A groundbreaking study reveals a surprising link between oral microbes and pancreatic cancer risk. Researchers found certain bacteria and fungi, inclu

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Dr. Diane Reidy-Lagunes outlines the current state of treatments for pancreatic neuroendocrine tumors (PNETs).

Chen et al. identify two distinct antigen-presenting cancer-associated fibroblast (apCAF) populations across multiple cancer types. Mesothelial-related apCAFs locate near cancer cells while fibrocyte-...

Nature Reviews Cancer, Published online: 25 September 2025; doi:10.1038/s41568-025-00873-0In this Review, Dong and Blanpain outline our current understanding of the epithelial-to-mesenchymal transition in cancer, which we now know is not a simple binary switch but the existence of a series of different tumour states. The authors also discuss the implications of this knowledge for pharmacologically targeting epithelial-to-mesenchymal transition to overcome therapy resistance.

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Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive disease, and standard of care therapies have failed to yield significant clinical benefit, with invasive surgery being the only curat...

Artificial intelligence models are too often assessed against flawed goals — a stumbling block for progress.

Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.

Overcoming resistance to KRAS∗-targeted therapy remains a major challenge. Theardy et al. demonstrate that YAP1 drives the recovery of surface SDC1 upon KRAS∗ inhibition by downregulating ARF6 GAPs, thereby activating RTKs and macropinocytosis to promote resistance. Targeting the YAP1-SDC1 axis represents a promising strategy to combat resistance in KRAS∗-driven cancers.

DNA segments that are naturally excised during immune-cell development can replicate, drive damage at various genomic sites and lead to cancer recurrence.

A wearable sensor enables dynamic and noninvasive monitoring of multiple stress hormones to personalize stress management.

Who should be screened for pancreatic cancer, and when should it start? In this episode of PancChat, host Alisyn Camerota speaks with leading experts Dr. Michael Goggins (Johns Hopkins) and Dr. Anirban Maitra (MD Anderson / NYU Langone) about identifying higher-risk individuals and creating...

Nature Reviews Gastroenterology & Hepatology, Published online: 31 July 2025; doi:10.1038/s41575-025-01100-9Artificial intelligence (AI) is a powerful tool that could be applied to microbiome research. This Perspective discusses best practices and current limitations with the application of AI in microbiome data research, giving insights into future use and practical advice and recommendations on its use.

A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants on cell state and function.

Background The evidence on associations between ultra-processed foods (UPF) and lung cancer risk is limited and inconsistent. Research question Are UPF associated with an increased risk of lung cance...

Chen et al. integrate sc/snRNA-seq with spatial transcriptomics to characterize cellular composition, lineage dynamics, and spatial architecture in PDAC tissues with varying neural invasion status, un...