Upbeat Former Prof
@upbeatprof.bsky.social
And remember: you must never, under any circumstances, despair. To hope and to act, these are our duties in misfortune.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
i always wish the main sites for neddylation involved the sequence FLANDERS
Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult Heart https://www.biorxiv.org/content/10.64898/2025.12.03.692150v1
December 7, 2025 at 10:14 PM
i always wish the main sites for neddylation involved the sequence FLANDERS
Reposted by Upbeat Former Prof
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling https://www.biorxiv.org/content/10.64898/2025.12.06.692499v1
December 7, 2025 at 10:02 PM
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling https://www.biorxiv.org/content/10.64898/2025.12.06.692499v1
Reposted by Upbeat Former Prof
Steve Leininger, the father of the TRS-80, running TRS-80 software on his phone.
December 7, 2025 at 9:16 PM
Steve Leininger, the father of the TRS-80, running TRS-80 software on his phone.
my thought on one of tonight's Bluesky topics.
December 7, 2025 at 2:55 AM
my thought on one of tonight's Bluesky topics.
Reposted by Upbeat Former Prof
Just been reminded of another of my all-time favourites, Ian Curtis rides a rollercoaster...
October 8, 2024 at 4:36 PM
Just been reminded of another of my all-time favourites, Ian Curtis rides a rollercoaster...
awesome. Face/Off is back on Netflix.
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
December 6, 2025 at 9:10 PM
awesome. Face/Off is back on Netflix.
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
Reposted by Upbeat Former Prof
RIP Frank Gehry
December 5, 2025 at 7:32 PM
RIP Frank Gehry
December 5, 2025 at 5:29 PM
man, Alien Covenant is... not good.
December 5, 2025 at 1:00 AM
man, Alien Covenant is... not good.
i have never felt more like the product
NEW: Your "end-to-end encrypted" poop pictures taken by this $599 (+ subscription) smart toilet camera are actually not end-to-end encrypted.
¯\_(ツ)_/¯
techcrunch.com/2025/12/03/e...
¯\_(ツ)_/¯
techcrunch.com/2025/12/03/e...
‘End-to-end encrypted’ smart toilet camera is not actually end-to-end encrypted | TechCrunch
Kohler, the makers of a smart toilet camera, can access customers' data stored on its servers, and can use customers’ bowl pictures to train AI.
techcrunch.com
December 4, 2025 at 3:09 PM
i have never felt more like the product
Kohler can make the funniest captcha of all time
December 4, 2025 at 3:34 AM
Kohler can make the funniest captcha of all time
Steve Cropper - The AMAZING Story Behind "Green Onions"
YouTube video by Musicians Hall of Fame & Museum
youtu.be
December 3, 2025 at 10:39 PM
Reposted by Upbeat Former Prof
One of the all-time greats - guitarist, songwriter, producer, icon. Rest easy, Steve. variety.com/2025/music/n...
Steve Cropper, Legendary Guitarist for Booker T. & the MG’s, Otis Redding and the Blues Brothers, Dies at 84
Steve Cropper, guitarist for Booker T. & the MG's, Otis Redding, the Blues Brothers and many more, has died. He was 84.
variety.com
December 3, 2025 at 10:09 PM
One of the all-time greats - guitarist, songwriter, producer, icon. Rest easy, Steve. variety.com/2025/music/n...
this is the worst book I've ever downloaded. my storage is embarrassed for me
December 3, 2025 at 9:57 PM
this is the worst book I've ever downloaded. my storage is embarrassed for me
Reposted by Upbeat Former Prof
Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!
December 3, 2025 at 7:15 PM
Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!
Reposted by Upbeat Former Prof
Hi #bioinformatics folk, I want to quickly extract metagenome reads that map to medium-sized piles of reference genomes (100s-1000s, but not 10_000s). I don't _necessarily_ care about the exact position. I'm using minimap2 right now but it's kinda choking on 1000 microbial genomes at once. Thoughts?
December 2, 2025 at 7:09 PM
Hi #bioinformatics folk, I want to quickly extract metagenome reads that map to medium-sized piles of reference genomes (100s-1000s, but not 10_000s). I don't _necessarily_ care about the exact position. I'm using minimap2 right now but it's kinda choking on 1000 microbial genomes at once. Thoughts?
Reposted by Upbeat Former Prof
“Have Yourself A Merriam Little Christmas”
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
December 2, 2025 at 7:18 PM
“Have Yourself A Merriam Little Christmas”
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
the older i get, the more the plot of THX-1138 seems like an allegory for the ironies of career progression
December 2, 2025 at 5:01 PM
the older i get, the more the plot of THX-1138 seems like an allegory for the ironies of career progression
Reposted by Upbeat Former Prof
I just think there should be a desktop centrifuge for pens. Yeah! I know it would make a mess! I know how physics works! I don't care, I want it. Get that ink ALL the way to the bottom. That's what I want.
December 1, 2025 at 7:53 PM
I just think there should be a desktop centrifuge for pens. Yeah! I know it would make a mess! I know how physics works! I don't care, I want it. Get that ink ALL the way to the bottom. That's what I want.
this is the exact opposite of the Jailbreak Bake and i love it
I just stopped by to deliver this freshly baked strawberry-rhubarb pie. I’ll be long gone before you discover the review invitation I baked into it.
Idea: a process server specializing in review invitations. Good news: that manila envelope the bicycle courier just handed you does NOT contain divorce papers. Bad news: it does contain a review invitation.
December 1, 2025 at 5:46 PM
this is the exact opposite of the Jailbreak Bake and i love it
Reposted by Upbeat Former Prof
{Mariah Carey voice}:
🎶All I want for Christmas...
...Is yooooooooooooouuuuuuuu...
...r review of this manuscript submission even though I know you are burnt out and ready for break 🎶
🎶All I want for Christmas...
...Is yooooooooooooouuuuuuuu...
...r review of this manuscript submission even though I know you are burnt out and ready for break 🎶
Hey, I just met you...
And this is crazy...
Do me a favor???
Review this paper?
And this is crazy...
Do me a favor???
Review this paper?
I just stopped by to deliver this freshly baked strawberry-rhubarb pie. I’ll be long gone before you discover the review invitation I baked into it.
December 1, 2025 at 4:20 PM
{Mariah Carey voice}:
🎶All I want for Christmas...
...Is yooooooooooooouuuuuuuu...
...r review of this manuscript submission even though I know you are burnt out and ready for break 🎶
🎶All I want for Christmas...
...Is yooooooooooooouuuuuuuu...
...r review of this manuscript submission even though I know you are burnt out and ready for break 🎶
if i gotta be stuck on an island watching one person's filmography forever, i don't care about the movies, to first order i want someone with a long, varied list...
Christopher Lee. Gene Hackman. Jane Lynch.
Christopher Lee. Gene Hackman. Jane Lynch.
This is a Bill Simmons game, but you’re stranded on a desert island. You can only have one actor’s filmography. You get it all, including cameos. But just the one performer.
I’m taking Cate Blanchett: Talented Mr. Ripley, LOTR, Life Aquatic, Black Bag, Tár, Ponyo, Hot Fuzz, Eyes Wide Shut, Thor
I’m taking Cate Blanchett: Talented Mr. Ripley, LOTR, Life Aquatic, Black Bag, Tár, Ponyo, Hot Fuzz, Eyes Wide Shut, Thor
December 1, 2025 at 6:01 AM
if i gotta be stuck on an island watching one person's filmography forever, i don't care about the movies, to first order i want someone with a long, varied list...
Christopher Lee. Gene Hackman. Jane Lynch.
Christopher Lee. Gene Hackman. Jane Lynch.
Reposted by Upbeat Former Prof
named my fists Miessler and Tarr because they're going to give you an improper rotation
named my fists Strunk and White because they help me omit needless words
Named my fists Ben and Jerry cause they're headed right for your mouth and stomach
December 1, 2025 at 3:12 AM
named my fists Miessler and Tarr because they're going to give you an improper rotation
Reposted by Upbeat Former Prof
named my fists rosencrantz and guildenstern because when they’re around I get answers
named my fists Strunk and White because they help me omit needless words
Named my fists Ben and Jerry cause they're headed right for your mouth and stomach
December 1, 2025 at 1:49 AM
named my fists rosencrantz and guildenstern because when they’re around I get answers
named my fists Strunk and White because they help me omit needless words
Named my fists Ben and Jerry cause they're headed right for your mouth and stomach
i named my fists Rodgers and Hammerstein cuz theyre always in my own little corner
December 1, 2025 at 1:27 AM
named my fists Strunk and White because they help me omit needless words