Tumor-selective ENPP1 inhibitor is highly sought after for cancer immunotherapy to activate anti-cancer innate immunity without systemic inflammation. Wang et al. achieved this with STF-1623, which has ultralong tumor residence time but fast systemic clearance. When combined with ionizing radiation or immune checkpoint blockade, STF-1623 shows unprecedented efficacy without apparent side effects.

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

The immune landscape of human and murine thrombosis remains unclear. Pekayvaz et al. map the immune landscape of thrombosis and describe prominent thrombolytic functions of immune cells, a pattern that they term immunothrombolysis: neutrophils recruited toward thrombi, attracted by non-classical monocytes, acquire a HIF1α-mediated thrombus-resolving profile.

Stunnenberg et al. use a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppr...

Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut microbial and immune environment, disrupting tissue homeostasis. IL-22 production by group 3 innate lymphoid cells (I...

Staphylococcus aureus skin infection induces eosinophil innate immune memory to exacerbate allergen-induced airway inflammation.

Bold claims of ‘biosignature’ molecules trigger an outpouring of scepticism.

We previously demonstrated that long-term trained immunity (TRIM) involves adaptations that imprint innate immune memory in long-lived myelopoiesis pr…

The response to vaccination and immune stimuli varies widely between individuals. To dissect population variation in immune function, Moorlag, Folkman, ter Horst, Krausgruber, et al. perform multi-omi...

Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may ena...

Rudalska et al. describe a novel class of p38α inhibitors with increased target residence time. They explore the drugs’ specificity, pharmacokinetics and toxicity profile and show that they are effica...