Tigem
@tigem.bsky.social
The Telethon Institute of Genetics and Medicine (TIGEM) is a Telethon Foundation research center located in Pozzuoli (Italy) that aims to help people with rare genetic disorders across the world.
Pinned
Tigem
@tigem.bsky.social
· Oct 6
🚀 Launch your career in advanced gene and cell therapies! 🚀
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
🎓Are you looking to pursue a #PhD and make real impact in science?
The new RAREFIND #MSCA-COFUND PhD Program offers a unique opportunity to dive into cutting-edge #genetherapy and #celltherapy research with top-tier, interdisciplinary training across 22 leading labs at TIGEM and SR-Tiget.
The new RAREFIND #MSCA-COFUND PhD Program offers a unique opportunity to dive into cutting-edge #genetherapy and #celltherapy research with top-tier, interdisciplinary training across 22 leading labs at TIGEM and SR-Tiget.
October 28, 2025 at 3:54 PM
🎓Are you looking to pursue a #PhD and make real impact in science?
The new RAREFIND #MSCA-COFUND PhD Program offers a unique opportunity to dive into cutting-edge #genetherapy and #celltherapy research with top-tier, interdisciplinary training across 22 leading labs at TIGEM and SR-Tiget.
The new RAREFIND #MSCA-COFUND PhD Program offers a unique opportunity to dive into cutting-edge #genetherapy and #celltherapy research with top-tier, interdisciplinary training across 22 leading labs at TIGEM and SR-Tiget.
🚀 Launch your career in advanced gene and cell therapies! 🚀
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
October 6, 2025 at 10:55 AM
🚀 Launch your career in advanced gene and cell therapies! 🚀
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
RAREFIND #MSCA-COFUND #PhD Programme opens its call for applications!
👉Know more and apply now: www.rarefind-cofund.eu
#RAREFINDPhD
Reposted by Tigem
Join our lab dibernardo.tigem.it for the #ERC-funded project DIMERCIRCUITS at @tigem.bsky.social. We are building synthetic gene circuits to power next-generation gene and cell therapies. We are looking for candidates with a PhD in #SyntheticBiology or related. Apply by email: [email protected]
September 10, 2025 at 10:36 AM
Join our lab dibernardo.tigem.it for the #ERC-funded project DIMERCIRCUITS at @tigem.bsky.social. We are building synthetic gene circuits to power next-generation gene and cell therapies. We are looking for candidates with a PhD in #SyntheticBiology or related. Apply by email: [email protected]
📢 Global Call for Scientific Talent – Join the #FondazioneTelethon Institutes!
We're looking for exceptional scientists to join #TIGEM and #SR-Tiget, two world-class research centers at the forefront of innovation in #genetherapy, #celltherapy, #geneediting, #genomics, and #molecularmedicine.
We're looking for exceptional scientists to join #TIGEM and #SR-Tiget, two world-class research centers at the forefront of innovation in #genetherapy, #celltherapy, #geneediting, #genomics, and #molecularmedicine.
June 3, 2025 at 10:51 AM
📢 Global Call for Scientific Talent – Join the #FondazioneTelethon Institutes!
We're looking for exceptional scientists to join #TIGEM and #SR-Tiget, two world-class research centers at the forefront of innovation in #genetherapy, #celltherapy, #geneediting, #genomics, and #molecularmedicine.
We're looking for exceptional scientists to join #TIGEM and #SR-Tiget, two world-class research centers at the forefront of innovation in #genetherapy, #celltherapy, #geneediting, #genomics, and #molecularmedicine.
Back From #ASGCT!!!
TIGEM was pleased to take part in the ASGCT Conference 2025, where we had the opportunity to present our latest research and engage with the gene and cell therapy community!
@asgct.bsky.social
TIGEM was pleased to take part in the ASGCT Conference 2025, where we had the opportunity to present our latest research and engage with the gene and cell therapy community!
@asgct.bsky.social
May 19, 2025 at 12:20 PM
Back From #ASGCT!!!
TIGEM was pleased to take part in the ASGCT Conference 2025, where we had the opportunity to present our latest research and engage with the gene and cell therapy community!
@asgct.bsky.social
TIGEM was pleased to take part in the ASGCT Conference 2025, where we had the opportunity to present our latest research and engage with the gene and cell therapy community!
@asgct.bsky.social
🌍 Attending #ASGCT2025 in #NewOrleans?
Don’t miss this Scientific Symposium hosted by the Coalition of International Gene Therapy Societies:
📌 Clinical Trials Around the Globe
🗓️ [Today, May 16th]
🕗 8:00 AM – 9:45 AM
📍 Room 293–296
#GeneTherapy #ASGCT #AAV #Retina #LiverGeneTherapy #RareDisease
Don’t miss this Scientific Symposium hosted by the Coalition of International Gene Therapy Societies:
📌 Clinical Trials Around the Globe
🗓️ [Today, May 16th]
🕗 8:00 AM – 9:45 AM
📍 Room 293–296
#GeneTherapy #ASGCT #AAV #Retina #LiverGeneTherapy #RareDisease
May 16, 2025 at 12:17 PM
🌍 Attending #ASGCT2025 in #NewOrleans?
Don’t miss this Scientific Symposium hosted by the Coalition of International Gene Therapy Societies:
📌 Clinical Trials Around the Globe
🗓️ [Today, May 16th]
🕗 8:00 AM – 9:45 AM
📍 Room 293–296
#GeneTherapy #ASGCT #AAV #Retina #LiverGeneTherapy #RareDisease
Don’t miss this Scientific Symposium hosted by the Coalition of International Gene Therapy Societies:
📌 Clinical Trials Around the Globe
🗓️ [Today, May 16th]
🕗 8:00 AM – 9:45 AM
📍 Room 293–296
#GeneTherapy #ASGCT #AAV #Retina #LiverGeneTherapy #RareDisease
🎗️ It’s MPS Awareness Day.
At TIGEM, we stand with patients — especially those with MPS VI (Maroteaux-Lamy syndrome), a rare lysosomal disorder caused by ARSB gene mutations.
At TIGEM, we stand with patients — especially those with MPS VI (Maroteaux-Lamy syndrome), a rare lysosomal disorder caused by ARSB gene mutations.
May 15, 2025 at 4:38 PM
🎗️ It’s MPS Awareness Day.
At TIGEM, we stand with patients — especially those with MPS VI (Maroteaux-Lamy syndrome), a rare lysosomal disorder caused by ARSB gene mutations.
At TIGEM, we stand with patients — especially those with MPS VI (Maroteaux-Lamy syndrome), a rare lysosomal disorder caused by ARSB gene mutations.
📢Applications for SEMM PhD program are now open! 🎉
We have 2 open positions at TIGEM in the PhD program in Systems Medicine.
Deadline: June 9th – don’t miss it!
Apply here: www.semm.it/education/ho...
#PhD #SystemsMedicine #TIGEM #SEMM #PhDOpportunity #BiomedicalResearch #CallForApplications
We have 2 open positions at TIGEM in the PhD program in Systems Medicine.
Deadline: June 9th – don’t miss it!
Apply here: www.semm.it/education/ho...
#PhD #SystemsMedicine #TIGEM #SEMM #PhDOpportunity #BiomedicalResearch #CallForApplications
May 9, 2025 at 8:06 AM
📢Applications for SEMM PhD program are now open! 🎉
We have 2 open positions at TIGEM in the PhD program in Systems Medicine.
Deadline: June 9th – don’t miss it!
Apply here: www.semm.it/education/ho...
#PhD #SystemsMedicine #TIGEM #SEMM #PhDOpportunity #BiomedicalResearch #CallForApplications
We have 2 open positions at TIGEM in the PhD program in Systems Medicine.
Deadline: June 9th – don’t miss it!
Apply here: www.semm.it/education/ho...
#PhD #SystemsMedicine #TIGEM #SEMM #PhDOpportunity #BiomedicalResearch #CallForApplications
Excited for the International Mammalian Synthetic Biology Workshop (mSBW2025) — the only conference fully focused on mammalian synthetic biology! 🧬
Meet top experts, including @diegodibi.bsky.social, Genomic Medicine Program Coordinator at TIGEM and part of this year’s Organizing Committee.
Meet top experts, including @diegodibi.bsky.social, Genomic Medicine Program Coordinator at TIGEM and part of this year’s Organizing Committee.
April 18, 2025 at 7:43 AM
Excited for the International Mammalian Synthetic Biology Workshop (mSBW2025) — the only conference fully focused on mammalian synthetic biology! 🧬
Meet top experts, including @diegodibi.bsky.social, Genomic Medicine Program Coordinator at TIGEM and part of this year’s Organizing Committee.
Meet top experts, including @diegodibi.bsky.social, Genomic Medicine Program Coordinator at TIGEM and part of this year’s Organizing Committee.
Today we mark #InternationalPompeDiseaseDay, raising awareness for this rare genetic disorder. At TIGEM, supported by #FondazioneTelethon, we combine genetics, molecular biology, clinical research, and patient advocacy to advance new therapies —
April 15, 2025 at 1:35 PM
Today we mark #InternationalPompeDiseaseDay, raising awareness for this rare genetic disorder. At TIGEM, supported by #FondazioneTelethon, we combine genetics, molecular biology, clinical research, and patient advocacy to advance new therapies —
Excited to share the latest work of Pastore group!
Loss of Folliculin drives liver cell damage and cholangiocarcinoma via MiT/TFE activation.
👉 Read the full article: doi.org/10.1038/s414...
Loss of Folliculin drives liver cell damage and cholangiocarcinoma via MiT/TFE activation.
👉 Read the full article: doi.org/10.1038/s414...
Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation - Cell Death & Differentiation
Cell Death & Differentiation - Folliculin depletion results in liver cell damage and cholangiocarcinoma through MiT/TFE activation
doi.org
April 15, 2025 at 9:35 AM
Excited to share the latest work of Pastore group!
Loss of Folliculin drives liver cell damage and cholangiocarcinoma via MiT/TFE activation.
👉 Read the full article: doi.org/10.1038/s414...
Loss of Folliculin drives liver cell damage and cholangiocarcinoma via MiT/TFE activation.
👉 Read the full article: doi.org/10.1038/s414...
🔬 From Sweden to Italy: @andpdb.bsky.social is bringing his expertise in Computational Structural Biology back home!
After working at #KTH (Stockholm), he’s now a Staff Scientist at TIGEM, using AI and physics-based models to design hyperactive enzymes that improve gene therapy for rare diseases.
After working at #KTH (Stockholm), he’s now a Staff Scientist at TIGEM, using AI and physics-based models to design hyperactive enzymes that improve gene therapy for rare diseases.
April 2, 2025 at 1:35 PM
🔬 From Sweden to Italy: @andpdb.bsky.social is bringing his expertise in Computational Structural Biology back home!
After working at #KTH (Stockholm), he’s now a Staff Scientist at TIGEM, using AI and physics-based models to design hyperactive enzymes that improve gene therapy for rare diseases.
After working at #KTH (Stockholm), he’s now a Staff Scientist at TIGEM, using AI and physics-based models to design hyperactive enzymes that improve gene therapy for rare diseases.
🚀 Exciting moments at #HydeParkCoroglio!
Our Prof. Alberto Auricchio, Scientific Director at Tigem in Pozzuoli, took the stage for an inspiring talk.
Our Prof. Alberto Auricchio, Scientific Director at Tigem in Pozzuoli, took the stage for an inspiring talk.
April 2, 2025 at 8:48 AM
🚀 Exciting moments at #HydeParkCoroglio!
Our Prof. Alberto Auricchio, Scientific Director at Tigem in Pozzuoli, took the stage for an inspiring talk.
Our Prof. Alberto Auricchio, Scientific Director at Tigem in Pozzuoli, took the stage for an inspiring talk.
🔬 AAV-based gene therapy for Stargardt disease is safe and effective in large animal models
A work of #IvanaTrapani and #AAVantgardeBio !!!
📄 #ScienceAdvances | doi.org/10.1126/sciadv.adt9354
#GeneTherapy #Ophthalmology #AAV #Stargardt #VisionResearch
A work of #IvanaTrapani and #AAVantgardeBio !!!
📄 #ScienceAdvances | doi.org/10.1126/sciadv.adt9354
#GeneTherapy #Ophthalmology #AAV #Stargardt #VisionResearch
Retinal gene therapy for Stargardt disease with dual AAV intein vectors is both safe and effective in large animal models
AAV-intein-based gene therapy for Stargardt disease proves to be safe and efficacious in large animal models.
doi.org
April 1, 2025 at 12:38 PM
🔬 AAV-based gene therapy for Stargardt disease is safe and effective in large animal models
A work of #IvanaTrapani and #AAVantgardeBio !!!
📄 #ScienceAdvances | doi.org/10.1126/sciadv.adt9354
#GeneTherapy #Ophthalmology #AAV #Stargardt #VisionResearch
A work of #IvanaTrapani and #AAVantgardeBio !!!
📄 #ScienceAdvances | doi.org/10.1126/sciadv.adt9354
#GeneTherapy #Ophthalmology #AAV #Stargardt #VisionResearch
🌟New Research Alert🌟
🧠 Cutting-edge neuroscience from De Leonibus' group, now in #NatureCommunications!
This study reveals how different doses of D1 dopamine agonists bidirectionally regulate memory capacity via fronto-striatal cAMP/PKA signaling in mice.
🧠 Cutting-edge neuroscience from De Leonibus' group, now in #NatureCommunications!
This study reveals how different doses of D1 dopamine agonists bidirectionally regulate memory capacity via fronto-striatal cAMP/PKA signaling in mice.
Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling - Nature Communications
D1 receptor agonists bidirectionally regulate working memory capacity (WMC). Here, the authors show that low doses enhance WMC by activating cAMP/PKA in the striatum, whereas high doses impair it via ...
doi.org
April 1, 2025 at 12:24 PM
🌟New Research Alert🌟
🧠 Cutting-edge neuroscience from De Leonibus' group, now in #NatureCommunications!
This study reveals how different doses of D1 dopamine agonists bidirectionally regulate memory capacity via fronto-striatal cAMP/PKA signaling in mice.
🧠 Cutting-edge neuroscience from De Leonibus' group, now in #NatureCommunications!
This study reveals how different doses of D1 dopamine agonists bidirectionally regulate memory capacity via fronto-striatal cAMP/PKA signaling in mice.
📣 We are hiring!!! 📣
Don't miss your chance to join TIGEM and be part of groundbreaking research! 🔬
🚨Exciting Postdoctoral Opportunity in Gene Therapy & Genome Editing! 🚨
👉 www.tigem.it/newsroom/car...
🚨Research Technician in Gene Therapy & Genome Editing🚨
👉 www.tigem.it/newsroom/car...
Don't miss your chance to join TIGEM and be part of groundbreaking research! 🔬
🚨Exciting Postdoctoral Opportunity in Gene Therapy & Genome Editing! 🚨
👉 www.tigem.it/newsroom/car...
🚨Research Technician in Gene Therapy & Genome Editing🚨
👉 www.tigem.it/newsroom/car...
Postdoctoral Fellow Position in Gene Therapy and Genome Editing – Trapani Lab (TIGEM)
www.tigem.it
March 20, 2025 at 3:30 PM
📣 We are hiring!!! 📣
Don't miss your chance to join TIGEM and be part of groundbreaking research! 🔬
🚨Exciting Postdoctoral Opportunity in Gene Therapy & Genome Editing! 🚨
👉 www.tigem.it/newsroom/car...
🚨Research Technician in Gene Therapy & Genome Editing🚨
👉 www.tigem.it/newsroom/car...
Don't miss your chance to join TIGEM and be part of groundbreaking research! 🔬
🚨Exciting Postdoctoral Opportunity in Gene Therapy & Genome Editing! 🚨
👉 www.tigem.it/newsroom/car...
🚨Research Technician in Gene Therapy & Genome Editing🚨
👉 www.tigem.it/newsroom/car...
Reposted by Tigem
Here is our latest paper in @commsbio.bsky.social We reveal a two-phase TFEB nuclear shuttling driven by calcium release and mTORC1 inhibition, using microfluidics & quantitative modelling. Kudos to Iacopo Ruolo & [email protected] @tigem.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling - Communications Biology
Mathematical modelling and real-time microfluidics-based measurements of nuclear shuttling dynamics of the transcription factor EB (TFEB) demonstrate its biphasic nature in response to nutrient depriv...
www.nature.com
March 17, 2025 at 7:39 AM
Here is our latest paper in @commsbio.bsky.social We reveal a two-phase TFEB nuclear shuttling driven by calcium release and mTORC1 inhibition, using microfluidics & quantitative modelling. Kudos to Iacopo Ruolo & [email protected] @tigem.bsky.social
www.nature.com/articles/s42...
www.nature.com/articles/s42...
🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.
March 12, 2025 at 5:36 PM
🚨 The latest study from #NatureCommunications, led by Pasquale Piccolo, systematically evaluated AAV-mediated liver transduction across different fibrosis models.
Reposted by Tigem
I am excited to help organize #mSBW2025. I hope you can join me and my lab to explore latest advances in this field. Learn more at www.aiche.org/sbe/conferen...
March 11, 2025 at 9:49 AM
I am excited to help organize #mSBW2025. I hope you can join me and my lab to explore latest advances in this field. Learn more at www.aiche.org/sbe/conferen...
🌟New Research Alert🌟
🔬 Exciting findings from Galietta's group, published in #JPhysiology!
This study uncovers how the apical mucus layer alters drug efficacy in the airway epithelium, impacting CFTR inhibition in cystic fibrosis research.
📖Read here: physoc.onlinelibrary.wiley.com/doi/full/10....
🔬 Exciting findings from Galietta's group, published in #JPhysiology!
This study uncovers how the apical mucus layer alters drug efficacy in the airway epithelium, impacting CFTR inhibition in cystic fibrosis research.
📖Read here: physoc.onlinelibrary.wiley.com/doi/full/10....
March 8, 2025 at 10:03 AM
🌟New Research Alert🌟
🔬 Exciting findings from Galietta's group, published in #JPhysiology!
This study uncovers how the apical mucus layer alters drug efficacy in the airway epithelium, impacting CFTR inhibition in cystic fibrosis research.
📖Read here: physoc.onlinelibrary.wiley.com/doi/full/10....
🔬 Exciting findings from Galietta's group, published in #JPhysiology!
This study uncovers how the apical mucus layer alters drug efficacy in the airway epithelium, impacting CFTR inhibition in cystic fibrosis research.
📖Read here: physoc.onlinelibrary.wiley.com/doi/full/10....
🌟New Research Alert 🌟
🔬 We are thrilled to share a groundbreaking study by De Matteis’s group, published in #LifeScienceAlliance, which uncovers a crucial link between mitochondrial dysfunction and protein aggregation in ALS8.
📖Read the article here: www.life-science-alliance.org/content/8/4/...
🔬 We are thrilled to share a groundbreaking study by De Matteis’s group, published in #LifeScienceAlliance, which uncovers a crucial link between mitochondrial dysfunction and protein aggregation in ALS8.
📖Read the article here: www.life-science-alliance.org/content/8/4/...
March 7, 2025 at 3:41 PM
🌟New Research Alert 🌟
🔬 We are thrilled to share a groundbreaking study by De Matteis’s group, published in #LifeScienceAlliance, which uncovers a crucial link between mitochondrial dysfunction and protein aggregation in ALS8.
📖Read the article here: www.life-science-alliance.org/content/8/4/...
🔬 We are thrilled to share a groundbreaking study by De Matteis’s group, published in #LifeScienceAlliance, which uncovers a crucial link between mitochondrial dysfunction and protein aggregation in ALS8.
📖Read the article here: www.life-science-alliance.org/content/8/4/...
Reposted by Tigem
🚀 PhD Opportunity – NC-mTORC1 & Genetic Diseases!
Join @tigem.bsky.social & Univ. of Naples to explore Non-Canonical mTORC1 signaling in mTORopathies like BHD & TSC!
Join @tigem.bsky.social & Univ. of Naples to explore Non-Canonical mTORC1 signaling in mTORopathies like BHD & TSC!
March 6, 2025 at 3:10 PM
🚀 PhD Opportunity – NC-mTORC1 & Genetic Diseases!
Join @tigem.bsky.social & Univ. of Naples to explore Non-Canonical mTORC1 signaling in mTORopathies like BHD & TSC!
Join @tigem.bsky.social & Univ. of Naples to explore Non-Canonical mTORC1 signaling in mTORopathies like BHD & TSC!
🚀 Our mission 🧬
Our mission is to push scientific boundaries through cutting-edge research, innovative therapies, and training the next generation of biomedical experts.
Learn more: www.tigem.it
✨ #Genetics #RareDiseases #MedicalResearch
Our mission is to push scientific boundaries through cutting-edge research, innovative therapies, and training the next generation of biomedical experts.
Learn more: www.tigem.it
✨ #Genetics #RareDiseases #MedicalResearch
March 5, 2025 at 4:59 PM
🚀 Our mission 🧬
Our mission is to push scientific boundaries through cutting-edge research, innovative therapies, and training the next generation of biomedical experts.
Learn more: www.tigem.it
✨ #Genetics #RareDiseases #MedicalResearch
Our mission is to push scientific boundaries through cutting-edge research, innovative therapies, and training the next generation of biomedical experts.
Learn more: www.tigem.it
✨ #Genetics #RareDiseases #MedicalResearch