, 2025 at 5:56 PM
Reposted by Arthur Esquer
erictopol.bsky.social
Evidence for a detrimental causal effect of social isolation on cognitive function in older adults
academic.oup.com/psychsocgero...
December 16, 2025 at 3:16 PM
arthuresquer.bsky.social
Les infections (notamment respiratoires ou urinaires) accélèreraient l’atrophie cérébrale, le déclin cognitif et la positivité des biomarqueurs #alzsky

link.springer.com/article/10.1...
Infections are associated with annual changes in machine learning-derived neuroimaging signatures. a Forest plot shows the associations of influenza, miscellaneous bacterial, upper respiratory tract, skin/subcutaneous, and urinary tract infections with rates of change in neuroimaging signatures that capture distinct patterns of age-related brain volume loss (i.e., subcortical, medial-temporal lobe, parieto- temporal lobe, diffuse cortical, and perisylvian). Higher values reflect greater atrophy. Annual changes of standardized brain atrophy signatures associated with history of a given infection () were derived from linear mixed effects models adjusted for demographic, physiological, and comorbid variables, and two- way interactions of covariates with time. Red shapes indicate statistical significance (p<0.05). b Scatterplots show parieto-temporal volume loss associated with influenza, miscellaneous bacterial, upper respiratory tract, skin/subcutaneous, and urinary tract infections. Annual changes of standardized brain atrophy signatures associated with history of a given infection () were derived from linear mixed effects models adjusted for the aforementioned covariates. c Rose plots show the rates of change in machine learning-derived neuroimaging signatures associated with upper respiratory tract, skin/subcutaneous, and urinary tract infections in an independent replication cohort (the UK Biobank; UKB). Insufficient cases prevented examination of influenza and miscellaneous bacterial infections. Annual changes of standardized brain atrophy signatures associated with history of a given infection () were derived from linear mixed effects models adjusted for demographic, physiological, and comorbid variables, and two- way interactions of covariates with time Infections are associated with biomarkers of Alzheimer’s disease and related dementias (ADRD). a The percentages (and corresponding frequencies) of amyloid- (A) positive (+) and negative (-) participants who maintain a history of influenza, miscellaneous bacterial, upper respiratory tract, skin/subcutaneous, and urinary tract infections. Odds of A+ (Odds Ratio) were derived from logistic regression models adjusted for demographic, physiological, and comorbid variables. Heatmaps show the b baseline and c longitudinal associations of infections with plasma biomarker levels. Differences and annual changes in plasma biomarker levels associated with history of a given infection () were derived from linear mixed effects models adjusted for demographic, physiological, and comorbid variables, and two-way interactions of covariates with time. Scatterplots show how a history of d upper respiratory tract e and urinary tract infections modifies the longitudinal associations of infection-related atrophy (i.e., parieto-temporal atrophy) with plasma NfL levels (infection*parieto-temporal atrophy*time). Annual changes in NfL levels associated with history of a given infection () were derived from linear mixed effects models adjusted for the aforementioned covariates. Individual-specific standardized slopes of NfL and parieto-temporal atrophy are displayed. Key: A42/40, amyloid-beta ratio; ADRD, Alzheimer’s disease and related dementias; GFAP, glial fibrillary acidic protein; NfL, neurofilament light chain; OR, odds ratio; pTau-181, phosphorylated tau-181; UKB, UK Biobank; URTIs, upper respiratory tract infections; UTIs, urinary tract infections
December 15, 2025 at 7:32 AM
Reposted by Arthur Esquer
francisb-sciences.bsky.social
Certains élus veulent limoger l'idiot du village RFK Jr.

C'était passé sous le radar. Témoignage glaçant. La directrice limogée du CDC, la Dr Susan Monarez, s'exprime sur les pressions exercées par RFK Jr.

Quand la pseudo science fait la loi à la vraie science. 🤢😣
December 12, 2025 at 2:26 PM
Reposted by Arthur Esquer
petrathepostdoc.bsky.social
my section was all about uterine tissues creating happy little "benign" tumors that make your life hell but since they are not cancerous it takes forever to diagnose and find a treatment that works for YOU!

#SciArt #endometriosis #fibroids #adenomyosis
cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - FIBROIDS- non-cancerous abnormal growths of muscle tissue extremely common, 2/3, ~50% asymptomatic unclear origin, estrogen? progesterone? at higher risk: African Caribbean, family history, early periods, obesity heavy bleeds, anemia, back pain infertility constipation, frequent urination Dr. Platypus fact: one of the biggest fibroid was 28kg in a 53 year old Singaporean patient! the middle drawing is of an uterus absolutely covered in pink blobs representing the different type of fibroids: pedunculate (outside), pedunculate (inside), subserosal, submucosal, utnramural cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ENDOMETRIOSIS- endometrial-like tissue growing outside of the uterus unclear origin (cells escaping fallopian tube at menstruation, immune dysfunction, local estrogen production, circulation, surgery, genetics) Dr. Platypus fact: endometriotic lesions were even found in the brain, which caused neurological and psychiatric symptoms! ~8 years to get diagnosed 1/10 people bleeding outside and inside infertility pelvic PAIN! during intercourse, bowel movement, urination, or for no good reason nausea the middle drawing is of an uterus, guts, kidneys ovaries and bladder covered in pink endometriotic lesions, none of the organs are happy about it, one ovary has a massive pink chocolate cyst on it (a cyst full of endometrial tissue and blood) cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ADENOMYOSIS- endometrial tissue frowing inside the muscles of the uterus 1/10 people, and they might not even have symptoms (one figure sayinh you telling me WHAT??) unclear origin... shocking i know... estrogen?? other hormones? most likely in: +30 years, abdominal surgery, given birth heavy abnormal bleeding, anemia, pain bloating, fullness infertility Dr. Platypus fact:you can have endometriosis, adenomyosis, and firboids ALL AT ONCE!... and they all have similar symptoms the middle drawing is of an uterus absolutely covered in pink blobs representing the endometrial tissue growing within the muscle: focal (adenomyoma), diffuse, enlarged uterus cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - MANAGING- there is no one-size-fits-all treatment, care ranges from less to more invasive first you need to diagnose the problem: ultrasound, blood markers, Magnetic Resonanse Imaging (MRI), surgery etc. PAIN CONTROL: painkillers and anti-inflammatory drugs, physiotherapy, heating pads or hot water bottles, transcutaneous electrical nerve stimulation (TENS) HORMONAL MEDICATION: IUS, mini pill, implants (progestogen only), combined pill, patches (progestogen + estrogen), hypothalamus pills injections (GnRH agonists and antagonists) SURGERY (diagnostic, to alleviate symptoms, and curative) laparoscopy, transvaginal hysteroscopy, abdominal (all biopsied) diseased tissue removal by laser or surgical hysterectomy: curative for adenomyosis and fibroids, but harder to access if <45 Dr. Platypus fact: platypuses don't have a uterus*(long oviduct, sometimes called the "uterus") so don't need to worry about any of this
November 27, 2025 at 10:47 PM
Reposted by Arthur Esquer
fzores.bsky.social
Prise de position de la Société Française de Diabétologie dans la prise en charge du DT2.

Enfin les choses commencent à bouger, mais si on ne va pas renverser la table en une seule fois...

www.sfdiabete.org/sites/www.sf...
www.sfdiabete.org
December 9, 2025 at 6:56 PM
arthuresquer.bsky.social
Dans des modèles murins, plusieurs modèles d’inflammation semblent liés à différents troubles du comportement (published ahead of print)
Network-level organization of systemic inflammation reflects early Alzheimer’s-like behavioral changes - Scientific Reports
Systemic immune alterations are increasingly recognized as features of Alzheimer’s disease (AD), yet their network-level organization in preclinical models is poorly understood. We profiled 60 in vivo...
www.nature.com
December 9, 2025 at 7:01 AM
arthuresquer.bsky.social
Corrélée au ralentissement du déclin cognitif, l’atrophie hippocampique pourrait être un marqueur intermédiaire d’efficacité des anticorps anti amyloïdes dans la MA
Hippocampal Atrophy on Magnetic Resonance Imaging as a Surrogate Marker for Clinical Benefit and Neurodegeneration in Early Symptomatic Alzheimer’s Disease: Synthesis of Evidence from Observational an...
Amyloid-plaque reduction is currently the only recognized surrogate outcome for Alzheimer’s disease (AD) trials, allowing accelerated approval of plaque-clearing amyloid antibodies. However, plaque re...
link.springer.com
December 9, 2025 at 6:55 AM
arthuresquer.bsky.social
Le conseil d’état confirme que l’accès au dossier patient informatisé en l’absence de prise en charge effective contrevient au secret médical, y compris sous motifs de recherche
Médecins : pas de prise en charge effective, pas d’accès au dossier patient
Dans une affaire récente(1), le Conseil d’Etat s’est prononcé sur le cas de l’accès aux DPI d’un service médical hospitalier par un professionnel de santé participant aux réunions d’équipe de ce servi...
www.egora.fr
December 9, 2025 at 6:46 AM
arthuresquer.bsky.social
État des lieux du diagnostic biologique des alpha-synucleinopathies, nous avons la chance à Strasbourg de disposer de SAA, et nous suivons également avec intérêt le développement des cartes aptamériques !
Diagnostic biomarkers for α-synucleinopathies- state of the art and future developments: a systematic review - Molecular Neurodegeneration
Molecular Neurodegeneration - Alpha-synucleinopathies are common disorders that are expected to become increasingly prevalent in the future along with the longer life expectancy. However, their...
link.springer.com
December 8, 2025 at 7:35 AM
Reposted by Arthur Esquer
alicepotiron.bsky.social
Mais en fait, un livre, c’est un TARDIS. C’est plus grand à l’intérieur qu’à l’extérieur et ça nous emmène partout à n’importe quelle époque.
December 5, 2025 at 12:58 PM
Reposted by Arthur Esquer
projetarcadie.com
L'article 20 établit aussi l'obligation vaccinale contre la grippe pour les résidents en EHPAD (sauf évidemment contre-indications médicales) #DirectAN #PLFSS2026
December 5, 2025 at 3:22 PM
Reposted by Arthur Esquer
projetarcadie.com
L'article 20, établissant l'obligation vaccinale pour les personnels soignants en EHPAD et dans les structures type crèches, a été adopté. #DirectAN #PLFSS2026
December 5, 2025 at 3:21 PM
Reposted by Arthur Esquer
c0nc0rdance.bsky.social
Fun DNA fact:
Five main nucleotide bases are A, G, C, T & U:

A - Adenine - 'ADEN' is Greek for "gland", found in pancreas
G - Guanine - found in bird GUANO
C - Cytosine - calf thymus, but named for CELLs
T - Thymine - Also isolated from calf THYMUS.
U - Uracil - isolated from URINE crystals.
the word dna is displayed on a screen with a glowing background .
Alt: the word dna is displayed on a screen with a glowing background and double helix animation behind it.
media.tenor.com
June 27, 2025 at 1:47 PM
arthuresquer.bsky.social
Dernières heures de collerette de la honte pour cette polissonne qui essaie d’arracher ses points #Abi
Un très beau chaton calico de 6 mois avec une collerette Un très beau chaton calico de 6 mois avec une collerette Un très beau chaton calico de 6 mois avec une collerette
December 5, 2025 at 2:34 PM
Reposted by Arthur Esquer
fredericblanc.bsky.social
Dementia with Lewy bodies (DLB) in the prodromal to mild stage: little change over 8 years. This confirms the neurofunctional status of DLB at onset, which can progress to a neurodegenerative status. The challenge is to prevent this transition from one to the other.
link.springer.com/article/10.1...
Long term cognitive outcome of prodromal and mild dementia with Lewy bodies: a cohort study - GeroScience
The cognitive evolution of early dementia with Lewy bodies (DLB) is less well known than that of Alzheimer’s disease (AD). During dementia, DLB progresses like AD. The aim of this study was to analyze...
link.springer.com
December 5, 2025 at 2:16 PM
arthuresquer.bsky.social
Fin des 13èmes rencontres scientifiques de la Fondation Alzheimer : temps riche d’échanges de pratiques, d’avancées en sciences cliniques et fondamentales et présentation de posters et communication orale par notre équipe du CMRR de Strasbourg
Avec @fredericblanc.bsky.social
Photo de l’équipe de Strasbourg devant les posters présentés Extrait du journal de l’évènement avec la photos et l’abstract des posters de : - Manon Querry : Quid des émotions dans la maladie à corps de Lewy ? Une étude comportementale - Léa Sanna : Perte d'autonomie dans la maladie à corps de Lewy et la maladie d'Alzheimer: rôles distincts du déclin cognitif et du syndrome parkinsonien. - Arthur Esquer : Étude comparative de volumétrie cérébrale en voxel-based morphometry d'une population de patients atteints d'une maladie d'Alzheimer ou d'une maladie à corps de Lewy définis sur une base biologique.
December 5, 2025 at 1:53 PM