TJ McCorvie
@allostericstate.bsky.social
Revealing the hidden world of shape shifting enzymes using Cryo-EM. Senior research associate at Newcastle University, UK. Currently working as part of Recon4IMD https://www.recon4imd.org Views are my own.
Congrats! Those FAM118 filaments look like they were tricky to process.
November 18, 2025 at 1:25 PM
Congrats! Those FAM118 filaments look like they were tricky to process.
Thank you Paula!
November 11, 2025 at 2:14 PM
Thank you Paula!
And of course the biggest amount of thanks to Douglas who did the majority of this work. Moving lab, COVID, and shifting focus from a CRISPR based project was not easy but Douglas overcame these challenges to successfully do something we have wanted to do for a long time.
November 11, 2025 at 1:29 PM
And of course the biggest amount of thanks to Douglas who did the majority of this work. Moving lab, COVID, and shifting focus from a CRISPR based project was not easy but Douglas overcame these challenges to successfully do something we have wanted to do for a long time.
Big thanks to the University of York, with their Glacios which we used for screening and another big thanks to eBIC which was used to do the larger data collections that produced our reported structures. Without these facilities our cryo-EM studies would have been far more difficult.
November 11, 2025 at 1:25 PM
Big thanks to the University of York, with their Glacios which we used for screening and another big thanks to eBIC which was used to do the larger data collections that produced our reported structures. Without these facilities our cryo-EM studies would have been far more difficult.