Upbeat Former Prof
@upbeatprof.bsky.social
And remember: you must never, under any circumstances, despair. To hope and to act, these are our duties in misfortune.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
like asking a friend to call you when you're on a date, as an emergency bailout
except instead of a friend it's a colleague, and instead of a date it's a meeting that lasts all day
except instead of a friend it's a colleague, and instead of a date it's a meeting that lasts all day
December 15, 2025 at 10:07 PM
like asking a friend to call you when you're on a date, as an emergency bailout
except instead of a friend it's a colleague, and instead of a date it's a meeting that lasts all day
except instead of a friend it's a colleague, and instead of a date it's a meeting that lasts all day
Reposted by Upbeat Former Prof
Interested to know what answer is expected here. I guess it's nothing like "It is impossible to generalize about the effects of methylation on expression", nor that "It's even harder to know the effects of methylation of enhancers". I cannot even imagine what they're looking for.
December 15, 2025 at 4:47 PM
Interested to know what answer is expected here. I guess it's nothing like "It is impossible to generalize about the effects of methylation on expression", nor that "It's even harder to know the effects of methylation of enhancers". I cannot even imagine what they're looking for.
Reposted by Upbeat Former Prof
Excited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️
I pride myself on open-science & this is probably the most intense release I've done!
I pride myself on open-science & this is probably the most intense release I've done!
December 15, 2025 at 9:26 AM
Excited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️
I pride myself on open-science & this is probably the most intense release I've done!
I pride myself on open-science & this is probably the most intense release I've done!
Reposted by Upbeat Former Prof
When Rob Reiner was on his all-time epic run at the start of his career, he had an opportunity to read a script that was looking for a production partner, and he lost his mind for it. He decided Castle Rock had to have it, no matter what.
December 15, 2025 at 7:37 AM
When Rob Reiner was on his all-time epic run at the start of his career, he had an opportunity to read a script that was looking for a production partner, and he lost his mind for it. He decided Castle Rock had to have it, no matter what.
Reposted by Upbeat Former Prof
Rob Reiner: I'm going to make a coming of age drama, a fantasy adventure story, a romantic comedy, a psychological horror and then a courtroom drama.
Us: Across your entire career?
Reiner: In a 6 year period.
Us: That sounds-
Reiner: -Each one will be arguably the best movie in that genre.
Us: Across your entire career?
Reiner: In a 6 year period.
Us: That sounds-
Reiner: -Each one will be arguably the best movie in that genre.
December 15, 2025 at 8:04 AM
Rob Reiner: I'm going to make a coming of age drama, a fantasy adventure story, a romantic comedy, a psychological horror and then a courtroom drama.
Us: Across your entire career?
Reiner: In a 6 year period.
Us: That sounds-
Reiner: -Each one will be arguably the best movie in that genre.
Us: Across your entire career?
Reiner: In a 6 year period.
Us: That sounds-
Reiner: -Each one will be arguably the best movie in that genre.
JFC Acme you sold me ten pounds of green potatoes
(all posts represent personal views only and not those of employers past or present)
(all posts represent personal views only and not those of employers past or present)
December 14, 2025 at 7:11 PM
JFC Acme you sold me ten pounds of green potatoes
(all posts represent personal views only and not those of employers past or present)
(all posts represent personal views only and not those of employers past or present)
Reposted by Upbeat Former Prof
I hate how much I enjoyed this
BIG NERD DESIGN ENERGY 🫦
BIG NERD DESIGN ENERGY 🫦
December 13, 2025 at 5:47 PM
I hate how much I enjoyed this
BIG NERD DESIGN ENERGY 🫦
BIG NERD DESIGN ENERGY 🫦
i just learned that SPIN nightclub in Chicago closed a while back, and I'm feeling sad about that
December 13, 2025 at 2:45 PM
i just learned that SPIN nightclub in Chicago closed a while back, and I'm feeling sad about that
Reposted by Upbeat Former Prof
Reposted by Upbeat Former Prof
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
December 13, 2025 at 1:38 PM
Download our large database of postdoc fellowships in all fields of research.
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Database freely available to all; 281 fellowships.
Download here: research.jhu.edu/rdt/funding-...
Reposted by Upbeat Former Prof
For this week’s DOOMSDAY MACHINES, I interviewed my good friend @cherylrofer.bsky.social about her +30 year career at Los Alamos — topics discussed include gender, lasers, and much more — doomsdaymachines.net/p/working-at...
Working at Cold War Los Alamos
A conversation with the chemist Cheryl Rofer about her over thirty year career at Los Alamos
doomsdaymachines.net
December 12, 2025 at 7:20 PM
For this week’s DOOMSDAY MACHINES, I interviewed my good friend @cherylrofer.bsky.social about her +30 year career at Los Alamos — topics discussed include gender, lasers, and much more — doomsdaymachines.net/p/working-at...
Reposted by Upbeat Former Prof
ICYMI
For this week’s DOOMSDAY MACHINES, I interviewed my good friend @cherylrofer.bsky.social about her +30 year career at Los Alamos — topics discussed include gender, lasers, and much more — doomsdaymachines.net/p/working-at...
Working at Cold War Los Alamos
A conversation with the chemist Cheryl Rofer about her over thirty year career at Los Alamos
doomsdaymachines.net
December 13, 2025 at 1:27 PM
ICYMI
Reposted by Upbeat Former Prof
Bayou St John, New Orleans
December 13, 2025 at 1:31 AM
Bayou St John, New Orleans
reminded of the "Charm School" course over IAP
December 13, 2025 at 2:57 AM
reminded of the "Charm School" course over IAP
the importance of learning to tell when people think you're being a jagoff
December 13, 2025 at 12:38 AM
the importance of learning to tell when people think you're being a jagoff
Reposted by Upbeat Former Prof
There are no adults. Everybody's just playing pretend.
Maturing is realizing that…
December 12, 2025 at 9:29 PM
There are no adults. Everybody's just playing pretend.
Reposted by Upbeat Former Prof
The process of shrinking the gap between your values and actions is a lifetime journey.
Maturing is realizing that…
December 12, 2025 at 9:05 PM
The process of shrinking the gap between your values and actions is a lifetime journey.
Reposted by Upbeat Former Prof
Read the WHOLE thread. We need this tonight.
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
'Skull of St. Thomas Aquinas being transported to Fossanova Abbey.'
Photograph by Daniel Ibanez
Photograph by Daniel Ibanez
December 11, 2025 at 3:16 AM
Read the WHOLE thread. We need this tonight.
Reposted by Upbeat Former Prof
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
'Skull of St. Thomas Aquinas being transported to Fossanova Abbey.'
Photograph by Daniel Ibanez
Photograph by Daniel Ibanez
December 10, 2025 at 5:10 PM
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
The Publican is now at ORD?
And I have time?
Yes please
And I have time?
Yes please
December 10, 2025 at 9:42 PM
The Publican is now at ORD?
And I have time?
Yes please
And I have time?
Yes please
Reposted by Upbeat Former Prof
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
November 13, 2025 at 1:47 AM
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
Reposted by Upbeat Former Prof
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
December 8, 2025 at 3:04 PM
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
i wore shoes all day. i deserve a treat
December 9, 2025 at 4:02 AM
i wore shoes all day. i deserve a treat
praise Doubler
(this joke is so niche there's like two people who *might* get it)
(this joke is so niche there's like two people who *might* get it)
December 8, 2025 at 4:17 PM
praise Doubler
(this joke is so niche there's like two people who *might* get it)
(this joke is so niche there's like two people who *might* get it)
Reposted by Upbeat Former Prof
Iran is in “water bankruptcy” extracting from its rivers & lakes (its checking account) & underground aquifers (its savings account) faster rate than they can replenish. Overuse, mismanagement & climate change drive the crisis, forcing plans to import water. shorturl.at/mfPWn
December 8, 2025 at 12:01 PM
Iran is in “water bankruptcy” extracting from its rivers & lakes (its checking account) & underground aquifers (its savings account) faster rate than they can replenish. Overuse, mismanagement & climate change drive the crisis, forcing plans to import water. shorturl.at/mfPWn