Niladri Sinha
@2primehydroxyl.bsky.social
Assistant Professor @ University of Utah | interested in ribosomes and translational control in health and disease
https://sinha.biochem.utah.edu
https://sinha.biochem.utah.edu
Pinned
Niladri Sinha
@2primehydroxyl.bsky.social
· Aug 21
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
Reposted by Niladri Sinha
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins
Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...
www.biorxiv.org
October 14, 2025 at 10:28 PM
Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇
We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky
Post Doc Res Assoc
Postdoc with a primary duty consisting research-related work. Required to meet FLSA threshold to be paid on a salaried basis, otherwise employment record will convert to hourly.
utah.peopleadmin.com
August 29, 2025 at 3:51 PM
We have an opening for a Postdoctoral Fellow to join us in exploring fundamental questions at the interface of protein synthesis defects and stress-responsive signaling pathways. utah.peopleadmin.com/postings/187... #RNAsky
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
The Sinha Lab
The Sinha lab studies key aspects of protein synthesis and translational control in healthy and diseased states. We study the multifaceted roles of ribosomes as critical sensors of cellular stress.
sinha.biochem.utah.edu
August 21, 2025 at 7:09 PM
I am delighted to share that I have started my lab in the Dept. of Biochemistry @uofubiochem.bsky.social at the University of Utah @utah.edu. My laboratory will study key aspects of protein synthesis and translational control in healthy and diseased states. #RNAsky sinha.biochem.utah.edu
Reposted by Niladri Sinha
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
www.quantamagazine.org/rna-is-the-c...
July 18, 2025 at 8:04 PM
“What a [sunburned] cell is trying to do is make decisions about whether to live or die based on how damaged the DNA is… but amazingly, it’s the RNA that signals that. That’s the remarkable observation.” — Rachel Green, biologist at Johns Hopkins University.
www.quantamagazine.org/rna-is-the-c...
www.quantamagazine.org/rna-is-the-c...
Reposted by Niladri Sinha
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
May 26, 2025 at 9:29 AM
We are happy to share that our snR30 story is finally out in @natureportfolio.nature.com 🥳 We report the first structure of a H/ACA snoRNP acting in ribosome synthesis thereby providing a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
Reposted by Niladri Sinha
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Cellular responses to RNA damage
RNA plays a central role in protein biosynthesis and performs diverse regulatory and
catalytic functions, making it essential for all processes of life. Like DNA, RNA
is constantly subjected to damage...
www.cell.com
February 20, 2025 at 6:37 PM
Happy to share our review on the cellular responses to RNA damage 🥂
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social
www.cell.com/cell/fulltex...
Reposted by Niladri Sinha
Latest work from our next door neighbors! #RNAsky #RNAbiology
Online Now: The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
The integrated stress response regulates 18S nonfunctional rRNA decay in mammals
To maintain translational fidelity, cells degrade decoding-incompetent ribosomes through the 18S nonfunctional rRNA decay (NRD) pathway. Coria et al. demonstrate that the concerted actions of GCN2, RNF10, and RIOK3 lead to a block in translation…
dlvr.it
February 12, 2025 at 10:49 PM
Latest work from our next door neighbors! #RNAsky #RNAbiology
Reposted by Niladri Sinha
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
December 13, 2024 at 7:43 PM
The life of each of us began when a sperm and an egg came together. But what happens at a molecular level?
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Our latest work in Cell led by @vdeneke.bsky.social & Andreas Blaha reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/11)
www.cell.com/cell/fulltex...
Reposted by Niladri Sinha
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
December 11, 2024 at 9:35 PM
Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...
Reposted by Niladri Sinha
m6A sites in the coding region trigger translation-dependent mRNA decay: Molecular Cell www.cell.com/molecular-ce...
m6A sites in the coding region trigger translation-dependent mRNA decay
Zhou et al. discovered a specific role of adenosine modifications in the coding region
of mRNAs. These chemical alterations slow down the movement of the ribosome during
translation and trigger degrad...
www.cell.com
November 24, 2024 at 5:53 PM
m6A sites in the coding region trigger translation-dependent mRNA decay: Molecular Cell www.cell.com/molecular-ce...
Reposted by Niladri Sinha
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
November 24, 2024 at 6:16 PM
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
Reposted by Niladri Sinha
This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...
Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes
The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....
www.science.org
November 21, 2024 at 8:03 PM
This is a very cool paper that I will add to my Mol Bio course. Specific tRNA recruitment of mRNA degradation complex to ribosome through the P site tRNA interactions with CCR4-NOT complex 1/ www.science.org/doi/10.1126/...
Reposted by Niladri Sinha
So many things happen on proteasomes! It was fun to dig into how a the active thioreductase TXNL1 engages the regulatory particle!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structure of the TXNL1-bound proteasome
Proteasomes degrade diverse proteins in different cellular contexts through incompletely defined regulatory mechanisms. Here, we report the cryo-EM structure of thioredoxin-like protein 1 (TXNL1) boun...
www.biorxiv.org
November 11, 2024 at 11:37 AM
So many things happen on proteasomes! It was fun to dig into how a the active thioreductase TXNL1 engages the regulatory particle!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...