Adam Marblestone
@adammarblestone.bsky.social
Technologist, scientist. Co-founder of Convergent Research.
Reposted by Adam Marblestone
Reposted by Adam Marblestone
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
November 12, 2025 at 8:03 PM
Cool work from our neighbors at @cultivarium.bsky.social using components from the POSSUM Toolkit! What will they (or you!) find next?
Check out the toolkit here: www.addgene.org/kits/cultiva...
Check out the toolkit here: www.addgene.org/kits/cultiva...
Reposted by Adam Marblestone
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
November 12, 2025 at 7:05 PM
Very happy to share our recent work @cultivarium.bsky.social on genetic tools for Ideonella sakaiensis, a (Betaproteo-)bacterium that degrades PET plastic.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
We identified a plasmid vector for the strain and generated a large RB-TnSeq library, screening for genes impacting plastic degradation.
Reposted by Adam Marblestone
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
The songbird basal ganglia connectome
The basal ganglia (BG) play an essential role in shaping vertebrate behavior, ranging from motor learning to emotions, but comprehensive maps of their canonical synaptic architecture are missing. In m...
www.biorxiv.org
October 30, 2025 at 6:07 PM
I am happy to share that the main story of my PhD is now available as a preprint! www.biorxiv.org/content/10.1...
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
We analyses over 8500 neurons in a songbird basal ganglia dataset.
To explore this and two other stories more interactively, also check out our website!
www.songbird-connectomics.org
Reposted by Adam Marblestone
Our new preprint outlining how to make 1000-plex mass tags!
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:41 PM
Our new preprint outlining how to make 1000-plex mass tags!
Reposted by Adam Marblestone
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:08 PM
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
Reposted by Adam Marblestone
We’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below:
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Microbe-Mineral Atlas Engineering
The Barstow lab at Cornell University is looking for a new postdoc for 2026 and beyond to help us with the next phase of our Microbe-Mineral Atlas project. We plan on going from basic scientific disco...
docs.google.com
October 19, 2025 at 7:52 PM
We’re starting to look for postdocs for 2026 and beyond. Nothing official yet, but if you want to use your synbio skills and the growing Microbe-Mineral Atlas to build cutting-edge biomining technologies read more below:
docs.google.com/document/d/1...
docs.google.com/document/d/1...
Reposted by Adam Marblestone
Thanks for contributing your expertise!!
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
prism.cultivarium.org
October 18, 2025 at 11:55 AM
Thanks for contributing your expertise!!
Reposted by Adam Marblestone
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
prism.cultivarium.org
October 17, 2025 at 6:59 PM
I got to editing a few clips to show how I make plant tissue culture leaf disks from leaves obtained in open air. Uploaded for your consideration to the PRISM collection. Enjoyyyyy.
prism.cultivarium.org/protocols/20...
prism.cultivarium.org/protocols/20...
Reposted by Adam Marblestone
October 16, 2025 at 2:54 PM
Reposted by Adam Marblestone
8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨
Semble | A social knowledge network for researchers
Follow your peers' research trails. Surface and discover new connections. Built on ATProto so you own your data.
semble.so
October 15, 2025 at 10:13 PM
8/ With semble.so and @cosmik.network we are aiming squarely at the CI space, but it is ultimately an ecosystem effort, so we’re excited to be building with the vibrant ATProto community ✨
Reposted by Adam Marblestone
Excited to try this! The waiting list makes me even more curious
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 3:56 PM
Excited to try this! The waiting list makes me even more curious
Reposted by Adam Marblestone
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
October 15, 2025 at 4:17 PM
Excited to share our new #biorxivpreprint:
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
“Sexual dimorphism in the complete connectome of the Drosophila male central nervous system” www.biorxiv.org/content/10.1...
We describe the #connectomics reconstruction and analysis of an entire adult #maleCNS #drosophila central nervous system. 1/10
Reposted by Adam Marblestone
💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others.
Try it out! live.lean-lang.org
Try it out! live.lean-lang.org
October 10, 2025 at 4:17 PM
💡Did you know you can run #LeanLang in your browser without installing anything? The Lean Playground provides a full environment for experimentation, learning, and for sharing code snippets with others.
Try it out! live.lean-lang.org
Try it out! live.lean-lang.org
Reposted by Adam Marblestone
Wait uh, what?? 🤩
Ballistic Microscopy (BaM) www.biorxiv.org/content/10.1101/2025.10.07.681030v1 #cryoem
October 10, 2025 at 12:56 AM
Wait uh, what?? 🤩
Reposted by Adam Marblestone
The development of new, transformative material processes has stagnated.
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
Manufacturing Abundance
Ages of human history are defined by materials that transformed societies and mark breakthroughs in mastery over matter. Rather than a single material, the next age will be defined by our ability to a...
link.aria.org.uk
October 10, 2025 at 11:33 AM
The development of new, transformative material processes has stagnated.
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
In our new thesis, PD Ivan Jayapurna proposes a ‘Universal Fabricator’ to rapidly discover and develop new processes for the scalable production of advanced materials. ↓
link.aria.org.uk/UF-thesis-BS
Reposted by Adam Marblestone
An Introduction to Mars Terraforming, 2025 Workshop Summary
arxiv.org/abs/2510.07344
arxiv.org/abs/2510.07344
An Introduction to Mars Terraforming, 2025 Workshop Summary
Terraforming Mars is an age old science fiction concept now worth revisiting through the lens of modern science and technology. This document serves as a summary of contemporary ideas about Mars terra...
arxiv.org
October 10, 2025 at 2:13 AM
An Introduction to Mars Terraforming, 2025 Workshop Summary
arxiv.org/abs/2510.07344
arxiv.org/abs/2510.07344
I have never seen a better conference name
ItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/
ItaLean 2025
pitmonticone.github.io
October 9, 2025 at 3:23 PM
I have never seen a better conference name
Reposted by Adam Marblestone
ItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/
ItaLean 2025
pitmonticone.github.io
October 9, 2025 at 12:31 PM
ItaLean : formal maths and AI in Italy (Bologna), Dec 2025. Lectures, hands-on tutorials, research talks from academia and industry etc. Register here pitmonticone.github.io/ItaLean2025/
Reposted by Adam Marblestone
Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood.
If you are curious to learn more, this short talk provides a good overview of why, what and how.
www.youtube.com/watch?v=gjIK...
If you are curious to learn more, this short talk provides a good overview of why, what and how.
www.youtube.com/watch?v=gjIK...
Nicole Rust - The representation of mood in the primate insula (May 6, 2025)
YouTube video by Simons Foundation
www.youtube.com
October 7, 2025 at 9:06 PM
Please spread the word! I am recruiting a PhD student this cycle (Fall 2026 start) to join my team in a new venture: the neuroscience of mood.
If you are curious to learn more, this short talk provides a good overview of why, what and how.
www.youtube.com/watch?v=gjIK...
If you are curious to learn more, this short talk provides a good overview of why, what and how.
www.youtube.com/watch?v=gjIK...
Reposted by Adam Marblestone
I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:
October 8, 2025 at 11:54 AM
I don’t think I’ve ever had more fun in the lab than when I was making MOFs myself (and trying to use them for small-molecule X-ray structure determination). So let me celebrate by posting a few of the MOF crystals I prepared:
Reposted by Adam Marblestone
Say what? 👍
We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...
www.biorxiv.org
October 8, 2025 at 3:19 AM
Say what? 👍
Reposted by Adam Marblestone
Soooooo when is bluesky deploying bridging systems
arxiv.org/abs/2301.09976
arxiv.org/abs/2301.09976
Bridging Systems: Open Problems for Countering Destructive Divisiveness across Ranking, Recommenders, and Governance
Divisiveness appears to be increasing in much of the world, leading to concern about political violence and a decreasing capacity to collaboratively address large-scale societal challenges. In this wo...
arxiv.org
October 8, 2025 at 4:15 AM
Soooooo when is bluesky deploying bridging systems
arxiv.org/abs/2301.09976
arxiv.org/abs/2301.09976
Reposted by Adam Marblestone
I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
Hidden networks in the brain
Dendritic nanotubes extend brain connectivity beyond synapses
www.science.org
October 4, 2025 at 7:14 AM
I love these new layers of complexity that people are discovering in the brain! Dendrites of different neurons can connect via nanotubes, which transport calcium and cargo such as amyloid-beta www.science.org/doi/10.1126/...
Reposted by Adam Marblestone
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
October 6, 2025 at 1:36 PM
Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...