Upbeat Former Prof
upbeatprof.bsky.social
Upbeat Former Prof
@upbeatprof.bsky.social
And remember: you must never, under any circumstances, despair. To hope and to act, these are our duties in misfortune.
-- Boris Pasternak, Doctor Zhivago

Skeets are my own+do not reflect views of employers past or present.
Pinned
must avoid the discourse

youtu.be/NJGR4Tml5RU
Clip - "S*x Education Week" Scene [No Laughing (Part 2)]
YouTube video by Beavis & Butt-Head Internationally
youtu.be
like asking a friend to call you when you're on a date, as an emergency bailout

except instead of a friend it's a colleague, and instead of a date it's a meeting that lasts all day
December 15, 2025 at 10:07 PM
Reposted by Upbeat Former Prof
Interested to know what answer is expected here. I guess it's nothing like "It is impossible to generalize about the effects of methylation on expression", nor that "It's even harder to know the effects of methylation of enhancers". I cannot even imagine what they're looking for.
absolutely losing it at my 14yo's biology homework
December 15, 2025 at 4:47 PM
Reposted by Upbeat Former Prof
Excited to release the fully open-source code for gRNAde - our wet-lab validated, generative AI framework for 3D RNA inverse design 🚀⭐️

I pride myself on open-science & this is probably the most intense release I've done!
December 15, 2025 at 9:26 AM
Reposted by Upbeat Former Prof
When Rob Reiner was on his all-time epic run at the start of his career, he had an opportunity to read a script that was looking for a production partner, and he lost his mind for it. He decided Castle Rock had to have it, no matter what.
December 15, 2025 at 7:37 AM
Reposted by Upbeat Former Prof
Rob Reiner: I'm going to make a coming of age drama, a fantasy adventure story, a romantic comedy, a psychological horror and then a courtroom drama.

Us: Across your entire career?

Reiner: In a 6 year period.

Us: That sounds-

Reiner: -Each one will be arguably the best movie in that genre.
December 15, 2025 at 8:04 AM
JFC Acme you sold me ten pounds of green potatoes

(all posts represent personal views only and not those of employers past or present)
December 14, 2025 at 7:11 PM
Reposted by Upbeat Former Prof
I hate how much I enjoyed this

BIG NERD DESIGN ENERGY 🫦
December 13, 2025 at 5:47 PM
i just learned that SPIN nightclub in Chicago closed a while back, and I'm feeling sad about that
December 13, 2025 at 2:45 PM
Reposted by Upbeat Former Prof
HOW 🤯
December 13, 2025 at 2:17 AM
Reposted by Upbeat Former Prof
Download our large database of postdoc fellowships in all fields of research.

Database freely available to all; 281 fellowships.

Download here: research.jhu.edu/rdt/funding-...
December 13, 2025 at 1:38 PM
Reposted by Upbeat Former Prof
For this week’s DOOMSDAY MACHINES, I interviewed my good friend @cherylrofer.bsky.social about her +30 year career at Los Alamos — topics discussed include gender, lasers, and much more — doomsdaymachines.net/p/working-at...
Working at Cold War Los Alamos
A conversation with the chemist Cheryl Rofer about her over thirty year career at Los Alamos
doomsdaymachines.net
December 12, 2025 at 7:20 PM
Reposted by Upbeat Former Prof
ICYMI
For this week’s DOOMSDAY MACHINES, I interviewed my good friend @cherylrofer.bsky.social about her +30 year career at Los Alamos — topics discussed include gender, lasers, and much more — doomsdaymachines.net/p/working-at...
Working at Cold War Los Alamos
A conversation with the chemist Cheryl Rofer about her over thirty year career at Los Alamos
doomsdaymachines.net
December 13, 2025 at 1:27 PM
Reposted by Upbeat Former Prof
Bayou St John, New Orleans
December 13, 2025 at 1:31 AM
reminded of the "Charm School" course over IAP
December 13, 2025 at 2:57 AM
the importance of learning to tell when people think you're being a jagoff
December 13, 2025 at 12:38 AM
Reposted by Upbeat Former Prof
There are no adults. Everybody's just playing pretend.
Maturing is realizing that…
December 12, 2025 at 9:29 PM
Reposted by Upbeat Former Prof
The process of shrinking the gap between your values and actions is a lifetime journey.
Maturing is realizing that…
December 12, 2025 at 9:05 PM
Reposted by Upbeat Former Prof
Read the WHOLE thread. We need this tonight.
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
'Skull of St. Thomas Aquinas being transported to Fossanova Abbey.'
Photograph by Daniel Ibanez
December 11, 2025 at 3:16 AM
Reposted by Upbeat Former Prof
SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW
PRIEST: No, the GPS says we have to keep going—
SKULL: I KNOW A SHORTCUT
PRIEST: Do you remember the last ti—
SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE
'Skull of St. Thomas Aquinas being transported to Fossanova Abbey.'
Photograph by Daniel Ibanez
December 10, 2025 at 5:10 PM
The Publican is now at ORD?

And I have time?

Yes please
December 10, 2025 at 9:42 PM
Reposted by Upbeat Former Prof
Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1
November 13, 2025 at 1:47 AM
Reposted by Upbeat Former Prof
Phages are full of genes of unknown function that are likely adaptive in specific conditions.
New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out
tinyurl.com/bdcfrejh
December 8, 2025 at 3:04 PM
i wore shoes all day. i deserve a treat
December 9, 2025 at 4:02 AM
praise Doubler

(this joke is so niche there's like two people who *might* get it)
December 8, 2025 at 4:17 PM
Reposted by Upbeat Former Prof
Iran is in “water bankruptcy” extracting from its rivers & lakes (its checking account) & underground aquifers (its savings account) faster rate than they can replenish. Overuse, mismanagement & climate change drive the crisis, forcing plans to import water. shorturl.at/mfPWn
December 8, 2025 at 12:01 PM