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Federico Gueli @siamosolocani.bsky.social · 1d

Many did not read this: www.cna.org/analyses/202...

Preparing for Civilian Harm Mitigation and Response in Large-Scale Combat Operations

The Department of Defense’s (DOD’s) 2022 Civilian Harm Mitigation and Response Action Plan states that DOD should be prepared to mitigate and respond to civilian harm in any operating environment. Thi...

www.cna.org

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Federico Gueli @siamosolocani.bsky.social · 1d

478T is very beneficial as of today on Nb.1.8.1 with 435S and LF.7 without 493E , could be a good mutation for BA.3.2.2 too probably

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Reposted by Federico Gueli

Ryan Hisner @ryanhisner.bsky.social · 1d

There's been some mixed results on this, but the FCS-adjacent T678 is thought by many to be O-glycosylated, i.e. to have a sugary molecule attached to it. T678I would eliminate that glycan, though what effect it would have is uncertain (as far as I know).

This is a busy region in BA.3.2. 4/6

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Reposted by Federico Gueli

Ryan Hisner @ryanhisner.bsky.social · 1d

@siamosolocani.bsky.social can correct me if I've forgotten any recent 478 mutations. It's apparently a very flexible residue, & this diversifying selection suggests it's on the run from antibodies.

S:339 might be the only site we've seen more variety in, but not quite at this same scale. 3/6

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Reposted by Federico Gueli

Ryan Hisner @ryanhisner.bsky.social · 1d

There's a new BA.3.2.2 from South Africa today. For the most part, there's been little substantial change in BA.3.2 over the past few months—mostly synonymous mutations & very little happening in spike.

But this new one has 3 spike mutations & looks quite interesting. 1/6

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Reposted by Federico Gueli

Ryan Hisner @ryanhisner.bsky.social · 1d

BA.3.2 continues to surprise. It's foothold in both Australia and South Africa is solid, so it's not going to disappear anytime soon. It's also not growing especially quickly or spreading rapidly internationally.

But given enough time to explore, it may do both before long. We'll see. 6/6

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Federico Gueli @siamosolocani.bsky.social · 1d

First ever S:L441V lineages designated both descendants of LP.8.1 both already dying off NY.26.1 and PD.1.2.1

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Federico Gueli @siamosolocani.bsky.social · 2d

Denial is always tricky, because it fails to explain the origin of a a behaviour, event, process, phenomenon.
It fails to give causes and effects.
So human, so old, so past.

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Federico Gueli @siamosolocani.bsky.social · 2d

Thanks Mike

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Reposted by Federico Gueli

Mike Honey @mikehoney.bsky.social · 3d

Huge thanks to all the dedicated variant hunters who persevere with their crucial work away from the limelight, especially to Federico Gueli for his tips on new lineages, eg
bsky.app/profile/siam...
🧵

Federico Gueli @siamosolocani.bsky.social · 3d

Quick Sars cov2 variant update.
XFG.17.2.1 ( 219S 679R) is the fastest then there PE.1.4/PE.1.7 but still an Oceania only lineage.
After them some new designations are to watch XFG.10.4 first XFG designated with 435S
PQ.2.8.1 has S:H445P.

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Federico Gueli @siamosolocani.bsky.social · 2d

a bunch of new XFG designations spanning from 845S to 679R and 704L. B ut the most interesting one is PL.6 a LF.7.1.10 (445P) that got 478T and S:T500A, becoming the ifrst lineage with S:T500A to get a designation

Federico Gueli @siamosolocani.bsky.social · 3d

Quick Sars cov2 variant update.
XFG.17.2.1 ( 219S 679R) is the fastest then there PE.1.4/PE.1.7 but still an Oceania only lineage.
After them some new designations are to watch XFG.10.4 first XFG designated with 435S
PQ.2.8.1 has S:H445P.

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Federico Gueli @siamosolocani.bsky.social · 3d

i would say tha on XFG backbone 679R is the most convergent beneficial mutation right now

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Federico Gueli @siamosolocani.bsky.social · 3d

@snpoehlm.bsky.social

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Reposted by Federico Gueli

Josette Schoenmakers @josetteschoenma.bsky.social · 4d

After 3 months, South Africa has uploaded another BA.3.2.2.

It has 3 mutations in common with the Australian samples, which we haven't seen outside of Australia before. T1195C, C2592T and T6856C. So, it probably migrated after it gained those.

It gained some extra mutations after that.

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Reposted by Federico Gueli

Mike Honey @mikehoney.bsky.social · 3d

Here's the latest variant picture with a global scope, to late September.

XFG.* "Stratus" was higher at 73%.

NB.1.8.1 "Nimbus" fell to 18%.

#COVID19 #SARSCoV2 #Global #NB_1_8_1 #Nimbus #XFG #Stratus
🧵

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Reposted by Federico Gueli

Mike Honey @mikehoney.bsky.social · 3d

The trickle of BA.3.2.2 samples from Western Australia has continued.

While the frequencies of this variant are still quite low, it’s ongoing spread (likely to many thousands of infections by now) gives it every opportunity to acquire the mutations it needs to succeed.

#COVID19 #Australia
🧵

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Federico Gueli @siamosolocani.bsky.social · 3d

Quick Sars cov2 variant update.
XFG.17.2.1 ( 219S 679R) is the fastest then there PE.1.4/PE.1.7 but still an Oceania only lineage.
After them some new designations are to watch XFG.10.4 first XFG designated with 435S
PQ.2.8.1 has S:H445P.

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Reposted by Federico Gueli

Ryan Hisner @ryanhisner.bsky.social · 19d

Attenuation of the SARS-2 furin-cleavage site (FCS) continues apace. It's beginning to look as if some form of FCS-weakening mutation might well become fixed in the near future. Collectively, they are at ~12% globally—a totally unprecedented level—& rising quickly. 1/4

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Reposted by Federico Gueli

Mitì Vigliero @mitivigliero.bsky.social · 5d

CVD

Caso Almasri, no della Camera al processo per Nordio, Piantedosi e Mantovano

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Reposted by Federico Gueli

thetranscendedman @atranscendedman.bsky.social · 8d

Researchers at HSE University and the Russian Academy of Sciences found a 2022 COVID sample from an HIV+ woman in Kaluga that evolved for about two years inside her body.

Clues suggest the virus persisted in her gut before reappearing in her airways.

www.frontiersin.org/journals/cel...

Frontiers | A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19

BackgroundAlthough COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesiz...

www.frontiersin.org

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Reposted by Federico Gueli

Otafuku3 @otafuku3.bsky.social · 8d

@doropfan.bsky.social

筆者欄すごい。HisnerさんやGueliさんも。

thetranscendedman @atranscendedman.bsky.social · 8d

Researchers at HSE University and the Russian Academy of Sciences found a 2022 COVID sample from an HIV+ woman in Kaluga that evolved for about two years inside her body.

Clues suggest the virus persisted in her gut before reappearing in her airways.

www.frontiersin.org/journals/cel...

Frontiers | A highly divergent sample from a nearly extinct SARS-CoV-2 lineage in a patient with long-term COVID-19

BackgroundAlthough COVID-19 is primarily an acute disease, there are cases of persistent infection, primarily in immunocompromised patients. It is hypothesiz...

www.frontiersin.org

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Federico Gueli @siamosolocani.bsky.social · 7d

i think the wave is gone quite globally, probably still up in Indonesia, Western Europe, central and Southern South America

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Reposted by Federico Gueli

JPWeiland @jpweiland.bsky.social · 8d

Both emergency dept and wastewater data suggest a rapid decline in prevalence after a relatively modest summer peak. The lull in evolution continues... with no new fast variants close behind XFG.

That being said, we're still watching BA.3.2*

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Reposted by Federico Gueli

WHO @who.int · 10d

October is Breast Cancer Awareness Month

#BreastCancer is the most common cancer among women globally and represents approximately a quarter of all cancers that occur in women every year.
Breast cancer is highly curable if detected in its early stages and adequate treatment is provided.

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Federico Gueli @siamosolocani.bsky.social · 8d

with the last upload BA.3.2.2 represents 20% of samples collected in September in Western Australia. and 40% of the most recent ones. the tree shows no cluster involved so it is circulation
nextstrain.org/fetch/genome...

Caveat Oceania and Australia have their own epi dynamics

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