Adrien Peyrache
@apeyrache.bsky.social
Space, Sleep, and Spikes | Associate Prof @ McGill, Montreal Neurological Institute | Co-director, The Quebec Sleep Research Network
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
November 13, 2025 at 3:02 PM
Five-star hydrotherapy for hardware that costs more than my car.
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
We recycle our probes many many times, even after chronic implants, saving $$$. Happy to share the protocol.
(And yes, I don’t have a car).
New lab colormap, courtesy of the tree outside my house.
October 24, 2025 at 5:32 PM
New lab colormap, courtesy of the tree outside my house.
Every neuroscience lecture ever, summarized in one dog video.
October 7, 2025 at 6:26 PM
Every neuroscience lecture ever, summarized in one dog video.
Post-tenure mid-life crisis project: complete ✅
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
September 21, 2025 at 6:09 PM
Post-tenure mid-life crisis project: complete ✅
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
3h27 at the marathon (PB!) and one very happy (if slightly zombie-like) man. Recovery phase starts now…
« Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells. »
A fundamental study now published @elife.bsky.social
elifesciences.org/reviewed-pre...
A fundamental study now published @elife.bsky.social
elifesciences.org/reviewed-pre...
September 17, 2025 at 12:05 PM
« Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells. »
A fundamental study now published @elife.bsky.social
elifesciences.org/reviewed-pre...
A fundamental study now published @elife.bsky.social
elifesciences.org/reviewed-pre...
How s this possible? Unlike cortex, the thalamus lacks local excitatory loops.
We found ADN neurons switch abruptly between silent and active states, a non-linear firing mode that can create structure from noise.
This was described by @dlevenstein.bsky.social
www.biorxiv.org/content/10.1...
9/13
We found ADN neurons switch abruptly between silent and active states, a non-linear firing mode that can create structure from noise.
This was described by @dlevenstein.bsky.social
www.biorxiv.org/content/10.1...
9/13
September 16, 2025 at 3:56 PM
How s this possible? Unlike cortex, the thalamus lacks local excitatory loops.
We found ADN neurons switch abruptly between silent and active states, a non-linear firing mode that can create structure from noise.
This was described by @dlevenstein.bsky.social
www.biorxiv.org/content/10.1...
9/13
We found ADN neurons switch abruptly between silent and active states, a non-linear firing mode that can create structure from noise.
This was described by @dlevenstein.bsky.social
www.biorxiv.org/content/10.1...
9/13
We silenced cortical feedback and saw LMN activity collapse into noise during non-REM, showing LMN relies on cortex to stay organized in sleep.
In the same condition, ADN neurons remained tightly coordinated even when PSB was silenced, showing the thalamus can self-organize coherent dynamics
8/13
In the same condition, ADN neurons remained tightly coordinated even when PSB was silenced, showing the thalamus can self-organize coherent dynamics
8/13
September 16, 2025 at 3:56 PM
We silenced cortical feedback and saw LMN activity collapse into noise during non-REM, showing LMN relies on cortex to stay organized in sleep.
In the same condition, ADN neurons remained tightly coordinated even when PSB was silenced, showing the thalamus can self-organize coherent dynamics
8/13
In the same condition, ADN neurons remained tightly coordinated even when PSB was silenced, showing the thalamus can self-organize coherent dynamics
8/13
During non-REM sleep, LMN activity becomes less coherent relative to wakefulness, but is not entirely random.
See here pairwise correlation during non-REM as a function of pairwise correlation during wake (ADN orange, LMN blue):
6/13
See here pairwise correlation during non-REM as a function of pairwise correlation during wake (ADN orange, LMN blue):
6/13
September 16, 2025 at 3:56 PM
During non-REM sleep, LMN activity becomes less coherent relative to wakefulness, but is not entirely random.
See here pairwise correlation during non-REM as a function of pairwise correlation during wake (ADN orange, LMN blue):
6/13
See here pairwise correlation during non-REM as a function of pairwise correlation during wake (ADN orange, LMN blue):
6/13
The question we always had was: what about their inputs (LMN)?
So we recorded HD cell populations from both LMN and ADN, and in several animals, we managed to do it simultaneously.
While ADN cells stayed coherent during non-REM, LMN cells lost their structure, they co-fired almost randomly.
4/13
So we recorded HD cell populations from both LMN and ADN, and in several animals, we managed to do it simultaneously.
While ADN cells stayed coherent during non-REM, LMN cells lost their structure, they co-fired almost randomly.
4/13
September 16, 2025 at 3:56 PM
The question we always had was: what about their inputs (LMN)?
So we recorded HD cell populations from both LMN and ADN, and in several animals, we managed to do it simultaneously.
While ADN cells stayed coherent during non-REM, LMN cells lost their structure, they co-fired almost randomly.
4/13
So we recorded HD cell populations from both LMN and ADN, and in several animals, we managed to do it simultaneously.
While ADN cells stayed coherent during non-REM, LMN cells lost their structure, they co-fired almost randomly.
4/13
HD cells tell the brain which way the head is pointing, critical for navigation.
They sit in a well-known circuit:
brainstem (lateral mammillary nuclei, LMN)
→ thalamus (anterodorsal nucleus, ADN)
→ cortex (postsubiculum, PSB)
and back to LMN! It's the Papez circuit after all.
2/13
They sit in a well-known circuit:
brainstem (lateral mammillary nuclei, LMN)
→ thalamus (anterodorsal nucleus, ADN)
→ cortex (postsubiculum, PSB)
and back to LMN! It's the Papez circuit after all.
2/13
September 16, 2025 at 3:56 PM
HD cells tell the brain which way the head is pointing, critical for navigation.
They sit in a well-known circuit:
brainstem (lateral mammillary nuclei, LMN)
→ thalamus (anterodorsal nucleus, ADN)
→ cortex (postsubiculum, PSB)
and back to LMN! It's the Papez circuit after all.
2/13
They sit in a well-known circuit:
brainstem (lateral mammillary nuclei, LMN)
→ thalamus (anterodorsal nucleus, ADN)
→ cortex (postsubiculum, PSB)
and back to LMN! It's the Papez circuit after all.
2/13
Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation?
Yes but explained variance is limited.
Now published in @elife.bsky.social
elifesciences.org/reviewed-pre...
Yes but explained variance is limited.
Now published in @elife.bsky.social
elifesciences.org/reviewed-pre...
September 15, 2025 at 12:05 PM
Does slow oscillation-spindle coupling contribute to sleep-dependent memory consolidation?
Yes but explained variance is limited.
Now published in @elife.bsky.social
elifesciences.org/reviewed-pre...
Yes but explained variance is limited.
Now published in @elife.bsky.social
elifesciences.org/reviewed-pre...
and it was high time to celebrate with the @mcgill.ca side of the team
September 11, 2025 at 9:15 PM
and it was high time to celebrate with the @mcgill.ca side of the team
Elevator ride is an underrated team building activity
September 4, 2025 at 8:16 PM
Elevator ride is an underrated team building activity
Sunday fun fact:
A 3rd-century BC Roman coin depicting a hippocampus — the mythical sea creature linked to Neptune.
One of 13,000 coins discovered while digging in the basement of a house in southern France, near the Pyrenees.
A 3rd-century BC Roman coin depicting a hippocampus — the mythical sea creature linked to Neptune.
One of 13,000 coins discovered while digging in the basement of a house in southern France, near the Pyrenees.
August 10, 2025 at 9:42 AM
Sunday fun fact:
A 3rd-century BC Roman coin depicting a hippocampus — the mythical sea creature linked to Neptune.
One of 13,000 coins discovered while digging in the basement of a house in southern France, near the Pyrenees.
A 3rd-century BC Roman coin depicting a hippocampus — the mythical sea creature linked to Neptune.
One of 13,000 coins discovered while digging in the basement of a house in southern France, near the Pyrenees.
The thing about going on vacation with a multinational family… it always feels a bit like a spy movie.
July 5, 2025 at 6:57 PM
The thing about going on vacation with a multinational family… it always feels a bit like a spy movie.
Nothing personal of course 😉🫶🏻
June 16, 2025 at 6:11 PM
Nothing personal of course 😉🫶🏻
I went to the Justice concert last night. Whether or not you're into their music, the show is worth it for the light experience alone. At several moments, I felt like I was seeing colors I'd never seen before - a fantasy I’ve had for a long time: to one day create a color that doesn’t exist.
June 7, 2025 at 1:47 PM
I went to the Justice concert last night. Whether or not you're into their music, the show is worth it for the light experience alone. At several moments, I felt like I was seeing colors I'd never seen before - a fantasy I’ve had for a long time: to one day create a color that doesn’t exist.
Sitting in Brenda Milner’s chair.
Standing on her shoulders.
Standing on her shoulders.
April 29, 2025 at 1:14 PM
Sitting in Brenda Milner’s chair.
Standing on her shoulders.
Standing on her shoulders.
Amazing lecture by Dr. Susan Dymecki on the serotonergic system @theneuro.bsky.social
Serotonergic neurons corelease glutamate in a region specific manner, and this co-release is plastic, depending on the duration of daylight (perhaps explaining seasonal change in mood)
🤯🤯🤯
Paper coming soon
Serotonergic neurons corelease glutamate in a region specific manner, and this co-release is plastic, depending on the duration of daylight (perhaps explaining seasonal change in mood)
🤯🤯🤯
Paper coming soon
April 8, 2025 at 9:01 PM
Amazing lecture by Dr. Susan Dymecki on the serotonergic system @theneuro.bsky.social
Serotonergic neurons corelease glutamate in a region specific manner, and this co-release is plastic, depending on the duration of daylight (perhaps explaining seasonal change in mood)
🤯🤯🤯
Paper coming soon
Serotonergic neurons corelease glutamate in a region specific manner, and this co-release is plastic, depending on the duration of daylight (perhaps explaining seasonal change in mood)
🤯🤯🤯
Paper coming soon
🚨 Registration is open for the Summer School in Sleep and AI. Don’t miss out!
May 28-29 2025, Universite de Montreal
Speakers include Emmanuel During, @introspection.bsky.social, @glajoie.bsky.social, & many others.
(note: talks will be either in French or English)
reseausommeil.ca/en/events/ec...
May 28-29 2025, Universite de Montreal
Speakers include Emmanuel During, @introspection.bsky.social, @glajoie.bsky.social, & many others.
(note: talks will be either in French or English)
reseausommeil.ca/en/events/ec...
April 8, 2025 at 2:24 PM
🚨 Registration is open for the Summer School in Sleep and AI. Don’t miss out!
May 28-29 2025, Universite de Montreal
Speakers include Emmanuel During, @introspection.bsky.social, @glajoie.bsky.social, & many others.
(note: talks will be either in French or English)
reseausommeil.ca/en/events/ec...
May 28-29 2025, Universite de Montreal
Speakers include Emmanuel During, @introspection.bsky.social, @glajoie.bsky.social, & many others.
(note: talks will be either in French or English)
reseausommeil.ca/en/events/ec...
Congrats Dr Gilberto R Vite! 🎉🍾
Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex.
Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏
Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex.
Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏
April 7, 2025 at 3:59 PM
Congrats Dr Gilberto R Vite! 🎉🍾
Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex.
Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏
Gilberto successfully defended his PhD, on the role of the thalamus in coordinating activity in the entorhinal cortex.
Big thanks to his committee, Laura Colgin, @markbrandonlab.bsky.social, Stuart Trenholm, and @sylvainbaillet.bsky.social 🙏🙏
Emmanuel Mignot delivers another fantastic lecture, today at the Canadian Sleep Society meeting.
His contribution to narcolepsy and sleep medicine in general is immense.
I hope the Nobel committee is seriously considering his name.
His contribution to narcolepsy and sleep medicine in general is immense.
I hope the Nobel committee is seriously considering his name.
March 14, 2025 at 9:55 PM
Emmanuel Mignot delivers another fantastic lecture, today at the Canadian Sleep Society meeting.
His contribution to narcolepsy and sleep medicine in general is immense.
I hope the Nobel committee is seriously considering his name.
His contribution to narcolepsy and sleep medicine in general is immense.
I hope the Nobel committee is seriously considering his name.
If you are new to data analysis or are looking for solutions to harmonize & share data analysis pipelines:
pip 🍍
Import 🍍 as 😴
@pynapple.bsky.social
www.pynapple.org
(👇 seen in the streets of Edmonton)
pip 🍍
Import 🍍 as 😴
@pynapple.bsky.social
www.pynapple.org
(👇 seen in the streets of Edmonton)
March 12, 2025 at 2:07 PM
If you are new to data analysis or are looking for solutions to harmonize & share data analysis pipelines:
pip 🍍
Import 🍍 as 😴
@pynapple.bsky.social
www.pynapple.org
(👇 seen in the streets of Edmonton)
pip 🍍
Import 🍍 as 😴
@pynapple.bsky.social
www.pynapple.org
(👇 seen in the streets of Edmonton)
Just finished Invisible Women by @ccriadoperez.bsky.social, a powerful investigation into the gender & sex data gaps that impact every level of society.
You think you're aware of the problem (at least I thought), but it's so much worse than you ever imagined.
More significant than ever.
You think you're aware of the problem (at least I thought), but it's so much worse than you ever imagined.
More significant than ever.
March 2, 2025 at 4:17 PM
Just finished Invisible Women by @ccriadoperez.bsky.social, a powerful investigation into the gender & sex data gaps that impact every level of society.
You think you're aware of the problem (at least I thought), but it's so much worse than you ever imagined.
More significant than ever.
You think you're aware of the problem (at least I thought), but it's so much worse than you ever imagined.
More significant than ever.