Adrien Peyrache
@apeyrache.bsky.social
Space, Sleep, and Spikes | Associate Prof @ McGill, Montreal Neurological Institute | Co-director, The Quebec Sleep Research Network
This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. While power is correlated across hemispheres, synchrony is significantly higher within a hemisphere than across.
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
On CA1 ripple oscillations: reevaluating asynchronicity evidence
doi.org
November 21, 2025 at 5:32 PM
This important study provides new insights into the synchronization of ripple oscillations in the hippocampus, both within and across hemispheres. While power is correlated across hemispheres, synchrony is significantly higher within a hemisphere than across.
doi.org/10.7554/eLif...
doi.org/10.7554/eLif...
Reposted by Adrien Peyrache
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
November 19, 2025 at 6:04 PM
I am recruiting graduate students for the experimental side of my lab @mcgill.ca for admission in Fall 2026!
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Get in touch if you're interested in how brain circuits implement distributed computation, including dopamine-based distributed RL and probabilistic representations.
Reposted by Adrien Peyrache
Arrived in San Diego for my first SfN, looking forward to showing you all my work with @apeyrache.bsky.social ; untangling the contribution of inhibition to the thalamic head direction attractor 💍
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
November 15, 2025 at 6:14 PM
Arrived in San Diego for my first SfN, looking forward to showing you all my work with @apeyrache.bsky.social ; untangling the contribution of inhibition to the thalamic head direction attractor 💍
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Come see me tonight at the TPDA poster session or on Tuesday morning with the lab!
#SfN25
Reposted by Adrien Peyrache
Will be presenting a poster on @apeyrache.bsky.social row, Tues AM, with an update our sequential predictive learning preprint:
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
TFW you land in San Diego and the bsky is hopping #sfn25
November 15, 2025 at 5:02 AM
Will be presenting a poster on @apeyrache.bsky.social row, Tues AM, with an update our sequential predictive learning preprint:
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
-CA3-like (sparse lognormal) connectivity gives a hippocampus-like (orthogonalized) map
-non-spatial representation! splitters, lap/time cells, action plan…we got it all🤑
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
November 13, 2025 at 3:02 PM
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
Reposted by Adrien Peyrache
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Sosa Lab - Postdoctoral Researchers
We are seeking postdocs to start in 2026!
www.sosaneurolab.com
November 7, 2025 at 10:53 PM
The Sosa Lab is going to #SfN25 and actively recruiting ✨postdocs✨ with systems neuroscience experience! We study both fundamental memory processes and how memory changes during pregnancy and postpartum.
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
If you are interested in meeting at SfN, please email me! www.sosaneurolab.com/join/postdoc...
Great study showing how histaminergic signaling shapes head-direction cell activity in the presence of objects, with important implications for how animals get oriented. A huge amount of work, really impressive.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
A Neuromodulatory Circuit Amplifies Object-based Head-direction Tuning for Spatial Memory
While the head-direction (HD) system is well-established as the brain’s internal compass, the mechanisms that allow it to be flexibly shaped by landmarks have remained unclear. Here we discovered that...
www.researchsquare.com
November 7, 2025 at 5:22 PM
Great study showing how histaminergic signaling shapes head-direction cell activity in the presence of objects, with important implications for how animals get oriented. A huge amount of work, really impressive.
www.researchsquare.com/article/rs-7...
www.researchsquare.com/article/rs-7...
A chemical extracted from carrot roots helped pave the way for flat-screen TVs, and six other discoveries that unintentionally changed the world.
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
7 basic science discoveries that changed the world
Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier — the very types of study being slashed by the US government.
www.nature.com
November 5, 2025 at 3:08 PM
A chemical extracted from carrot roots helped pave the way for flat-screen TVs, and six other discoveries that unintentionally changed the world.
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Perfect talking points for when you need to defend basic science, whether it’s to your grumpy uncle or your MP.
www.nature.com/articles/d41...
Reposted by Adrien Peyrache
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
3 Postdoctoral Research Fellows
Champalimaud Foundation (Fundação D. Anna de Sommer Champalimaud e Dr.
euraxess.ec.europa.eu
November 4, 2025 at 5:11 PM
🚨Job alert🚨
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
The lab has up to *3 postdoc openings* for comp systems neuroscientists interested in describing and manipulating neural population dynamics mediating behaviour
This is part of a collaborative ARIA grant "4D precision control of cortical dynamics"
euraxess.ec.europa.eu/jobs/383909
Reposted by Adrien Peyrache
a gross parliamentary overreach — article by @picardonhealth.bsky.social in the globe and mail; #academicsky #neuroskyence #psychscisky www.theglobeandmail.com/gift/91587b9...
How much are MPs entitled to know about research grants? Not as much as they think
A parliamentary committee is asking for academics’ private information on a strange anti-DEI crusade
www.theglobeandmail.com
November 4, 2025 at 11:30 AM
a gross parliamentary overreach — article by @picardonhealth.bsky.social in the globe and mail; #academicsky #neuroskyence #psychscisky www.theglobeandmail.com/gift/91587b9...
New lab colormap, courtesy of the tree outside my house.
October 24, 2025 at 5:32 PM
New lab colormap, courtesy of the tree outside my house.
Reposted by Adrien Peyrache
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
A mean-field model of neural networks with PV and SOM interneurons reveals connectivity-based mechanisms of gamma oscillations
Classic theoretical models of cortical oscillations are based on the interactions between two populations of excitatory and inhibitory neurons. Nevertheless, experimental studies and network simulatio...
biorxiv.org
October 24, 2025 at 11:02 AM
Various theoretical properties derived for gamma oscillations based on canonical E-SOM-PV microcircuit connectivity using mean-field modelling, which moves beyond classic Wilson-Cowan models in important ways
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
biorxiv.org/content/10.1... - w. Farzin Tahvili & Matteo Di Volo
Looking forward to seeing all the great science that will come out of @adrian-du.bsky.social’s lab, aka the DuLab!!
Congrats Adrian!
Congrats Adrian!
Thrilled to announce I'll be joining the Division of Neuroscience at @manchester.ac.uk as a Lecturer in Feb '26!
The DuLab will explore how the brain integrates sensory streams into internal maps 🌐 using the rodent head-direction circuit, the 'neural compass', as a starting point for the journey 🧭
The DuLab will explore how the brain integrates sensory streams into internal maps 🌐 using the rodent head-direction circuit, the 'neural compass', as a starting point for the journey 🧭
October 20, 2025 at 8:39 PM
Looking forward to seeing all the great science that will come out of @adrian-du.bsky.social’s lab, aka the DuLab!!
Congrats Adrian!
Congrats Adrian!
Reposted by Adrien Peyrache
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
www.sciencedirect.com
October 15, 2025 at 8:10 PM
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
🚨new paper: the head-direction circuit as a model of primary thalamocortical system. Check this out 👇
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
Really excited to share this Opinion piece we've been working on with fellow head-direction cell geeks @apeyrache.bsky.social @desdemonafricker.bsky.social and (bsky-less?) Andrea Burgalossi! While head-direction cells pop up in many cortical regions, we think that one of them is quite unique (1/8)
The postsubiculum as a head-direction cortex
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive…
www.sciencedirect.com
October 15, 2025 at 9:39 PM
🚨new paper: the head-direction circuit as a model of primary thalamocortical system. Check this out 👇
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
kudos to @adrian-du.bsky.social for the huge amount of work put into this opinion piece, starting with the beautiful figures comparing the different thalamocortical systems 🤩
Totally agree with @gershbrain.bsky.social. Science will never explain art.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
When I was an undergrad, I saw a talk by Oliver Sacks about music. During the Q&A, someone asked Sacks if he thought science would reveal the deepest mysteries of art. Sacks (a rare humanist among scientists) said that he doubted it, at which Eric Kandel (the host) leaped up and grabbed the mic.
October 15, 2025 at 1:19 PM
Totally agree with @gershbrain.bsky.social. Science will never explain art.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Yet the two share an important trait: a constant search for new representations of nature, of data, of reality, of emotions, in forms that make sense of what once seemed inscrutable.
Reposted by Adrien Peyrache
The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI!
More info below 👇
More info below 👇
📣 WTI is hiring faculty positions! Are you interested in advancing our understanding of the brain + how it gives rise to cognition?
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
Two calls are open:
Open-rank search, Neurocomputation, deadline: 12.1.25
Senior search, Neurodevelopment, rolling review
🔗 wti.yale.edu/opportunities
#KnowTogether
October 8, 2025 at 12:14 PM
The Wu Tsai Institute at Yale is hiring another faculty member in neurocomputation. Come work with us in a growing community at the interface of neuroscience and AI!
More info below 👇
More info below 👇
Every neuroscience lecture ever, summarized in one dog video.
October 7, 2025 at 6:26 PM
Every neuroscience lecture ever, summarized in one dog video.
Reposted by Adrien Peyrache
I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !
With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
October 2, 2025 at 3:46 PM
I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !
With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics
Reposted by Adrien Peyrache
🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus
Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)
Led by @jordandekraker.bsky.social
docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
HippoMaps: multiscale cartography of the human hippocampus
Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)
Led by @jordandekraker.bsky.social
docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
October 2, 2025 at 11:50 AM
🚨 New paper in Nature Methods:
HippoMaps: multiscale cartography of the human hippocampus
Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)
Led by @jordandekraker.bsky.social
docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
HippoMaps: multiscale cartography of the human hippocampus
Open-source tools & data to explore structure and function of the 🍤🧠 (histology, in/ex vivo MRI, iEEG)
Led by @jordandekraker.bsky.social
docs: hippomaps.readthedocs.io
paper: doi.org/10.1038/s415...
Reposted by Adrien Peyrache
Just the most remarkable person and truly a beautiful soul
Breaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt
October 1, 2025 at 6:59 PM
Just the most remarkable person and truly a beautiful soul
Reposted by Adrien Peyrache
🕊️ The world has lost a revered conservationist -- a colossal power for what is truly good.
🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman.
🕊️ She was brave, brilliant and introduced us to the best things among us: animals.
🕊️ I grieve her passing.
🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman.
🕊️ She was brave, brilliant and introduced us to the best things among us: animals.
🕊️ I grieve her passing.
October 1, 2025 at 6:56 PM
🕊️ The world has lost a revered conservationist -- a colossal power for what is truly good.
🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman.
🕊️ She was brave, brilliant and introduced us to the best things among us: animals.
🕊️ I grieve her passing.
🕊️ Jane Goodall is a legend who helped open the door to science to the best humans among us: woman.
🕊️ She was brave, brilliant and introduced us to the best things among us: animals.
🕊️ I grieve her passing.
Reposted by Adrien Peyrache
Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
Professor - Computational Cognitive Neuroscience
Professor - Computational Cognitive Neuroscience
jobs.utoronto.ca
September 5, 2025 at 8:22 AM
Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...
Post-tenure mid-life crisis project: complete ✅
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
September 21, 2025 at 6:09 PM
Post-tenure mid-life crisis project: complete ✅
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
Fascinating work! It pinpoints the origin of dopaminergic signaling as a filter of striatal activity computing temporal difference.
Excited to dig into this manuscript.
Excited to dig into this manuscript.
🚨Our preprint is online!🚨
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
www.biorxiv.org/content/10.1...
How do #dopamine neurons perform the key calculations in reinforcement #learning?
Read on to find out more! 🧵
September 19, 2025 at 2:34 PM
Fascinating work! It pinpoints the origin of dopaminergic signaling as a filter of striatal activity computing temporal difference.
Excited to dig into this manuscript.
Excited to dig into this manuscript.