David Teis
@teislab.bsky.social
Reposted by David Teis
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 14, 2025 at 10:02 AM
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
bravo Maria 👍🥳
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
Yeast cells utilize a TORC2 feedback loop for plasma membrane adaptation to mechanical stress, with increased sterol transport from plasma membrane to endoplasmic reticulum activating TORC2 signaling
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
Robbie Loewith, Aurélien Roux @rouxlab.bsky.social and coworkers
www.embopress.org/doi/full/10....
November 15, 2025 at 6:25 AM
bravo Maria 👍🥳
...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
cool!
Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes https://www.biorxiv.org/content/10.1101/2025.11.06.686945v1
November 8, 2025 at 10:18 AM
...explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
cool!
....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
cool!
Homeostasis! Membranes! Evolution! Yay
Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes https://www.biorxiv.org/content/10.1101/2025.11.06.686945v1
November 8, 2025 at 10:16 AM
....explores an 'experiment of nature' to highlight the broad principles underlying the organisation and evolution of membrane homeostasis....
cool!
cool!
👏👏
Proud to share our study on #LipidDroplet #Motility #Mitochondria #MembraneContactSite now in Cell Reports @cp-cellreports.bsky.social! Big thanks to @rwedlichsoldner.bsky.social, @flofroehlich.bsky.social, @ruferbus.bsky.social, Daniel Kümmel lab, Thomas Becker lab! www.cell.com/cell-reports...
The Myo2 adaptor Ldm1 and its receptor Ldo16 mediate actin-dependent lipid droplet motility
Zhao et al. identify the molecular machinery for lipid droplet motility, consisting
of the type V myosin Myo2, the Myo2 adaptor protein Ldm1, and its surface receptor
Ldo16. They uncover a molecular l...
www.cell.com
November 7, 2025 at 2:48 PM
👏👏
Reposted by David Teis
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
November 7, 2025 at 11:02 AM
We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.
Reposted by David Teis
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Reposted by David Teis
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by David Teis
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
October 31, 2025 at 6:24 AM
Our latest review is now online! 👇
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
@martenslab.bsky.social
Mechanism of autophagy initiation by transmembrane selective autophagy receptors | The EMBO Journal www.embopress.org/doi/full/10....
👏👏
🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
October 27, 2025 at 1:11 PM
👏👏
Reposted by David Teis
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted by David Teis
How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
October 24, 2025 at 2:57 PM
How do cells curb nutrient uptake during quiescence & does it matter?
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
@teislab.bsky.social & Co. show TXNIP-dependent endocytosis of amino acid transporter LAT1/SLC7A5 is essential to prevent cell death and human disease
#RefereedPreprint c/o @reviewcommons.org
www.embopress.org/doi/full/10....
Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease.
More info in our new paper 👇
More info in our new paper 👇
TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence | The EMBO Journal www.embopress.org/doi/full/10....
TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence | The EMBO Journal
imageimageIt remains unclear how cells reduce nutrient uptake in quiescence. This work shows
that the α-arrestin TXNIP couples reduced AKT signaling to endocytosis of the amino
acid transporter LAT1/S...
www.embopress.org
October 20, 2025 at 4:03 PM
Quiescent cells stay alive by eating less. They downregulate amino acid transporters to match reduced demand. When this brake fails -> cell death & disease.
More info in our new paper 👇
More info in our new paper 👇
Reposted by David Teis
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by David Teis
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!
September 4, 2025 at 1:10 PM
🥳 MEGA NEWS: Michi Ebner has been awarded an ERC Starting Grant for his research on Lysosomal Lipid Logistics!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!
PhD students and Postdocs: Join him at the Institute of Molecular Biochemistry (biochem.i-med.ac.at/ebner) at the Biocenter of the Medical University of Innsbruck!
Just awesome science!
rob! way to go🥳 congrats!
While not new, I'm excited to share the official publication of Fountain, Mansat et al. on phagocytic appetite exhaustion, which was selected as a highlighted paper and used as the cover page. Woohoo. journals.biologists.com/jcs/issue/13...
Volume 138 Issue 16 | Journal of Cell Science | The Company of Biologists
journals.biologists.com
September 1, 2025 at 2:16 PM
rob! way to go🥳 congrats!
🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
rdcu.be/evyfX
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
rdcu.be
July 9, 2025 at 7:09 PM
🥳 congrats hesso and team - targeting the folded protein response kills multiple myeloma
Reposted by David Teis
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
rdcu.be/evyfX
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia - Targeting proteostasis in multiple myeloma through inhibition of LTK
rdcu.be
July 9, 2025 at 5:55 PM
Our new paper is out in Leukemia on Targeting proteostasis in multiple myeloma through inhibition of LTK. Thanks to Ludvig and Thea for this great collaborative work
rdcu.be/evyfX
rdcu.be/evyfX
excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps
May 8, 2025 at 4:01 PM
excellent PhD opportunity if you are interested in studying the cell biology of CART cell and AML interaction!! apply now ! also we work in a nice location in the heart of the alps
Reposted by David Teis
Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!
April 15, 2025 at 4:06 PM
Our lab is hiring 1 PhD and 1 Postdoc to study the mechanism of lipid transport using computational methods (Molecular Dynamics, AI). Fully funded by @snsf-ch.bsky.social for 4 years, with amazing collaborators and excellent life and working conditions. Apply by email. Please share and repost!
Reposted by David Teis
Bryce Brownfield's review on the structural biology of Golgi trafficking has been published!
authors.elsevier.com/a/1kqrY3PA3s...
Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!
authors.elsevier.com/a/1kqrY3PA3s...
Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!
authors.elsevier.com
March 28, 2025 at 1:21 PM
Bryce Brownfield's review on the structural biology of Golgi trafficking has been published!
authors.elsevier.com/a/1kqrY3PA3s...
Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!
authors.elsevier.com/a/1kqrY3PA3s...
Bryce is now a postdoc in the @buzbarstow.bsky.social lab, we miss him dearly!
thank you - it’s an important paper!!
I want to thank @jcb.org and the @teislab.bsky.social for this nice highlight, which saves me from writing a long thread (it is all nicely summarized there)! Hopefully it is not the last scramblase we discover (stay tuned….). (2/2)
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Lipid juggling: Any1 scrambles membranes for endosome biogenesis | Journal of Cell Biology | Rockefeller University Press
Schwabl et al. discuss work from Gao et al. demonstrating that the endosomal scramblase Any1 coordinates membrane remodeling and lipid transfer via Vps13 t
rupress.org
March 19, 2025 at 4:20 PM
thank you - it’s an important paper!!
Reposted by David Teis
Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/...
#Membrane #lipid #Organelles #Biochemistry
#Membrane #lipid #Organelles #Biochemistry
March 13, 2025 at 2:38 PM
Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/...
#Membrane #lipid #Organelles #Biochemistry
#Membrane #lipid #Organelles #Biochemistry
Reposted by David Teis
Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...
An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4
Rhomboid proteases are ubiquitous intramembrane serine proteases that can cleave transmembrane substrates within lipid bilayers. They exhibit many and…
sciencedirect.com
February 14, 2025 at 7:14 PM
Our work is finally published! We developed a robust in vitro platform to study a disease relevant membrane protease, notoriously difficult to isolate.This protease has linked to cancer & neurodegen,and our platform opens new doors for structural & drug discovery.
sciencedirect.com/science/arti...
sciencedirect.com/science/arti...