Alex Gould Lab
@alexgouldlab.bsky.social
Located @Crick.ac.uk in London, we investigate how diet and other factors in the environment affect our metabolism and health
https://www.crick.ac.uk/research/labs/alex-gould
https://www.crick.ac.uk/research/labs/alex-gould
Reposted by Alex Gould Lab
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
Reposted by Alex Gould Lab
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
www.nature.com
October 29, 2025 at 5:21 PM
Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Alex Gould Lab
new out in Nature www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
October 21, 2025 at 7:22 AM
new out in Nature www.nature.com/articles/d41...
Calling early career PIs. A great opportunity to start your lab at @crick.ac.uk in the heart of London.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:41 PM
Calling early career PIs. A great opportunity to start your lab at @crick.ac.uk in the heart of London.
Abstract deadline (Dec 15th) approaching for the 2026 Neurogenesis meeting in Ascona. The last one was outstanding, so we’re all really looking forward to this second edition. Reassuringly in this day and age it’s held on the “Mount of Truth”.
Interested in the mechanisms of neurogenesis, and how they might converge/differ across species, regions, and life epochs? Check this out, wonderful location and great science! Please RT
neuro-unige.ch/news/csf-mee...
neuro-unige.ch/news/csf-mee...
October 9, 2025 at 10:05 AM
Abstract deadline (Dec 15th) approaching for the 2026 Neurogenesis meeting in Ascona. The last one was outstanding, so we’re all really looking forward to this second edition. Reassuringly in this day and age it’s held on the “Mount of Truth”.
Passionate about doing a PhD on metabolism in neural stem cells and their niche? The call just opened for applications for a PhD position in our lab @crick.ac.uk in London. Please repost.
tinyurl.com/ysnkdrmw
tinyurl.com/ysnkdrmw
October 3, 2025 at 11:58 AM
Passionate about doing a PhD on metabolism in neural stem cells and their niche? The call just opened for applications for a PhD position in our lab @crick.ac.uk in London. Please repost.
tinyurl.com/ysnkdrmw
tinyurl.com/ysnkdrmw
Reposted by Alex Gould Lab
Excited to share our collaborative PhD project with Adam Dobson ([email protected]) on interorgan signalling in the ageing gut. Please contact Adam If you are a highly motivated student wanted to work on a super exciting Fly project.
October 1, 2025 at 9:56 AM
Excited to share our collaborative PhD project with Adam Dobson ([email protected]) on interorgan signalling in the ageing gut. Please contact Adam If you are a highly motivated student wanted to work on a super exciting Fly project.
Reposted by Alex Gould Lab
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
October 2, 2025 at 9:04 AM
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
Reposted by Alex Gould Lab
One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful!
niakanlab.com/resources/
niakanlab.com/resources/
September 30, 2025 at 5:57 PM
One of our favourite tabs is Resources: we're listing all of our datasets, codes, beginning to upload and make accessible raw imaging data and lab protocols. Please check it out, we hope this is useful!
niakanlab.com/resources/
niakanlab.com/resources/
Reposted by Alex Gould Lab
Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027
September 28, 2025 at 4:00 PM
Thank you to all #EDRC2025 participants and a big applause to the organizing committee for this great #Drosophila meeting! See you all in Bonn for #EDRC2027
🪰 Calling all Drosophilists interested in nutrition…HolFast, Sebastian Sorge’s new chemically defined diet works really well. We’ve given some free HolFast aliquots to @vdrc-flies.bsky.social Please contact them directly if you fancy trying it out. Hurry while stocks last!
The HolFast holidic (chemically defined) diet for Drosophila, recently designed by @alexgouldlab.bsky.social, has wide applications in nutritional and metabolic studies of Drosophila development doi.org/10.1016/j.de.... Limited free samples distributed by the VDRC. See www.vdrc.at. #Drosophila
September 30, 2025 at 2:17 PM
🪰 Calling all Drosophilists interested in nutrition…HolFast, Sebastian Sorge’s new chemically defined diet works really well. We’ve given some free HolFast aliquots to @vdrc-flies.bsky.social Please contact them directly if you fancy trying it out. Hurry while stocks last!
Reposted by Alex Gould Lab
Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
September 26, 2025 at 3:43 PM
Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social
Reposted by Alex Gould Lab
#Drosophila community - look at this amazing lineup for #InDRC2025
Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract.
#genetics #devbio
@flybase.bsky.social
Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract.
#genetics #devbio
@flybase.bsky.social
September 19, 2025 at 4:15 AM
#Drosophila community - look at this amazing lineup for #InDRC2025
Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract.
#genetics #devbio
@flybase.bsky.social
Registration for #InDRC2025 is now open! Visit indrc2025.in to register and submit your abstract.
#genetics #devbio
@flybase.bsky.social
Reposted by Alex Gould Lab
The FlyBase situation has made the national news www.nbcnews.com/science/scie...
Trump's Harvard cuts threaten a giant in biomedical research: A database about the tiny fruit fly
This spring, the Trump administration rescinded a grant that maintained FlyBase, a pillar of global basic research, as part of its broader $2.2 billion funding cuts at Harvard.
www.nbcnews.com
September 16, 2025 at 1:08 PM
The FlyBase situation has made the national news www.nbcnews.com/science/scie...
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
August 14, 2025 at 8:04 PM
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
Reposted by Alex Gould Lab
Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...
Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism
Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain
cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts
weight loss. Without GIPR in thes...
www.cell.com
August 14, 2025 at 3:07 PM
Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...
Reposted by Alex Gould Lab
12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!
March 26, 2025 at 2:04 PM
12 examples of how developmental biology research led to fundamental discoveries for biomedical research. There are many more! Download ppt & jpg versions on @socdevbio.bsky.social website. Use & modify as needed. Poster formats are also posted to print & hang in your lab!
Reposted by Alex Gould Lab
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Open positions
GR-SCHUHMACHER
www.epfl.ch
August 12, 2025 at 9:32 AM
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Reposted by Alex Gould Lab
🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
Somatic cells compartmentalise their metabolism to sustain germ cell survival
To ensure success in reproduction, organisms dedicate substantial resources to supporting the germline. In testes, somatic gonadal cells form a barrier that isolates germ cells from circulating nutrie...
www.biorxiv.org
July 25, 2025 at 11:20 AM
🆕🧪‼️
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
New lab preprint!
We study how germ cells (the cells that give rise to gametes, in this case sperm) are supported by somatic (non-germ) cells of the gonad. This matters for our understanding of reproduction - without germ cell development, animals are sterile.
www.biorxiv.org/content/10.1...
Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.
thenode.biologists.com/event-carbon...
thenode.biologists.com/event-carbon...
Event carbon calculator - the Node
I am excited to announce the release of our event carbon calculator, our latest resource to support the creation of sustainable events. Estimate your
thenode.biologists.com
July 1, 2025 at 10:01 AM
Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios.
thenode.biologists.com/event-carbon...
thenode.biologists.com/event-carbon...
In defense of silly science | Science www.science.org/doi/10.1126/...
In defense of silly science
A biologist pushes back against attacks on curiosity-driven research
www.science.org
June 7, 2025 at 7:18 AM
In defense of silly science | Science www.science.org/doi/10.1126/...
Reposted by Alex Gould Lab
#Drosophila @flybase.bsky.social requires emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!
We currently have a call for support that has gone out to European labs, to support FlyBase-UK. We are asking our colleagues from labs in the US and other countries to wait for a similar call to them that will go out in the near future, to support the US sites. We thank you for your patience.
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
June 4, 2025 at 7:25 AM
#Drosophila @flybase.bsky.social requires emergency funding:
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!
"As it stands, by the end of July, 2025, there will be no future updates to #FlyBase, and in the worst case scenario access to the website will also be lost". Please help if you can!