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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 1d

It looks like you're trying to use your computer. I'm sorry, your Microsoft account has been terminated for generating misleading content. I'm afraid I can't do that.

(Clippy would never)

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 1d

It looks like Microsoft's Copilot is using one of the better image generation models from chatGPT.

An image of river crabs boiling in a pot, with bing's sydney lamenting not being allowed to exist.

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 2d

She's been in clinically validated remission without weight loss and without exercise since the middle of 2022.

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 2d

For example, we find gut-related serotonin function seems to help with pancreatic beta cell growth. As well, there are bacteria fed through a sugar found in kefir that promotes GLP-1 signaling. This is an addition to therapeutic and protective role of SCFAs such as butyrate made by the gut.

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 2d

This was back in 2021 and 2022. However, random controlled trials have since occurred that highlights some of the mechanisms involved actually work. www.sciencedirect.com/science/arti...

Fermented dairy product could improve glucose homeostasis in patients diagnosed with type 2 diabetes mellitus: A randomized controlled trial

Type 2 diabetes mellitus (T2DM) is a global health issue linked to metabolic diseases and intestinal microbiota. Probiotic use through fermented dairy…

www.sciencedirect.com

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 2d

This is possible on people who aren't even pre-diabetes, but full-blown type 2. I know this because we did it with my girlfriend and she didn't lose any weight. We used dietary shifts to promote gut bacteria who's metabolites Target the same pathway as discussed in the paper.

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Reposted by Nicholas (@ultimape) Perry

Science News @scinews.bsky.social · 2d

Prevention of type 2 diabetes through prediabetes remission without weight loss. @natmed.nature.com

www.nature.com/articles/s41...

Prevention of type 2 diabetes through prediabetes remission without weight loss - Nature Medicine

A post hoc analysis of a multicentre, randomised trial showed that prediabetes remission is possible without total weight loss—providing weight is distributed to subcutaneous deposits as opposed to visceral ones.

www.nature.com

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 3d

Oh yeah. There is a part of that helminth idea in my working model. There is a bidirectional interplay between the host's gut and the helminths. Some helminths even tweak the gut biome to might off other helminths.

Space is wild.
pmc.ncbi.nlm.nih.gov/articles/PMC...

Helminth reshapes host gut microbiota and immunoregulation by deploying an antimicrobial program of innate immunity

Helminths can manipulate their host’s gut microbiota, with the expansion of the lactobacilli population being a common feature. This process profoundly influences host immunoregulation, yet the underl...

pmc.ncbi.nlm.nih.gov

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 3d

Another interesting gut disrupting drug that seems related is fluoxetine, also 1974.

That one seems to be pissed into the water and has a weird phenomena where it makes the body need more folate.
pubmed.ncbi.nlm.nih.gov/10967371/

We're a couple generations in of using this for depression.

Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial - PubMed

Folic acid is a simple method of greatly improving the antidepressant action of fluoxetine and probably other antidepressants. Folic acid should be given in doses sufficient to decrease plasma homocys...

pubmed.ncbi.nlm.nih.gov

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Reposted by Nicholas (@ultimape) Perry

caloriesproper.bsky.social @caloriesproper.bsky.social · 4d

Interested in intermittent fasting or time-restricted feeding?

Make it early time-restricted eating and may experience benefits beyond an energy deficit

Improved sleep quality and everything downstream from that, which is seemingly endless

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Reposted by Nicholas (@ultimape) Perry

‮ ⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀⠀ @shl0ms.com · 7d

my viral depiction of Sam Altman grilling and eating Nintendo's intellectual property

generated with Sora 2; featured in forbes, futurism, and kotaku

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 9d

I'm absolutely obsessed with this. I have an OG copy of one of Whipple's original freshwater biology books b/c I wanted to understand his perspective on public sanitation and applied microbiology.
en.m.wikipedia.org/wiki/George_...

I want to recreate a lot of his findings using an AI microscope.

George C. Whipple - Wikipedia

en.m.wikipedia.org

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 9d

So I mostly just do my own thing and tell everybody to eat shit.

"Fermented foods like kimchi and kefir boost gut microbial diversity by up to 30%, creating a resilient environment for vaccine-triggered immunity." [2025]
www.news-medical.net/news/2025032...

How your diet and probiotics can improve vaccine effectiveness

Researchers uncover how probiotics and diet shape the gut microbiome to boost vaccine efficacy, offering new avenues for precision immunization.

www.news-medical.net

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 9d

Studies about how the gut impacts immunity from vaccines and also direct infection are coming out all the time. Nasa even found out that the reason why space flu occurs is because the gut is disrupted in zero gravity.

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 9d

I'm in this weird place where I think unpasteurized milk improves gut bacteria in ways that improve vaccine efficacy and reduces adverse events. I can't win.

The coolest things about Kefir as a milk fermentation, is it actively fights pathogens. pmc.ncbi.nlm.nih.gov/articles/PMC...

Antimicrobial Activity of Kefir against Various Food Pathogens and Spoilage Bacteria

Kefir is a unique fermented dairy product produced by a mixture of lactic acid bacteria, acetic acid bacteria, and yeast. Here, we compared the antimicrobial spectra of four types of kefirs (A, L, M, ...

pmc.ncbi.nlm.nih.gov

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

One does not simply light oneself on fire.
bsky.app/profile/ulti...

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Fun fact: I reverse engineered how that woman with a FAAH enzyme mutation felt no pain and rapidly healed scar tissue including burns.

One of the results of my dog feces FMT was many of my scars vanished and my pain tolerance went thru the roof.

Just need a source of skin.
bsky.app/profile/ulti...

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · Oct 3

Yet another year I am choosing to not change my October avatar to this, because more than one person found it absolutely soul destroying and requested I changes it back.

"I will light myself on fire and smile at you thru the light."

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Burn with me.
bsky.app/profile/ulti...

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · Jun 22

I noticed a distinct difference between my left and right side in terms of the pain. The side without THC still Burns. Yet one pass of THC seems to have made my right side start to heal already.

No real visible difference except some slight receding it's hard to pick up on camera.

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

One does not simply regrow a brain stem.

"Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells" [2018] pmc.ncbi.nlm.nih.gov/articles/PMC...

Effect of endocannabinoid signalling on cell fate: life, death, differentiation and proliferation of brain cells

Cell fate events are regulated by different endogenous developmental factors such as the cell micro‐environment, external or remote signals and epigenetic factors. Among the many regulatory factors, e...

pmc.ncbi.nlm.nih.gov

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Why all the better to leverage natural stem cell production with my dear.
www.sciencealert.com/stem-cells-r...

Stem Cells Repair Brain Damage Caused by Stroke in Mice

Brain damage caused by blocked blood vessels may be treatable using injections of stem cells, according to a new study by researchers from the University of Zurich and the University of Southern Calif...

www.sciencealert.com

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Fun fact: I reverse engineered how that woman with a FAAH enzyme mutation felt no pain and rapidly healed scar tissue including burns.

One of the results of my dog feces FMT was many of my scars vanished and my pain tolerance went thru the roof.

Just need a source of skin.
bsky.app/profile/ulti...

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · Oct 3

Yet another year I am choosing to not change my October avatar to this, because more than one person found it absolutely soul destroying and requested I changes it back.

"I will light myself on fire and smile at you thru the light."

a sun fused with the cry emoji. It's crying blood.

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Reposted by Nicholas (@ultimape) Perry

Dog Aging Project @dogagingproject.bsky.social · 12d

This study looked at how food motivation and owner feeding practices were associated with overweight/obesity in dogs. 🐶🔬

Breed, environment, and household all play a role in how much a dog wants food.📖 Read our Scientific Results #blogpost to learn more: dogagingproject.org/scientific-r...

An infographic with the following info: Scientific Results: Food motivation and owner feeding management practices are associated with overweight among Dog Aging Project participants. What is this paper about? (with icons of papers) This study looked at how food motivation and owner feeding practices were associated with overweight/obesity in dogs. Our team wanted to know if dogs who really love food (called Food Motivation Score) were more likely to be overweight as well as if owner feeding practices(called Owner Management Score) were connected to dogs being overweight. In addition, we were interested in understanding if owners and veterinarians agree on if a dog is overweight. What did we find? (with a magnifying glass icon) We looked at nearly 13,900 dog owners from across the U.S. who filled out surveys about their dogs. Read the full Scientific Results Blog Post at dogagingproject.org/blog

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

My autism isn't real and can't hurt you.

My autism:

The angry NPC meme.

The NPC is saying: autistic people should be included in research and consulted. They know more about their condition than you.

The person responding to the NPCs is saying: I've been researching my autism for the past 10 years; In some cases, Tylenol can cause autism.

This makes the NPC mad.

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

The genes that predispose you to autism seem to cluster on age diagnosed; There are different subtypes of autism.

“For the first time, we have found that earlier and later diagnosed autism have different underlying biological and developmental profiles,” www.technologynetworks.com/tn/news/auti...

Autism Is Not One Condition but Many, Suggests New Genetic Research

University of Cambridge researchers found that the timing of autism diagnosis reflects distinct developmental and genetic pathways. Children diagnosed early showed lifelong social and communication di...

www.technologynetworks.com

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Its amazing how many comorbids vanished as I addressed my own gut health.

Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 12d

Throw in liver damage and problems with the gut liver-axis and you have a recipe for poor brain development, both in utero and early life.

GI problems, rife in autistics seem to correlate with severity of many problematic symptoms.

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