ToxicoloGee Whiz, PhD
@toxicologee.bsky.social
Bioinformatics PhD, cheminformatics, data scientist, statistics, toxicology and coding at Eli Lilly... I do it all! Currently focused in off-target ID for genetic medicines. Mom to a kid and a cat. Thoughts and opinions are my own
Reposted by ToxicoloGee Whiz, PhD
We would like to bring our EVOLVE consortium with its PhD positions to your attention again! Sharing is also much appreciated.
🧪Here are our current open positions:
www.benferinga.com/vacancies/
- PhD on Functional DNA-Rotator Motors
- PhD in the Origin of Homochirality
- PhD on Expanding Prebiotic Chemistry Through Reactivity in Oil Droplets
- Postdoc Molecular motors based DNA-walkers
www.benferinga.com/vacancies/
- PhD on Functional DNA-Rotator Motors
- PhD in the Origin of Homochirality
- PhD on Expanding Prebiotic Chemistry Through Reactivity in Oil Droplets
- Postdoc Molecular motors based DNA-walkers
March 12, 2025 at 3:55 PM
We would like to bring our EVOLVE consortium with its PhD positions to your attention again! Sharing is also much appreciated.
Reposted by ToxicoloGee Whiz, PhD
Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.
Adapting systems biology to address the complexity of human disease in the single-cell era go.nature.com/3XBo6Vh #Review by @davidsebfischer.bsky.social, Martin A. Villanueva, Peter S. Winter & Alex K. Shalek @broadinstitute.org @mitofficial.bsky.social @ragoninstitute.bsky.social
Adapting systems biology to address the complexity of human disease in the single-cell era - Nature Reviews Genetics
Differences between humans and experimental models create a translational gap that makes it difficult to extrapolate research findings. The authors review systems-focused approaches to identify and co...
go.nature.com
March 13, 2025 at 3:53 AM
Currently, there's a lot of interest in quantitative models that would help us understand and predict features of the complex cellular systems that underlie human health and disease - think about virtual cells, for example. On can trace some of these ideas back to the early days of systems biology.
Reposted by ToxicoloGee Whiz, PhD
Kickking off the second day our @bcbhubcsic.bsky.social meeting with scientific sesions with Victor Sánchez Gaya, presenting POSTRE, a tool to predict the funcional impact of pstructural variants @hitseq.bsky.social @ibv-csic.bsky.social @csic-vaact.bsky.social
March 13, 2025 at 8:34 AM
Kickking off the second day our @bcbhubcsic.bsky.social meeting with scientific sesions with Victor Sánchez Gaya, presenting POSTRE, a tool to predict the funcional impact of pstructural variants @hitseq.bsky.social @ibv-csic.bsky.social @csic-vaact.bsky.social
Reposted by ToxicoloGee Whiz, PhD
Next, Ana Martinez and Carmen Gil from @cib-csic.bsky.social presenting how to use a consortium
of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub
of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub
March 13, 2025 at 8:44 AM
Next, Ana Martinez and Carmen Gil from @cib-csic.bsky.social presenting how to use a consortium
of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub
of AI tools for drug design, with múltiple applicatons in the clínic @bcbhubcsic.bsky.social @csic-vaact.bsky.social #2AsambleaBCBHub
Reposted by ToxicoloGee Whiz, PhD
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
March 12, 2025 at 12:36 PM
Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See
lnkd.in/dVVk4N3s. #microsky
lnkd.in/dVVk4N3s. #microsky
Reposted by ToxicoloGee Whiz, PhD
🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.
March 12, 2025 at 5:36 PM
🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.
Reposted by ToxicoloGee Whiz, PhD
The #Nextflow #Training week has begun! 🎉
New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace!
hubs.la/Q03b2-Rk0
New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace!
hubs.la/Q03b2-Rk0
Hello Nextflow: Intro and setup
Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.
hubs.la
March 10, 2025 at 11:07 AM
The #Nextflow #Training week has begun! 🎉
New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace!
hubs.la/Q03b2-Rk0
New to Nextflow or need a guided intro? Watch the brand new on-demand walkthrough videos for the "Hello Nextflow" course, and learn at your own pace!
hubs.la/Q03b2-Rk0
Reposted by ToxicoloGee Whiz, PhD
Quantifying Metagenomic Strain Associations from Microbiomes with Anpan www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats 📦 github.com/biobakery/an...
March 10, 2025 at 8:00 PM
Quantifying Metagenomic Strain Associations from Microbiomes with Anpan www.biorxiv.org/content/10.1... 🧬🖥️🧪 #Rstats 📦 github.com/biobakery/an...
Reposted by ToxicoloGee Whiz, PhD
Common gynaecological disorders linked to raised heart and cerebrovascular disease risk
"They include polycystic ovary syndrome, endometriosis, heavy or irregular periods"
heart.bmj.com/content/earl...
"They include polycystic ovary syndrome, endometriosis, heavy or irregular periods"
heart.bmj.com/content/earl...
February 25, 2025 at 12:47 AM
Common gynaecological disorders linked to raised heart and cerebrovascular disease risk
"They include polycystic ovary syndrome, endometriosis, heavy or irregular periods"
heart.bmj.com/content/earl...
"They include polycystic ovary syndrome, endometriosis, heavy or irregular periods"
heart.bmj.com/content/earl...
Reposted by ToxicoloGee Whiz, PhD
PLOS has issued a statement on recent US Executive Orders and scientific integrity.
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
PLOS statement on recent US Executive Orders and scientific integrity - The Official PLOS Blog
Since its founding over twenty five years ago PLOS has been dedicated to advancing open science, ensuring that knowledge is accessible to…
plos.io
February 21, 2025 at 3:41 PM
PLOS has issued a statement on recent US Executive Orders and scientific integrity.
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry.
plos.io/3D4O8cH
Reposted by ToxicoloGee Whiz, PhD
Is this real? I published it again on Brain @brain1878.bsky.social 😆
Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇
The blood–brain barrier: a help & a hindrance
#Aging #Stroke #Neurodegeneration
Crossing #BBB 😎
academic.oup.com/brain/advanc...
Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇
The blood–brain barrier: a help & a hindrance
#Aging #Stroke #Neurodegeneration
Crossing #BBB 😎
academic.oup.com/brain/advanc...
February 21, 2025 at 1:15 PM
Is this real? I published it again on Brain @brain1878.bsky.social 😆
Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇
The blood–brain barrier: a help & a hindrance
#Aging #Stroke #Neurodegeneration
Crossing #BBB 😎
academic.oup.com/brain/advanc...
Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇
The blood–brain barrier: a help & a hindrance
#Aging #Stroke #Neurodegeneration
Crossing #BBB 😎
academic.oup.com/brain/advanc...
Reposted by ToxicoloGee Whiz, PhD
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
buff.ly
February 21, 2025 at 7:41 PM
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.
Reposted by ToxicoloGee Whiz, PhD
A paper in Nature Methods presents Segment Anything for Microscopy, a tool for segmentation and tracking in multidimensional microscopy data. https://go.nature.com/3QiRonW
February 16, 2025 at 8:43 PM
A paper in Nature Methods presents Segment Anything for Microscopy, a tool for segmentation and tracking in multidimensional microscopy data. https://go.nature.com/3QiRonW
Reposted by ToxicoloGee Whiz, PhD
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
February 3, 2025 at 10:11 PM
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective @jclinical-invest.bsky.social www.jci.org/articles/vie...
Reposted by ToxicoloGee Whiz, PhD
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted www.nature.com/articles/s4...
February 4, 2025 at 3:00 AM
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted www.nature.com/articles/s4...
Reposted by ToxicoloGee Whiz, PhD
What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy 🧪 @plosbiology.org plos.io/42FTqFO
February 4, 2025 at 7:16 PM
What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy 🧪 @plosbiology.org plos.io/42FTqFO
Reposted by ToxicoloGee Whiz, PhD
I have big news: @ellis.eu has launched its 2nd major research center, @ellisfinland.bsky.social! I have agreed to start as founding director & the first call for PI positions is open. This is a major opportunity for outstanding researchers, join us! ellisinstitute.fi/PI-recruit
Principal Investigator positions at ELLIS Institute Finland | ELLIS Institute Finland
Now recruiting new PIs in artificial intelligence and machine learning
ellisinstitute.fi
February 4, 2025 at 2:40 PM
I have big news: @ellis.eu has launched its 2nd major research center, @ellisfinland.bsky.social! I have agreed to start as founding director & the first call for PI positions is open. This is a major opportunity for outstanding researchers, join us! ellisinstitute.fi/PI-recruit
Reposted by ToxicoloGee Whiz, PhD
📣
Applications for our Grant Programs will be reopening soon! 🎉
🌱 BWCB wants to assist our members in reaching their goals and overcoming obstacles that hinder their advancement in the field of #ComputationalBiology.
🔗 Coming February, 2025
🗓️ Applications due March 1, 2025
🌱 BWCB wants to assist our members in reaching their goals and overcoming obstacles that hinder their advancement in the field of #ComputationalBiology.
🔗 Coming February, 2025
🗓️ Applications due March 1, 2025
February 4, 2025 at 7:41 PM
📣
Reposted by ToxicoloGee Whiz, PhD
🚨 PhD in Bioinformatics & Gene Regulation 🚨
Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me!
www.jobbnorge.no/en/available...
Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me!
www.jobbnorge.no/en/available...
PhD Research Fellow in Bioinformatics and Gene Regulation (274506) | University of Oslo
Job title: PhD Research Fellow in Bioinformatics and Gene Regulation (274506), Employer: University of Oslo, Deadline: Friday, February 28, 2025
www.jobbnorge.no
February 4, 2025 at 7:45 PM
🚨 PhD in Bioinformatics & Gene Regulation 🚨
Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me!
www.jobbnorge.no/en/available...
Join the Bioinformatics in Life Science (BiLS) initiative through a multidisciplinary project to unravel gene regulation from DNA to proteins, co-supervised by E. Valen @jonnings.bsky.social and me!
www.jobbnorge.no/en/available...
Reposted by ToxicoloGee Whiz, PhD
In @science.org today, the discovery of the neuroimmune itch-scratch circuit. And why scratching can makes things worse
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
January 30, 2025 at 9:45 PM
In @science.org today, the discovery of the neuroimmune itch-scratch circuit. And why scratching can makes things worse
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by ToxicoloGee Whiz, PhD
The feasibility of patching a severely damaged heart with stem cells as a bridge to transplant, actualized in a 46-year-old woman @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
January 29, 2025 at 11:48 PM
The feasibility of patching a severely damaged heart with stem cells as a bridge to transplant, actualized in a 46-year-old woman @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/d41...
www.nature.com/articles/s41...
www.nature.com/articles/d41...
Reposted by ToxicoloGee Whiz, PhD
#Liver #metabolism is divided between pericentral & periportal zones, but what are the broader consequences of this zonation? This study shows that proper liver zonation, regulated by R-spondin3, contributes to systemic glucose metabolism & body composition 🧪 @plosbiology.org plos.io/3PR0E2a
January 28, 2025 at 5:48 PM
#Liver #metabolism is divided between pericentral & periportal zones, but what are the broader consequences of this zonation? This study shows that proper liver zonation, regulated by R-spondin3, contributes to systemic glucose metabolism & body composition 🧪 @plosbiology.org plos.io/3PR0E2a
Reposted by ToxicoloGee Whiz, PhD
We hope other labs find it as useful as we do! Given that it's free, we also hope it can be used in teaching labs, which are often low resourced. Congratulations to all authors! #zebrafish 🧠🧪🧬 bmcbioinformatics.biomedcentral.com/articles/10....
Marigold: a machine learning-based web app for zebrafish pose tracking - BMC Bioinformatics
Background High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and lar...
bmcbioinformatics.biomedcentral.com
January 28, 2025 at 4:23 PM
We hope other labs find it as useful as we do! Given that it's free, we also hope it can be used in teaching labs, which are often low resourced. Congratulations to all authors! #zebrafish 🧠🧪🧬 bmcbioinformatics.biomedcentral.com/articles/10....
Reposted by ToxicoloGee Whiz, PhD
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
January 26, 2025 at 12:13 AM
Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵
Reposted by ToxicoloGee Whiz, PhD
We are hiring!
We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration.
Background in data visualization useful but not required.
If you’re interested or know of anyone, please get in touch or pass along!
RaredonLab.com
Description & teasers attached:
We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration.
Background in data visualization useful but not required.
If you’re interested or know of anyone, please get in touch or pass along!
RaredonLab.com
Description & teasers attached:
January 26, 2025 at 1:12 PM
We are hiring!
We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration.
Background in data visualization useful but not required.
If you’re interested or know of anyone, please get in touch or pass along!
RaredonLab.com
Description & teasers attached:
We have a fully-funded 2-year T32 post-doc slot to study spatial biology in lung regeneration.
Background in data visualization useful but not required.
If you’re interested or know of anyone, please get in touch or pass along!
RaredonLab.com
Description & teasers attached: