Federico Gueli
@siamosolocani.bsky.social
Variant Spotter SC2 .
Reposted by Federico Gueli
Happy US Thanksgiving to those who celebrate!
It’s a dark world at the moment, so finding moments of joy and brightness is important to replenish our achy breaky hearts
It’s a dark world at the moment, so finding moments of joy and brightness is important to replenish our achy breaky hearts
a cartoon of charlie brown and snoopy holding a turkey with the words happy thanksgiving sweetie
Alt: a cartoon of charlie brown and snoopy holding a turkey with the words happy thanksgiving sweetie
media.tenor.com
November 27, 2025 at 11:30 AM
Happy US Thanksgiving to those who celebrate!
It’s a dark world at the moment, so finding moments of joy and brightness is important to replenish our achy breaky hearts
It’s a dark world at the moment, so finding moments of joy and brightness is important to replenish our achy breaky hearts
Reposted by Federico Gueli
6/ The simulation showed that where the wind blew, the virus followed.
In the first few weeks of the virus’ spread, I found that farms downwind were 20x as likely to see outbreaks.
In the first few weeks of the virus’ spread, I found that farms downwind were 20x as likely to see outbreaks.
November 18, 2025 at 9:11 PM
6/ The simulation showed that where the wind blew, the virus followed.
In the first few weeks of the virus’ spread, I found that farms downwind were 20x as likely to see outbreaks.
In the first few weeks of the virus’ spread, I found that farms downwind were 20x as likely to see outbreaks.
Reposted by Federico Gueli
BA.3.2 detected again in New Zealand wastewater 💩
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
November 27, 2025 at 4:46 AM
BA.3.2 detected again in New Zealand wastewater 💩
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Week ended:
💠5 Oct 3.7%
💠2 Nov 1.4%
💠9 Nov 2.0%
#BA32 🎃
Variants with a national percentage of less than 1% are not shown
1/
Reposted by Federico Gueli
Wastewater variants for week ended 9 Nov 2025:
💠NB.1.8.1 (Nimbus) 41.9%
💠XFG (Stratus) 23.0%
💠PE.1.4 17.2%
💠MC.10.2.1 9.6%
💠BA.3.2 3.7%
45% of NZ covered by testing:
💠Auckland
💠Rotorua
💠Wellington
💠Christchurch
💠Dunedin
💠Queenstown
poops.nz
2/
💠NB.1.8.1 (Nimbus) 41.9%
💠XFG (Stratus) 23.0%
💠PE.1.4 17.2%
💠MC.10.2.1 9.6%
💠BA.3.2 3.7%
45% of NZ covered by testing:
💠Auckland
💠Rotorua
💠Wellington
💠Christchurch
💠Dunedin
💠Queenstown
poops.nz
2/
ESR Wastewater Surveillance
poops.nz
November 27, 2025 at 4:46 AM
Wastewater variants for week ended 9 Nov 2025:
💠NB.1.8.1 (Nimbus) 41.9%
💠XFG (Stratus) 23.0%
💠PE.1.4 17.2%
💠MC.10.2.1 9.6%
💠BA.3.2 3.7%
45% of NZ covered by testing:
💠Auckland
💠Rotorua
💠Wellington
💠Christchurch
💠Dunedin
💠Queenstown
poops.nz
2/
💠NB.1.8.1 (Nimbus) 41.9%
💠XFG (Stratus) 23.0%
💠PE.1.4 17.2%
💠MC.10.2.1 9.6%
💠BA.3.2 3.7%
45% of NZ covered by testing:
💠Auckland
💠Rotorua
💠Wellington
💠Christchurch
💠Dunedin
💠Queenstown
poops.nz
2/
9 more BA.3.2 yesterday
4 SA, 1 Ireland, 2 QLD, 2 Germany,
4 SA, 1 Ireland, 2 QLD, 2 Germany,
November 27, 2025 at 7:19 AM
9 more BA.3.2 yesterday
4 SA, 1 Ireland, 2 QLD, 2 Germany,
4 SA, 1 Ireland, 2 QLD, 2 Germany,
Reposted by Federico Gueli
Shoutout to Mike Honey, Ryan Hisner @ryanhisner.bsky.social, and Federico Gueli @siamosolocani.bsky.social for their incredible variant-tracking work. Your contributions keep us all informed. Truly appreciated.
November 25, 2025 at 3:46 AM
Shoutout to Mike Honey, Ryan Hisner @ryanhisner.bsky.social, and Federico Gueli @siamosolocani.bsky.social for their incredible variant-tracking work. Your contributions keep us all informed. Truly appreciated.
BA.3.2 reaches now 100 sequences
November 26, 2025 at 5:28 PM
BA.3.2 reaches now 100 sequences
Reposted by Federico Gueli
Fascinating story about evidence that #H5N1 #birdflu infected vampire bats in South America, raising the prospect of a potential new & dangerous host for the virus. Some good news: The virus didn't appear to spread well among the bats. By @martinenserink.bsky.social. www.science.org/content/arti...
Vampire bats may have contracted H5N1 bird flu in Peru, raising worries about further spread
Bats could form a bridge between marine and terrestrial mammals, scientists say
www.science.org
November 26, 2025 at 4:32 PM
Fascinating story about evidence that #H5N1 #birdflu infected vampire bats in South America, raising the prospect of a potential new & dangerous host for the virus. Some good news: The virus didn't appear to spread well among the bats. By @martinenserink.bsky.social. www.science.org/content/arti...
Reposted by Federico Gueli
GLP-1 drugs may be associated with an increased risk of chronic cough
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough
This cohort study examines the clinical association between glucagon-like peptide 1 receptor agonists and chronic cough.
jamanetwork.com
November 26, 2025 at 4:59 PM
GLP-1 drugs may be associated with an increased risk of chronic cough
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Federico Gueli
Fighting antimicrobial resistance: role of mRNA for lung delivery vs multi-drug resistant bacterial pneumonia www.nature.com/articles/s41...
November 26, 2025 at 5:20 PM
Fighting antimicrobial resistance: role of mRNA for lung delivery vs multi-drug resistant bacterial pneumonia www.nature.com/articles/s41...
Reposted by Federico Gueli
I was very sorry to learn that Walt Dowdle, a former #CDC scientist & leader, has died. Dr. Dowdle served at CDC in several positions, including acting director.
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
Walter Reid Dowdle Obituary November 17, 2025 - McLane Funeral & Cremation Services
View Walter Reid Dowdle's obituary, send flowers, find service dates, and sign the guestbook.
www.mclanefuneralservices.com
November 23, 2025 at 3:55 PM
I was very sorry to learn that Walt Dowdle, a former #CDC scientist & leader, has died. Dr. Dowdle served at CDC in several positions, including acting director.
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
I met him after he'd retired. A font of knowledge, he was always generous with his time. www.mclanefuneralservices.com/obituaries/w...
Reposted by Federico Gueli
This one spotted by @siamosolocani.bsky.social - SUCH a cool example of SARS-CoV-2 evolution! Triple strike! (this happened with Omicron as well, where it took out three serines in a triple strike too).
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
November 23, 2025 at 5:52 PM
This one spotted by @siamosolocani.bsky.social - SUCH a cool example of SARS-CoV-2 evolution! Triple strike! (this happened with Omicron as well, where it took out three serines in a triple strike too).
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
Reposted by Federico Gueli
“Two Black women said they were denied immediate medical attention despite being minutes away from giving birth.
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
Black mothers in Texas and Indiana say hospital staff ignored cries for care while they were in labor
“It was really a horrific situation to be treated like a dog, or not even like a dog, like less than,” mother Mercedes Wells said.
www.nbcnews.com
November 23, 2025 at 2:46 PM
“Two Black women said they were denied immediate medical attention despite being minutes away from giving birth.
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
“The incidents, which happened days apart in different states, highlight long-standing disparities in health outcomes for Black women, health experts say.”
Reposted by Federico Gueli
Vive la différence!
November 19, 2025 at 1:56 PM
Vive la différence!
Reposted by Federico Gueli
This is explosive stuff. Evidence that Jeffrey Epstein not only ran a child sex trafficking operation for powerful men, he also seems to have advised & supported Farage’s far right political projects in Europe and the UK, including Brexit, via Steve Bannon.
bylinetimes.com/2025/11/19/d...
bylinetimes.com/2025/11/19/d...
Dinner with Mr Brexit: Bannon’s European Revolution – Planned with Farage, Backed by Epstein
Nigel Farage was the figurehead and his partner Laure Ferrari started it. Steve Bannon and convicted sex offender Jeffrey Epstein were providing almost daily support
bylinetimes.com
November 20, 2025 at 7:41 AM
This is explosive stuff. Evidence that Jeffrey Epstein not only ran a child sex trafficking operation for powerful men, he also seems to have advised & supported Farage’s far right political projects in Europe and the UK, including Brexit, via Steve Bannon.
bylinetimes.com/2025/11/19/d...
bylinetimes.com/2025/11/19/d...
Reposted by Federico Gueli
Combined with the probable AI bubble burst... this is worrisome.
USA: Total outstanding public debt in billion $.
As off yesterday it is $2 trillion higher then on the 4th of July when the "Big Beautiful Bill" was signed, shifting the debt ceiling.
As off yesterday it is $2 trillion higher then on the 4th of July when the "Big Beautiful Bill" was signed, shifting the debt ceiling.
November 19, 2025 at 10:30 PM
Combined with the probable AI bubble burst... this is worrisome.
Reposted by Federico Gueli
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Sentinel Awarded $100 Million to Prevent Pandemics
www.macfound.org
November 18, 2025 at 10:17 PM
Thrilled to see this finally announced - and glad to see good things still happening to good people!
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Congratulations to Pardis, Christian, and the rest of the Sentinel team! 👏🥳
www.macfound.org/press/press-...
Reposted by Federico Gueli
3 papers @thelancet.com today on the health dangers of ultraprocessed foods and a call for action
The health risks
www.thelancet.com/journals/lan...
The health risks
www.thelancet.com/journals/lan...
November 18, 2025 at 11:42 PM
3 papers @thelancet.com today on the health dangers of ultraprocessed foods and a call for action
The health risks
www.thelancet.com/journals/lan...
The health risks
www.thelancet.com/journals/lan...
Reposted by Federico Gueli
Cue the "progressive" Carney loyalists to rationalize Canada moving backwards on climate.
At COP30 Canada just got awarded the fossil of the day — first time since 2014 (the harper years). Clear sign of how Carney’s pro fossil fuel agenda and backsliding on climate policy is being noticed internationally.
November 19, 2025 at 1:23 AM
Cue the "progressive" Carney loyalists to rationalize Canada moving backwards on climate.
Reposted by Federico Gueli
Fascinating one. Massive increase in ACE2 binding with S:I358F according to @jbloomlab.bsky.social DMS—among the highest of any viable mutation. Seems to inhibit entry and increases vulnerability to antibodies, but with a colossal ACE2 boost like that, it could easily find other Ab-evading muts.
November 19, 2025 at 1:50 AM
Fascinating one. Massive increase in ACE2 binding with S:I358F according to @jbloomlab.bsky.social DMS—among the highest of any viable mutation. Seems to inhibit entry and increases vulnerability to antibodies, but with a colossal ACE2 boost like that, it could easily find other Ab-evading muts.
New branch spotted, it captured my attention from the first sample uploaded to Gisaid.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
November 18, 2025 at 11:43 PM
New branch spotted, it captured my attention from the first sample uploaded to Gisaid.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
One GBW(US-airport surveillance) sample from Fiji Island.
With a rare mutation ( <100seqs in the pandemic) in the RBD and another a bit after the FCS region. and some interesting orf1b mutations in the tree.
Reposted by Federico Gueli
The Gelder Valley is the poultry-dense region where an outbreak of another HPAI subtype, H7N7, started in 2003, spreading across the Netherlands and into Germany and Belgium. It caused the deaths of approximately 30 million chickens. It also spread to at least 89 people, one of whom died. (2/3)
November 18, 2025 at 5:19 AM
The Gelder Valley is the poultry-dense region where an outbreak of another HPAI subtype, H7N7, started in 2003, spreading across the Netherlands and into Germany and Belgium. It caused the deaths of approximately 30 million chickens. It also spread to at least 89 people, one of whom died. (2/3)
Reposted by Federico Gueli
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
November 18, 2025 at 5:19 AM
Worrisome: HIghly pathogenic avian influenza (HPAI, likely H5N1) was reported in a poultry farm (62 thousand layer hens) in Terschuur, The Netherlands. This farm is located in the poultry-dense Gelder Valley, with 195 other poultry farms in a 10-km radius. (1/3)
www.rijksoverheid.nl/actueel/nieu...
www.rijksoverheid.nl/actueel/nieu...
Reposted by Federico Gueli
two new BA.3.2.2 from NSW clustering with previous samples from there, likely local circualtion has started:
nextstrain.org/fetch/genome...
nextstrain.org/fetch/genome...
nextstrain.org
November 17, 2025 at 10:31 AM
Reposted by Federico Gueli
As @siamosolocani.bsky.social has pointed out, these two sequences from Sydney are related to previous BA.3.2 collected there, indicating local spread, not a separate introduction.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
November 17, 2025 at 12:03 PM
As @siamosolocani.bsky.social has pointed out, these two sequences from Sydney are related to previous BA.3.2 collected there, indicating local spread, not a separate introduction.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.
Collection dates in the NSW upload ranged from Sept 20-Nov 2, w/the BA.3.2 being among the more recent: Oct 20 & 27.