Beuzón & Ruiz-Albert Lab
@type3lab.bsky.social
Research group on molecular plant-pathogen interactions (mainly Pseudomonas syringae), co-lead by Carmen R. Beuzon and Javier Ruiz-Albert at IHSM_CSIC_UMA (Málaga - Spain)
http://www.type3secretionlab.es
http://www.type3secretionlab.es
Pinned
Pseudomonas syringae subpopulations cooperate by coordinating flagellar and type III secretion spatiotemporal dynamics to facilitate plant infection
Nature Microbiology - Single-cell gene expression analysis reveals phenotypic heterogeneity to enable bacterial specialization over the course of plant colonization.
rdcu.be
How Bacteria Outsmart Plants—Then Flee the Scene!
#MicroSky #PlantScience #Pseudomonas
Our new research in Nature Microbiology uncovers the sophisticated teamwork of Pseudomonas syringae, a notorious plant pathogen.
🔗 rdcu.be/egczU
#MicroSky #PlantScience #Pseudomonas
Our new research in Nature Microbiology uncovers the sophisticated teamwork of Pseudomonas syringae, a notorious plant pathogen.
🔗 rdcu.be/egczU
Reposted by Beuzón & Ruiz-Albert Lab
The GT goes to Stuttgart! A (brief) trip, nice scenery, good food, a touch of (mostly fictitious) science, and excellent company! What else could one wish for in a lab retreat? (Ah — it was also the 10th anniversary of the lab!) 🎂🌱🦠
November 27, 2025 at 6:37 PM
The GT goes to Stuttgart! A (brief) trip, nice scenery, good food, a touch of (mostly fictitious) science, and excellent company! What else could one wish for in a lab retreat? (Ah — it was also the 10th anniversary of the lab!) 🎂🌱🦠
Reposted by Beuzón & Ruiz-Albert Lab
What an incredible 10 years! Here’s to another 10 and beyond! 🥳🎉👏🏻CONGRATULATIONS, @geminiteamlab.bsky.social 💚🦠🌱 #plantvirus #postdoclife #virology #labretreat
The GT goes to Stuttgart! A (brief) trip, nice scenery, good food, a touch of (mostly fictitious) science, and excellent company! What else could one wish for in a lab retreat? (Ah — it was also the 10th anniversary of the lab!) 🎂🌱🦠
November 27, 2025 at 6:46 PM
What an incredible 10 years! Here’s to another 10 and beyond! 🥳🎉👏🏻CONGRATULATIONS, @geminiteamlab.bsky.social 💚🦠🌱 #plantvirus #postdoclife #virology #labretreat
Reposted by Beuzón & Ruiz-Albert Lab
How do plants fight disease? 🌱 #NASmember Jane Parker studies NLR proteins that help plants sense attackers and launch powerful immune defenses. She shares her latest findings on how these proteins signal plants to resist disease in a new @pnas.org QnAs: www.pnas.org/doi/10.1073/...
November 26, 2025 at 6:00 PM
How do plants fight disease? 🌱 #NASmember Jane Parker studies NLR proteins that help plants sense attackers and launch powerful immune defenses. She shares her latest findings on how these proteins signal plants to resist disease in a new @pnas.org QnAs: www.pnas.org/doi/10.1073/...
Reposted by Beuzón & Ruiz-Albert Lab
Excited to bring to your attention 2-year work by @sylvain-vicente.bsky.social and collaborators #BIOSP #MathNum @inrae-dpt-spe.bsky.social. A re-evaluation of STAMP modelling, introducing a much needed time-resolution. Works also on Animal-bacterial infection models. www.biorxiv.org/content/10.1...
November 23, 2025 at 5:34 PM
Excited to bring to your attention 2-year work by @sylvain-vicente.bsky.social and collaborators #BIOSP #MathNum @inrae-dpt-spe.bsky.social. A re-evaluation of STAMP modelling, introducing a much needed time-resolution. Works also on Animal-bacterial infection models. www.biorxiv.org/content/10.1...
Reposted by Beuzón & Ruiz-Albert Lab
Secreting bacteria undergo drastic changes.
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
November 24, 2025 at 10:56 PM
Secreting bacteria undergo drastic changes.
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
We found that in Yersinia, T3SS activation triggers rapid, large-scale reorganisation of chromosomal and plasmid DNA. This links secretion to growth inhibition-revealing a new connection between virulence and bacterial cell biology.
doi.org/10.1016/j.ce...
Reposted by Beuzón & Ruiz-Albert Lab
The scientific world would be a better place if reviews routinely reflected this degree of critical thinking and graphical excellence.
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
November 24, 2025 at 9:54 AM
The scientific world would be a better place if reviews routinely reflected this degree of critical thinking and graphical excellence.
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Thanks for putting this together @plaschkalab.bsky.social @rupertfaraway.bsky.social and @thezenklusen.bsky.social
Reposted by Beuzón & Ruiz-Albert Lab
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted by Beuzón & Ruiz-Albert Lab
Flagellar location determines the stability of bacterial surface entrapment | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
November 23, 2025 at 6:19 PM
Flagellar location determines the stability of bacterial surface entrapment | PNAS www.pnas.org/doi/10.1073/...
Reposted by Beuzón & Ruiz-Albert Lab
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
CRISPR-Cas–mediated heritable chromosome fusions in Arabidopsis
The genome of Arabidopsis thaliana consists of 10 chromosomes. By inducing CRISPR-Cas–mediated breaks at subcentromeric and subtelomeric sequences, we fused entire chromosome arms, obtaining two eight...
www.science.org
November 21, 2025 at 10:20 AM
And now we have Arabidopsis plants with 8 chromosomes instead of 10 and no obvious phenotypic differences, this week in @science.org
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
#PlantScience
Paper here: www.science.org/doi/10.1126/...
Perspective here:
www.science.org/doi/10.1126/...
Reposted by Beuzón & Ruiz-Albert Lab
Reposted by Beuzón & Ruiz-Albert Lab
Finally published!
Our new study in Curr Biol @currentbiology.bsky.social analyzes how CYP707A1 promoter variation drives an evolutionary trade-off between stomatal defense and gas exchange across Brassicaceae species.
Free-access link:
authors.elsevier.com/a/1m7H93QW8S...
Our new study in Curr Biol @currentbiology.bsky.social analyzes how CYP707A1 promoter variation drives an evolutionary trade-off between stomatal defense and gas exchange across Brassicaceae species.
Free-access link:
authors.elsevier.com/a/1m7H93QW8S...
authors.elsevier.com
November 21, 2025 at 10:32 AM
Finally published!
Our new study in Curr Biol @currentbiology.bsky.social analyzes how CYP707A1 promoter variation drives an evolutionary trade-off between stomatal defense and gas exchange across Brassicaceae species.
Free-access link:
authors.elsevier.com/a/1m7H93QW8S...
Our new study in Curr Biol @currentbiology.bsky.social analyzes how CYP707A1 promoter variation drives an evolutionary trade-off between stomatal defense and gas exchange across Brassicaceae species.
Free-access link:
authors.elsevier.com/a/1m7H93QW8S...
Reposted by Beuzón & Ruiz-Albert Lab
New guidance was published to aid academics/SMEs with interpreting the MHRA “Regulatory considerations for therapeutic use of bacteriophages in the UK”, published earlier this year.
Read the interpretation guidance here: doi.org/10.1099/mic.... #MicrobioJ
Read the interpretation guidance here: doi.org/10.1099/mic.... #MicrobioJ
November 21, 2025 at 11:06 AM
New guidance was published to aid academics/SMEs with interpreting the MHRA “Regulatory considerations for therapeutic use of bacteriophages in the UK”, published earlier this year.
Read the interpretation guidance here: doi.org/10.1099/mic.... #MicrobioJ
Read the interpretation guidance here: doi.org/10.1099/mic.... #MicrobioJ
Reposted by Beuzón & Ruiz-Albert Lab
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Intracellular competition shapes plasmid population dynamics
From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...
www.science.org
November 20, 2025 at 9:42 PM
Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Beuzón & Ruiz-Albert Lab
Reposted by Beuzón & Ruiz-Albert Lab
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize Type IX secretion signals and target effectors to their final destinations in Flavobacterium johnsoniae
Communications Biology - Bacteroidota use the Type IX secretion system to secrete proteins with a conserved C-terminal domain (CTD) secretion signal domain. Type B CTDs require specific shuttle...
www.nature.com
November 15, 2025 at 3:55 PM
Happy to share the last paper form the lab:
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Specialized shuttle proteins recognize
T9SS signals and target
effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social
www.nature.com/articles/s42...
Reposted by Beuzón & Ruiz-Albert Lab
Are you expecting a new age of microbiome engineering
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 14, 2025 at 8:08 AM
Are you expecting a new age of microbiome engineering
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
www.science.org/doi/10.1126/...
Reposted by Beuzón & Ruiz-Albert Lab
Many nice #RNA & #ribosome papers in the latest issue of @narjournal.bsky.social 🦠💫 academic.oup.com/nar/issue/53...
⬇️links in comments
⬇️links in comments
November 12, 2025 at 7:58 PM
Many nice #RNA & #ribosome papers in the latest issue of @narjournal.bsky.social 🦠💫 academic.oup.com/nar/issue/53...
⬇️links in comments
⬇️links in comments
Reposted by Beuzón & Ruiz-Albert Lab
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
November 12, 2025 at 4:21 PM
What if even the core of bacterial nanomachines wasn’t static?
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
We found that the T3SS core protein SctD in Yersinia dynamically exchanges subunits — and this flexibility is essential for proper assembly & function.
🔗 www.nature.com/articles/s41...
@kit.edu @t3sss.bsky.social
Reposted by Beuzón & Ruiz-Albert Lab
Our first accepted manuscript at my new lab (@kitkarlsruhe) is out in Communications Biology! 🎉
We show how Pseudomonas aeruginosa coordinates its virulence systems, T3SS, H1-T6SS, flagellum, at single-cell resolution.
🔗 www.nature.com/articles/s42...
@t3sss.bsky.social @NaturePortfolio.bsky.social
We show how Pseudomonas aeruginosa coordinates its virulence systems, T3SS, H1-T6SS, flagellum, at single-cell resolution.
🔗 www.nature.com/articles/s42...
@t3sss.bsky.social @NaturePortfolio.bsky.social
August 20, 2025 at 2:43 PM
Our first accepted manuscript at my new lab (@kitkarlsruhe) is out in Communications Biology! 🎉
We show how Pseudomonas aeruginosa coordinates its virulence systems, T3SS, H1-T6SS, flagellum, at single-cell resolution.
🔗 www.nature.com/articles/s42...
@t3sss.bsky.social @NaturePortfolio.bsky.social
We show how Pseudomonas aeruginosa coordinates its virulence systems, T3SS, H1-T6SS, flagellum, at single-cell resolution.
🔗 www.nature.com/articles/s42...
@t3sss.bsky.social @NaturePortfolio.bsky.social
Reposted by Beuzón & Ruiz-Albert Lab
Using live-cell microscopy, we uncovered distinct bacterial subpopulations that primarily use certain combinations of these nanomachines:
• some prioritize motility & T3SS
• others shift to T6SS for antagonism
All tuned by the usual suspect: cyclic di-GMP.
• some prioritize motility & T3SS
• others shift to T6SS for antagonism
All tuned by the usual suspect: cyclic di-GMP.
August 20, 2025 at 2:46 PM
Using live-cell microscopy, we uncovered distinct bacterial subpopulations that primarily use certain combinations of these nanomachines:
• some prioritize motility & T3SS
• others shift to T6SS for antagonism
All tuned by the usual suspect: cyclic di-GMP.
• some prioritize motility & T3SS
• others shift to T6SS for antagonism
All tuned by the usual suspect: cyclic di-GMP.
Reposted by Beuzón & Ruiz-Albert Lab
T3SS activity comes at a cost—bacteria that use the system pay with reduced growth. We found how Yersinia balance costs and benefits: at higher densities, they actively suppress T3SS activity and adhesion, switching from colonization to replication and dissemination.
doi.org/10.1371/jour...
@kit.edu
doi.org/10.1371/jour...
@kit.edu
Yersinia actively downregulates type III secretion and adhesion at higher cell densities
Author summary Bacteria can use the type III secretion system (T3SS), a molecular syringe-like device, to manipulate host cells by injecting effector proteins. Yersinia enterocolitica, a pathogenic ba...
doi.org
September 2, 2025 at 8:34 PM
T3SS activity comes at a cost—bacteria that use the system pay with reduced growth. We found how Yersinia balance costs and benefits: at higher densities, they actively suppress T3SS activity and adhesion, switching from colonization to replication and dissemination.
doi.org/10.1371/jour...
@kit.edu
doi.org/10.1371/jour...
@kit.edu
Reposted by Beuzón & Ruiz-Albert Lab
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system - Nature Communications
Bacteria use the type III secretion system (T3SS) to inject proteins into target cells. Here, Brianceau et al. show that a core structural component, SctD, exchanges between a T3SS-bound and a freely ...
www.nature.com
November 11, 2025 at 9:28 PM
Continuous exchange of an inner-membrane ring component is required for assembly and function of the type III secretion system
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Beuzón & Ruiz-Albert Lab
A reminder that the abundance of 'housekeeping' proteins varies significantly across cells and tissues.
GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues.
How do you define a 'housekeeping' protein ?
GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues.
How do you define a 'housekeeping' protein ?
November 11, 2025 at 11:56 AM
A reminder that the abundance of 'housekeeping' proteins varies significantly across cells and tissues.
GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues.
How do you define a 'housekeeping' protein ?
GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues.
How do you define a 'housekeeping' protein ?