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Reposted by Simon Cleary

Keith Hornberger @krhornberger.bsky.social · 1d

Some good weekend reading. If you thought we’d put the final nails in the coffin of ivermectin as a Covid treatment, you’d be right. But this Perspective goes the extra mile to put the coffin in a lead-lined box and sink it to the bottom of the ocean. 🧵

Membrane Perturbations and Assay Interferences by Ivermectin Explain Its In Vitro SARS-CoV-2 Antiviral Activities and Lack of Translatability

The antiparasitic drug ivermectin was proposed as a repurposed drug for the treatment of SARS-CoV-2 infection based on in vitro studies, but proved ineffective in high-quality clinical trials. When ex...

pubs.acs.org

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Claire Masson @wclairemasson.bsky.social · 4d

It’s official! 🎉
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇

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Siân Culley @superresolusian.bsky.social · 15d

BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share! www.kcl.ac.uk/jobs/126345-...

Bioimage Analysis Specialist | King's College London

www.kcl.ac.uk

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Lori O'Brien @llobrienlab.bsky.social · 17d

For this #FluorescenceFriday, a gorgeous image of an adult mouse kidney labeled with AQP2 and alpha SMA antibodies. AQP2 (green) marks the collecting duct and distal connecting segment while SMA marks the arterial tree. Courtesy of talented postdoc Sarah McLarnon.

Image of a fluorescently labeled adult mouse kidney showing AQP2 staining of collecting ducts and connecting segment in green and alpha SMA staining of the arterial tree in magenta. The collecting ducts look like squiggly branches.

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Simon Cleary @simoncleary.bsky.social · 19d

PhD scholarships available incl. a project with me & Alex Ivetic at King's College London - great programme, facilities, city, colleagues!

Please forward to any suitable undergraduates/MSc students/research assistants.

Info: kcl-mrcdtp.com/project/enha...

Enhancing pulmonary vascular function to heal injured lungs - MRC DTP

To develop improved treatments for inflammatory diseases, we need a better understanding of how pro-inflammatory leukocyte responses resolve. During inflammatory resolution, some recruited leukocytes ...

kcl-mrcdtp.com

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Will Branchett @wjbranchett.bsky.social · 20d

Pleased to see this out now in @jem.org 🔬

We characterise the early immune response during M. tuberculosis infection in mouse models and demonstrate a detrimental role for type I interferon activated neutrophils in TB lesions. Thanks to all involved @crick.ac.uk and i3S, Porto.

Journal of Experimental Medicine @jem.org · 20d

William J. Branchett, Anne O’Garra @crick.ac.uk et al. reveal that type I signaling early during M. #tuberculosis infection favors #neutrophil swarming and limits CD4+ T cell–#macrophage interactions in #TB lesions, impeding TB disease control. rupress.org/jem/article/...

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Daniyal Jafree @daniyaljafree.bsky.social · 26d

🚨 New paper in @jclinical-invest.bsky.social!

Kidney lymphatics are a promising target in transplant rejection

🗺️ In rejection, lymphatics expand and adversely remodel

⚡️ Although they have an anti-inflammatory profile, they are attacked by the immune system

www.jci.org/articles/vie...

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Dan Davis @dandavis101.bsky.social · Sep 10

New postdoc position available in my lab team! For microscopy of immune cells: please apply or repost or pass on: www.imperial.ac.uk/jobs/search-...

Description

Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...

www.imperial.ac.uk

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Simon Cleary @simoncleary.bsky.social · Aug 19

PhD opportunity: please contact me if you know someone with a strong interest in respiratory science who would like to apply for a Sir David Jack PhD scholarship.
Details here: www.bps.ac.uk/membership-a...
Course fee waivers possible for outstanding international students.

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Beth Psaila @bethpsaila.bsky.social · Aug 15

Thrilled that our paper is in print @science.org!!
*Platelets sequester cell free DNA, including free fetal and tumour-derived DNA*
Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

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Alejo Rodriguez-Fraticelli @alejofraticelli.bsky.social · Aug 5

Vav-Cre has been transformative for the field, but it is a pain in the a** of a line to work with. Has anyone made a better pan-hematopoietic line? Which one? How specific is it?

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Pedro Papotto @ph-papotto.bsky.social · Aug 4

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

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Richard Hewitt @drrjhewitt.bsky.social · Jul 24

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Closing date 7th August.

Please do consider applying!

my.corehr.com/pls/coreport...

my.corehr.com

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Simon Cleary @simoncleary.bsky.social · Jul 18

Enjoyed writing about this important discovery of a 'sluice gate' system enabling lymphatic vessels in the lungs to sense injury and respond by increasing uptake of fluid from the spaces around blood vessels and airways:
rdcu.be/ewCMo

Congrats Chou Chou, Hasina Outtz Reed and colleagues!

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SchurichLab @schurichlab.bsky.social · Jul 17

Very excited to share our new study comparing the metabolic profile of patient-derived CAR-T cells ex vivo.

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients: Cell Reports www.cell.com/cell-reports...

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients

Cook et al. investigate the metabolic profile of DLBCL patient-derived CAR-T cells ex vivo. Comparing Axi-cel (CD28-co-stimulated) and Tisa-cel (4-1BB-co-stimulated) products, they find divergent meta...

www.cell.com

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Jose M. Adrover @adrover.bsky.social · Jul 17

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Hellmut Augustin @hellmutaugustin.bsky.social · Jul 14

Spread the word: The European Center for Angioscience @uniheidelberg.bsky.social continues to grow: We have openings for 2 additional Junior Group Leader positions. Get in touch with us if you are ready to start your own lab. See also corresponding ad in @nature.com: www.nature.com/naturecareer...

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Richard Hewitt @drrjhewitt.bsky.social · May 28

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social

thorax.bmj.com/content/earl...

Epithelial damage and ageing: the perfect storm

Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchymal scarring that is triggered by repeated microinjury to a vulnerable alveolar epithelium. It is increasingly r...

thorax.bmj.com

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Simon Cleary @simoncleary.bsky.social · Jun 27

Public access link: rdcu.be/er3Iq

Nature Reviews Cancer @natrevcancer.nature.com · Jun 26

🚨 Tools of the Trade 🚨

Here, Simon Cleary describes the development of a new stabilization window for intravital imaging, allowing visualization of leukocytes, cancer cells and fluids moving through living lungs.

Imaging lung lymphatics in action in metastatic cancer - Nature Reviews Cancer

In this Tools of the Trade article, Simon Cleary describes the development of a new stabilization window for intravital imaging, which allows the visualization of leukocytes, cancer cells and fluid moving through living lungs.

www.nature.com

Simon Cleary @simoncleary.bsky.social · Jun 23

Interested in new ways to study interactions between cancers and the immune system? If yes, have a read of this article on mine and Longhui Qiu's recent work, featured in Nature Reviews Cancer's Tools of the Trade series: rdcu.be/er3Iq

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Lori O'Brien @llobrienlab.bsky.social · Jun 20

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

Image captured by a light-sheet microscope showing the arterial tree of an adult mouse kidney in magenta

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Neil Dufton @neildufton.bsky.social · Jun 13

My PhD student isolated some liver endothelial cells and got this brilliant image showing the gradual transition of health EC to full EndMT in a very satisfying circle. #fluorescencefriday #fibrosis

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Dave Barry @david-j-barry.bsky.social · May 30

Need help with bioimage analysis? Contact the UK Euro-BioImaging Node to see how we can help!

www.eurobioimaging-access.eu/nodes/uk-node

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Rita Strack @ritastrack.bsky.social · May 28

Very excited about this paper that came online today! InterpolAI can predict missing image data from light microscopy to H&E to MRI for improved volumetric imaging and image analysis.

Nature Methods @natmethods.nature.com · May 28

Can a deep learning model know your data well enough to predict missing parts? InterpolAI accurately interpolates synthetic images between pairs of authentic images to “repair” tissue damage and reduce stitching artifacts across diverse modalities. @deniswirtz.bsky.social bit.ly/453o1i1

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Tatsuya Tsukui @tatsuyatsukui.bsky.social · May 27

You did scRNA-seq of the lung, but can't decide on stromal annotation? Or trying to pick up Xenium probes? We got you! We wrote a review of stromal heterogeneity in the adult lung delineated by recent single-cell genomics studies. journals.physiology.org/doi/full/10....

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