TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
Reposted by TJ McCorvie
I’ve just been informed that not permitting scientific misinformation on my feed, including claims that SARS-CoV-2 is airborne HIV, is “tone policing”.
It’s actually fact-checking. I don’t give a shit who is posting misinformation or why. Zero tolerance.
It’s actually fact-checking. I don’t give a shit who is posting misinformation or why. Zero tolerance.
November 26, 2025 at 1:03 AM
I’ve just been informed that not permitting scientific misinformation on my feed, including claims that SARS-CoV-2 is airborne HIV, is “tone policing”.
It’s actually fact-checking. I don’t give a shit who is posting misinformation or why. Zero tolerance.
It’s actually fact-checking. I don’t give a shit who is posting misinformation or why. Zero tolerance.
Reposted by TJ McCorvie
Breaking Barriers: Transitioning from X-ray Crystallography to Cryo-EM for Structural Studies of ATAD2B pubmed.ncbi.nlm.nih.gov/41279824/ #cryoem
November 25, 2025 at 5:33 PM
Breaking Barriers: Transitioning from X-ray Crystallography to Cryo-EM for Structural Studies of ATAD2B pubmed.ncbi.nlm.nih.gov/41279824/ #cryoem
Reposted by TJ McCorvie
Another thing that is making this an "interesting" time to be the head of Integrity in Publishing at a scientific publisher 🥲
We really need major oversight at institutions, before things are sent for publication. Data provenance is key.
We really need major oversight at institutions, before things are sent for publication. Data provenance is key.
I tried an even harder example on Gemini Pro image generation and this is quite scary/amazing. I asked for a microscopy image of around 20 HeLa cells, GFP tagged 20% nuclear, 10% membrane, +1 nuclear staining, + overlap. Image below and prompt in the following post.
November 22, 2025 at 7:52 PM
Another thing that is making this an "interesting" time to be the head of Integrity in Publishing at a scientific publisher 🥲
We really need major oversight at institutions, before things are sent for publication. Data provenance is key.
We really need major oversight at institutions, before things are sent for publication. Data provenance is key.
Reposted by TJ McCorvie
"We’ve arranged a society on science and technology in which nobody understands anything about science and technology, and this combustible mixture of ignorance and power sooner or later is going to blow up in our faces."
- Carl Sagan.
- Carl Sagan.
November 21, 2025 at 3:04 PM
"We’ve arranged a society on science and technology in which nobody understands anything about science and technology, and this combustible mixture of ignorance and power sooner or later is going to blow up in our faces."
- Carl Sagan.
- Carl Sagan.
Reposted by TJ McCorvie
🚀 Hiring: Cryo-EM Application Scientist, Marketing!
Develop and deliver high-impact scientific marketing content, illustrate the value of new #CryoSPARC features and #cryoEM advances, and help scientists understand how our tools can help solve their problems.
structura.bio/careers/appl...
Develop and deliver high-impact scientific marketing content, illustrate the value of new #CryoSPARC features and #cryoEM advances, and help scientists understand how our tools can help solve their problems.
structura.bio/careers/appl...
Structura Bio | Structura Bio
structura.bio
November 20, 2025 at 9:00 PM
🚀 Hiring: Cryo-EM Application Scientist, Marketing!
Develop and deliver high-impact scientific marketing content, illustrate the value of new #CryoSPARC features and #cryoEM advances, and help scientists understand how our tools can help solve their problems.
structura.bio/careers/appl...
Develop and deliver high-impact scientific marketing content, illustrate the value of new #CryoSPARC features and #cryoEM advances, and help scientists understand how our tools can help solve their problems.
structura.bio/careers/appl...
New electron market has just opened up for electron microscope manufacturers. 😂 🟩🔬
I laughed at loud. These people are so pathetic; our enemies are numbskulls. They will kill us all and still not know hs physics.
COWEN: The stupidest question possible: Why don’t we just make more GPUs?
ALTMAN: Because we need to make more electrons.
conversationswithtyler.com/episodes/sam...
COWEN: The stupidest question possible: Why don’t we just make more GPUs?
ALTMAN: Because we need to make more electrons.
conversationswithtyler.com/episodes/sam...
November 19, 2025 at 1:42 PM
New electron market has just opened up for electron microscope manufacturers. 😂 🟩🔬
Reposted by TJ McCorvie
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 18, 2025 at 10:43 PM
Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by TJ McCorvie
The UK must not lose its focus on science and innovation - sadly the UK govt is currently obsessed with placating racists.
https://www.nature.com/articles/d41586-025-03757-3
https://www.nature.com/articles/d41586-025-03757-3
The UK must not lose its focus on science and innovation
An ambitious plan to create a trillion-dollar technology company comes with risks.
www.nature.com
November 19, 2025 at 7:31 AM
The UK must not lose its focus on science and innovation - sadly the UK govt is currently obsessed with placating racists.
https://www.nature.com/articles/d41586-025-03757-3
https://www.nature.com/articles/d41586-025-03757-3
Reposted by TJ McCorvie
#1 lesson I give to protein designers for wet lab purposes : Please design with a Trp and/or multiple Tyr. Please do not design with 10 cysteines.
November 18, 2025 at 1:48 PM
#1 lesson I give to protein designers for wet lab purposes : Please design with a Trp and/or multiple Tyr. Please do not design with 10 cysteines.
Reposted by TJ McCorvie
"Despite widespread claims linking gut health to autism spectrum disorder, a comprehensive analysis published in the journal Neuron has found no scientific evidence supporting the hypothesis that the gut microbiome causally contributes to autism."
No, Your Gut Microbiome Doesn't Contribute to Autism—New Study Dismantles Decades of Misleading Claims
A comprehensive analysis has found no scientific evidence supporting the hypothesis that the gut microbiome causally contributes to autism.
thedebrief.org
November 17, 2025 at 9:28 PM
"Despite widespread claims linking gut health to autism spectrum disorder, a comprehensive analysis published in the journal Neuron has found no scientific evidence supporting the hypothesis that the gut microbiome causally contributes to autism."
Reposted by TJ McCorvie
The Fribourg Declaration
forbetterscience.com/2025/11/17/t...
forbetterscience.com/2025/11/17/t...
The Fribourg Declaration
“The papermill crisis is not an external attack on science but a mirror held up to its dysfunctional ecosystem. The for-profit publishing industry, posing as a newly found saviour of research…
forbetterscience.com
November 17, 2025 at 6:13 AM
The Fribourg Declaration
forbetterscience.com/2025/11/17/t...
forbetterscience.com/2025/11/17/t...
Reposted by TJ McCorvie
A paper critiquing post-publication peer review has numerous made-up references, including a @nature.com article falsely attributed to our Ivan Oransky.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
PubPeer - An expert criticism on post-publication peer review platform...
There are comments on PubPeer for publication: An expert criticism on post-publication peer review platforms: the case of pubpeer (2025)
pubpeer.com
November 16, 2025 at 9:11 AM
A paper critiquing post-publication peer review has numerous made-up references, including a @nature.com article falsely attributed to our Ivan Oransky.
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by TJ McCorvie
The weird reality of 'rare' diseases is that almost everyone knows someone who is affected by one.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 Americans have a rare disease, but few have treatments
The scientific community has identified more than 10,000 rare diseases, but the path to accurately diagnosing and treating these illnesses has been
www.statnews.com
November 13, 2025 at 5:18 PM
The weird reality of 'rare' diseases is that almost everyone knows someone who is affected by one.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
1 in 10 people in the US, and *at least* 1 in 20 globally, will have a rare disease during their lifetime.
Reposted by TJ McCorvie
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 9:57 AM
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
Reposted by TJ McCorvie
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
November 13, 2025 at 1:44 PM
Very cool structures, congrats to all! #microsky
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Link seemed broken though so here's a working one:
www.pnas.org/doi/10.1073/...
Reposted by TJ McCorvie
I find the premise that science should serve capital really troublesome to begin with
The UK government says it wants to make Britain one of the top three places in the world to create, invest in and scale-up a fast-growing technology business
go.nature.com/4ifRp9n
go.nature.com/4ifRp9n
Can UK science really spawn a $1-trillion company?
The British government wants the country to be home to a supersized tech firm within the next decade.
go.nature.com
November 12, 2025 at 4:57 PM
I find the premise that science should serve capital really troublesome to begin with
Reposted by TJ McCorvie
The entire interview is great, obviously. But, this is perhaps the best part.
November 10, 2025 at 7:35 PM
The entire interview is great, obviously. But, this is perhaps the best part.
Reposted by TJ McCorvie
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Structural insights into cobalamin loading and reactivation of human methionine synthase
Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...
www.biorxiv.org
November 11, 2025 at 12:48 PM
I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
Reposted by TJ McCorvie
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
November 11, 2025 at 8:35 AM
The number of low-quality or fraudulent publications is rising to hundreds of thousands per year. It is time to reevaluate current publishing models and outline a global plan. Read the 'Reformation of science publishing: the Stockholm Declaration': royalsocietypublishing.org/doi/10.1098/... #RSOS 🧪
Reposted by TJ McCorvie
Join us in a highly collaborative environment. At the IMP everything is possible.
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 11, 2025 at 9:56 AM
Join us in a highly collaborative environment. At the IMP everything is possible.
Reposted by TJ McCorvie
Using Leishmania as a model, we determined the cryo-EM structure of the doublet microtubule to pinpoint the position of each dynein. This gave us a detailed map of where every “rower” sits on the ciliary “boat.”
November 10, 2025 at 5:45 PM
Using Leishmania as a model, we determined the cryo-EM structure of the doublet microtubule to pinpoint the position of each dynein. This gave us a detailed map of where every “rower” sits on the ciliary “boat.”
Reposted by TJ McCorvie
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
November 10, 2025 at 9:30 PM
Join us at the Vienna BioCenter and @impvienna.bsky.social! Full disclaimer: I’m obviously biased but: mind-blowing facilities (!!!) and a great collaborative research culture make this an ideal place for anyone; especially suited to build up a lab. Plus Vienna is an amazing city to live in 😊
Reposted by TJ McCorvie
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
November 10, 2025 at 6:15 PM
📢 Postdoc position: Biochemistry & Bacterial cell biology
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
in our group at Marburg University, Germany, funded by the ERC Advanced Grant "C-SWITCH"
🔗More information at shorturl.at/OlvlL
📅Deadline: Nov 30, 2025
Please repost. #Postdoc
Reposted by TJ McCorvie
Every day I understand the Butlerian Jihad more and more
November 10, 2025 at 4:26 PM
Every day I understand the Butlerian Jihad more and more