Upbeat Former Prof
@upbeatprof.bsky.social
And remember: you must never, under any circumstances, despair. To hope and to act, these are our duties in misfortune.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
-- Boris Pasternak, Doctor Zhivago
Skeets are my own+do not reflect views of employers past or present.
Reposted by Upbeat Former Prof
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
November 13, 2025 at 1:47 AM
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
Reposted by Upbeat Former Prof
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
December 8, 2025 at 3:04 PM
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
i wore shoes all day. i deserve a treat
December 9, 2025 at 4:02 AM
i wore shoes all day. i deserve a treat
praise Doubler
(this joke is so niche there's like two people who *might* get it)
(this joke is so niche there's like two people who *might* get it)
December 8, 2025 at 4:17 PM
praise Doubler
(this joke is so niche there's like two people who *might* get it)
(this joke is so niche there's like two people who *might* get it)
Reposted by Upbeat Former Prof
Iran is in “water bankruptcy” extracting from its rivers & lakes (its checking account) & underground aquifers (its savings account) faster rate than they can replenish. Overuse, mismanagement & climate change drive the crisis, forcing plans to import water. shorturl.at/mfPWn
December 8, 2025 at 12:01 PM
Iran is in “water bankruptcy” extracting from its rivers & lakes (its checking account) & underground aquifers (its savings account) faster rate than they can replenish. Overuse, mismanagement & climate change drive the crisis, forcing plans to import water. shorturl.at/mfPWn
i always wish the main sites for neddylation involved the sequence FLANDERS
Neddylation Regulates Mitochondrial Dynamics and Turnover in the Adult Heart https://www.biorxiv.org/content/10.64898/2025.12.03.692150v1
December 7, 2025 at 10:14 PM
i always wish the main sites for neddylation involved the sequence FLANDERS
Reposted by Upbeat Former Prof
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling https://www.biorxiv.org/content/10.64898/2025.12.06.692499v1
December 7, 2025 at 10:02 PM
Discovering Glycosylation-Dependent Protein Function by Thermal Proteome Profiling https://www.biorxiv.org/content/10.64898/2025.12.06.692499v1
Reposted by Upbeat Former Prof
Steve Leininger, the father of the TRS-80, running TRS-80 software on his phone.
December 7, 2025 at 9:16 PM
Steve Leininger, the father of the TRS-80, running TRS-80 software on his phone.
my thought on one of tonight's Bluesky topics.
December 7, 2025 at 2:55 AM
my thought on one of tonight's Bluesky topics.
Reposted by Upbeat Former Prof
Just been reminded of another of my all-time favourites, Ian Curtis rides a rollercoaster...
October 8, 2024 at 4:36 PM
Just been reminded of another of my all-time favourites, Ian Curtis rides a rollercoaster...
awesome. Face/Off is back on Netflix.
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
December 6, 2025 at 9:10 PM
awesome. Face/Off is back on Netflix.
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
(remembering an only-OK first date for coffee, that turned epic when some idiot needed to be taken to the ER, anyway we watched Face/Off at...some point)
Reposted by Upbeat Former Prof
RIP Frank Gehry
December 5, 2025 at 7:32 PM
RIP Frank Gehry
December 5, 2025 at 5:29 PM
man, Alien Covenant is... not good.
December 5, 2025 at 1:00 AM
man, Alien Covenant is... not good.
i have never felt more like the product
NEW: Your "end-to-end encrypted" poop pictures taken by this $599 (+ subscription) smart toilet camera are actually not end-to-end encrypted.
¯\_(ツ)_/¯
techcrunch.com/2025/12/03/e...
¯\_(ツ)_/¯
techcrunch.com/2025/12/03/e...
‘End-to-end encrypted’ smart toilet camera is not actually end-to-end encrypted | TechCrunch
Kohler, the makers of a smart toilet camera, can access customers' data stored on its servers, and can use customers’ bowl pictures to train AI.
techcrunch.com
December 4, 2025 at 3:09 PM
i have never felt more like the product
Kohler can make the funniest captcha of all time
December 4, 2025 at 3:34 AM
Kohler can make the funniest captcha of all time
Steve Cropper - The AMAZING Story Behind "Green Onions"
YouTube video by Musicians Hall of Fame & Museum
youtu.be
December 3, 2025 at 10:39 PM
Reposted by Upbeat Former Prof
One of the all-time greats - guitarist, songwriter, producer, icon. Rest easy, Steve. variety.com/2025/music/n...
Steve Cropper, Legendary Guitarist for Booker T. & the MG’s, Otis Redding and the Blues Brothers, Dies at 84
Steve Cropper, guitarist for Booker T. & the MG's, Otis Redding, the Blues Brothers and many more, has died. He was 84.
variety.com
December 3, 2025 at 10:09 PM
One of the all-time greats - guitarist, songwriter, producer, icon. Rest easy, Steve. variety.com/2025/music/n...
this is the worst book I've ever downloaded. my storage is embarrassed for me
December 3, 2025 at 9:57 PM
this is the worst book I've ever downloaded. my storage is embarrassed for me
Reposted by Upbeat Former Prof
Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!
December 3, 2025 at 7:15 PM
Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!
Reposted by Upbeat Former Prof
Hi #bioinformatics folk, I want to quickly extract metagenome reads that map to medium-sized piles of reference genomes (100s-1000s, but not 10_000s). I don't _necessarily_ care about the exact position. I'm using minimap2 right now but it's kinda choking on 1000 microbial genomes at once. Thoughts?
December 2, 2025 at 7:09 PM
Hi #bioinformatics folk, I want to quickly extract metagenome reads that map to medium-sized piles of reference genomes (100s-1000s, but not 10_000s). I don't _necessarily_ care about the exact position. I'm using minimap2 right now but it's kinda choking on 1000 microbial genomes at once. Thoughts?
Reposted by Upbeat Former Prof
“Have Yourself A Merriam Little Christmas”
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
December 2, 2025 at 7:18 PM
“Have Yourself A Merriam Little Christmas”
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
Merriam, a career-oriented lexicographer from the city, returns to her small town for the holidays and meets Webster, a ruggedly handsome librarian, who shows her the true DEFINITION of Christmas.
the older i get, the more the plot of THX-1138 seems like an allegory for the ironies of career progression
December 2, 2025 at 5:01 PM
the older i get, the more the plot of THX-1138 seems like an allegory for the ironies of career progression
Reposted by Upbeat Former Prof
I just think there should be a desktop centrifuge for pens. Yeah! I know it would make a mess! I know how physics works! I don't care, I want it. Get that ink ALL the way to the bottom. That's what I want.
December 1, 2025 at 7:53 PM
I just think there should be a desktop centrifuge for pens. Yeah! I know it would make a mess! I know how physics works! I don't care, I want it. Get that ink ALL the way to the bottom. That's what I want.
this is the exact opposite of the Jailbreak Bake and i love it
I just stopped by to deliver this freshly baked strawberry-rhubarb pie. I’ll be long gone before you discover the review invitation I baked into it.
Idea: a process server specializing in review invitations. Good news: that manila envelope the bicycle courier just handed you does NOT contain divorce papers. Bad news: it does contain a review invitation.
December 1, 2025 at 5:46 PM
this is the exact opposite of the Jailbreak Bake and i love it